; and (2) issue a rule establishing current good manufacturing standards consistent, to the extent the Secretary determines practicable and appropriate, with such national and international standards. (b) Content of regulations The regulations issued pursuant to subsection (a)(2)— (1) may specify requirements for the use of certain analytical or recordkeeping methods by a manufacturer as may be necessary to ensure that a cosmetic product or cosmetic formulation is not injurious to health under the recommended or suggested conditions of use, or customary or usual use of the product or formulation; and (2) shall not— (A) impose standards for which there is no current and generally available analytic method; or (B) apply to facilities meeting the criteria to be considered a facility under section 604(6), including retail stores or counters offering customized or personalized cosmetics to consumers, or to entities that are in compliance with the good manufacturing practice regulations specified in parts 210 and 211 of title 21, Code of Federal Regulations (or any successor regulations). (c) Timeframe The Secretary shall publish a proposed rule described in subsection (a) not later than 24 months after the date of enactment of the Cosmetic Safety Enhancement Act of 2019 and shall publish a final such rule not later than 36 months after such date of enactment. . (b) Effective date for cosmetic manufacturers Regulations issued pursuant to section 610 of the Federal Food, Drug, and Cosmetic Act (as added by subsection (a)) shall apply with respect to— (1) large manufacturers (as defined in section 744L of such Act (as added by section 202 of this Act)), beginning 180 days after the date on which the final rule described in subsection (a) is effective; (2) midsize manufacturers (as defined in section 744L of such Act (as added by section 202 of this Act)), beginning 210 days after such date