; (3) an analysis of the risk to the Government in providing the Federal guarantee described under section 4(b); (4) any improvements to eye bonds that the Secretary should consider; (5) the applicability of financial instruments similar to eye bonds to other biomedical research areas such as cancer, Alzheimer’s disease, rare diseases or conditions (as defined in section 526 of the Federal Food, Drug, and Cosmetic Act ( 21 U.S.C. 360bb )) and syndromes of particular concern to children; and (6) any other matter that the Comptroller General or the Director, respectively, determines is appropriate.