; (5) awarding grants and contracts to specifically develop new and needed vaccines to address TB; (6) awarding grants and contracts to support the training and development of clinical researchers whose research improves the landscape of tools to combat TB; and (7) awarding grants and contracts to support capacity-building and develop clinical trial site infrastructure in the United States and in TB endemic countries to support the aforementioned research activities. I Osteoarthritis and Musculoskeletal Diseases 785. Findings Congress finds as follows: (1) Eighty percent of African-American women and nearly 74 percent of Hispanic men are either overweight or obese, speeding the onset and progression of arthritis. (2) Arthritis affects 46,000,000 people in the United States, and that number will rise to 67,000,000 by the year 2030. (3) Twenty-seven million people in the United States suffer from osteoarthritis, the most common form of arthritis, making it the leading cause of disability in the United States. Osteoarthritis is sometimes referred to as degenerative joint disease. (4) Obesity accelerates the onset of arthritis: 70 percent of obese adults with mild osteoarthritis of the knee at age 60 will develop advanced end-stage disease by age 80. In contrast, just 43 percent of non-obese adults will have end-stage disease over the same time period. (5) Arthritis affects 1 in 5 people in the United States and is the single greatest cause of chronic pain and disability in the United States. (6) Women, African Americans, and Hispanics have more severe arthritis and functional limitations. These same individuals are more likely to be obese, diabetic, and have higher incidence of heart disease—medical conditions that can be improved with physical activity. Instead of moving