; (ii) National Laboratories; and (iii) industry entities. (B) Requirements In carrying out the subprogram established under subparagraph (A), the Secretary shall— (i) invest in competitive, nuclear energy-related infrastructure enhancement activities carried out at National Laboratories to ensure researchers have access to state-of-the-art research and development resources; (ii) coordinate with other research and development programs of the Office of Nuclear Energy to ensure that developed technologies and capabilities are part of an integrated investment strategy, the overall focus of which is improving safety, security, reliability, and economics of operating nuclear power plants; and (iii) focus on— (I) new capabilities relating to nuclear energy research and development; (II) enabling technologies beyond individual programs; (III) coordinating capabilities among research and development programs of the Office of Nuclear Energy; (IV) examining new classes of materials not considered for nuclear applications; (V) high-risk research, which could potentially overcome technological limitations