; (ii) the cost-effectiveness of proposed and final rules; (iii) other economic issues that are relevant to rulemaking under this section or other sections of this part; and (iv) risk assessments that are relevant to rulemaking under this section and other sections of this part. (B) Agency analysis of rules (i) In general The rigor of the cost-benefit analysis required by the guidelines established under subparagraph (A) shall be commensurate, as determined by the Administrator, with the economic impact of a rule. (ii) Risk assessment guidelines Guidelines for a risk assessment described in subparagraph (A)(iv) shall include criteria for— (I) selecting studies and models; (II) evaluating and weighing evidence; and (III) conducting peer reviews. (C) Updating guidelines Not less frequently than once every 10 years, the Administrator shall update the guidelines established under subparagraph (A) to enable each agency to use the best available techniques to quantify and evaluate present and future benefits, costs, other economic issues, and risks as objectively and accurately as practicable. (2) Simplification of rules (A) Issuance of guidelines The Administrator shall issue guidelines to promote coordination, simplification, and harmonization of agency rules during the rulemaking process. (B) Requirements The guidelines issued by the Administrator under subparagraph (A) shall advise each agency to— (i) avoid rules that are inconsistent or incompatible with, or duplicative of, other regulations of the agency and those of other agencies