1. Short title This Act may be cited as the Opioid Response Enhancement Act . 2. Opioid grant program reauthorization (a) In general Section 1003 of the 21st Century Cures Act ( 42 U.S.C. 290ee–3 note) is amended— (1) in subsection (b)— (A) in paragraph (2)(A), by adding at the end the following: (iii) For each of fiscal years 2019 through 2023, $2,000,000,000. ; and (B) in paragraph (3)— (i) in subparagraph (A)— (I) by striking 2017 and 2018 and inserting 2019 through 2023 ; and (II) by inserting after paragraph (2)(A), the following: and in each of the fiscal years 2019 through 2023, there is authorized to be appropriated from the Account to the Secretary, for the grant program described in subsection (c)(3), $400,000,000, ; and (ii) in subparagraph (B), by striking 2017 and 2018 and inserting 2019 through 2023 ; (2) in subsection (c)— (A) in paragraph (1)— (i) by inserting and Tribal entities after grants to States ; (ii) by inserting and Tribal entities after preference to States ; and (iii) by inserting or Tribal entities before the period at the end; (B) in paragraph (2)— (i) in the matter preceding subparagraph (A)— (I) by inserting , including activities supported by community-based organizations and counties, after carrying out activities ; and (II) by striking to a State ; (ii) in subparagraph (E), by inserting or Tribal entity after State each place that such term appears; and (iii) by adding at the end the following: (F) In addition to carrying out activities related to addressing the opioid epidemic, a State or Tribal entity may use grants awarded under this section for carrying out public-health activities related to addressing other substance abuse, as determined appropriate and as determined to be a substantial or similar public health threat as the opioid epidemic by the State or Tribal entity.