; and (ii) by redesignating subparagraphs (A) and (B) as clauses (i) and (ii), respectively, and moving the margins of such clauses (as so redesignated) two ems to the right; (B) by redesignating paragraphs (1), (2) (as so amended), and (3) as subparagraphs (A), (B), and (C), respectively, and moving the margins of such subparagraphs (as so redesignated) two ems to the right; (C) in the matter preceding subparagraph (A) (as so redesignated), by striking shall establish guidelines for the following: and inserting the following: , with respect to all research conducted or supported by the National Institutes of Health, do the following: (1) Establish and maintain animal care guidelines for the following: ; and (D) by adding at the end the following: (2) Establish a system of meaningful incentives to encourage the use of existing humane and scientifically satisfactory nonanimal methods in research proposals. (3) Ensure that, before any research involving the use of animals is approved or performed all scientifically satisfactory nonanimal methods for obtaining the results sought have been fully evaluated. (4) Ensure that— (A) research proposals are reviewed by at least one person who has expertise in nonanimal research methods; and (B) reviewers of the research proposals have access to a reference librarian with expertise in evaluating the adequacy of the searches for nonanimal methods described in the research proposals. (5) Establish and maintain research proposal guidelines for conducting thorough searches for nonanimal alternatives to the use of animals for biomedical and behavioral research. ; and (2) in subsection (c)(1)— (A) in subparagraph (A), by striking and at the end; and (B) by adding at the end the following: (C) a statement of assurance that a scientifically satisfactory nonanimal method of obtaining the result sought is not available