; (C) research related to improving the quality of life for individuals with CCM and their families; (D) contributions of genetic variation to clinical presentation as targets for therapy; (E) early detection, diagnosis, and treatment of CCM; (F) clinical training programs aimed at increasing the number of scientists and clinicians who are trained to treat patients and carry out the research described in this paragraph; (G) continued development and expansion of novel animal models for preclinical research relating to CCM; (H) pre-clinical and clinical research related to repurposing currently approved drugs for treatment of CCM; (I) proteomic, pharmacological, and cell biological analysis of CCM molecules; (J) biological mechanisms for lesion genesis, development, and maturation; (K) biological mechanisms for lesion bleeding and symptomology; and (L) novel biomedical and pharmacological interventions designed to inhibit new lesion development, lesion growth, and lesion bleeding. (2) Facilitation of research resources