; (B) the alien otherwise meets the definition of a refugee, except that the alien may apply from inside his or her country of nationality; (C) (i) the alien presents himself or herself at a Designated Application Processing Center for consideration of refugee status under this section; or (ii) in the case of an alien who is a minor, a parent or legal guardian of the alien presents an application for the alien; and (D) the alien passes all relevant medical, national security, and background checks. (2) Effect of denial of refugee status The denial of refugee status under the Central American Minors Program— (A) shall not be held determinative with respect to an adjudication under this section; and (B) shall not prejudice the results of an adjudication under this section. (e) Designated Application Processing Centers (1) Establishment Not later than 180 days after the date of the enactment of this Act, the Secretary of State shall establish a minimum of 4 Designated Application Processing Centers in 4 different physical locations in the countries referred to in paragraph (2), with the consent of the host country, if necessary. (2) Locations The Secretary of State shall ensure that at least 1 Designated Application Processing Center is established in— (A) El Salvador, Guatemala, Honduras, and Mexico; and (B) any other country in Central America selected by the Secretary of State. (3) Application for refugee status The Secretary of State shall ensure that any alien who is physically present at a Designated Application Processing Center is permitted— (A) to apply for refugee status under this section; (B) to include his or her family in the application for refugee status, regardless of such alien’s status