1. Short title This Act may be cited as the Combating the Opioid Epidemic Act . 2. Additional funding for the State response (a) Funding Section 1003 of the 21st Century Cures Act ( 42 U.S.C. 290ee–3 note) is amended— (1) in subsection (a), by striking under subsection (b) and inserting under subsection (b)(3) and the appropriations under subsection (b)(4) ; (2) in subsection (b), by adding at the end the following: (4) Additional appropriations In addition to the amounts transferred to the Account under paragraph (2)(A), there are authorized to be appropriated, and there are appropriated, to the Secretary, out of monies in the Treasury not otherwise obligated, $4,474,800,000 for each of fiscal years 2018 through 2027, to carry out the grant program described in subsection (c). Such funds shall remain available until expended. ; and (3) by striking subsection (f). (b) Activities Section 1003(c)(1) of the 21st Century Cures Act ( 42 U.S.C. 290ee–3 note) is amended— (1) by redesignating subparagraph (E) as subparagraph (G)