; annual reports The Director of the Centers for Disease Control and Prevention shall, each year, update the report entitled Antibiotic Use in the United States to include updated information on progress and opportunities with respect to data, programs, and resources for prescribers to promote appropriate use of antimicrobial drugs. (c) Report on antimicrobial prophylactics Not later than 3 years after the date of enactment of this part, the Director of the Centers for Disease Control and Prevention shall publish a report on antimicrobial prophylactics. 399OO–6. Definitions In this part— (1) the term antimicrobial drug — (A) means, subject to subparagraph (B), a product that is— (i) a drug that directly inhibits replication of or kills bacteria or fungi, or acts on the substances produced by such bacteria or fungi, relevant to the proposed indication at concentrations likely to be attainable in humans to achieve the intended therapeutic effect; or (ii) a biological product that acts directly on bacteria or fungi or on the substances produced by such bacteria or fungi; and (B) does not include— (i) a drug that achieves the effect described by subparagraph (A)(i) only at a concentration that cannot reasonably be studied in humans because of its anticipated toxicity; or (ii) a vaccine; and (2) the term Committee means the Committee on Critical Need Antimicrobials established under section 399OO(a). .