D-Deprenyl
Introduction '''-Deprenyl''', also known as or '''''dextro''-''N''-propargyl-''N''-methylamphetamine''', is an MAO-B inhibitor that metabolizes into -amphetamine and -methamphetamine and is therefore also a norepinephrine–dopamine releasing agent. It is the opposite enantiomer of -deprenyl (selegiline).-Deprenyl, also an MAO-B inhibitor, metabolizes to -amphetamine and -methamphetamine, which are both norepinephrine releasing agents. In contrast, -deprenyl additionally has dopaminergic effects and has been found to be reinforcing in scientific research, whereas -deprenyl is not known to have any appreciable psychological reinforcement.In addition to its actions as an MAO-B inhibitor and NDRA, -deprenyl has been found to bind with high affinity to the σ1 receptor (Ki = 79 nM) similarly to various other amphetamine derivatives. Its -isomer, selegiline, binds with 3.5-fold lower affinity in comparison.
See also * Clorgiline* Tranylcypromine
References