Demexiptiline
Introduction '''Demexiptiline''' (brand names '''Deparon''', '''Tinoran''') is a tricyclic antidepressant (TCA) used in France for the treatment of depression. It acts primarily as a norepinephrine reuptake inhibitor similarly to desipramine.
Synthesis The synthesis is similar to that reported for Noxiptiline but also differs in a couple of respects.Synthesis: Patents:The condensation between Dibenzosuberenone 2222-33-5 ('''1''') and hydroxylamine ('''2''') gives the oxime, 1021-91-6 ('''3'''). Base catalyzed attachment of the sidechain by reaction with 2-Chloro-N-Methylethanamine 32315-92-7 ('''4''') completed the synthesis of demexiptiline ('''5''').
References
Further reading *