Hydrazine (antidepressant)
Introduction Iproniazid, the first hydrazine MAOI to be discovered.The '''hydrazine''' antidepressants are a group of non-selective, irreversible monoamine oxidase inhibitors (MAOIs) which were discovered and initially marketed in the 1950s and 1960s. Most have been withdrawn due to toxicity, namely hepatotoxicity, but a few still remain in clinical use.Tranylcypromine, a structurally unrelated MAOI introduced around the same time as the hydrazines, was originally advertised as ''non-hydrazine'' as a result of its diminished propensity for causing hepatotoxicity.
List of hydrazine antidepressants ===Marketed===* Benmoxin (Neuralex, Nerusil) ‡* Iproclozide (Sursum) ‡* Iproniazid (Marsilid) ‡* '''Isocarboxazid''' (Marplan)* Mebanazine (Actomol) ‡* Nialamide (Niamid) ‡* Octamoxin (Ximaol, Nimaol) ‡* '''Phenelzine''' (Nardil)* Pheniprazine (Catron) ‡* Phenoxypropazine (Drazine) ‡* Pivhydrazine (Tersavid) ‡* Safrazine (Safra) ‡Legend: ‡ = Withdrawn from the market; † = Partially discontinued; '''Bolded names''' indicate major drugs.===Never marketed===* Carbenzide* Cimemoxin* Domoxin* Metfendrazine===Parkinson's===*Carbidopa===Tranquillosedative===*Centazolone
References *