; or (ii) poses an immediate and serious threat of harm to herself or others that cannot reasonably be prevented by other means; or (B) a health care professional responsible for the health and safety of the prisoner determines that the use of medical restraints is appropriate for the medical safety of the prisoner, and such professional reviews such determination not later than every 6 hours after such use is initially approved until such use is terminated. (2) Least restrictive restraints In the case that restraints are used pursuant to an exception under paragraph (1), only the least restrictive restraints necessary to prevent the harm or risk of escape described in paragraph (1) may be used. (A) Application The exceptions under paragraph (1) may not be applied— (i) to place restraints around the ankles, legs, or waist of a prisoner; (ii) to restrain a prisoner’s hands behind her back; (iii) to restrain a prisoner using four-point restraints