; (II) the date on which any hearing with respect to such order is denied under subparagraph (C)(i); (III) the date on which a final decision is made following any hearing with respect to such order under subparagraph (C)(v); or (IV) if no hearing is requested, the date on which the time for requesting a hearing expires. (5) Expedited procedure with respect to administrative orders initiated by the Secretary (A) Imminent hazard to the public health (i) In general In the case of a determination by the Secretary that a monograph drug poses an imminent hazard to the public health, the Secretary may, after informally communicating with any sponsor that will be the subject of such determination, not later than 48 hours before issuance of an order under this subparagraph— (I) issue an interim final administrative order for such drug or combination of drugs under paragraph (1), together with a detailed statement of the reasons for such order; (II) publish in the Federal Register a notice of availability of such order; and (III) provide for a public comment period of at least 45 calendar days after issuance of such interim final order. (ii) Nondelegation The Secretary may not delegate the authority to issue an interim final administrative order under this subparagraph. (B) Safety labeling changes (i) In general In the case of a determination by the Secretary that a change in the labeling of a drug, class of drugs, or combination of drugs subject to this section is reasonably expected to mitigate a significant or unreasonable risk of a serious adverse event associated with use of the drug, the Secretary may, after informally communicating with any sponsor that will be the subject of such determination, not later than 48 hours before issuance of an order under this subparagraph— (I) issue an interim final administrative order in accordance with paragraph (1) to require such change, together with a detailed statement of the reasons for such order; (II) publish in the Federal Register a notice of availability of such order