; (2) identify, track, and publicly report drug resistance data, and trends using available data related to the antimicrobial drug; (3) develop and implement education and communications strategies, including communications for individuals with limited English proficiency and individuals with disabilities, for health care professionals and patients about appropriate use of the antimicrobial drug; (4) submit an appropriate use assessment to the Secretary, the Committee, the Administrator of the Food and Drug Administration, and the Director of the Centers for Disease Control and Prevention every 2 years regarding use of the antimicrobial drug, including how the drug is being marketed; (5) submit a plan for registering the drug in additional countries where an unmet medical need exists; (6) ensure a reliable drug supply chain, where any interruption to the supply chain will not last for more than 60 days in the United States; (7) complete any postmarketing studies required by the Food and Drug Administration in a timely manner; (8) produce the drug at a reasonable volume determined with the Director to ensure patient access to the drug; (9) abide by the manufacturing and environmental best practices in the supply chain for the control of discharge of antimicrobial active pharmaceutical ingredients to ensure minimal discharge into, or contamination of, the environment by antimicrobial agents or products as a result of the manufacturing process