; and (B) by inserting the following after the first sentence: Any member appointed to fill a vacancy occurring before the expiration of the term for which the member’s predecessor was appointed shall be appointed for the remainder of that term and thereafter may be eligible for reappointment to a full term. A member may serve after the expiration of that member’s term until a successor has been appointed. . (c) Consideration of full range of outcomes data Subsection (d)(2) of such section 1181 is amended by adding at the end the following subparagraph: (F) Consideration of full range of outcomes data Research shall be designed, as appropriate, to take into account and capture the full range of clinical and patient-centered outcomes relevant to, and that meet the needs of, patients, clinicians, purchasers, and policy makers in making informed health decisions. In addition to the relative health outcomes and clinical effectiveness, clinical and patient-centered outcomes shall include the potential burdens and economic impacts of the utilization of medical treatments, items, and services on different stakeholders and decision makers respectively. These potential burdens and economic impacts include medical out-of-pocket costs, including health plan benefit and formulary design, non-medical costs to the patient and family, including caregiving, effects on future costs of care, workplace productivity and absenteeism, and healthcare utilization. . (d) Establishment of expert advisory panel Subsection (d)(4)(A) of such section 1181 is amended by adding at the end the following new clause: (iv) Expert advisory panel for high-impact research The Institute shall appoint an expert advisory panel for purposes of assisting and advising the Institute on ways to take into account and target diseases, conditions, and care interventions that have a high-impact on national health expenditures and advance the incorporation of practical evidence into health care delivery in the national priorities for research and the research