; (2) in subparagraph (B), by striking the period and inserting ; or ; and (3) by adding at the end the following: (C) high impact cutting-edge research that fosters scientific creativity and increases fundamental biological understanding leading to the prevention, diagnosis, or treatment of diseases and disorders, or research urgently required to respond to a public health threat. . 202. Pain research Section 409J(b) of the Public Health Service Act ( 42 U.S.C. 284q(b) ) is amended— (1) in paragraph (5)— (A) in subparagraph (A), by striking and treatment of pain and diseases and disorders associated with pain and inserting treatment, and management of pain and diseases and disorders associated with pain, including information on best practices for utilization of non-pharmacologic treatments, non-addictive medical products, and other drugs approved, or devices approved or cleared, by the Food and Drug Administration ; (B) in subparagraph (B), by striking on the symptoms and causes of pain; and inserting the following: “on— (i) the symptoms and causes of pain; (ii) the diagnosis, prevention, treatment, and management of pain; and (iii) risk factors for, and early warning signs of, substance use disorders; and ; (C) by striking subparagraphs (C) through (E) and inserting the following: (C) make recommendations to the Director of NIH— (i) to ensure that the activities of the National Institutes of Health and other Federal agencies are free of unnecessary duplication of effort; (ii) on how best to disseminate information on pain care; and (iii) on how to expand partnerships between public entities and private entities to expand collaborative, cross-cutting research. ; (2) by redesignating paragraph (6) as paragraph (7)