1. Short title This Act may be cited as the DeOndra Dixon INCLUDE Project Act of 2024 . 2. Down syndrome research Part A of title IV of the Public Health Service Act ( 42 U.S.C. 281 et seq. ) is amended by adding at the end the following: 404P. Down syndrome research (a) In general The Secretary, acting through the Office of the Director of NIH, and in consultation with other Federal agencies and partners, shall carry out a program of research, training, and investigation related to Down syndrome to be known as the INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE Project or the INCLUDE Project . (b) Program elements The program under subsection (a) shall include research, training, and investigation related to— (1) high-risk, high reward basic science studies of the effects of chromosome 21 on human development and health; (2) assembling and maintaining a large study population of individuals with Down syndrome; (3) expanding the number of clinical trials that are inclusive of, or expressly for, individuals with Down syndrome, including novel biomedical and pharmacological interventions and other therapies designed to promote or enhance activities of daily living; (4) the biological mechanisms in individuals with Down syndrome responsible for structural and functional anomalies in cells, tissues, and organs, cognitive and behavioral dysfunction, and stunted growth; (5) the identification of biomarkers for the detection of risk factors, diagnosis, and customized interventions and treatments for conditions co-occurring with Down syndrome; (6) why several co-occurring conditions, such as Alzheimer’s Disease and autoimmunity, are prevalent in individuals with Down syndrome and how such conditions can be treated concurrently with Down syndrome; and (7) improving the quality of life of individuals with Down syndrome and their families. (c) Coordination