; and (B) a progress report with respect to designating the conditions under subsection (c)(1) and establishing the description of clearly defined treatments described in subsection (c)(3). (2) Periodic demonstration reports Beginning after the first year of the demonstration project and annually thereafter for each year of the demonstration project and not later than one year after the completion of the demonstration, the Secretary shall submit to Congress a report that includes the following data for each hospital participating under the demonstration project: (A) With respect to each condition or set of symptom designated under subsection (c)(1), the number of individuals treated. (B) With respect to each such condition, the number of individuals treated only with an alternative to opioids. (C) With respect to each such condition, the number of individuals treated first with an alternative to opioids, followed by an opioid in the same visit. (D) With respect to each such condition, the number of individuals treated only with an opioid. (E) With respect to each individual described in subparagraph (A) treated for such a condition or set of symptoms, whether or not the individual involved returned to the emergency department of the hospital or an emergency department of a different hospital for the same condition or symptoms. (F) The difference in cost between treating an individual with an alternative to opioid versus an opioid. (G) Any additional information the Secretary determines necessary. 3. Opioids and STOP Pain Initiative (a) Establishment There is established an Opioids and STOP Pain Initiative, to be administered by the Director of the National Institutes of Health, in coordination with other agencies, as appropriate, which shall include efforts to support research on the following: (1) Section 108 of the Comprehensive Addiction and Recovery Act of 2016 ( 42 U.S.C. 284q–1 ), known as the STOP Pain Act, which directs the National Institutes of Health to intensify and coordinate fundamental,