; and (B) provide the prescription drug manufacturer with reasonable compensation, which shall be determined by the Bureau, based on the information submitted by the manufacturer under this section including— (i) the risk-adjusted value of any Federal Government subsidies and investments in research and development used to support the development of such drug; (ii) the risk-adjusted value of any investment made by such manufacturer in the research and development of such drug; (iii) the impact of the price, including license compensation payments, on meeting the medical need of all patients; (iv) the relationship between the price of such drug, including compensation payments and the health benefits of such drug