; or (B) the safety standard results in exposure to the amount or concentration of an ingredient or cosmetic that is shown to produce no adverse health effects, incorporating an margin of safety of at least 1,000 and considering the impact of cumulative exposure from all sources (including environmental sources). (3) Use of other Federal standards If any Federal agency has promulgated a standard for an ingredient that satisfies the requirements under paragraph (1) , the Secretary may treat such standard as the safety standard under paragraph (1) for purposes of such ingredient. (4) Application of safety standard The Secretary may only determine that an ingredient or a cosmetic meets the safety standard under paragraph (1) if there is a reasonable certainty of no harm from exposure to the ingredient or cosmetic. (b) Good manufacturing practices (1) In general The Secretary shall issue guidance prescribing good manufacturing practices for cosmetics and ingredients, including quality control procedures that the Secretary determines are necessary, and shall update such regulations as necessary. (2) Consideration of small business In developing the guidance under paragraph (1) , the Secretary shall consider how such practices will impact small businesses. 615. Cosmetic and ingredient safety information (a) Required submission of all safety information (1) In general Brand owners of cosmetics shall submit to the Secretary (in an electronic format that the Secretary shall determine) all data and information that the brand owner can access regarding the safety of the— (A) ingredients listed on the cosmetic label under section 613 for a cosmetic