; (2) a description of all programs and activities funded by the Department of Health and Human Services that are related to the surveillance, diagnosis, treatment, education, or prevention of Lyme disease or other tick-borne disease, and an evaluation of progress and performance based on mission and purpose, and discussion of significant challenges or barriers to performance, to include— (A) for the initial report under this section, a description of the intramural and extramural research portfolios of the Centers for Disease Control and Prevention, the National Institutes of Health, and other agencies and offices of the Department of Health and Human Services which conducted or contracted for research projects related to Lyme disease or on other tick-borne disease or disorder, including information on— (i) the award amount, institution, primary investigator, principal investigative question or questions, and significant conclusions; and (ii) studies that received Federal funds and were terminated, in progress, or initiated in the fiscal year including the date of enactment of this Act and the 5 prior fiscal years; (B) for reports in subsequent years, all of the information described in subparagraph (A), except the reference in subparagraph (A)(ii) to Federal funds terminated, in progress, or awarded in the 6 prior fiscal years shall be treated as reference to such funds in the 2 prior fiscal years; (C) a status and summary report on the National Tick-Borne Disease Surveillance System, including— (i) the type of information collected and stored in the System; (ii) the use, distribution, and availability of such information, including guidelines for such use; and (iii) the use and coordination of surveillance and patient information databases; and (D) information on agreements, partnerships, cooperation, coordination, and data sharing with external entities, such as State and local governments, other Federal agencies, working groups, and global entities