## Protocol Section
### Identification Module
**NCT ID:** NCT06412783

**Brief Title:** Population-based Investigation of Aneurysm Incidence

**Official Title:** Population-based Investigation of Aneurysm Incidence

#### Organization Study ID Info
**ID:** 2021YFC2501103
#### Organization
**Class:** OTHER
**Full Name:** Beijing Tiantan Hospital
### Status Module
#### Completion Date
**Date:** 2024-04-30

**Type:** ACTUAL

#### Expanded Access Info
#### Last Update Post Date
**Date:** 2024-05-14

**Type:** ACTUAL

**Last Update Submit Date:** 2024-05-13

**Overall Status:** COMPLETED

#### Primary Completion Date
**Date:** 2023-11-30

**Type:** ACTUAL

#### Start Date
**Date:** 2023-10-01

**Type:** ACTUAL

**Status Verified Date:** 2024-05

#### Study First Post Date
**Date:** 2024-05-14
**Type:** ACTUAL
**Study First Submit Date:** 2023-11-12
**Study First Submit QC Date:** 2024-05-13
### Sponsor Collaborators Module

#### Lead Sponsor

**Class:** OTHER

**Name:** Beijing Tiantan Hospital

#### Responsible Party

**Investigator Affiliation:** Beijing Tiantan Hospital

**Investigator Full Name:** Wang Shuo

**Investigator Title:** Director of Department of Cerebrovascular Neurosurgery

**Type:** PRINCIPAL_INVESTIGATOR

### Oversight Module

**Is FDA Regulated Device:** False

**Is FDA Regulated Drug:** False

**Oversight Has DMC:** False

### Description Module

**Brief Summary:** Most intracranial aneurysms are found accidentally in neurovascular imaging. And these inspection methods are limited by the problems of instrument fixation, radiation, time-consuming, contrast agent toxicity and so on. At present, blood test is an ideal alternative method for early diagnosis. Compared with imaging examination, it is economical, general screening and convenient. Blood test is simple to operate, easy to be accepted by patients, and less invasive. Early screening of aneurysms can be performed.

### Conditions Module

**Conditions:**

- Intracranial Aneurysm

**Keywords:**

- Intracranial Aneurysms

- Screening

- Blood test

### Design Module

#### Design Info

**Allocation:** NA

**Intervention Model:** SINGLE_GROUP

##### Masking Info

**Masking:** NONE

**Primary Purpose:** DIAGNOSTIC

#### Enrollment Info

**Count:** 1500

**Type:** ACTUAL

**Phases:**

- NA

**Study Type:** INTERVENTIONAL

### Arms Interventions Module

#### Arm Group 1

**Intervention Names:**

- Diagnostic Test: blood test

**Label:** blood test group

**Type:** EXPERIMENTAL

### Interventions

#### Intervention 1

**Arm Group Labels:**

- blood test group

**Description:** performing blood tests on the participants for specific markers.

**Name:** blood test

**Type:** DIAGNOSTIC_TEST

### Outcomes Module

#### Primary Outcomes

**Description:** oleic acid, arachidonic acid, docasa-hexaenoic acid, interleukin 1β， interleukin 1ra, tumor necrosis factors, SOD3, PPIA, S100A8, S100A9, MPO, APOA4, THBS1.

**Measure:** Specific markers are detected

**Time Frame:** 1hours after blood collection

### Eligibility Module

**Eligibility Criteria:** Inclusion Criteria:

* Age 35-75
* Individuals with normal cognitive and communication abilities
* No serious complications, such as uncontrolled hypertension, diabetes or other chronic diseases that may affect the test results.
* Basic blood test is normal or close to normal range.

Exclusion Criteria:

* Pregnancy
* Severe heart disease, renal insufficiency, liver dysfunction and other major diseases.
* In the past 6 months, there were strokes, or other types of intracranial tumors, infections and other diseases that may affect the screening results.
* There are metal implants, including dentures, pacemakers, etc.
* Using or recently used drugs that may affect blood biomarkers ( such as anticoagulant drugs, immunosuppressive agents, etc. ).
* There are serious mental illness or cognitive dysfunction, such as claustrophobia, unable to cooperate with the completion of the test.
* It is currently participating in other clinical trials or has participated in other clinical trials in the past 3 months.

**Healthy Volunteers:** True

**Maximum Age:** 75 Years

**Minimum Age:** 35 Years

**Sex:** ALL

**Standard Ages:**

- ADULT

- OLDER_ADULT

### Contacts Locations Module

#### Locations

**Location 1:**

**City:** Beijing

**Country:** China

**Facility:** Capital Medical University Affiliated Beijing Tiantan Hospital

**State:** Beijing

## Derived Section

### Condition Browse Module - Ancestors

- ID: D000014652

- Term: Vascular Diseases

- ID: D000002318

- Term: Cardiovascular Diseases

- ID: D000020765

- Term: Intracranial Arterial Diseases

- ID: D000002561

- Term: Cerebrovascular Disorders

- ID: D000001927

- Term: Brain Diseases

- ID: D000002493

- Term: Central Nervous System Diseases

- ID: D000009422

- Term: Nervous System Diseases

### Condition Browse Module - Browse Branches

- Abbrev: BC14

- Name: Heart and Blood Diseases

- Abbrev: All

- Name: All Conditions

- Abbrev: BC10

- Name: Nervous System Diseases

### Condition Browse Module - Browse Leaves

- ID: M4113

- Name: Aneurysm

- Relevance: HIGH

- As Found: Aneurysm

- ID: M5781

- Name: Intracranial Aneurysm

- Relevance: HIGH

- As Found: Intracranial Aneurysm

- ID: M17400

- Name: Vascular Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M22521

- Name: Intracranial Arterial Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M5810

- Name: Cerebrovascular Disorders

- Relevance: LOW

- As Found: Unknown

- ID: M5204

- Name: Brain Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M5742

- Name: Central Nervous System Diseases

- Relevance: LOW

- As Found: Unknown

### Condition Browse Module - Meshes

- ID: D000002532

- Term: Intracranial Aneurysm

- ID: D000000783

- Term: Aneurysm

### Misc Info Module

- Version Holder: 2024-05-31
