The boy, 16, suffered serious injuries in the attack in Chatham High Street at the junction of Upbury Way between 19:30 GMT and 20:15 GMT on Friday.
Two men aged 18 and 19-years-old have been arrested following the incident and are currently in custody.
The 16-year-old and the two men in custody are believed to be known to each other, Kent Police said.
The force said it was seeking to speak to a further two suspects.
A teenage boy is in a serious condition after he was allegedly struck by two cars then chased and assaulted.