Zomebazam
Introduction '''Zomebazam''' produced by Hoechst is a pyrazolodiazepinone derivative drug with anxiolytic properties. It is structurally related to  razobazam and zometapine.
Synthesis Synthesis: Patent:The catalytic hydrogenation of N,2,5-trimethyl-4-phenyldiazenylpyrazol-3-amine  CID:136203602 ('''1''') over Raney Nickel gives 4-amino-1,3-dimethyl-5-methylaminopyrazole,  CID:10219477 ('''2'''). Treatment with methyl malonyl chloride 37517-81-0 ('''3''') gives 4-a-ethoxycarbonylacetylamino-1,3-dimethyl-5-methylaminopyrazole,  CID:20561101 ('''4'''). Base catalyzed lactamization gives ('''5'''). The Goldberg reaction completes the synthesis Zomebazam ('''6''').
See also *Benzodiazepine
References