That was just below its record performance achieved the previous year, although 2015 included a one-off gain from licensing fees.
Turnover was up 14% to £447m while employee numbers were up by 12% to almost 4,000.
Almac operates across the world, with more than half its staff based in Craigavon.
The company said 2016 had seen "significant investment" on expanding its US HQ at Souderton, Pennsylvania.
Almac also recently announced a £5m investment at its global HQ campus in Craigavon to build an additional lab and office facility.
Further investment is being planned as part of its global expansion strategy and will be announced throughout the year.
In January the firm bought a factory in the Republic of Ireland as a direct result of Brexit.
A major part of the Craigavon-based business is making products for big drugs firms.
It told a Commons committee its customers need it to have a guaranteed presence in the EU for regulatory reasons.
Group chief executive Alan Armstrong said: "2016 was a very successful year for Almac as we continued to deliver upon our global expansion strategy including investment of around £31m in new facilities, equipment and resources."

9 October 2016 Last updated at 10:18 BST
But one of them, Donald Trump, has landed himself in some big trouble after comments he made about women 11 years ago were released.
In the past Donald Trump has used words like "pig", "fat" and "ugly" to describe women he disagreed with.
Now a 2005 video has come out, in which he said even worse things about women.
Since the recording was made public, Donald Trump has released a video statement where he apologised for the comments.
But Hillary Clinton has said that Trump should not be president after what he has said.
She says that his words will have a negative effect on women and girls.
People in Donald Trump's own party have said they strongly disagree with the things he has said. Some of them have said they will no longer be supporting him in the election.
The president of the United States is one of the most powerful and important jobs in the world, and the winner of this year's election will take over from current president Barack Obama.
These big presidential debates are shown on TV to try to help people make their mind up about who they want to vote for in the election.

The government has announced contracts with Asian companies worth $4.5bn billion dollars.
President Ali Bongo signed the agreements on the eve of the country's 50th anniversary of its independence from France.
The projects will revamp infrastructure and create about 50,000 jobs.
Gabon's oil output has been declining for years and the new deals are presented as the first steps towards diversification.
The largest deal is the with OLAM, a Singapore-based company which plans to develop a huge palm oil plantation in the south east.
The government wants to become the leading palm oil producer in Africa.
In terms of infrastructure, the OLAM deal involves the construction of a refinery, and there are plans for a possible port.
Another agreement was signed with the Indian company M3M,  to build 5,000 low-cost housing units over the next two years.
Ramky Infrastructure, another Indian construction company, will build 1,000 kilometres of tarred road over the next three years in a $1.5bn project that will be jointly financed by the Gabonese government.
Gabon has already attracted a number of Asian investors, notably Malaysian and Chinese companies, but most of them were interested in the mining and timber sectors.
Almac, the Craigavon-based pharmaceutical firm, made a pre-tax profit of almost £27m in 2016.
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A big debate takes place on Sunday night in America between Hillary Clinton and Donald Trump, the two people trying to become the next US president.
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Gabon has signed deals to diversify its economy in an attempt to be less reliant on its dwindling oil reserves.