Three men were injured in the blast at the premises on Plumpton Road in Hoddesdon, Hertfordshire, last October.
Two of them, Jashar Lamallari, 37, and Ardian Lamallari, 42, both from Wood Green, London, later died in hospital.
Simon Thomerson, 40, from Southerland Avenue in Maida Vale, London, has been charged with two counts of manslaughter by gross negligence.
He also faces charges of breaching health and safety laws.
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The explosion happened at about at 16:40 BST on 3 October.
At the time Hertfordshire Police said the unit was unoccupied, but it was believed the men had been carrying out some work on the building.
Mr Thomerson was released on bail and will appear before magistrates in St Albans on 16 August.
A man has been charged following the deaths of two brothers in an explosion at an industrial unit.