## Protocol Section
### Identification Module
**NCT ID:** NCT06433817

**Brief Title:** Spectral CT in Radiotherapy for Cervical Cancer

**Official Title:** The Clinical Research of Spectral CT in Radiotherapy for Cervical Cancer

#### Organization Study ID Info
**ID:** SPRTCC-Trial
#### Organization
**Class:** OTHER
**Full Name:** Peking Union Medical College Hospital
### Status Module
#### Completion Date
**Date:** 2026-12-31

**Type:** ESTIMATED

#### Expanded Access Info
#### Last Update Post Date
**Date:** 2024-05-30

**Type:** ACTUAL

**Last Update Submit Date:** 2024-05-27

**Overall Status:** RECRUITING

#### Primary Completion Date
**Date:** 2026-05-22

**Type:** ESTIMATED

#### Start Date
**Date:** 2024-05-22

**Type:** ESTIMATED

**Status Verified Date:** 2024-05

#### Study First Post Date
**Date:** 2024-05-30
**Type:** ACTUAL
**Study First Submit Date:** 2024-05-08
**Study First Submit QC Date:** 2024-05-27
### Sponsor Collaborators Module

#### Lead Sponsor

**Class:** OTHER

**Name:** Peking Union Medical College Hospital

#### Responsible Party

**Type:** SPONSOR

### Oversight Module

**Is FDA Regulated Device:** True

**Is FDA Regulated Drug:** False

### Description Module

**Brief Summary:** The purpose of this study was to explore the potential application of spectral CT for radiotherapy in cervical cancer.

### Conditions Module

**Conditions:**

- Cervical Cancer

- Radiotherapy

### Design Module

#### Design Info

**Observational Model:** COHORT

**Time Perspective:** PROSPECTIVE

#### Enrollment Info

**Count:** 150

**Type:** ESTIMATED

**Study Type:** OBSERVATIONAL

### Arms Interventions Module

### Interventions

#### Intervention 1

**Description:** Spectral CT scans acquisition performed during the arterial phase and venous phase for cervical cancer

**Name:** Spectral computed tomography scan

**Type:** RADIATION

### Outcomes Module

#### Primary Outcomes

**Description:** To evaluate the tumor response of using quantitative parameters in spectral CT for cervical cancer patients according to RECIST 1.1

**Measure:** Comparison of spectral CT derived data with response evaluation in cervical cancer

**Time Frame:** through study completion, an average of 2 year

#### Secondary Outcomes

**Description:** To evaluate the diagnostic performances of using spectral CT for identifying metastatic lymph nodes in patients with cervical cancer

**Measure:** Identifying metastatic lymph nodes in cervical cancer with spectral CT

**Time Frame:** through study completion, an average of 2 year

**Description:** The ability to reduce metal artifact and assist in target delineation

**Measure:** Application of energy spectrum CT in brachytherapy of cervical cancer

**Time Frame:** through study completion, an average of 2 year

### Eligibility Module

**Eligibility Criteria:** Inclusion Criteria:

1. All patients were confirmed cervical cancer by pathology
2. patients were treated with concurrent chemoradiotherapy
3. Spectral CT scans acquisition performed during the arterial phase and venous phase
4. All the patients underwent a 18F-FDG PET/CT before treatment

Exclusion Criteria:

1. CT without spectral scans
2. History of allergy to intravenous contrast
3. Pregnant or potentially pregnant female subjects

**Minimum Age:** 18 Years

**Sampling Method:** NON_PROBABILITY_SAMPLE

**Sex:** FEMALE

**Standard Ages:**

- ADULT

- OLDER_ADULT

**Study Population:** adult patients with newly stablished diagnosis of cervical cancer complying with selection criteria for cervical cancer.

### Contacts Locations Module

#### Central Contacts

**Contact 1:**

**Email:** zhangfq@pumch.cn

**Name:** Fuquan Zhang, Porf

**Phone:** 86 01069154072

**Role:** CONTACT

#### Locations

**Location 1:**

**City:** Beijing

**Contacts:**

***Contact 1:***

- **Email:** zengzheng1206@163.com

- **Name:** Zheng Zeng, MD.

- **Phone:** 86 01069154073

- **Role:** CONTACT

**Country:** China

**Facility:** Peking Union Medical College Hospital

**State:** Beijing

**Status:** RECRUITING

**Zip:** 100010

### IPD Sharing Statement Module

**IPD Sharing:** NO

## Derived Section

### Condition Browse Module - Ancestors

- ID: D000014594

- Term: Uterine Neoplasms

- ID: D000005833

- Term: Genital Neoplasms, Female

- ID: D000014565

- Term: Urogenital Neoplasms

- ID: D000009371

- Term: Neoplasms by Site

- ID: D000009369

- Term: Neoplasms

- ID: D000002577

- Term: Uterine Cervical Diseases

- ID: D000014591

- Term: Uterine Diseases

- ID: D000005831

- Term: Genital Diseases, Female

- ID: D000052776

- Term: Female Urogenital Diseases

- ID: D000005261

- Term: Female Urogenital Diseases and Pregnancy Complications

- ID: D000091642

- Term: Urogenital Diseases

- ID: D000091662

- Term: Genital Diseases

### Condition Browse Module - Browse Branches

- Abbrev: BC04

- Name: Neoplasms

- Abbrev: BXS

- Name: Urinary Tract, Sexual Organs, and Pregnancy Conditions

- Abbrev: All

- Name: All Conditions

### Condition Browse Module - Browse Leaves

- ID: M5830

- Name: Uterine Cervical Neoplasms

- Relevance: HIGH

- As Found: Cervical Cancer

- ID: M17342

- Name: Uterine Neoplasms

- Relevance: LOW

- As Found: Unknown

- ID: M8945

- Name: Genital Neoplasms, Female

- Relevance: LOW

- As Found: Unknown

- ID: M17315

- Name: Urogenital Neoplasms

- Relevance: LOW

- As Found: Unknown

- ID: M5825

- Name: Uterine Cervical Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M17339

- Name: Uterine Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M8943

- Name: Genital Diseases, Female

- Relevance: LOW

- As Found: Unknown

- ID: M2876

- Name: Genital Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M2875

- Name: Urogenital Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M27093

- Name: Female Urogenital Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M14127

- Name: Pregnancy Complications

- Relevance: LOW

- As Found: Unknown

- ID: M8399

- Name: Female Urogenital Diseases and Pregnancy Complications

- Relevance: LOW

- As Found: Unknown

### Condition Browse Module - Meshes

- ID: D000002583

- Term: Uterine Cervical Neoplasms

### Misc Info Module

- Version Holder: 2024-05-31
