; preemption A safety determination accepted or made by the Secretary or established under this section shall apply in every State. No State may establish or enforce a safety determination for a cosmetic or an ingredient or nonfunctional constituent of a cosmetic. (f) Effective date of regulations Any regulation or guidance by the Secretary pursuant to this section concerning the safety of a cosmetic or an ingredient or nonfunctional constituent of a cosmetic shall apply beginning no earlier than the date that is 2 years after the date on which such regulation or guidance is issued as final, unless the Secretary determines, after public notice and an opportunity for public comment, that an earlier date of applicability is required to prevent serious adverse health consequences or death to humans. . 9. National Cosmetic Regulatory Databank Chapter VI ( 21 U.S.C. 361 et seq.), as amended by sections 3, 4, 5, 6, 7, and 8, is further amended by adding at the end the following: 610. National Cosmetic Regulatory Databank (a) In general For the purpose of consolidating information pertaining to the regulation of cosmetic safety, the Secretary shall establish and maintain in the center of the Food and Drug Administration with primary responsibility for regulating cosmetics a database, to be known as the National Cosmetic Regulatory Databank, containing— (1) the information submitted to the Secretary under sections 605, 606, 607, and 609