9 December 2014 Last updated at 16:43 GMT
Mrs Mujuru, once seen as a future possible leader, has denied plotting against the president.
State media and Mr Mugabe's wife, Grace, have conducted a campaign against her for months.
BBC Africa reviews the demise of Mr Mugabe's main opponents - in 90 seconds.
Video produced by Baya Cat
President Robert Mugabe of Zimbabwe has sacked his Vice-President, Joice Mujuru, after accusing her of plotting to kill him.