; and (B) the Secretary has a senior claim on all assets and collateral under the eye bond to the extent the guarantee provided by the Secretary is not extinguished. (3) Limitation The Secretary may not guarantee— (A) more than $1,000,000,000 for all eye bonds issued pursuant to this Act; and (B) more than $250,000,000 for all eye bonds issued pursuant to this Act in any single fiscal year. (c) Issuance schedule The Secretary shall, in consultation with the Secretary of the Treasury and issuers, establish a schedule for the issuance of eye bonds that ensures that funded projects represent a reasonable sample of diverse causes of vision loss. (d) Risk-Share pool (1) In general With respect to an eye bond guaranteed under this section, the Secretary may allow a risk-share pool capitalized by issuers to provide a first-loss guarantee of the principal and interest of such bond, if the Secretary determines that such first-loss guarantee would— (A) be a robust source of protection for the United States, as guarantor of the eye bond, that reduces the cost of the Federal guarantee to the United States; (B) encourage the flow of private sector capital into biomedical translational research; (C) create a prudent incentive for issuers to contribute additional private capital for biomedical translational research