; and (B) chronic stress can potentially affect the expression of genes that regulate the stress response across the life course. (10) According to a 2018 article in the North Carolina Medical Journal entitled Adverse Childhood Experiences (ACEs): An Important Element of a Comprehensive Approach to the Opioid Crisis , adverse childhood experiences (ACEs) are traumatic or stressful experiences, including emotional, physical, or sexual abuse, domestic violence, household substance abuse, household mental illness, parental separation or divorce, and the incarceration of a household family member. (11) According to a 2016 report in Development and Psychopathology entitled Childhood Adversity and Epigenetic Regulation of Glucocorticoid Signaling Genes: Associations in Children and Adults — (A) children and adults are at risk of developing psychiatric disorders and other medical conditions if they have had an adverse childhood experience (ACE); and (B) adults who have had numerous ACEs die nearly 20 years earlier, on average, than adults who have not had numerous ACEs. 3. Sense of Congress It is the sense of Congress that— (1) it is time to build on the reduction in preventable child deaths worldwide achieved by focusing new efforts and attention on— (A) saving children’s lives; and (B) supporting the healthy development of children’s brains; (2) methods of delivering parent training and education on nurturing care, such as the Center for Disease Control and Prevention’s Maternal, Infant, and Early Childhood Home Visiting programs, could help other countries realize greater gains in early childhood development; (3) negative early childhood experiences can obstruct lifelong health and opportunity; (4) well-developed and inquisitive children are the global leaders of tomorrow; (5) countries will only be able to reach and exceed their development goals if their youngest children get a strong start