; or (ii) the use of animals in any manner in a for-profit business or operation; (D) does not use the animals for entertainment purposes or in a traveling exhibit; (E) does not breed any animals, whether intentionally or by failing to use adequate birth control methods; (F) does not allow members of the public the opportunity to come into physical contact with the animals; and (G) provides an ethologically appropriate environment. (8) Systematic review The term systematic review means an analysis of evidence that is conducted based on a predetermined, comprehensive search strategy, which is designed— (A) to capture all appropriate studies; and (B) to reduce bias in analyzing the data gleaned from those studies. 4. Systematic reviews by the National Academy of Sciences (a) Preexisting fields of research (1) In general Not later than 180 days after the date of enactment of this Act, the National Academy of Sciences shall conduct a systematic review for each preexisting field of research in which the field of research has conducted nonhuman primate research to determine whether the nonhuman primate research has, with respect to the field of research— (A) an established history of advancing that field of research; and (B) resulted in meaningful clinical interventions. (2) Continued review For any preexisting field of research for which a systematic review under paragraph (1) has concluded that the use of nonhuman primates meets the requirements described in subparagraphs (A) and (B) of paragraph (1), a systematic review shall be reconducted every 5 years. (b) New fields of research For any new field of research in which the standing committee approves the use of nonhuman primates, the National Academy of Sciences shall, on request of the standing committee, conduct a systematic review to determine whether the nonhuman primate research has— (1) advanced that field of research