; and (ii) will be evaluated through a well-designed and rigorous study, as described in subparagraph (A)(iv). (C) Secretaries The term Secretaries means the Secretary of Education and the Secretary of Health and Human Services. (D) Substance use The term substance use may include the misuse or abuse of alcohol, prescription opioids, methamphetamine, or other legal or illegal substances. (3) Program authorized (A) In general The Secretaries, in accordance with the interagency agreement described in paragraph (4), may award, on a competitive basis, grants to institutions of higher education, or consortia of institutions of higher education, with high incidences of substance use disorders, overdoses, and deaths, in order to prevent and address the effects of substance use on the campuses of the institutions of higher education. (B) Duration A grant under this subsection shall be for a period of not more than 5 years, and may be renewed for an additional 2 years if satisfactory progress is made in preventing and reducing substance use disorders as described in paragraph (5)(A). (C) Reservation for rural areas The Secretaries shall ensure that at least 25 percent of funds are awarded to institutions of higher education in rural areas. (4) Interagency agreement The Secretary of Education and the Secretary of Health and Human Services shall jointly administer the program under this subsection in accordance with such terms as the Secretaries set forth in an interagency agreement. Such interagency agreement shall include a description of the respective roles and responsibilities of the Secretaries (both jointly and separately). (5) Application An institution of higher education, or consortium of institutions of higher education, desiring a grant under paragraph (3)(A) shall submit an application at such time and in such manner as the Secretaries may require. Such application shall include— (A) a description of the impact of substance use disorders on students enrolled in each participating institution of higher