and antibiotic-resistant strains of Clostridium difficile are on the rise. (6) The Centers for Disease Control and Prevention estimate that the annual impact of antibiotic‐resistant infections on the United States economy is more than $20,000,000,000 in excess direct health care costs. Additional costs to the United States economy for lost productivity from antibiotic-resistant infections may be as great as $35,000,000,000 per year. (7) Data from the Centers for Disease Control and Prevention indicate that at least 30 percent of antibiotic drugs used in hospitals are unnecessary or prescribed incorrectly. Similarly, the Centers for Disease Control and Prevention estimate that approximately 30 percent of antibiotic drugs prescribed in outpatient clinics are unnecessary and that approximately 40 percent of orders for antibiotic drugs in nursing homes lacked important prescribing information. Thus, improvements in prescribing antibiotic drugs are necessary across health care settings. (8) The National Action Plan for Combating Antibiotic-Resistant Bacteria, published in March 2015, in response to Executive Order 13676 of September 18, 2014 (79 Fed. Reg. 56931