; appropriations To carry out this section, there is authorized to be appropriated to the Office, and there is appropriated, out of any monies in the Treasury not otherwise appropriated, $35,000,000 for each of fiscal years 2024 through 2027. . 5. Bolstering commitments to State grants for substance use disorder treatment and prevention (a) State opioid response grants (1) In general To carry out activities under section 1003 of the 21st Century Cures Act ( 42 U.S.C. 290ee–3 note) relating to opioids by the State agency responsible for administering the substance abuse prevention and treatment block grant under subpart II of part B of title XIX of the Public Health Service Act ( 42 U.S.C. 300x–21 et seq. ), there is authorized to be appropriated, and there is appropriated, $5,500,000,000 for each of fiscal years 2024 through 2028. (2) Flexibility in use of funds Section 1003(b) of the 21st Century Cures Act ( 42 U.S.C. 290ee–3 note) is amended by adding at the end the following: (3) Flexibility States and Indian tribes may use amounts provided under grants under this subsection to support substance use disorder treatment care and related services regardless of whether the patient involved has a primary diagnosis of opioid use disorder, so long as the individual has a substance use disorder diagnosis. (4) Rule of construction Nothing in this subsection shall be construed to prohibit States from using grant funds under this subsection to allocate amounts to local governments to establish subgrantee awards in such localities. . (3) Substance abuse prevention and treatment block grants Section 1935(a) of the Public Health Service Act ( 42 U.S.C. 300x–35(a) ) is amended to read as follows: (a) Appropriations To carry out this subpart, subpart III, and section 505(d), there is authorized to be appropriated, and there is appropriated, out of any monies in the Treasury not otherwise appropriated, $3,000,000,000 for each of fiscal years 2024 through 2028, and $2,500,000,000 for each of fiscal years 2029 through 2033. .