of the Personal Care Products Safety Act and shall publish a final such rule not later than 3 years after such date of enactment. . (b) Effective date for cosmetic manufacturers (1) Large businesses For businesses of a size greater than the Small Business Administration’s standard for a small business, section 608 of the Federal Food, Drug, and Cosmetic Act (as added by subsection (a)) shall take effect beginning 180 days after the date on which the Food and Drug Administration makes effective cosmetic good manufacturing practices. (2) Small businesses For businesses of a size that meets the Small Business Administration’s standard for a small business, section 608 of the Federal Food, Drug, and Cosmetic Act (as added by subsection (a)) shall take effect beginning 2 years after the date the Food and Drug Administration makes effective cosmetic good manufacturing practices. 104. Adverse event reports Chapter VI of the Federal Food, Drug, and Cosmetic Act ( 21 U.S.C. 361 et seq.), as amended by section 103(a), is further amended by adding at the end the following: 609. Adverse event reporting for cosmetics (a) In general With respect to any cosmetic product distributed in the United States, the responsible person shall submit to the Food and Drug Administration a report of any serious adverse event associated with such cosmetic product, when used in the United States, accompanied by a copy of the label on or with the retail packaging of the cosmetic, any new medical information, related to a submitted serious adverse event report that is received by the responsible person, and an annual report for all adverse events received by the responsible person. (b) Definitions In this section: (1) An adverse event for a cosmetic product is a health-related event associated with the use of this product that is adverse. (2) A serious adverse event for a cosmetic product is an adverse event that— (A) results in— (i) death