Lenperone
Introduction '''Lenperone''' ('''Elanone-V''') is a typical antipsychotic of the butyrophenone chemical class. It was first reported as an anti-emetic in 1974, and its use in treatment of acute schizophrenia was reported in 1975.Related early antipsychotic agents include declenperone and milenperone.Lenperone was never approved by the FDA for use in humans in the United States, but prior to 1989 it was approved for use in veterinary medicine for sedation.
Synthesis Synthesis (cmp#21): Patent (74%): Enbodiment 19 (62%):The alkylation between 2-(3-chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane 3308-94-9 ('''1''') and 4-(4-fluorobenzoyl)piperidine 56346-57-7 ('''2''') gives 2-(p-fluorophenyl)-2-{3-4-(p-fluorobenzoyl)piperidinopropyl}-1,3-dioxolane,  CID:20318874 ('''3'''). Deprotection of the ketal function completes the synthesis of lenperone ('''4''').
See also * Glemanserin* Pruvanserin* Roluperidone* VolinanserinChemically related drugs containing the same 4-(''p''-fluorobenzoyl)piperidine group:* Altanserin * Ketanserin* Setoperone* Lidanserin
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