event of significance determination may be submitted to the appropriate Federal official, if the appropriate Federal official has not independently determined that such an event of significance has occurred, by any of the following: (A) The Governor of an affected State. (B) A leadership official of an affected Indian Tribe. (C) The executive official of the District of Columbia or a territory or possession of the United States, including Puerto Rico, the Virgin Islands, Guam, the Commonwealth of the Northern Mariana Islands, and the Trust Territories of the Pacific Islands, and American Samoa, if affected. (D) Any other comparable elected or politically appointed representative as determined by the Secretary, if affected. (2) Harmful algal bloom or hypoxia event of significance determination At the discretion of an appropriate Federal official, or at the request of an eligible requester under subsection(b)(1), an appropriate Federal official, in consultation with the Steering Committee and NOAA, shall determine whether a harmful algal bloom or hypoxia event is an event of significance. (3) Considerations In making a determination under paragraph (2), the appropriate Federal official shall consider such factors as the following: (A) The risk to public health and the potential severity of the detrimental environmental effects of the harmful algal bloom or hypoxia event at issue. (B) The potential to spread, the potential economic, social, and subsistence use impacts of such event. (C) The relative magnitude of impacts in relation to past occurrences of harmful algal blooms or hypoxia events that occur on a recurrent or annual basis. (D) The geographic scope, including the potential to affect several municipalities, to affect more than one State, or to cross an international boundary. (4) Mitigation relief Upon determination that a harmful algal bloom or hypoxia event of significance has occurred under paragraph (2), the appropriate Federal official is authorized to make sums available, from funds appropriated for