List of vaccine excipients
Introduction This is a list of excipients per vaccine, as published by the United States Centers for Disease Control. Vaccine ingredients and production in other nations are substantially the same. Also listed are substances used in the manufacturing process.VaccineExcipientsAdenovirus vaccineThis list refers to the type 4 and type 7 adenovirus vaccine tablets licensed in the US: Acetone, alcohol, anhydrous lactose, castor oil, cellulose acetate phthalate, dextrose, D-fructose, D-mannose, FD&C Yellow #6 aluminum lake dye, fetal bovine serum, human serum albumin, magnesium stearate, micro crystalline cellulose, plasdone C, Polacrilin potassium, potassium phosphate, sodium bicarbonate, sucroseAnthrax vaccine (BioThrax)Aluminum hydroxide, amino acids, benzethonium chloride, formaldehyde, inorganic salts and sugars, vitaminsBCG (Bacillus Calmette-Guérin) (Tice BCG)Asparagine, citric acid, lactose, glycerin, iron ammonium citrate, magnesium sulfate, potassium phosphateCOVID-19 vaccines, mRNA-based (Pfizer-BioNTech COVID-19 Vaccine ) (Moderna COVID-19 Vaccine) Lipids, salts, sucrose, plus in the Moderna COVID-19 Vaccine: tromethamine, acids and acid stabilizersDTaP (Daptacel)Aluminum phosphate, formaldehyde, Glutaraldehyde, 2-phenoxyethanolDTaP (Infanrix)Aluminum hydroxide, bovine extract, formaldehyde, glutaraldhyde, polysorbate 80DTaP (Tripedia)Aluminum potassium sulfate, ammonium sulfate, bovine extract, formaldehyde, gelatin, peptone, polysorbate 80, sodium phosphate, thimerosalDTaP-Hib (TriHIBit)Aluminum potassium sulfate, ammonium sulfate, bovine extract, formaldehyde or formalin, gelatin, polysorbate 80, sucrose, thimerosalDTaP-IPV (Kinrix)Aluminum hydroxide, calf serum, formaldehyde, glutaraldehyde, lactalbumin hydrolysate, neomycin sulfate, polymyxin B, polysorbate 80DTaP-HepB-IPV (Pediarix)Aluminum hydroxide, aluminum phosphate, calf serum, lactalbumin hydrolysate, formaldehyde, glutaraldhyde, neomycin sulfate, polymyxin B, polysorbate 80, yeast proteinDTaP-IPV-Hib (Pentacel)Aluminum phosphate, bovine serum albumin, formaldehyde, glutaraldehyde, MRC-5 cellular protein, neomycin, polymyxin B sulfate, polysorbate 80, 2-phenoxyethanolDT vaccine (diphtheria vaccine plus tetanus vaccine) (Sanofi)Aluminum potassium sulfate, bovine extract, formaldehyde, thimerosalDT vaccine (Massachusetts)Aluminum hydroxide, formaldehyde or formalinHib vaccine (ActHIB)Ammonium sulfate, formaldehyde, sucroseHib vaccine (PedvaxHib)Aluminum hydroxyphosphate sulfateHib vaccine (Hiberix)Formaldehyde, lactoseHib-HepB (Comvax)Amorphous aluminum hydroxyphosphate sulfate, amino acids, dextrose, formaldehyde, hemin chloride, mineral salts, nicotinamide adenine dinucleotide, potassium aluminum sulfate, sodium borate, soy peptone, yeast proteinHepatitis A vaccine (Havrix)Aluminum hydroxide, amino acid supplement, formalin, MRC-5 cellular protein, neomycin sulfate, phosphate buffers, polysorbate 20Hepatitis A vaccine (Vaqta)Amorphous aluminum hydroxyphosphate sulfate, bovine albumin or serum, formaldehyde, MRC-5 cellular protein, sodium borateHepatitis B vaccine (Engerix-B)Aluminum hydroxide, phosphate buffers, yeast proteinHepatitis B vaccine (Recombivax HB)Amorphous aluminum hydroxyphosphate sulfate, amino acids, dextrose, formaldehyde, mineral salts, potassium aluminum sulfate, soy peptone, yeast proteinHepA-HepB vaccine (Twinrix)Aluminum hydroxide, aluminum phosphate, amino acids, formalin, MRC-5 cells, neomycin sulfate, phosphate buffers, polysorbate 20, yeast proteinHuman papillomavirus (HPV) (Cervarix)Aluminum hydroxide, amino acids, lipids, mineral salts, sodium dihydrogen phosphate dehydrate, type 16 viral protein L1, type 18 viral protein L1, vitaminsHuman papillomavirus (HPV) (Gardasil)Amino acids, amorphous aluminum hydroxyphosphate sulfate, carbohydrates, L-histidine, mineral salts, polysorbate 80, sodium borate, vitamins, yeast proteinInfluenza vaccine (Afluria)Beta-propiolactone, calcium chloride, dibasic sodium phosphate, egg protein, monobasic potassium phosphate, monobasic sodium phosphate, neomycin sulfate, polymyxin B, potassium chloride, sodium taurodeoxychoalate, thimerosal (multi-dose vials only)Influenza vaccine (Agriflu)Egg proteins, formaldehyde, polysorbate 80, cetyltrimethylammonium bromide, neomycin sulfate, kanamycinInfluenza vaccine (Fluad)Squalene, polysorbate 80, sorbitan trioleate, sodium citrate dehydrate, citric acid monohydrate, neomycin, kanamycin, barium, egg proteins, CTAB(cetyltrimethylammonium bromide), formaldehydeInfluenza vaccine (Fluarix)Formaldehyde, octoxynol-10 (Triton X-100), α-tocopheryl hydrogen succinate, polysorbate 80 (Tween 80), hydrocortisone, gentamicin sulfate, ovalbumin, sodium deoxycholate, sucrose, phosphate bufferInfluenza vaccine (Flublok)Monobasic sodium phosphate, dibasic sodium phosphate, polysorbate 20, baculovirus and host cell proteins, baculovirus and cellular DNA, Triton X-100, lipids, vitamins, amino acids, mineral saltsInfluenza vaccine (Flucelvax)Madin Darby Canine Kidney (MDCK) cell protein, MDCK cell DNA, polysorbate 80, cetyltrimethlyammonium bromide, β-propiolactone, phosphate bufferInfluenza vaccine (Flulaval)Formaldehyde, á-tocopheryl hydrogen succinate, polysorbate 80, sodium deoxycholate, thimerosal, ovalbuminInfluenza vaccine (Fluvirin)Beta-propiolactone, egg protein, neomycin, nonylphenol ethoxylate, polymyxin, thimerosal (multi-dose containers), thimerosal (single-dose syringes)Influenza vaccine (Fluzone)Egg protein, formaldehyde, gelatin (standard formulation only), octylphenol ethoxylate (Triton X-100), sodium phosphate, thimerosal (multi-dose containers only)Influenza vaccine (FluMist)Arginine, dibasic potassium phosphate, egg protein, ethylenediaminetetraacetic acid, gentamicin sulfate, hydrolyzed porcine gelatin, monobasic potassium phosphate, monosodium glutamate, sucroseJapanese encephalitis vaccine (JE-Vax)Formaldehyde or formalin, gelatin, mouse serum protein, polysorbate 80, thimerosalJapanese encephalitis vaccine (Ixiaro)Aluminum hydroxide, bovine serum albumin, formaldehyde, protamine sulfate, sodium metabisulphiteMeningococcal vaccine (Menactra)Formaldehyde (Each 0.5 mL dose may contain residual amounts of formaldehyde of less than 2.66 µg (0.000532%), by calculation), phosphate buffersMeningococcal vaccine (Menomune)Lactose, thimerosal (multi-dose vial only)Meningococcal vaccine (Menveo)Amino acids, formaldehyde, yeast extractMMR vaccine (MMR-II)Amino acids, fetal bovine serum, glutamate, hydrolyzed gelatin, neomycin, recombinant human serum albumin, sodium phosphate, sorbitol, sucrose, vitaminsMMRV vaccine (ProQuad)Bovine calf serum, dibasic potassium phosphate, dibasic sodium phosphate, human albumin, human serum albumin, hydrolyzed gelatin, monobasic potassium phosphate, monosodium L-glutamate, MRC-5 cellular protein, neomycin, sodium bicarbonate, sorbitol, sucrose, potassium chloridePneumococcal vaccine (Pneumovax)PhenolPneumococcal vaccine (Prevnar)Aluminum phosphate, ammonium sulfate, casamino acid, polysorbate 80, succinate buffer, yeastPolio vaccine (IPV – Ipol)Calf serum protein, formaldehyde, neomycin, 2-phenoxyethanol, polymyxin B, streptomycinPolio vaccine (IPV – Poliovax)sodium chlorideRabies vaccine (Imovax)Albumin, MRC-5 cells, neomycin sulfate, phenolRabies vaccine (RabAvert, Greedo)Amphotericin B, beta-propiolactone, chicken protein, chlortetracycline, human serum albumin, neomycin, ovalbumin, polygeline (processed bovine 14 gelatin), potassium glutamateRotavirus vaccine (RotaTeq)fetal bovine serum, sodium citrate, sodium phosphate monobasic monohydrate, sodium hydroxide, sucrose, polysorbate 80Rotavirus vaccine (Rotarix)Amino acids, calcium carbonate, dextran, sorbitol, sucrose, vitamins, xanthanTd vaccine (Decavac)Aluminum potassium sulfate, bovine muscle tissue, formaldehyde, peptone, thimerosalTd vaccine (Massachusetts)Aluminum phosphate, ammonium phosphate, bovine extracts, formaldehyde, thimerosal (some multi-dose vials)Tdap vaccine (Adacel)Aluminum phosphate, ammonium sulfate, formaldehyde, glutaraldehyde, 2-phenoxyethanolTdap vaccine (Boostrix)Aluminum hydroxide, bovine extract, formaldehyde, glutaraldehyde, polysorbate 80Typhoid vaccine (inactivated – Typhim VI)Disodium phosphate, monosodium phosphate, phenol, polydimethylsiloxane, hexadecyltrimethylammonium bromideTyphoid vaccine (oral – Ty21a/Vivotif)Amino acids, ascorbic acid, casein, dextrose, galactose, lactose, sucrose, yeast extractVaccinia (ACAM2000)Glycerin, human serum albumin, mannitol, neomycin, phenol, polymyxin BVaricella vaccine (Varivax)Dibasic sodium phosphate, ethylenediamine tetra acetic acid sodium (EDTA), fetal bovine serum, gelatin, glutamate, monobasic potassium phosphate, monobasic sodium phosphate, monosodium L-glutamate, MRC-5 DNA and cellular protein, neomycin, phosphate, potassium chloride, sucroseYellow fever vaccine (YF-Vax)Egg protein, gelatin, sorbitolZoster vaccine (Zostavax)Bovine calf serum, dibasic sodium phosphate, hydrolyzed porcine gelatin, monosodium L-glutamate, MRC-5 DNA and cellular protein, monobasic potassium phosphate, neomycin, potassium chloride, sucrose
See also * Excipient* Vaccine types* Vaccination schedule* Adjuvant* Preservative* Cell culture* Growth medium
References The initial list is based on information from the Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA) and thus limited to US-approved vaccines.