Proud went under 46 seconds for the first time, beating his own record in the men's 4x100m freestyle with 45.97.
Aimee Willmott won her fourth medal with 400m individual medley gold.
Lizzie Simmonds, who set a British record in the 100m backstroke on the opening night, took gold in the 200m in a season's best 2:00.91, just outside her own British record.
Proud, 21, of the Plymouth Leander team, broke Mark Foster's 14-year-old short-course 50m freestyle British record on the opening day, clocked 46.69 in the 100m freestyle and on Sunday added the 50m butterfly with a time of 22.39 seconds.
Willmott, 22 - who also won gold in the 200m IM and 400m freestyle, plus silver in the 200m butterfly - captured the 400m title in 4:28.26, an impressive six seconds ahead of the rest of the field.
Stockport Metro's Liam Selby took gold in the men's 50m butterfly with a narrow victory in a time of 23.56.
Anna Hopkin of Bath University lowered the personal best time she posted in the morning heats to win 50m freestyle gold in 24.44.
A superb anchor leg from Rebecca Turner guided the City of Sheffield, also featuring Maya Westlake, Darcy Deakin and Ellie Faulkner, to gold in the women's 4x100 freestyle relay in 7:53.70.
Calum Tait finished more than a body length ahead of the next placed swimmer in the men's 200m breaststroke, posting a personal best 2:05.42.
The women's 200m freestyle final went down to the final touch but it was Loughborough University's Sophie Smith who touched first to take gold in 1:56.03, only 0.02 seconds outside her lifetime best.
In the men's 200m freestyle final, Loughborough University's Adam Barrett won in a season's best 1:43.72.

Homes in Elnor lane, Whaley Bridge, Derbyshire, had to be evacuated following reports of the explosion at about 22:30 BST on Wednesday.
An army Explosive Ordnance Disposal team attended the address early on Thursday morning. No-one has been reported injured.
The man is being held on suspicion of causing an explosion to endanger life.
Live updates from the East Midlands
High Peak councillor Andrew Fox, who lives nearby, said: "We heard a large explosion around 10:30pm, we rang the police and reported our concerns."
Residents in Elnor Lane were asked to leave their homes during the investigation but have since returned.
One house remains cordoned off by police. Police and fire investigators are trying to establish the cause of the explosion.

The picture of Men Drinking in a Pub appears to have another work on the reverse, partly covered by wall paint.
The piece was found during renovation of the artist's previous home in Whitworth Terrace, Spennymoor, by new owners Joe and Deborah Smith.
Auctioneer and art expert John Anderson said it was "a piece of salvage that may yield a masterpiece".
"Most artists, if suddenly touched by the muse will grab whatever is available to work out the inspiration," he said.
The artist, who died last year, started working in the mines when he was 14 and became famous for his paintings of everyday life in the industrial North East after attending the Pitman's Academy.
"In this case, presumably, he looked at it and thought 'there's a painting I'm not satisfied with'," said Mr Anderson.
"Rather than going to the shop when he was panelling the bathroom cupboard, this was a cheap and convenient expedient."
Mrs Smith, whose father was Cornish's cousin, said the panel was not signed but "it is definitely a Cornish because his son-in-law Michael has authenticated it and has written a letter of authentication".
The painting is to be auctioned by Anderson and Garland in September.
An early self-portrait of the artist with a hidden portrait of his wife on the other side was sold by the auctioneers for Â£13,500 in January.
Ben Proud claimed his fourth British record of the ASA National Winter Meet on the final day in Sheffield.
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A man has been arrested following a "large explosion" at a house in a village.
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A painting by "Pitman painter" Norman Cornish has been discovered being used as a bath panel in his former home.