; (2) in subparagraph (B), by striking the period and inserting ; or ; and (3) by adding at the end the following: (C) high impact cutting-edge research that fosters scientific creativity and increases fundamental biological understanding leading to the prevention, diagnosis, or treatment of diseases and disorders, or research urgently required to respond to a public health threat. . 7042. Pain research Section 409J(b) of the Public Health Service Act ( 42 U.S.C. 284q(b) ) is amended— (1) in paragraph (5)— (A) in subparagraph (A), by striking and treatment of pain and diseases and disorders associated with pain and inserting treatment, and management of pain and diseases and disorders associated with pain, including information on best practices for the utilization of non-pharmacologic treatments, non-addictive medical products, and other drugs or devices approved or cleared by the Food and Drug Administration ; (B) in subparagraph (B), by striking on the symptoms and causes of pain; and inserting the following: “on— (i) the symptoms and causes of pain, including the identification of relevant biomarkers and screening models and the epidemiology of acute and chronic pain; (ii) the diagnosis, prevention, treatment, and management of acute and chronic pain, including with respect to non-pharmacologic treatments, non-addictive medical products, and other drugs or devices approved or cleared by the Food and Drug Administration; and (iii) risk factors for, and early warning signs of, substance use disorders in populations with acute and chronic pain; and ; and (C) by striking subparagraphs (C) through (E) and inserting the following: (C) make recommendations to the Director of NIH— (i) to ensure that the activities of the National Institutes of Health and other Federal agencies are free of unnecessary duplication of effort; (ii) on how best to disseminate information on pain care and epidemiological data related to acute and chronic pain