1. Short title This Act may be cited as the Gene Synthesis Safety and Security Act . 2. Gene synthesis (a) Guidance Not later than 1 year after the date of enactment of this Act, the Secretary of Health and Human Services (referred to in this section as the Secretary ) shall update the Screening Framework Guidance for Providers of Synthetic Double-Stranded DNA to account for scientific and technological advancements with respect to mitigating risk of unauthorized individuals or individuals with malicious intent from using nucleic acid synthesis technologies to obtain biological agents or toxins of concern. Such guidance shall include recommendations related to— (1) screening for sequences that the Secretary determines may contribute to toxicity, pathogenicity, or virulence; (2) screening and verification of the identity and legitimacy of customers; (3) the identification, evaluation, and use of appropriate software or other tools to enable the screening described in paragraphs (1) and (2); (4) ensuring nucleic acid synthesis activities are carried out in compliance with existing regulations under part 73 of chapter 42, part 331 of chapter 7, part 121 of chapter 9, and part 774 of chapter 15, Code of Federal Regulations (or successor regulations); (5) implementing appropriate safeguards, which may include the use of such software or other tools, in gene synthesis equipment to facilitate screening of nucleic acid sequences and, as applicable, customers; (6) maintaining records of customer orders, metadata, and screening system or protocol performance in specified formats, which may include standardized machine-readable and interoperable data formats