## Protocol Section
### Identification Module
**NCT ID:** NCT06437561

**Brief Title:** Report of Ten Cases of Venous Aneurysm in Extremities

**Official Title:** Venous Aneurysm: a Case Series and Review of Literature

#### Organization Study ID Info
**ID:** 114099
#### Organization
**Class:** OTHER
**Full Name:** Golestan University of Medical sciences
### Status Module
#### Completion Date
**Date:** 2024-03-15

**Type:** ACTUAL

#### Expanded Access Info
#### Last Update Post Date
**Date:** 2024-05-31

**Type:** ESTIMATED

**Last Update Submit Date:** 2024-05-25

**Overall Status:** COMPLETED

#### Primary Completion Date
**Date:** 2024-03-11

**Type:** ACTUAL

#### Start Date
**Date:** 2024-02-13

**Type:** ACTUAL

**Status Verified Date:** 2024-05

#### Study First Post Date
**Date:** 2024-05-31
**Type:** ESTIMATED
**Study First Submit Date:** 2024-05-25
**Study First Submit QC Date:** 2024-05-25
### Sponsor Collaborators Module

#### Lead Sponsor

**Class:** OTHER

**Name:** Golestan University of Medical sciences

#### Responsible Party

**Investigator Affiliation:** Golestan University of Medical sciences

**Investigator Full Name:** Pezhman Kharazm, MD

**Investigator Title:** Vascular Surgeon

**Type:** PRINCIPAL_INVESTIGATOR

### Oversight Module

**Is FDA Regulated Device:** False

**Is FDA Regulated Drug:** False

**Oversight Has DMC:** False

### Description Module

**Brief Summary:** Venous aneurysms are not common in general, but because of the inherent risk of thrombosis in aneurysms, their timely diagnosis and treatment are recommended in most of the current sources. Ten cases of venous aneurysms were diagnosed and managed in our vascular surgery department from October 2018 to January 2024. Patient information was extracted from their files retrospectively.

**Detailed Description:** A vascular aneurysm is defined as the focal dilatation of a vessel. Aneurysm is classically used for arterial dilatations, although dilatations can occur in any part of the vascular system including veins. Venous aneurysms are not common in general, but with the increase in the use of duplex ultrasound, the number of cases diagnosed with venous aneurysms has recently increased. Venous aneurysms are more common in the lower limbs, and in the lower limbs, the involvement of the deep venous system is much more than the superficial venous system. According to reports, 77% of venous aneurysms are present in the lower limbs, of which 57% are in the deep venous system and 1.5% in the superficial venous system.

Considering their rarity, venous aneurysms may cause diagnostic challenges in some cases.

The importance of these aneurysms, especially in the lower limbs, which inherently have relative stasis due to the opposite flow direction of gravity, is that by creating venous stasis and whirlwind blood flow inside the aneurysm, they increase the susceptibility to clotting. Also, due to dysfunction of the pigeon nest valves, they cause chronic venous insufficiency. Although clot formation and subsequent pulmonary embolism are more common in deep venous aneurysms, cases of pulmonary embolism secondary to superficial venous aneurysms of the lower limbs have also been reported.

Complications caused by chronic venous insufficiency are more common in aneurysms that occur at the main junctions of superficial and deep veins, including saphenous femoral and saphenous popliteal junctions.

Considering the possible complications mentioned about venous aneurysms, these aneurysms need treatment, regardless of their location, and although in the superficial system, surgical resection is the most commonly recommended method, other surgical methods such as aneurysmectomy and primary repair, resection, and graft interposition, and also endovascular methods have been used. Of course, in case of insufficiency in the venous system, specific treatment of the cause of insufficiency (such as stripping of the large saphenous vein) is necessary in addition to the treatment of the aneurysm.

Regarding the follow-up after the treatment of aneurysms of the superficial system, most articles have recommended short-term treatment with anticoagulants and control of the superficial and deep systems through color doppler.

In this case series, we present 10 cases of venous aneurysms and discuss their presentation, diagnosis, and management.

### Conditions Module

**Conditions:**

- Venous Aneurysm Nos

- Arteriovenous Malformations

- Vascular Diseases

**Keywords:**

- aneurysm

- venous malformation

- vascular surgery

### Design Module

#### Design Info

**Observational Model:** CASE_ONLY

**Time Perspective:** RETROSPECTIVE

#### Enrollment Info

**Count:** 10

**Type:** ACTUAL

**Study Type:** OBSERVATIONAL

### Outcomes Module

#### Primary Outcomes

**Description:** different clinical presentations of extremity venous aneurysms and their prevalence

**Measure:** clinical presentation of extremity venous aneurysms

**Time Frame:** 6 years

**Description:** prevalence of extremity venous aneurysms in different ages

**Measure:** age distribution of extremity venous aneurysms

**Time Frame:** 6 years

**Description:** prevalence of extremity venous aneurysms in upper vs. lower limbs as well as left side vs. right side

**Measure:** location distribution of extremity venous aneurysms

**Time Frame:** 6 years

**Description:** prevalence of extremity venous aneurysms in both sexes

**Measure:** sex distribution of extremity venous aneurysms

**Time Frame:** 6 years

### Eligibility Module

**Eligibility Criteria:** Inclusion Criteria:

- Presence of extremity venous aneurysm

Exclusion Criteria:

-

**Sampling Method:** NON_PROBABILITY_SAMPLE

**Sex:** ALL

**Standard Ages:**

- CHILD

- ADULT

- OLDER_ADULT

**Study Population:** all patients with extremity venous aneurysm since 2018 to 2024

### Contacts Locations Module

#### Locations

**Location 1:**

**City:** Gorgan

**Country:** Iran, Islamic Republic of

**Facility:** Pezhman Kharazm, MD

**State:** Golestan

**Zip:** 4917956808

### IPD Sharing Statement Module

**Info Types:**

- STUDY_PROTOCOL

- SAP

- ICF

- CSR

- ANALYTIC_CODE

**IPD Sharing:** YES

## Derived Section

### Condition Browse Module - Ancestors

- ID: D000002318

- Term: Cardiovascular Diseases

- ID: D000054079

- Term: Vascular Malformations

- ID: D000018376

- Term: Cardiovascular Abnormalities

### Condition Browse Module - Browse Branches

- Abbrev: BC14

- Name: Heart and Blood Diseases

- Abbrev: All

- Name: All Conditions

- Abbrev: BC16

- Name: Diseases and Abnormalities at or Before Birth

### Condition Browse Module - Browse Leaves

- ID: M4113

- Name: Aneurysm

- Relevance: HIGH

- As Found: Aneurysm

- ID: M17400

- Name: Vascular Diseases

- Relevance: HIGH

- As Found: Vascular Disease

- ID: M4473

- Name: Arteriovenous Malformations

- Relevance: HIGH

- As Found: Arteriovenous Malformations

- ID: M12

- Name: Congenital Abnormalities

- Relevance: HIGH

- As Found: Malformations

- ID: M27558

- Name: Vascular Malformations

- Relevance: LOW

- As Found: Unknown

- ID: M20503

- Name: Cardiovascular Abnormalities

- Relevance: LOW

- As Found: Unknown

### Condition Browse Module - Meshes

- ID: D000000783

- Term: Aneurysm

- ID: D000014652

- Term: Vascular Diseases

- ID: D000001165

- Term: Arteriovenous Malformations

- ID: D000000013

- Term: Congenital Abnormalities

### Misc Info Module

- Version Holder: 2024-05-31
