Fibronectin type III domain
Introduction The '''Fibronectin type III domain ''' is an evolutionarily conserved protein domain that is widely found in animal proteins. The fibronectin protein in which this domain was first identified contains 16 copies of this domain. The domain is about 100 amino acids long and possesses a beta sandwich structure. Of the three fibronectin-type domains, type III is the only one without disulfide bonding present. Fibronectin domains are found in a wide variety of extracellular proteins. They are widely distributed in animal species, but also found  sporadically in yeast, plant and bacterial proteins.
Human proteins containing this domain ABI3BP;    ANKFN1;    ASTN2;     AXL;       BOC;       BZRAP1;    C20orf75;  CDON;CHL1;      CMYA5;     CNTFR;     CNTN1;     CNTN2;     CNTN3;     CNTN4;     CNTN5;CNTN6;     COL12A1;   COL14A1;   COL20A1;   COL7A1;    CRLF1;     CRLF3;     CSF2RB;CSF3R;     DCC;       DSCAM;     DSCAML1;   EBI3;      EGFLAM;    EPHA1;     EPHA10;EPHA2;     EPHA3;     EPHA4;     EPHA5;     EPHA6;     EPHA7;     EPHA8;     EPHB1;EPHB2;     EPHB3;     EPHB4;     EPHB6;     EPOR;      FANK1;     FLRT1;     FLRT2;FLRT3;     FN1;       FNDC1;     FNDC3A;    FNDC3B;    FNDC4;     FNDC5;     FNDC7;FNDC8;     FSD1;      FSD1L;     FSD2;      GHR;       HCFC1;     HCFC2;     HUGO;IFNGR2;    IGF1R;     IGSF22;    IGSF9;     IGSF9B; IL4R;   IL11RA;    IL12B;     IL12RB1;IL12RB2;   IL20RB;    IL23R;     IL27RA;    IL31RA;    IL6R;      IL6ST;     IL7R;INSR;      INSRR;     ITGB4;     KAL1;      KALRN;     L1CAM;     LEPR;LIFR;      LRFN2;     LRFN3;     LRFN4;     LRFN5;     LRIT1;     LRRN1;     LRRN3;MERTK;     MID1;      MID2;      MPL;       MYBPC1;    MYBPC2;    MYBPC3;    MYBPH;MYBPHL;    MYLK;      MYOM1;     MYOM2;     MYOM3;     NCAM1;     NCAM2;     NEO1;NFASC;     NOPE;      NPHS1;     NRCAM;     OBSCN;     OBSL1;     OSMR;      PHYHIP;PHYHIPL;   PRLR;      PRODH2;    PTPRB;     PTPRC;     PTPRD;     PTPRF;     PTPRG;PTPRH;     PTPRJ;     PTPRK;     PTPRM;     PTPRO;     PTPRS;     PTPRT;     PTPRU;PTPRZ1;    PTPsigma;  PUNC;      RIMBP2;    ROBO1;     ROBO2;     ROBO3;     ROBO4;ROS1;      SDK1;      SDK2;      SNED1;     SORL1;     SPEG;      TEK;       TIE1;TNC;       TNN;       TNR;       TNXB;      TRIM36;    TRIM42;    TRIM46;    TRIM67;TRIM9;     TTN;       TYRO3;     UMODL1;    USH2A;     VASN;      VWA1;      dJ34F7.1;fmi;
See also * Monobodies are engineered (synthetic) antibody mimetics based on a fibronectin type III domain (specifically, the 10th FN3 domain of human fibronectin). Monobodies feature either diversified loops or diversified strands of a flat beta-sheet surface, which serve as interaction epitopes. Monobody binders have been selected a wide variety of target molecules, and have expanded beyond the potential range of binding interfaces observed in both natural and synthetic antibodies.
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