; (2) has undergone independent scientific review for transparency, completeness, and quality; and (3) reflects the best available science and the weight of the available scientific evidence. 7B. Scientific standards Covered assessments carried out under section 7 and discussion of such assessments and review of third-party assessments carried out under section 7A shall be conducted using scientific information, technical procedures, measures, methods, protocols, methodologies, or models in a manner consistent with the best available science. In carrying out such an assessment, the relevant program office shall integrate all lines of scientific evidence and consider, as applicable, the following: (1) The extent to which the scientific information, technical procedures, measures, methods, protocols, methodologies, or models employed to generate the scientific information are reasonable for and consistent with the intended use of the scientific information. (2) The extent to which the scientific information is relevant for the relevant program office’s use in making a decision regarding a chemical substance. (3) The degree of clarity and completeness with which the data, assumptions, methods, quality assurance, and analyses employed to generate the scientific information are documented and publicly available in a manner that honors legal and ethical obligations to reduce the risks of unauthorized disclosure and re-identification. (4) The extent to which the variability and uncertainty in the scientific information, or in the procedures, measures, methods, protocols, methodologies, or models, are evaluated and characterized. (5) The extent of independent verification or peer review of the scientific information or of the procedures, measures, methods, protocols, methodologies, or models. (6) The ability of the scientific findings and research to be replicated or reproduced. (7) The extent to which the available scientific information supports dose-response modeling, using non-linear approaches. .