; and (B) incorporate by reference standards regarding packaging or disposal set forth in an official compendium, established by a nationally or internationally recognized standard development organization, or described on the public Internet website of the Food and Drug Administration, so long as the order includes the rationale for incorporation of such standard. (4) Orders applicable to drug class When a concern about the risk of abuse or misuse of a drug relates to a pharmacological class, the Secretary may, after consultation with relevant stakeholders, issue an order under paragraph (1) which applies to the pharmacological class. (b) Compliance The holder of a covered application shall— (1) submit a supplement containing proposed changes to the covered application to comply with an order issued under subsection (a) not later than— (A) 180 calendar days after the date on which the order is issued; or (B) (i) such longer time period as specified by the Secretary in such order; or (ii) if a request for an alternative date is submitted by the holder of such application not later than 60 calendar days after the date on which such order is issued— (I) such requested alternative date if agreed to by the Secretary; or (II) another date as specified by the Secretary; and (2) implement the changes approved pursuant to such supplement not later than the later of— (A) 90 calendar days after the date on which the supplement is approved; or (B) the end of such longer period as is— (i) determined to be appropriate by the Secretary