AIDS response and human rights. The Supreme Court found this requirement unconstitutional as it applies to United States nongovernmental organizations and their foreign affiliates in 2013. (11) According to the Trans Murder Monitoring Project, which monitors homicides of transgender individuals, there were at least 327 cases of reported killings of trans and gender-diverse people between October 1, 2021, and September 30, 2022. (12) In many countries, intersex individuals experience prejudice and discrimination because their bodies do not conform to general expectations about sex and gender. Because of these expectations, medically unnecessary interventions are often performed in infancy without the consent or approval of intersex individuals, in violation of international human rights standards. (13) Asylum and refugee protection are critical last-resort protections for LGBTQI individuals, but those who seek such protections face ostracization and abuse in refugee camps and detention facilities. They are frequently targeted for violence, including sexual assault, in refugee camps and in immigration detention. LGBTQI individuals may be segregated against their will for long periods in solitary confinement, in an effort to protect them from such violence, but prolonged solitary confinement itself represents an additional form of abuse that is profoundly damaging to the social and psychological well-being of any individual. (14) The global COVID–19 pandemic has exacerbated inequalities that LGBTQI individuals face, including access to health care, stigma, and discrimination, undermining LGBTQI rights around the world. (15) In December 2011, President Barack Obama directed all Federal foreign affairs agencies to ensure that their diplomatic, humanitarian, health and foreign assistance programs take into account the needs of marginalized LGBTQI communities and persons. (16) In 2015, the Department of State established the position of Special Envoy for the Human Rights of LGBTQI Persons. (17) In 2021, President