; and (C) by adding at the end the following: (3) Targeted response enhancement grants (A) In general Subject to the availability of appropriations, the Secretary shall use 50 percent of the amount transferred under subsection (b)(2)(A)(iii) in each fiscal year to award supplemental funding grants to at least 10 States and Tribal entities, to expand and enhance grant activities required under this subsection. In awarding such grants, the Secretary shall give preference to areas of greatest need, including as indicated by higher mortality rates associated with opioid overdoses. (B) Use of funds Grants awarded to a State or Tribal entity under this paragraph shall be used for carrying out activities to supplement activities otherwise carried out under this subsection to expand and enhance prevention, treatment, and recovery support efforts in States and Tribal entities hardest hit by the opioid epidemic, which may include public health-related activities such as the following: (i) Expansion of evidence-based strategies for the provision of prevention, treatment, and recovery support services for individuals with opioid use disorders. (ii) Expansion and enhancement of integrated systems of care, including the co-location of services to address the primary and behavioral healthcare needs of individuals with opioid use disorders. (iii) Expansion of efforts to distribute overdose reversal drugs and educate first responders and other relevant community members on the use of such drugs to prevent overdose-related deaths. (iv) Expansion of any activity authorized under the State or Tribal entity grant under paragraph (1) to address the State's or Tribal entity's specific needs related to combatting the opioid crisis. (4) Set aside Of the amount made available for each fiscal year to award grants under paragraph (1), not less than 10 percent of such amount in each such fiscal year shall be provided to Tribal entities. ; (3) by redesignating subsections (d) through (f) as subsections (e) through (g), respectively