; (11) in paragraph (14), as redesignated by paragraph (5), by striking providing, and all that follows through the period at the end and inserting providing services to children in an early childhood education program. ; (12) by inserting after paragraph (14), as redesignated by paragraph (5), the following: (15) Evidence-based The term evidence-based means any educational activity, strategy, intervention, or policy design that demonstrates a statistically significant effect on improving relevant outcomes for intended beneficiaries at the individual, classroom, program, school, institutional, education, or workforce system level based on evidence from at least 1 well-designed and well-implemented study capable of causal inference, particularly randomized-control trials. (16) Evidence use The term evidence use means activities that build the capacity of practitioners to effectively understand evidence-based practices and scientifically valid research— (A) to comprehend the design principles of evidence-based practices and identify, select, implement, and adapt such practices in heterogeneous local educational contexts; (B) to support high-quality teaching and learning and the continuous improvement of education systems; and (C) which may be informed by the synthesis of an evidence base related to a specific activity, strategy, intervention, or policy design, based on consistent findings across multiple studies or sites to support the generality of results and conclusions. ; (13) in paragraph (17), as redesignated by paragraph (5), by striking (including teachers and other practitioners) and that conforms to standards and inserting in collaboration with practitioners or education system leaders and that conforms to the principles ; (14) by inserting after paragraph (17), as redesignated by paragraph (5), the following: (18) Geographic region The term geographic region means each of the 10 geographic regions served by the regional educational laboratories.