; and (C) a description of the effectiveness of such recommendations at preventing the diversion of legally prescribed controlled substances; and (7) recommendations, as appropriate, on— (A) whether site-of-use, in-home controlled substance disposal products and packaging technologies require Federal oversight and, if so, which agency or agencies should be responsible for such oversight and, as applicable, review of such products or technologies; and (B) whether there are applicable standards that should be considered to ensure the effectiveness of such products. 5 Postapproval study requirements 3041. Clarifying FDA postmarket authorities (a) Definition of adverse drug experience Section 505–1(b)(1)(E) of the Federal Food, Drug, and Cosmetic Act ( 21 U.S.C. 355–1(b)(1)(E) ) is amended by striking of the drug and inserting of the drug, which may include reduced effectiveness under the conditions of use prescribed in the labeling of such drug, but which may not include reduced effectiveness that is in accordance with such labeling . (b) Safety labeling changes Section 505(o)(4) of the Federal Food, Drug, and Cosmetic Act ( 21 U.S.C. 355(o)(4) ) is amended— (1) in subparagraph (A) by— (A) striking Safety information and inserting Safety or new effectiveness information ; and (B) by striking If the Secretary becomes and all that follows through in the labeling of the drug and inserting If the Secretary becomes aware of new information, including any new safety information or information related to reduced effectiveness, that the Secretary determines should be included in the labeling of the drug ; (2) in clause (i) of subparagraph (B), by inserting before the semicolon , or new effectiveness information ; (3) in subparagraph (C) by striking safety information and inserting safety or new effectiveness information