greater risk to human health and there is not an alternative method for testing the cosmetic ingredient that is accepted by the Secretary and the Interagency Coordinating Committee on Validation of Alternative Methods. (3) The animal test was conducted to comply with a requirement of another Federal agency or a State or foreign regulatory authority. (4) In the case of a cosmetic product, cosmetic formulation, or cosmetic ingredient that is also a drug, the animal test was conducted with respect to the approval under chapter V of the application submitted with respect to such product, formulation, or ingredient. (5) The animal test was conducted for purposes not related to developing or manufacturing the cosmetic product, cosmetic formulation, or cosmetic ingredient, and in response to a requirement of a Federal, State, or foreign regulatory authority. . (b) Applicability The amendment made by subsection (a) shall apply with respect to cosmetic products or cosmetic formulations introduced or delivered for introduction into interstate commerce on or after the date that is two years after the date of enactment of this Act. (c) Guidance Not later than 1 year after the date of enactment of this Act, the Secretary shall issue guidance on the acceptability of scientifically reliable and relevant alternatives to animal testing for the safety of cosmetic products, cosmetic formulations, and cosmetic ingredients, and encouraging the use of such methods. (d) Resources regarding animal testing alternatives Not later than 180 days after the date of enactment of this Act, the Secretary shall publish information on the internet website of the Food and Drug Administration regarding resources available for information about non-animal methods, and methods that reduce animal usage, in testing for the safety of cosmetic products, cosmetic formulations, and cosmetic ingredients. (e) Rules of construction (1) Use of evidence Nothing in this section, or the amendment made by this section, shall be construed to prohibit any entity