; and (2) publish prior notice of such meeting in the Federal Register. (e) GAO study Not later than 4 years after the date of enactment of this Act, the Comptroller General of the United States shall submit to the Committee on Energy and Commerce and the Committee on Ways and Means of the House of Representatives and the Committee on Health, Education, Labor, and Pensions of the Senate a report that— (1) addresses the impacts of this Act on— (A) rare disease drug development in the United States; and (B) the increased availability of pediatric information on drugs and biological products for indications for which orphan designation has been granted under section 526 of the Federal Food, Drug, and Cosmetic Act ( 21 U.S.C. 360bb ); and (2) includes— (A) the findings of a survey of companies of varying sizes engaged in the development of orphan drugs