; (II) is shovel ready; and (III) will expand the applicant’s capacity for research, prevention or patient care, or is necessary to improve or maintain the quality of the applicant’s research, prevention, or patient care; and (ii) the applicant will— (I) have sufficient funds to meet the non-Federal share of the cost of the infrastructure improvement; (II) use the facility improved or resulting from the project for its intended use for a period of at least 20 years after completion of the project and has sufficient funds available to demonstrate effective use of such facility for its intended use; (III) facilitate reasonable depth and breadth of research activities in each of the three major areas of laboratory research, clinical research, and population-based research, with substantial transdisciplinary research that bridges these scientific areas; (IV) initiate and conduct investigator-initiated, early phase, innovative clinical trials; (V) perform community service, outreach, dissemination, and education and training of biomedical researchers and health care professionals; and (VI) develop and implement strategies or activities designed to reduce racial or ethnic, gender, age, or socioeconomic health disparities in cancer research, cancer care, cancer patient outcomes, or directly in the communities in which the center is located