Daly replaces lock Courtney Lawes in the only change from the squad that beat Italy.
"Elliot Daly has impressed in training and is now ready to be part of the matchday 23," Jones said.
England won their opening two matches and top the table, while Ireland lost to France and drew with Wales.
Daly, 23, has played four times for England Saxons and also represented England at under-18 and under-20 level.
Ireland could also bring a debutant into midfield, with Ulster's Stuart McCloskey in contention for a first cap if fitness-doubt Jared Payne is ruled out.
Backs: Mike Brown (Harlequins), Danny Care (Harlequins), Elliot Daly (Wasps), Owen Farrell (Saracens), George Ford (Bath Rugby), Alex Goode (Saracens), Jonathan Joseph (Bath Rugby), Jack Nowell (Exeter Chiefs), Anthony Watson (Bath Rugby), Ben Youngs (Leicester Tigers).
Forwards: Dan Cole (Leicester Tigers), Jack Clifford (Harlequins), Jamie George (Saracens), Dylan Hartley (Northampton Saints), James Haskell (Wasps), Paul Hill (Northampton Saints), Maro Itodje (Saracens), George Kruis (Saracens), Joe Launchbury (Wasps), Joe Marler (Harlequins), Chris Robshaw (Harlequins), Billy Vunipola (Saracens), Mako Vunipola (Saracens).
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Wasps centre Elliot Daly is set for his England debut after being named in Eddie Jones' 23-man squad for Saturday's match against Ireland.