Jason Roy hit 59 and Alex Hales 40, putting on 92 for the first wicket inside seven overs in Abu Dhabi.
Although the tourists faltered as they posted 174-6, the UAE managed only 95-9 in reply, with off-spinner Moeen Ali taking 4-11 and Chris Jordan 2-14.
The first T20 of the three-match series is in Dubai on Thursday at 16:00 GMT.
Eoin Morgan's side are building towards the World Twenty20 in India, which starts in March 2016.
Pakistan won the Test series 2-0 before England took the one-day series 3-1.
England eased to a 79-run win over the United Arab Emirates in their only warm-up game before the Twenty20 series against Pakistan.