grants or contracts, a program of research, training, and investigation related to Down syndrome to be known as the INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE Project or the INCLUDE Project. (b) Program elements The program under subsection (a) shall include research, training, and investigation related to— (1) high-risk, high reward basic science studies of the effects of chromosome 21 on human development and health