The League One champions have confirmed Leon Barnett, Ryan Jennings, Kevin McNaughton and Reece Wabara will be allowed to exit.
Midfielders Chris McCann and Jordan Flores are offered new deals.
Emyr Huws, Jack Hendry, Billy Mckay, Andrew Taylor, Dan Lavercombe and Danny Whitehead have all been out on loan but will return for pre-season.
Wigan Athletic have announced that four players will leave the club when their contracts expire during the summer.