1. Short title This Act may be cited as the Respond to the Needs in the Opioid War Act or the Respond NOW Act . I Opioid Epidemic Response Fund 101. Opioid Epidemic Response Fund (a) In general The Secretary of Health and Human Services (referred to in this section as the Secretary ) shall use any funds appropriated pursuant to the authorization of appropriations under subsection (c) to carry out the programs and activities described in subsection (d) to address the opioid and substance use epidemic. Such funds shall be in addition to any funds which are otherwise available to carry out such programs and activities. (b) Opioid Epidemic Response Fund (1) Establishment of account There is established in the Treasury an account, to be known as the Opioid Epidemic Response Fund (referred to in this subsection as the Funds ), for purposes of funding the programs and activities described in subsection (d). (2) Transfer For each of fiscal years 2018 through 2022, $5,000,000,000 shall be transferred to the Fund from the general fund of the Treasury. (3) Amounts deposited Any amounts transferred under paragraph (2) shall remain unavailable in the Fund until such amounts are appropriated pursuant to subsection (c). (c) Appropriations (1) Authorization of appropriations For the period of fiscal years 2018 through 2022, there is authorized to be appropriated from the Fund to the Department of Health and Human Services, for the purpose of carrying out the programs and activities described in subsection (d), an amount not to exceed the total amount transferred to the Fund under subsection (b)(2), to remain available until expended. (2) Offsetting future appropriations For any of fiscal years 2018 through 2022, for any discretionary appropriation to the Department of Health and Human Services (or any agency therein) pursuant to the authorization of appropriations under paragraph (1) for the purpose of carrying out the programs and activities described in subsection (d), the total amount of such appropriations for the