suggesting a risk of harm that was probably caused by the treatment and that was severe or frequent. (iii) Promising practice A practice shall be considered to be a promising practice if the practice is superior to an appropriate comparison practice using conventional standards of statistical significance (in terms of demonstrated meaningful improvements in validated measures of important child and parent outcomes, such as mental health, substance abuse, and child safety and well-being), as established by the results or outcomes of at least one study that— (I) was rated by an independent systematic review for the quality of the study design and execution and determined to be well-designed and well-executed