SCH-5472
Introduction '''SCH-5472'''. is a stimulant drug developed by Schering-Plough in the 1950s.
Synthesis Synthesis:Potassium amide was made from the reaction of potassium metal with liquid ammonia. The coupling between the carbanion created from diphenylmethane 101-81-5 ('''1''') and ethyl 2-furoate 614-99-3 1335-40-6 ('''2''') gives 2-furyl benzhydryl ketone,  CID:63950182 ('''3'''). This was reacted with concentrated liquid ammonia in methanol solvent in an autoclave. The product of this step was 2-benzhydrylpyridin-3-ol,  CID:125491889 ('''4'''). Reduction of the pyridine gave 2-(diphenylmethyl)piperidin-3-ol,  CID:209477 ('''5''').
See also * AL-1095* Desoxypipradrol* Difemetorex
References