; and (B) for any other evidence-based activity for preventing controlled substance misuse, abuse, and overdoses as the Director determines appropriate. (4) Research The Director, in coordination with the Assistant Secretary for Mental Health and Substance Use and the National Mental Health and Substance Use Policy Laboratory established under section 501A, as appropriate and applicable, may conduct studies and evaluations to address substance use disorders, including preventing substance use disorders or other related topics the Director determines appropriate. (b) Enhanced controlled substance overdose data collection, analysis, and dissemination grants (1) In general The Director of the Centers for Disease Control and Prevention may— (A) to the extent practicable, carry out any controlled substance overdose data collection activities described in paragraph (2); (B) provide training and technical assistance to States, localities, and Indian tribes for purposes of carrying out such activity; (C) award grants to States, localities, and Indian tribes for purposes of carrying out such activity