The charges include rape, attempted rape, child prostitution, child pornography and drug charges linked to boys from Leicester and Coventry.
The men, aged between 24 and 78, face accusations the boys were abused by a group of men who befriended them.
One man appeared at Birmingham magistrates court on Tuesday and has been remanded into custody.
Tahir Hussain, 33, from St Joseph's Road in Ward End, Birmingham, appeared before magistrates on Tuesday and is charged with four counts of rape, one charged of sexual assault, three of sexual activity with a boy, six of facilitating child prostitution and a count of trafficking for the purposes of sexual exploitation.
Six of the offences are said to have been carried out against in a 15-year-old in February 2010. He has been remanded in custody until 24 August.
The other nine men have been bailed until 18 August.
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Ten men from London and the Midlands have been charged with child sexual exploitation offences against two boys.