; or (C) significant adverse effects on competition, employment, investment, productivity, innovation, public health and safety, or the ability of United States-based enterprises to compete with foreign-based enterprises in domestic and export markets; (18) major rule means any rule that the Administrator determines is likely to cause— (A) an annual effect on the economy of $100,000,000 or more, adjusted once every 5 years to reflect increases in the Consumer Price Index for All Urban Consumers, as published by the Bureau of Labor Statistics of the Department of Labor; (B) a major increase in costs or prices for consumers, individual industries, Federal, State, local, or tribal government agencies, or geographic regions; or (C) significant adverse effects on competition, employment, investment, productivity, innovation, public health and safety, or the ability of United States-based enterprises to compete with foreign-based enterprises in domestic and export markets; (19) Office of Information and Regulatory Affairs means the office established under section 3503 of title 44 and any successor to that office; and (20) Administrator means the Administrator of the Office of Information and Regulatory Affairs. . 3. Rulemaking Section 553 of title 5, United States Code, is amended— (1) in the section heading, by striking Rule making and inserting Rulemaking ; (2) in subsection (a), by striking (a) This section applies and inserting (a) Applicability —This section applies