; (B) a science-based definition of responsible offshore aquaculture feed or other inputs , including guidance on sourcing feed or other inputs to address long- or short-term concerns, including the availability and scalability of such inputs; (C) potential adverse effects on the environment, wildlife, and human well-being, including from— (i) the use of antibiotics and other pharmaceuticals by offshore aquaculture facilities, including through analyses necessary to establish acceptable rates, impact levels, and risk thresholds, such as analyses of organism antibiotic consumption or metabolization versus excretion to the surrounding environment; (ii) assimilation of pollution originating from such facilities on marine organisms; (iii) the risk posed by misplaced or damaged equipment; (iv) the risk of harmful interactions with wildlife; (v) interbreeding and the spread of disease; (vi) the source and environmental impacts associated with the collection and removal of brood stock for offshore aquaculture operations and impacts of hatcheries and prestocking rearing operations that are specific to offshore aquaculture; (vii) large-scale cultivation of filter-feed bivalve organisms and seaweed on the marine food webs; (viii) offshore aquaculture facilities acting as aggregating devices and increasing the vulnerability of wild fisheries and wildlife populations to fishing or other sources of mortality; (ix) predator control devices and methods; and (x) the use of nonsustainable sources of feed or other inputs, including the use of globally limited marine resources for feed ingredients, environmental impacts, and scalability of alternatives, including— (I) novel ingredients (for example, insect, single cell protein, and algae); (II) traditional ingredients (for example, soya); and (III) other inputs; (D) potential methods and technologies to mitigate adverse effects, including the effects identified under subparagraph (C)