; (II) an application for a patent described in subclause (I)(aa) that is sought by the sponsor of the application or holder of the licensure described in clause (i); or (III) such other patent or application for a patent as the Secretary determines appropriate. (iv) (I) Except as provided in subclause (II), clause (i) shall apply with respect to any original application submitted under this subsection on or after the date of enactment of the Medication Affordability and Patent Integrity Act and to any amendments or supplements to such original application. (II) In the case of an application submitted under this subsection before the date of enactment of the Medication Affordability and Patent Integrity Act , the requirements of clause (i) apply with respect to— (aa) any applicable patent issued on or after such date of enactment