LY-379,268
Introduction '''LY-379,268''' is a drug that is used in neuroscience research, which acts as a potent and selective agonist for the group II metabotropic glutamate receptors (mGluR2/3).It is derived from the older mGluR group II agonist eglumegad, and led on to the development of the more potent  compound LY-404,039, but is still widely used in research itself. LY-379,268 has sedative, neuroprotective, anti-addictive and anticonvulsant effects in animals, and blocks the effects of PCP and DOI, which has led to research into LY-379,268 and similar compounds as antipsychotic drugs for the treatment of schizophrenia in animals.There are inconsistent findings about an additional activity as a dopamine D2 receptor partial agonist.
See also * HYDIA
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