clinical practice guidelines may submit amendments to that clinical practice guideline at any time to the Secretary for review by the Secretary. (3) Notification required for certain updates An amendment under paragraph (2) may not add, materially change, or remove a guideline from a set of guidelines, unless notification of such update is made available to applicable eligible professionals. 502. Development (a) Guideline standards The Secretary shall ensure that, to the extent practicable, the development of clinical practice guidelines are guided by the Standards for Developing Trustworthy Clinical Practice Guidelines of the Institute of Medicine and— (1) are developed through a transparent process that minimizes conflicts of interest