; or (B) permits a change in the conditions of use of a sunscreen ingredient, for which human data studies conducted or sponsored by the requestor (or for which the requestor has an exclusive right of reference) were essential to the issuance of such order. (3) Marketed sunscreen The marketed sunscreen ingredients described this paragraph are sunscreen ingredients— (A) marketed in accordance with a final monograph issued under part 330 of title 21, Code of Federal Regulations (including conditions of use thereunder), as in effect on the day before the date of enactment of this section; (B) marketed as category I or III in accordance with a tentative final monograph issued under such part 330 (including conditions of use and any applicable subsequent determinations thereunder), as so in effect; (C) marketed as category I in accordance with an advance notice of proposed rulemaking issued under such part 330 (including conditions of use and any applicable subsequent determinations thereunder), as so in effect; or (D) marketed in accordance with a final order issued under this section. (4) Limitations on product differentiation (A) Only one period Only one 2-year period may be granted per ingredient under paragraph (1). (B) Exclusions No period of product differentiation under this subparagraph shall apply to changes to a sunscreen that are— (i) Tier 2 changes described in section 744L(14)(A); (ii) safety-related changes described in section 744L–1(a)(2)(C), required under section 505G(c)(5), or any other change the Secretary determines necessary to ensure safe use