; and (4) $301,991,000 shall be for expenses necessary to prepare for or respond to an influenza pandemic, of which $274,000,000 shall remain available until expended for activities including the development and purchase of vaccines, antivirals, necessary medical supplies, diagnostics, and surveillance tools: Provided , That notwithstanding section 496(b) of the PHS Act, funds allocated under this paragraph may be used for the construction or renovation of privately owned facilities for the production of pandemic influenza vaccines and other biologics, if the Secretary finds such construction or renovation necessary to secure sufficient supplies of such vaccines or biologics: Provided, That of the amounts made available under this heading, $300,000,000 is designated by the Congress as being for an emergency requirement pursuant to section 251(b)(2)(A)(i) of the Balanced Budget and Emergency Deficit Control Act of 1985. OPERATIONS, PREPAREDNESS, AND EMERGENCY RESPONSE For carrying out titles III, XII, and subtitles A and B of title XXVIII of the PHS Act, operations and emergency response activities related to countering potential chemical biological, radiological, and nuclear threats and other public health emergencies, $541,686,000: Provided, That of the amounts made available under this heading, $5,000,000 shall remain available through September 30, 2026, to support emergency operations: Provided further, That of the amounts made available under this heading, $50,000,000 shall remain available through September 30, 2025, to support coordination of the development, production, and distribution of vaccines, therapeutics, and other medical countermeasures. MANUFACTURING AND PRODUCTION For carrying out title III and subtitles A and B of title XXVIII of the PHS Act, for advanced research and development, manufacturing, production, procurement, distribution, and the acquisition, construction, alteration, or renovation of non-federally owned facilities for the production and purchase of medical countermeasures,