Cystic nephroma
Introduction A '''cystic nephroma''', also known as '''multilocular cystic nephroma''', '''mixed epithelial stromal tumour (MEST)''' and '''renal epithelial stromal tumour (REST)''', is a type of rare benign kidney tumour.
Symptoms Cystic nephromas are often asymptomatic. They are typically discovered on medical imaging incidentally (i.e. an incidentaloma).
Diagnosis Cystic nephromas are diagnosed by biopsy or excision. It is important to correctly diagnose them as, radiologically, they may mimic the appearance of a renal cell carcinoma that is cystic.===Pathologic diagnosis===High magnification micrograph of a '''cystic nephroma''' showing the characteristic simple epithelium with hobnail morphology, and the ovarian-like stroma. H&E stain.The characteristics of cystic nephromas are:*Cysts lined by a simple epithelium with a ''hobnail morphology'', i.e. the nuclei of the cyst lining epithelium bulges into the lumen of the cysts,*Ovarian-like stroma that has a:**Spindle cell morphology, and has a**Basophilic cytoplasm.Cystic nephromas have an immunostaining pattern like ovarian stroma; they are positive for:*Estrogen receptor (ER),*Progesterone receptor (PR) and*CD10.===Differential diagnosis===incidences and prognoses. Cystic nephroma is seen at bottom right in pie chart. *cystic partially differentiated nephroblastoma*cystic standard nephroblastoma (cystic Wilm's tumor)*cystic mesoblastic nephroma*cystic renal cell carcinoma*other renal cysts
Additional images Image:Cystic_nephroma_intermed_mag.jpg|Micrograph of a '''cystic nephroma'''. H&E stain.
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