Nobiletin
Introduction '''Nobiletin''' is a flavonoid isolated from citrus peels. It is an ''O''-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment.
Potential pharmacology Nobiletin was found to potentially inhibit cartilage degradation.Nobiletin was shown to augment AMPA receptor activity and long-term potentiation in cell culture. Synergistic chemopreventive effects of nobiletin and atorvastatin on colon carcinogenesis have been described.Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer5.
References 5  Kim E, Kim YJ, Ji Z, Kang JM, Wirianto M, Paudel KR, Smith JA, Ono K, Kim JA, Eckel-Mahan K, Zhou X. ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer. Cell death & disease. 2022 Apr 19;13(4):374.
External links *  Nobiletin, phytochemicals.info