; and (2) in paragraph (2)(C)— (A) by striking supplement, or and inserting supplement, ; and (B) by inserting , or a de novo classification request after class III device . (e) Small Businesses; Fee Reduction Regarding Premarket Notification Submissions Section 738(e)(2)(C) of the Federal Food, Drug, and Cosmetic Act ( 21 U.S.C. 379j(e)(2)(C) ) is amended by striking 50 and inserting 25 . (f) Fee Waiver or Reduction (1) Repeal Section 738 of the Federal Food, Drug, and Cosmetic Act ( 21 U.S.C. 379j ) is amended by striking subsection (f). (2) Conforming changes (A) Section 515(c)(4)(A) of the Federal Food, Drug, and Cosmetic Act ( 21 U.S.C. 360e(c)(4)(A) ) is amended by striking 738(h) and inserting 738(g) . (B) Section 738 of the Federal Food, Drug, and Cosmetic Act ( 21 U.S.C. 379j ), as amended by paragraph (1), is further amended— (i) by redesignating subsections (g) through (l) as subsections (f) through (k); (ii) in subsection (a)(2)(A), by striking (d), (e), and (f) and inserting (d) and (e) ; and (iii) in subsection (a)(3)(A), by striking and subsection (f) . (g) Effect of failure To pay fees Subsection (f)(1), as redesignated, of section 738 of the Federal Food, Drug, and Cosmetic Act ( 21 U.S.C. 379j ) is amended— (1) by striking or periodic reporting concerning a class III device and inserting periodic reporting concerning a class III device, or de novo classification request ; and (2) by striking all fees and inserting all such fees . (h) Conditions Subsection (g)(1)(A), as redesignated, of section 738 of the Federal Food, Drug, and Cosmetic Act ( 21 U.S.C. 379j ) is amended by striking $280,587,000 and inserting $320,825,000 . (i) Crediting and Availability of Fees Subsection (h), as redesignated, of section 738 of the Federal Food, Drug, and Cosmetic Act ( 21 U.S.C. 379j ) is amended— (1) in paragraph (3)— (A) by striking 2013 through 2017 and inserting 2018 through 2022 ; and (B) by striking subsection (c) and all that follows through the period at the end and inserting subsection (c).