Levopropylhexedrine
Introduction '''Levopropylhexedrine''' ('''Eventin''') is an adrenergic alkylamine used as an anorectic in Germany and patented by Smith Kline & French in 1947.It has also been used in the anticonvulsant preparation barbexaclone in combination with phenobarbital to offset sedation. Levopropylhexedrine is the levorotatory ''S''-enantiomer of propylhexedrine. The dextrorotatory counterpart is known as dextropropylhexedrine.
Synthesis The enantiopure synthesis of levopropylhexedrine may be accomplished in a two step reaction. The first step is the Wenker synthesis of the relevant aziridine. The second step is the simple catalytic hydrogenation of the propylhexedrine-aziridine.Selective synthesis of Levopropylhexedrine
See also * Barbexaclone* Propylhexedrine
References