; (ii) is juxtaposed with the term natural ; and (iii) appears with the largest or most prominent use of the term natural on each panel of the label on which the term appears, in the same style and color print and at least one-half the size of the term natural. (D) A disclaimer under subparagraph (C) is not required when the term natural is used in reference to one ingredient and is not referring to the whole product. (h) Guidance on certain topics (1) In general The Secretary shall issue guidance with respect to pet food addressing each of the following topics: (A) Methods for substantiating nutritional adequacy of pet foods. (B) Pet food metabolizable energy protocols. (C) Affidavits for pet food testing protocol completion. (D) Data to support a calorie content claim. (E) Analytical variations (Avs). (F) Recommendations for use of menadione sodium bisulfite complex (MSBC) in animal feed. (2) Initial guidance (A) Timing Not later than 18 months after the date of enactment of the PURR Act of 2024 , the Secretary shall issue initial guidance under this subsection. (B) Basis The initial guidance under subparagraph (A) shall be based on the guidance contained in the 2024 edition of the AAFCO Official Publication . . 4. Responsibilities Title X of the Federal Food, Drug, and Cosmetic Act ( 21 U.S.C. 391 et seq. ) is amended by adding at the end the following: 1015. Responsibilities for pet food regulation (a) Delegation of responsibility The Secretary shall delegate to the Director of the Center for Veterinary Medicine responsibility for carrying out section 425 and, as appropriate, other responsibilities and authorities of the Food and Drug Administration with respect to pet food. (b) Duties The responsibilities of the Director of the Center for Veterinary Medicine shall include— (1) conducting and coordinating science-based reviews of pet food ingredient submissions