Police, fire and ambulance personnel were called to scene at about 15:00. They were assisted by a coastguard rescue helicopter.
Unconfirmed reports have said a Ford Transit van and a campervan collided head-on.
One person is thought to have been taken to hospital by helicopter with serious injuries.
Traffic Scotland has warned drivers in the area to expect delays.
The A9 Perth to Inverness road has been closed in both directions following an accident near Kincraig.