; and (iii) in the case of a determination described in subparagraph (C) of subsection (d)(4), within 180 days of the close of the applicable comment period under subsection (d)(2), issue a final administrative order, with respect to such cosmetic ingredient or nonfunctional constituent (or category thereof), in accordance with subsection (d)(3) specifying the date by which sale of such ingredient or nonfunctional constituent must cease. (g) Safety assessment standards (1) In general In assessing the safety of an ingredient or nonfunctional constituent (or category thereof) under this section, the Secretary shall consider— (A) whether there is adequate evidence to support a reasonable certainty among competent scientists that— (i) in the case of a cosmetic ingredient, the ingredient is not harmful under the recommended or suggested conditions of use or customary or usual use; or (ii) in the case of a nonfunctional constituent, that the nonfunctional constituent is not harmful under the recommended or suggested tolerance levels or the level at which it is customarily or usually present; (B) the probable human exposure to the ingredient or nonfunctional constituent (or category thereof) from expected use in cosmetic products and cosmetic formulations; (C) the probable cumulative and aggregate effect in humans of relevant exposure to the ingredient or nonfunctional constituent (or category thereof) or to any chemically or pharmacologically related substances from use in cosmetics or other products with similar routes of exposure under recommended or suggested conditions of use or their customary use, to the extent adequate data are available for analysis, and if appropriate, available information on the total exposure to a cosmetic ingredient or nonfunctional constituent from all sources