2,6-Di-tert-butylpyridine
Introduction '''2,6-Di-''tert''-butylpyridine''' is an organic compound with the formula (Me3C)2C5H3N. This colourless, oily liquid is derived from pyridine by replacement of the two H atoms with tert-butyl groups. It is a hindered base. For example, it can be protonated, but it does not form an adduct with boron trifluoride.
Preparation 2,6-Di-''tert''-butylpyridine is prepared by the reaction of tert-butyllithium with pyridine. The synthesis is reminiscent of the Chichibabin reaction.Some related bulky pyridine compounds have been described, including 2,4,6-tri-t-butylpyridine and 2,6-di-tert-butyl-4-methylpyridine.
See also *2,4,6-Tri-tert-butylpyrimidine, a bulky base that is less expensive than the tert-butylpyridines
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