; (iv) expand the number of collaborative multi-institutional research grants related to tick-borne disease; and (v) involve additional national research institutes and national centers of the National Institutes of Health in intramural and extramural research on tick-borne disease, such as the National Institute of Neurological Disorders and Stroke conducting or sponsoring research on neurologic Lyme disease. (D) Evaluation Not later than 2 years after the date of enactment of this Act, the Secretary shall evaluate and make findings on— (i) the feasibility and potential value to the research community of establishing a deidentified human subjects database for Lyme disease and other tick-borne diseases and disorders; (ii) existing government or private biorepositories for Lyme disease and other tick-borne diseases and disorders and whether— (I) specimens and samples are adequate and available to meet researcher needs; or (II) there are problems or challenges for researcher acquisition of samples and specimens; and (iii) the scope and use of specimens and samples from cadavers, the questions and answers such research may provide, and the need for additional support of researchers using cadaver specimens. (E) Priority In carrying out this paragraph, the Secretary shall make it a priority to determine the extent of posttreatment persistence of Borrelia burgdorferi and the clinical significance of such persistence. (2) Development of new and improved diagnostic tests (A) In general The Secretary, in cooperation with the Director of the Office, and acting through the Directors of the Centers for Disease Control and Prevention and the Director of the National Institutes of Health, shall conduct and support research to— (i) provide for the timely evaluation of promising new and improved diagnostic methods, including direct-detection tests, antibody-based tests, and tests based on biosignature and biomarker profiles to make a specific diagnosis or aid in differential diagnoses