DuPhos
Introduction DuPhos ligands'''DuPhos''' is a class of organophosphorus compound that are used ligands for asymmetric synthesis. The name DuPhos is derived from (1) the chemical company that sponsored the research leading to this ligand's invention, DuPont and (2) the compound is a diphosphine ligand type. Specifically it is classified as a C2-symmetric ligand, consisting of two phospholanes rings affixed to a benzene ring.The ligand was introduced in 1991 by M.J. Burk and first demonstrated in asymmetric hydrogenation of certain enamide esters to amino acid precursors::Hydrogenation DupHos Burk 1993Other chiral diphosphine ligands were known at the time of invention, e.g. DIOP, DIPAMP, CHIRAPHOS, but DuPhos was found to be more effective.
Description The ligand consists of two 2,5-alkyl-substituted phospholane rings connected by a 1,2-phenyl bridge. The alkyl group can be methyl, ethyl, propyl, or isopropyl. In the closely related bis(dimethylphospholano)ethane or '''BPE ligand'''  the ''o''-phenylene bridge is replaced by a 1,2-ethylene bridge. Both compounds can be obtained from the corresponding chiral diol through conversion to the cyclic sulfate and reaction with lithiated phenylbisphosphine. In DuPhos the phosphorus atoms are electron-rich making the resulting metal complexes reactive. The phosphorus atoms also introduce a kind of pseudo-chirality  making   enantioselection independent of the overall chemical conformationAnother early application is the synthesis of unnatural chiral amino acids in a formal reductive amination for example starting from benzophenone and the hydrazone of benzoyl chloride::Reductive Amination DuPhos Burk 1994In the original scope the metal catalyst was rhodium but catalysis by ruthenium was introduced in 1995   with the hydrogenation of the ketone group in β-keto esters::Hydrogenation ketoester DuPhos Genet 1994
Applications An application of an asymmetric synthesis with a DuPhos ligand is the hydrogenation of dehydrowarfarin to warfarin::Warfarin synthesisDuphos is also applied in the synthesis of tryptophan derivatives.
In polymerization catalysis DuPhos ligands are used in metal catalyzed alpha-olefin/carbon monoxide copolymerization to form chiral isotactic polyketones. The first publication in this field dates back to 1994 with catalyst system Pd(Me-DuPhos(MeCN)2)(BF4)2
BozPhos ligand Mono oxidation of (R,R)-Me-Duphos using borane dimethylsulfide as protective group and hydrogen peroxide as oxidizing agent gives bozPhos  This ligand is useful in copper-catalyzed asymmetric addition of diorganozinc reagents to N-diphenylphosphinoylimines.
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