; or (ii) any updates prompted by new information that demonstrates that an ingredient fails to meet the safety standard, or requires restrictions on use to meet such standard. (B) Chemicals identified pursuant to NIH-funded research The Secretary shall— (i) consult with the Director of the National Institute of Environmental Health Sciences to identify any chemicals that are determined to be of concern pursuant to investigations funded under section 463C of the Public Health Service Act; and (ii) review any such chemicals in accordance with this section to determine whether such chemicals should be prohibited or subject to restrictions under this section. (5) Manufacturer requirements Not later than 1 year after the date on which an ingredient is placed on a list under this subsection, any manufacturer using such ingredient in a cosmetic shall reformulate such cosmetic to— (A) eliminate the use of the ingredient, if it is listed under paragraph (1)(A); or (B) modify the use of the ingredient if it is listed under paragraph (1)(B), to meet the restrictions specified under paragraph (3). (c) Safe without limits list (1) In general Not later than 2 years after the date of the enactment of this subchapter, the Secretary shall issue, by regulation, a list of ingredients that the Secretary has determined are safe for use in cosmetics, without limits or restrictions. (2) Standard for inclusion in list The Secretary may only include an ingredient on the list under paragraph (1) if the Secretary determines that the ingredient meets the safety standard under section 614(a), regardless of— (A) the type and form of cosmetic the ingredient is used in; and (B) the concentration of the ingredient that is used in a cosmetic. (3) Updates and redeterminations After promulgating the initial list pursuant to paragraph (1), the Secretary— (A) shall annually update the list under paragraph (1)