Noxiptiline
Introduction '''Noxiptiline''' (brand names '''Agedal''', '''Elronon''', '''Nogedal'''), also known as '''noxiptyline''' and '''dibenzoxine''', is a tricyclic antidepressant (TCA) that was introduced in Europe in the 1970s for the treatment of depression. It has imipramine-like effects, acting as a serotonin and norepinephrine reuptake inhibitor, among other properties. Of the TCAs, noxiptiline has been described as one of the most effective, rivaling amitriptyline in clinical efficacy.
Synthesis Ths synthesis is similar to that for Demexiptiline.Synthesis: Patent:The condensation of dibenzosuberone ('''1''') with hydroxylamine ('''2''') gives the corresponding oxime 1785-74-6 ('''3'''). This is then reacted with 2-(dimethylamine)ethyl chloride 4584-46-7 ('''4''').
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