; and (B) the number of applicable drugs for which a triggered SPIKE increase would occur for such year of such an alternative percentage, dollar amount, or period were applied for such year. (c) Justification described (1) In general The justification described in this subsection, with respect to a triggered SPIKE increase described in subsection (b)(1) of an applicable drug of a manufacturer, is— (A) all of the information described in paragraph (2); (B) all of the information and supporting documentation described in paragraph (3), as applicable to the increase and drug; and (C) a certification described in paragraph (4). (2) Required information For purposes of paragraph (1), the information described in this paragraph is the following: (A) The individual factors that have contributed to the increase in the wholesale acquisition cost. (B) An explanation of the role of each factor in contributing to such increase. (3) Information as applicable For purposes of paragraph (1), the information and supporting documentation described in this paragraph is the following: (A) Total expenditures of the manufacturer on— (i) materials and manufacturing for such drug; (ii) acquiring patents and licensing for each drug of the manufacturer; and (iii) costs to purchase or acquire the drug from another company, if applicable. (B) The percentage of total expenditures of the manufacturer on research and development for such drug that was derived from Federal funds. (C) The total expenditures of the manufacturer on research and development for such drug. (D) The total revenue and net profit generated from the applicable drug for each calendar year since drug approval. (E) The total costs associated with marketing and advertising for the applicable drug. (F) Additional information specific to the manufacturer of the applicable drug, such as— (i) the total revenue and net profit of the manufacturer for the period of such increase, as determined by the Secretary; (ii) metrics used to determine executive compensation