; and (ii) the first business day after the date of enactment of an appropriations Act providing for the collection and obligation of fees under this section for such year. (2) Monograph drug order request fee (A) In general Each person that submits a monograph drug order request shall be subject to a fee for a monograph drug order request. The monograph drug order request fee under paragraph (2) shall be— (i) for a Tier 1 monograph drug order request, $500,000, adjusted for inflation for the fiscal year (as determined under subsection (c)(1)); and (ii) for a Tier 2 monograph drug order request other than a Tier 1 request, $100,000 adjusted for inflation for the fiscal year (as determined under subsection (c)(1)). (B) Due date The monograph drug order request fees required under subparagraph (A) shall be due on the date of submission of the monograph drug order request. (C) Exception for certain safety changes A person who is named as the requestor in a monograph drug order shall not be subject to a fee under subparagraph (A) if the Secretary finds that the monograph drug order request seeks to change the Drug Facts labeling of a monograph drug product in a way that would add to or strengthen— (i) a contraindication, warning, or precaution; (ii) a statement about risk associated with misuse or abuse