Ubenimex
Introduction '''Ubenimex''' (INN), also known more commonly as '''bestatin''', is a competitive, reversible protease inhibitor. It is an inhibitor of arginyl aminopeptidase (aminopeptidase B), leukotriene A4 hydrolase (a zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities), alanyl aminopeptidase (aminopeptidase M/N), leucyl/cystinyl aminopeptidase (oxytocinase/vasopressinase), and membrane dipeptidase (leukotriene D4 hydrolase). It is being studied for use in the treatment of acute myelocytic leukemia and lymphedema.It is derived from ''Streptomyces olivoreticuli''. Ubenimex has been found to inhibit the enzymatic degradation of oxytocin, vasopressin, enkephalins, and various other peptides and compounds.Crystal structure of ubenimex in the binding pocket of leukotriene A4 hydrolase. Rendered from PDB  1HS6.
See also * Amastatin* Pepstatin
References
External links * The MEROPS online database for peptidases and their inhibitors:  Bestatin