; and (ii) in the case of an ingredient or cosmetic which is not marketed for sale on or before such date— (I) not later than the end of the 14-month period beginning on the date of the enactment of this subchapter; or (II) if the ingredient or cosmetic is first marketed for sale in interstate commerce after the end of the period described in subclause (I) , not later than 60 days after the date on which such ingredient or cosmetic is first marketed for sale. (B) Updates (i) In general Subject to clause (ii) , a brand owner shall update the data and information submitted under subparagraph (A) annually. (ii) Adverse health effects In the case of information related to an adverse health effect that is suspected to be caused by an ingredient or a cosmetic, a brand owner shall update the information not later than 60 days after receiving such information. (4) Supplier and manufacturer information (A) Use of supplier or manufacturer information In order to meet the requirements of paragraph (1) with respect to an ingredient, a brand owner may submit safety data and information provided by the supplier or manufacturer of the ingredient or cosmetic. (B) Supplier or manufacturer provision of information If a brand owner requests that a supplier or manufacturer of an ingredient provide to such brand owner any of the data and information described under paragraph (2) or under section 617, such supplier or manufacturer shall provide such data and information to such brand owner not later than 90 days after receiving such request. (b) Database (1) Initial publication Not later than 1 year after the date of the enactment of this subchapter, the Secretary shall publish a comprehensive database that— (A) is publicly accessible, including on the public Web site of the Food and Drug Administration