; and (4) $315,000,000 shall be for expenses necessary to prepare for or respond to an influenza pandemic, of which $280,000,000 shall remain available until expended for activities including the development and purchase of vaccines, antivirals, necessary medical supplies, diagnostics, and surveillance tools: Provided, That notwithstanding section 496(b) of the PHS Act, funds allocated under this paragraph may be used for the construction or renovation of privately owned facilities for the production of pandemic influenza vaccines and other biologics, if the Secretary finds such construction or renovation necessary to secure sufficient supplies of such vaccines or biologics: Provided further , That funds provided under this heading for purposes of acquisition of security countermeasures shall be in addition to any other funds made available for such purposes: Provided further, That products purchased with funds made available under this heading may, at the discretion of the Secretary, be deposited in the Strategic National Stockpile pursuant to section 319F–2 of the PHS Act. OPERATIONS, PREPAREDNESS, AND EMERGENCY RESPONSE For carrying out titles III, XII, and subtitles A and B of title XXVIII of the PHS Act, operations and emergency response activities related to countering potential chemical, biological, radiological, and nuclear threats and other public health emergencies, $499,606,000: Provided, That of the amounts made available under this heading, $5,000,000 shall remain available through September 30, 2026, to support emergency operations: Provided further, That of the amounts made available under this heading, $15,000,000 shall remain available through September 30, 2025, to support coordination of the development, production, and distribution of vaccines, therapeutics, and other medical countermeasures: Provided further, That of the amounts made available under this heading, $10,000,000 shall remain available until September 30, 2025, for advanced research and development, manufacturing, production,