SKF-83,959
Introduction '''SKF-83,959''' is a synthetic benzazepine derivative used in scientific research which acts as an agonist at the D1–D2 dopamine receptor heteromer. It behaves as a full agonist at the D1 protomer and a high-affinity partial agonist at the D2 protomer. It was further shown to act as an allosteric modulator of the sigma-1 receptor. SKF-83,959 additionally inhibits sodium channels as well as delayed rectifier potassium channels. SKF-83,959 is a racemate that consists of the ''R''-(+)- and ''S''-(−)-enantiomers MCL-202 and MCL-201, respectively.SKF-83,959 was described as a SNDRI. The synthesis has been described:
References
Further reading * *