; and (ii) to which subparagraphs (A), (B), (C), and (D) of paragraph (1) do not apply. (B) Applicability of other provisions Nothing in this paragraph shall be construed to preclude or limit the applicability of any other provision of this Act. (C) No effect on other authorities Nothing in this subsection shall be construed to prohibit the Secretary from issuing an order under this section finding a drug to be not generally recognized as safe and effective. (c) Administrative orders (1) In general (A) Generally recognized as safe and effective The Secretary may, on the initiative of the Secretary or at the request of one or more requestors, issue an administrative order determining whether there are requirements under which a specific drug, class of such drugs, or combination of such drugs is determined to be, after substantive review of evidence— (i) not subject to section 503(b)(1); (ii) generally recognized as safe and effective within the meaning of section 201(p)(1); and (iii) not required to be approved under section 505. (B) Not generally recognized as safe and effective The Secretary shall issue an order determining that a drug is not generally recognized as safe and effective within the meaning of section 201(p)(1) for the specified requirements if, after substantive review of evidence, the Secretary determines that— (i) the evidence shows that the drug is not generally recognized as safe and effective within the meaning of section 201(p)(1); or (ii) the evidence is inadequate to show that the drug is generally recognized as safe and effective within the meaning of section 201(p)(1). (2) Nonapplication of certain requirements The requirements of subchapter II of chapter 5 of title 5, United States Code, shall not apply with respect to administrative orders issued under this section. (3) Administrative orders initiated by the Secretary