; (2) the extent to which the scientific information is relevant for the relevant program office’s use in making a decision about a chemical substance; (3) the degree of clarity and completeness with which the data, assumptions, methods, quality assurance, analyses employed to generate the scientific information are documented and publicly available in a manner that honors legal and ethical obligations to reduce the risks of unauthorized disclosure and re-identification; (4) the extent to which the variability and uncertainty in the scientific information, or in the procedures, measures, methods, protocols, methodologies, or models, are evaluated and characterized; (5) the extent of independent verification or peer review of the scientific information or of the procedures, measures, methods, protocols, methodologies, or models; (6) the ability of the scientific findings and research to be replicated or reproduced; and (7) the extent to which the available scientific information supports dose-response modeling, using non-linear approaches. .