## Protocol Section
### Identification Module
**NCT ID:** NCT06422897

**Acronym:** OCT

**Brief Title:** Role of AS-OCT in Assessment of Corneal Perforation

**Official Title:** Role of Anterior Segment Optical Coherence Tomography in Assessment of Healing of Thin or Perforated Cornea Treated by Amniotic Membrane Graft and Platelet Rich Plasma Clot

#### Organization Study ID Info
**ID:** 1133/04/2024
#### Organization
**Class:** OTHER
**Full Name:** Minia University
### Status Module
#### Completion Date
**Date:** 2024-06-05

**Type:** ESTIMATED

#### Expanded Access Info
#### Last Update Post Date
**Date:** 2024-05-21

**Type:** ACTUAL

**Last Update Submit Date:** 2024-05-15

**Overall Status:** RECRUITING

#### Primary Completion Date
**Date:** 2024-05-30

**Type:** ESTIMATED

#### Start Date
**Date:** 2024-04-15

**Type:** ACTUAL

**Status Verified Date:** 2024-05

#### Study First Post Date
**Date:** 2024-05-21
**Type:** ACTUAL
**Study First Submit Date:** 2024-05-15
**Study First Submit QC Date:** 2024-05-15
### Sponsor Collaborators Module

#### Lead Sponsor

**Class:** OTHER

**Name:** Minia University

#### Responsible Party

**Investigator Affiliation:** Minia University

**Investigator Full Name:** Ahemd Abdelghany

**Investigator Title:** Associate professor

**Type:** PRINCIPAL_INVESTIGATOR

### Oversight Module

**Is FDA Regulated Device:** False

**Is FDA Regulated Drug:** False

**Oversight Has DMC:** False

### Description Module

**Brief Summary:** Assessment of healing of thin and perforated cornea after surgical treatment by anterior segment optical coherence tomography

**Detailed Description:** * thin and perforated cornea (small perforation) is surgically treated by amniotic membrane graft and platelet rich plasma clot
* anterior segment optical coherence tomography is performed preoperative and 1 month postoperative to assess healing

### Conditions Module

**Conditions:**

- Corneal Perforation

### Design Module

#### Design Info

**Observational Model:** CASE_ONLY

**Time Perspective:** PROSPECTIVE

#### Enrollment Info

**Count:** 15

**Type:** ESTIMATED

**Study Type:** OBSERVATIONAL

### Arms Interventions Module

#### Arm Group 1

**Description:** cases are assessed by Anterior segment optical coherence tomography 1 month after surgical managemnt

**Intervention Names:**

- Other: anterior segment optical coherence tomography

**Label:** cases after surgical management

### Interventions

#### Intervention 1

**Arm Group Labels:**

- cases after surgical management

**Description:** surgically treated corneal perforation by amniotic membrane graft and platelet rich plasma clot is assessed by anterior segment optical coherence tomography 1 month postoperative

**Name:** anterior segment optical coherence tomography

**Type:** OTHER

### Outcomes Module

#### Primary Outcomes

**Description:** complete corneal healing

**Measure:** healing

**Time Frame:** 1 month

### Eligibility Module

**Eligibility Criteria:** Inclusion Criteria:

* thin cornea about to perforate
* small corneal perforation

Exclusion Criteria:

* active infection

**Maximum Age:** 80 Years

**Minimum Age:** 18 Years

**Sampling Method:** NON_PROBABILITY_SAMPLE

**Sex:** ALL

**Standard Ages:**

- ADULT

- OLDER_ADULT

**Study Population:** patients from both sexes was thin cornea or small corneal perforation surgically treated by amniotic membrane graft and platelet rich plasma clot

### Contacts Locations Module

#### Central Contacts

**Contact 1:**

**Email:** ahmeda.abdelghany82@gmail.com

**Name:** Ahmed A Abdelghany, professor

**Phone:** 00201020009630

**Role:** CONTACT

#### Locations

**Location 1:**

**City:** Minya

**Contacts:**

***Contact 1:***

- **Name:** Ahmed Abdelghany, Ass prof

- **Role:** CONTACT

**Country:** Egypt

**Facility:** Faculty of Medicine

**Status:** RECRUITING

#### Overall Officials

**Official 1:**

**Affiliation:** professor

**Name:** Ahmed A Abdelghany, professor

**Role:** PRINCIPAL_INVESTIGATOR

### IPD Sharing Statement Module

**IPD Sharing:** UNDECIDED

### References Module

#### References

**Citation:** Abdelghany AA, Bahrawy ME, Alio JL. Combined Platelet Rich Plasma and Amniotic membrane in the treatment of Perforated Corneal Ulcers. Eur J Ophthalmol. 2022 Jul;32(4):2148-2152. doi: 10.1177/11206721211049100. Epub 2021 Oct 8.

**PMID:** 34623187

## Derived Section

### Condition Browse Module - Ancestors

- ID: D000065306

- Term: Corneal Injuries

- ID: D000005131

- Term: Eye Injuries

- ID: D000005151

- Term: Facial Injuries

- ID: D000006259

- Term: Craniocerebral Trauma

- ID: D000020196

- Term: Trauma, Nervous System

- ID: D000009422

- Term: Nervous System Diseases

- ID: D000003316

- Term: Corneal Diseases

- ID: D000005128

- Term: Eye Diseases

- ID: D000014947

- Term: Wounds and Injuries

### Condition Browse Module - Browse Branches

- Abbrev: BC10

- Name: Nervous System Diseases

- Abbrev: BC11

- Name: Eye Diseases

- Abbrev: BC26

- Name: Wounds and Injuries

- Abbrev: All

- Name: All Conditions

- Abbrev: BC23

- Name: Symptoms and General Pathology

### Condition Browse Module - Browse Leaves

- ID: M28724

- Name: Corneal Perforation

- Relevance: HIGH

- As Found: Corneal Perforation

- ID: M6539

- Name: Corneal Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M30499

- Name: Corneal Injuries

- Relevance: LOW

- As Found: Unknown

- ID: M8274

- Name: Eye Injuries

- Relevance: LOW

- As Found: Unknown

- ID: M21089

- Name: Facies

- Relevance: LOW

- As Found: Unknown

- ID: M8294

- Name: Facial Injuries

- Relevance: LOW

- As Found: Unknown

- ID: M17685

- Name: Wounds and Injuries

- Relevance: LOW

- As Found: Unknown

- ID: M9349

- Name: Craniocerebral Trauma

- Relevance: LOW

- As Found: Unknown

- ID: M22023

- Name: Trauma, Nervous System

- Relevance: LOW

- As Found: Unknown

- ID: M8271

- Name: Eye Diseases

- Relevance: LOW

- As Found: Unknown

### Condition Browse Module - Meshes

- ID: D000057112

- Term: Corneal Perforation

### Misc Info Module

- Version Holder: 2024-05-31
