; and (2) by adding at the end of Schedule I the following: (e) (1) Unless specifically exempted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of fentanyl-related substances, or which contains their salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation. (2) In paragraph (1), the term fentanyl-related substances includes the following: (A) Any substance that is structurally related to fentanyl by one or more of the following modifications: (i) By replacement of the phenyl portion of the phenethyl group by any monocycle, whether or not further substituted in or on the monocycle. (ii) By substitution in or on the phenethyl group with alkyl, alkenyl, alkoxy, hydroxy, halo, haloalkyl, amino or nitro groups. (iii) By substitution in or on the piperidine ring with alkyl, alkenyl, alkoxy, ester, ether, hydroxy, halo, haloalkyl, amino or nitro groups. (iv) By replacement of the aniline ring with any aromatic monocycle whether or not further substituted in or on the aromatic monocycle. (v) By replacement of the N-propionyl group by another acyl group. (B) 4′-Methyl acetyl fentanyl. (C) Crotonyl fentanyl. (D) 2′-Fluoro ortho-fluorofentanyl. (E) Ortho-Methyl acetylfentanyl. (F) Thiofuranyl fentanyl. (G) Ortho-Fluorobutyryl fentanyl. (H) Ortho-Fluoroacryl fentanyl. (I) Beta-Methyl fentanyl. (J) Phenyl fentanyl. (K) Para-Methylfentanyl. (L) Beta′-Phenyl fentanyl. (M) Benzodioxole fentanyl. . 3. Removal from schedule I (e) of fentanyl-related substances Section 201 of the Controlled Substances Act ( 21 U.S.C. 811 ) is amended by adding at the end the following new subsection: (k) (1) If the Secretary finds, based on the factors specified in paragraph (4), that a substance listed in schedule I(e) has no potential for abuse, the Secretary shall— (A) notify the Attorney General at least 90 days prior to submitting an evaluation scientific and medical evaluation