; (6) a strategy for improving interactions, coordination, and partnerships with other Federal agencies, State and local governments, and global entities; and (7) the latest recommendations of the Tick-Borne Disease Working Group and the steps taken by the agencies and offices of the Department of Health and Human Services to implement those recommendations. 4. Federal activities related to the diagnosis, surveillance, and prevention of, and research on, Lyme disease and other tick-borne diseases and disorders (a) In general The Secretary, in coordination with the Director of the Office, acting as the Secretary determines appropriate through the Director of the Centers for Disease Control and Prevention, the Director of the National Institutes of Health, the Commissioner of Food and Drugs, the Director of the Agency for Healthcare Research and Quality, the Administrator of the Health Resources and Services Administration, the Director of the Indian Health Service, and the heads of other Federal agencies, and in consultation with the Tick-Borne Disease Working Group, shall provide for— (1) the conduct or support of the activities described in paragraphs (1) through (8) of subsection (b); and (2) the coordination of all programs and activities of the Department of Health and Human Services related to Lyme disease and other tick-borne diseases and disorders and Bartonella. (b) Activities The activities to be conducted or supported under subsection (a)(1) consist of the following: (1) Expansion and enhancement of research (A) In general The Secretary shall expand and intensify epidemiological, basic, translational, and clinical research regarding Lyme disease and other tick-borne disease and disorders and bartonellosis to better understand— (i) the pathophysiology of Borrelia burgdorferi and other tick-borne microorganisms that are human pathogens and of Bartonella; (ii) pathophysiological changes over time, including pathogen persistence profiles for patients with differing treatment histories