; and (B) as appropriate and necessary, the heads of other Federal departments and agencies. (4) Rural, medium-sized, and economically distressed communities and regions (A) Rural areas (i) In general The Secretary shall ensure that an amount that is not less than 50 percent of the funds provided through the implementation grants for any fiscal year is made available for projects for which the eligible entity is located in a rural area. (ii) Exception Notwithstanding clause (i), the Secretary shall reduce the amount of funds made available under such clause for such projects if the Secretary does not receive a sufficient number of applications of sufficient quality. (B) Medium-sized areas (i) In general The Secretary shall ensure that an amount that is not less than 25 percent of the funds provided through the implementation grants for any fiscal year is made available for projects for which the eligible entity is located in a medium-sized area. (ii) Exception Notwithstanding clause (i), the Secretary shall reduce the amount of funds made available under such clause for such projects if the Secretary does not receive a sufficient number of applications of sufficient quality. (C) Economically distressed community or region The Secretary shall ensure that, to the greatest extent practicable, funds provided through the planning and implementation grants are made available for projects that will serve an economically distressed community or region. (d) Uses of implementation grant funds (1) Economic development and job creation An eligible entity that receives an implementation grant may use the grant funds for a project to— (A) support the creation of new businesses and jobs in a variety of industries and occupations with middle and high-skill jobs; (B) implement local and regional strategies for job creation and growth and economic diversification; (C) cultivate entrepreneurship, including strengthening the entrepreneurial ecosystem, developing entrepreneurship education, and developing business incubator programs