; and (ii) none of the information specified in subsection (e)(2) has substantially changed, except as described in supplements approved under paragraph (4). (B) Content An application for renewal under this paragraph shall include information concerning one or more representative in vitro clinical tests in accordance with subsection (e)(2)(G), except that such representative test or tests shall be different from the representative test or tests relied upon as the representative assay in any prior technology certification that has not yet been reviewed, if applicable. (C) Process The Secretary’s action on an application for renewal of technology certification under this paragraph shall be conducted, to the extent practicable, in coordination with inspections conducted under section 353 of the Public Health Service Act, and any order resulting from such renewal application shall be treated as a technology certification order for purposes of this subchapter. (4) Supplements and reports (A) Supplements Except as provided in subparagraph (B), any person with a technology certification order in effect may seek a supplement to such order upon a change or changes to the information provided in the application for technology certification under subparagraphs (C), (D), and (E) of subsection (e)(2), provided that— (i) such person is an eligible person under subsection (b)(1)