; (4) by inserting after paragraph (2) the following new paragraphs: (3) Composition (A) In general The Task Force shall be composed of individuals that collectively have appropriate scientific expertise, including in fields of health sciences research, health economics, health promotion, disease prevention, and clinical care. The Task Force shall include balanced representation of practicing primary and specialty care providers (including in the fields of health services research, health economics, and clinical care), and patient and health care consumers. (B) Notice Before appointing members to the Task Force, the Director shall provide notice in the Federal Register to give persons an opportunity to nominate potential members. (4) Review and consultation (A) Research plans (i) In general In conducting its reviews under paragraph (1), the Task Force, shall publish one or more proposed research plans (in this subsection referred to as a research plan ) to guide the Task Force’s systematic review of the evidence. Each such plan shall include an analytic framework, key questions, and a literature search strategy or research approach, and shall incorporate the methodological guidelines developed under clause (ii). The Agency shall provide for the publication in the Federal Register of a request for public comments on each plan and shall accept comments during a period of at least 45 days. Any final research plan shall be made available to the public and include a discussion of the comments received and responses to such comments. The Task Force, with the concurrence of the Director, may change such a research plan through the same process as applied to the initial adoption of such plan. (ii) Criteria The Director shall design and regularly update guidelines for proper methodological standards for incorporation into such research plans. Such guidelines shall include measures for appropriate validity, for risk adjustment, for timeliness, for input from relevant experts and peers in the respective communities, for