; and (ii) indicates the effective dates of such changes. (B) Periodic notification for manufacturing changes otherwise subject to 30-day notice A requestor whose quality system is certified under this section that effectuates device-related changes with respect to in-scope devices, without prior submission of a 30-day notice, shall provide notification to the Secretary of such changes in the requestor’s next periodic report under section 814.84(b) of title 21, Code of Federal Regulations (or any successor regulation). Such notification shall— (i) describe the changes made; and (ii) indicate the effective dates of such changes. (C) Periodic notification for device-related changes otherwise subject to special pma supplement A requestor whose quality system is certified under this section that effectuates device-related changes with respect to in-scope devices, without prior submission of a Special PMA Supplement, shall provide notification to the Secretary of such changes in the requestor’s next periodic report under section 814.84(b) of title 21, Code of Federal Regulations (or any successor regulation). Such notification shall— (i) describe the changes made, including a full explanation of the basis for the changes; and (ii) indicate the effective dates of such changes. (D) Use of notifications for program evaluation purposes Information submitted to the Secretary under subparagraphs (A) through (C) shall be used by the Secretary for purposes of the program evaluation under subsection (d). (c) Duration and effect of certification A certification under this section— (1) shall remain in effect for a period of 2 years from the date such certification is accepted by the Secretary, subject to paragraph (6); (2) may be renewed through the process described in subsection (a)(3); (3) shall continue to apply with respect to device-related changes made during such 2-year period, provided the certification remains in effect, irrespective of whether such certification is renewed after such 2-year period