for each of fiscal years 2019 through 2021, to remain available until expended. (i) Set aside Of the amounts made available for each fiscal year to award grants under subsection (b) for a fiscal year, 5 percent of such amount for such fiscal year shall be made available to Indian tribes, and up to 15 percent of such amount for such fiscal year may be set aside for States with the highest age-adjusted mortality rate associated with opioid use disorders based on the ordinal ranking of States according to the age-adjusted overdose mortality rates of the Centers for Disease Control and Prevention. . (b) Previously appropriated amounts (1) Appropriation of amounts remaining in Account Any unobligated amounts remaining, on the date of enactment of this Act, in the Account For the State Response to the Opioid Abuse Crisis established under section 1003(b) of the 21st Century Cures Act ( Public Law 114–255 ) (as in effect on the day before the date of enactment of this Act) are hereby appropriated to the Secretary of Health and Human Services for purposes of carrying out the grant program under subsection (b) of section 1003 of the 21st Century Cures Act ( Public Law 114–255 ) (as redesignated by subsection (a)(3) of this section). (2) Available until expended Amounts appropriated under paragraph (1) of this subsection or section 1003(b)(3) of the 21st Century Cures Act (as in effect on the day before the date of enactment of this Act) shall remain available until expended. (c) Conforming amendment Section 1004(c) of the 21st Century Cures Act ( Public Law 114–255 ) is amended by striking , the FDA Innovation Account, or the Account For the State Response to the Opioid Abuse Crisis and inserting or the FDA Innovation Account . II Research and innovation 201. Advancing cutting-edge research Section 402(n)(1) of the Public Health Service Act ( 42 U.S.C. 282(n)(1) ) is amended— (1) in subparagraph (A), by striking or