; and (2) wherever possible, ensure that the surveillance program is coordinated with the data and sample collection activities of the National Institutes of Health under section 409K. (d) Technical assistance In making awards under this section, the Secretary may provide direct technical assistance, including personnel support. (e) Coordination with clinical centers The Secretary shall ensure that epidemiological information is made available to clinical centers as supported by the Director of the National Institutes of Health under section 409K. (f) Authorization of appropriations There are authorized to be appropriated such sums as may be necessary to carry out this section. . 5. Food and Drug Administration cerebral cavernous malformations clinical trial preparedness and support program (a) Biomarker qualification program The Secretary of Health and Human Services, acting through the Commissioner of Food and Drugs, shall coordinate with clinical centers, investigators, and advocates to support the qualification of appropriate surrogate biomarkers in an effort to hasten the pace of clinical trials for cerebral cavernous malformation. (b) Clinical outcome assessment qualification The Secretary of Health and Human Services, acting through the Commissioner of Food and Drugs, shall coordinate with clinical centers, investigators, and advocates to support qualification of newly developed patient reported outcome measures for qualify of life as a clinical outcome in an effort to hasten the pace of clinical trials for cerebral cavernous malformation. (c) Investigational new drug application The Secretary of Health and Human Services, acting through the Commissioner of Food and Drugs, shall coordinate with clinical centers, investigators, and advocates to support appropriate investigational new drug applications under section 505(i) of the Federal Food, Drug, and Cosmetic Act ( 21 U.S.C. 355(i) ) in an effort to hasten the pace of clinical trials for cerebral cavernous malformation. (d) Adaptive trial design and