; and (ii) incorporate measures to strengthen the recommendations in the December 2022 guidance of the Food and Drug Administration titled Best Practices for Convening a GRAS Panel . (G) The revision shall create a process that requires the Secretary to systematically reassess any substance that was determined to be GRAS if the initial determination did not meet the revised standards for such a determination, in accordance with the procedures and resources in section 409A of the Federal Food, Drug, and Cosmetic Act, as added by section 3. 3. Office of Food Chemical Safety, Dietary Supplements, and Innovation Chapter IV of the Federal Food, Drug, and Cosmetic Act ( 21 U.S.C. 341 et seq. ) is amended by inserting after section 409 ( 21 U.S.C. 348 ) the following: 409A. Office of Food Chemical Safety, Dietary Supplements, and Innovation (a) Definitions In this section: (1) Food contact substance The term food contact substance has the meaning given such term in section 409(h)(6). (2) Generally recognized as safe for use in food The term generally recognized as safe for use in food means, with respect to the use of a substance in food, that the substance is generally recognized, among experts qualified by scientific training and experience to evaluate its safety, as having been adequately shown through scientific procedures (or, in the case of a substance used in food prior to January 1, 1958, through either scientific procedures or experience based on common use in food) to be safe under the conditions of its intended use, as described in section 201(s). (3) Prior-sanctioned substance The term prior-sanctioned substance means a substance described in paragraph (4) of section 201(s). (4) Reproductive or developmental toxicity The term reproductive or developmental toxicity means— (A) adverse effects on the reproductive systems of female or male humans or animals, that may include alterations to the female or male reproductive system development, the endocrine system, fertility, pregnancy, pregnancy outcomes, or