Phenylpiperidines
Introduction '''Phenylpiperidines''' are chemical compounds with a phenyl moiety directly attached to piperidine. There are a variety of pharmacological effects associated with phenylpiperidines including morphine-like activity or other central nervous system effects.+ "Phenyl"piperidines Compound  N  4-position  3-position  4'-position  Type of pharmacology MPPPMePhH–OCOEtOpioid analgesic ProdineMePhMe–OCOEtOpioid analgesic PEPAPCH2CH2Ph PhH–OCOMeOpioid analgesic Pethidine  Me PhH–CO2Et mu-Agonist with serotonin reuptake inhibitor properties Budipine ''t''-BuPhHPhAntiparkinson agent Ketobemidone  Me 3-HO–PhH–COEt Opioid and NMDA antagonist Paroxetine  H 4-F–Ph–CH2OArH Selective serotonin reuptake inhibitor (and norepinephrine transporter) Femoxetine  Me Ph–CH2O(4-MeOPh)H Selective serotonin reuptake inhibitor CPCA  Me  4-Cl–Ph  –CO2Me  H  Monoamine reuptake inhibitor Methylphenidate is a ''benzyl''piperidine.
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