; (D) the opportunities specifically afforded by the International Space Station (ISS) to support high priority scientific research and technological developments useful in expanding and sustaining a human presence in cis-lunar space and beyond; (E) a range of exploration mission architectures and approaches for the missions identified under paragraph (1), including capabilities for the Orion crew capsule and the Space Launch System; (F) a comparison of architectures and approaches based on— (i) assessed value of factors including cost effectiveness, schedule resiliency, safety, sustainability, and opportunities for international collaboration; (ii) the extent to which certain architectures and approaches may enable new markets and opportunities for United States private industry, provide compelling opportunities for scientific discovery and technological excellence, sustain United States competitiveness and leadership, and address critical national security considerations and requirements; and (iii) the flexibility of such architectures and approaches to adjust to evolving technologies, partners, priorities, and budget projections and constraints; (G) measures for setting standards for ensuring crew health and safety, including limits regarding radiation exposure and countermeasures necessary to meet those limits, means and methods for addressing urgent medical conditions or injuries, and other such safety, health, and medical issues that can be anticipated in the conduct of the missions identified under paragraph (1); (H) a description of crew training needs and capabilities (including space suits and life support systems) necessary to support the conduct of missions identified under paragraph (1); (I) a detailed plan for prioritizing and phasing near-term intermediate destinations and missions identified under paragraph (1)