## Protocol Section
### Identification Module
**NCT ID:** NCT06429774

**Brief Title:** Comparative Effectiveness of Intervention in Multi-level Hospitals for Acute Traumatic Brain Injury(Metric-TBI)

**Official Title:** Comparative Effectiveness of Intervention in Multi-level Hospitals for Acute Traumatic Brain Injury: a Prospective, Multicenter, Observational Cohort Study

#### Organization Study ID Info
**ID:** SF 2024-1-2042
#### Organization
**Class:** OTHER
**Full Name:** Beijing Tiantan Hospital
### Status Module
#### Completion Date
**Date:** 2026-12-31

**Type:** ESTIMATED

#### Expanded Access Info
#### Last Update Post Date
**Date:** 2024-05-28

**Type:** ACTUAL

**Last Update Submit Date:** 2024-05-23

**Overall Status:** NOT_YET_RECRUITING

#### Primary Completion Date
**Date:** 2026-12-31

**Type:** ESTIMATED

#### Start Date
**Date:** 2024-07-01

**Type:** ESTIMATED

**Status Verified Date:** 2024-05

#### Study First Post Date
**Date:** 2024-05-28
**Type:** ACTUAL
**Study First Submit Date:** 2024-05-16
**Study First Submit QC Date:** 2024-05-23
### Sponsor Collaborators Module

#### Lead Sponsor

**Class:** OTHER

**Name:** Beijing Tiantan Hospital

#### Responsible Party

**Investigator Affiliation:** Beijing Tiantan Hospital

**Investigator Full Name:** Weiming Liu

**Investigator Title:** Professor

**Type:** PRINCIPAL_INVESTIGATOR

### Oversight Module

**Is FDA Regulated Device:** False

**Is FDA Regulated Drug:** False

**Oversight Has DMC:** True

### Description Module

**Brief Summary:** A prospective, multicenter, observational cohort study is designed to compare the effectiveness of intervention in multi-grade hospitals for acute traumatic brain injury and to optimize clinical outcomes.

**Detailed Description:** Traumatic brain injury (TBI) is associated with significant morbidity, mortality, and disability, profoundly impacting public health. This study aims to establish a database for acute craniocerebral trauma within the Beijing-Tianjin-Hebei region, and compiles indicators of hospital treatment capabilities and patient data, including neuroimaging, clinical progression, and rehabilitation prognoses.The study is bifurcated into two segments: the initial phase surveys the current status of acute treatment outcomes for TBI inpatients across hospitals in the Beijing-Tianjin-Hebei region and conducts a comparative effectiveness analysis to identify the clinical interventions to optimize. Subsequent phases build on the former by applying optimized treatment strategies to improve efficacy and establish collaborative optimized treatment protocols.

This is a prospective, multicenter, observational study designed to enroll 2,000 patients under the age of 90 years with traumatic brain injury in the presence of clinical symptoms confirmed by computed tomography or magnetic resonance imaging.The primary outcome is the Extended Glasgow Outcome Score within 12 months. Secondary outcomes include the Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9(PHQ-9), Rivermead post-concussion symptoms questionnaire(RPQ), PTSD Checklist-5 Version(PCL-5)，Six-Item Screener (SIS) and 12-Item Short-Form Health Survey version 2(SF-12v2).

The objective of this study is anticipated to the Beijing-Tianjin-Hebei region a 20 percent increase in the number of cases treated by optimized clinical practice guidelines and a 10 percent decrement in mortality and disability rates among TBI patients in the region.

### Conditions Module

**Conditions:**

- Traumatic Brain Injury

**Keywords:**

- Traumatic Brain Injury

- Beijing-Tianjin-Hebei region

- Database

- Comparative effectiveness of intervention

- Clinical Treatment Guideline

### Design Module

#### Bio Spec

**Description:** * vein blood
* hematoma fluid
* dura mater
* hematoma outer membrane

**Retention:** SAMPLES_WITH_DNA

#### Design Info

**Observational Model:** COHORT

**Time Perspective:** PROSPECTIVE

#### Enrollment Info

**Count:** 2000

**Type:** ESTIMATED

**Patient Registry:** True

**Study Type:** OBSERVATIONAL

**Target Duration:** 1 Year

### Arms Interventions Module

#### Arm Group 1

**Description:** TBI patients recruited from neurosurgical departments at 50 medical centers in China have apparent clinical symptoms that are confirmed by computed tomography or magnetic resonance imaging.

The exclusion criteria are those who fulfill one of the following conditions:

1. patients ≥90 years of age;
2. patients who did not accept follow-up visits or were unable to complete follow-up assessments;
3. patients with incomplete information;
4. patients who did not obtain written informed consent;
5. patients with concomitant cancer or other serious illnesses.

**Intervention Names:**

- Other: Neurological function

- Other: Mental State, cognitive function, and life quality assessment

- Other: Peripheral blood test

- Other: Hematoma test

**Label:** TBI Group

### Interventions

#### Intervention 1

**Arm Group Labels:**

- TBI Group

**Description:** Neurological function will be examined using Glasgow Coma Scale (GCS) and Extended Glasgow Outcome Scale (GOSE).The GOSE was created as an advancement from the original GOS. The GOSE score categorizes the prognosis of patients with traumatic brain injury into eight categories.The 8 categories are: Dead, Vegetative State, Lower Severe Disability, Upper Severe Disability, Lower Moderate Disability, Upper Moderate Disability, Lower Good Recovery, and Upper Good Recovery.

**Name:** Neurological function

**Type:** OTHER

#### Intervention 2

**Arm Group Labels:**

- TBI Group

**Description:** Mental State, cognitive function, and life quality will be examined using the Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9(PHQ-9), Rivermead post-concussion symptoms questionnaire(RPQ), PTSD Checklist-5 Version(PCL-5)，Six-Item Screener（SIS） and 12-Item Short-Form Health Survey version 2(SF-12v2).

**Name:** Mental State, cognitive function, and life quality assessment

**Type:** OTHER

#### Intervention 3

**Arm Group Labels:**

- TBI Group

**Description:** Collect peripheral blood samples from patients.

**Name:** Peripheral blood test

**Type:** OTHER

#### Intervention 4

**Arm Group Labels:**

- TBI Group

**Description:** Collect hematoma fluid, dura mater, and hematoma outer membrane samples from patients.

**Name:** Hematoma test

**Type:** OTHER

### Outcomes Module

#### Primary Outcomes

**Description:** The Extended Glasgow Outcome Scores(GOSE) range from 1 to 8, with higher scores indicating a better outcome. The summary of the scale is below:1.Dead;2. Vegetative State;3. Lower Severe Disability;4. Upper Severe Disability;5. Lower Moderate Disability;6. Upper Moderate Disability;7. Lower Good Recovery;8.Upper Good Recovery.Therefore, a score of 1 represents the worst outcome (death), and a score of 8 represents the best outcome (upper good recovery).

The rates of death or severe disability (GOSE scores 1-3) due to traumatic brain injury in the short term (at discharge) and in the long term (3, 6, and 12 months post-discharge) give an indication of the extent to which a patient recovers from different treatments.

**Measure:** Difference in the Extended Glasgow Outcome Score

**Time Frame:** From discharge up to 12 months postoperatively

#### Secondary Outcomes

**Description:** Patients were scored on their subsequent level of mental health at 3, 6, and 12 months after discharge based on the Generalized Anxiety Disorder-7 Scale(GAD-7).

The GAD-7 scale consists of seven items, each describing a symptom of Generalized Anxiety Disorder(GAD), and respondents rate how often they've been bothered by each symptom over the past two weeks.The GAD-7 score of 10 suggests moderate anxiety, on a scale ranging from 0 (minimal anxiety) to 21 (severe anxiety), with higher scores indicating worse outcomes.

**Measure:** Difference in the Generalized Anxiety Disorder-7 Scale in post-traumatic mental health recovery

**Time Frame:** From discharge up to 12 months postoperatively

**Description:** Patients were scored on their subsequent level of mental health at 3, 6, and 12 months after discharge based on the Patient Health Questionnaire-9 Scale(PHQ-9).

The PHQ-9 scale consists of nine items, each describing a symptom of depression, and respondents rate how often they've been bothered by each symptom over the past two weeks. The PHQ-9 scores between 10-14 suggest moderate depression, on a scale ranging from 0 (minimal depression) to 27 (severe depression), with higher scores indicating worse outcomes.

**Measure:** Difference in the Patient Health Questionnaire-9 Scale in post-traumatic mental health recovery

**Time Frame:** From discharge up to 12 months postoperatively

**Description:** Patients were scored on their subsequent level of mental health at 3, 6, and 12 months after discharge based on the Rivermead Post-Concussive Symptoms Questionnaire(RPQ).

The RPQ score ranges from 0 (no symptoms) to 64 (severe symptoms). Higher scores on the RPQ indicate a greater severity of post-concussive symptoms and a worse outcome. This information helps healthcare providers assess the impact of the concussion on the patient's daily life and track their recovery progress.

**Measure:** Difference in the Rivermead Post-Concussive Symptoms Questionnaire Scale in post-traumatic mental health recovery

**Time Frame:** From discharge up to 12 months postoperatively

**Description:** Patients were scored on their subsequent level of mental health at 3, 6, and 12 months after discharge based on the Post-Traumatic Stress Disorder Checklist-5 (PCL-5). Each of the 20 items on the PCL-5 is rated on a scale from 0 ("Not at all") to 4 ("Extremely"). The PCL-5 score ranges from 0 to 80, with higher scores indicating worse Post-traumatic stress disorder(PTSD) symptoms.

**Measure:** Difference in the Post-Traumatic Stress Disorder Checklist-5 Scale in post-traumatic mental health recovery

**Time Frame:** From discharge up to 12 months postoperatively

**Description:** Patients were scored on their subsequent level of quality of life at 3, 6, and 12 months after discharge based on different scores on the 12-item Short-Form Health Survey 2 (SF-12v2).

The SF-12v2 provides two summary scores: the Physical Component Summary (PCS) score and the Mental Component Summary (MCS) score. For both the PCS and MCS scores range from 0(the lowest level of health) to 100(the highest level of health). Higher scores on the PCS and MCS indicate better physical and mental health, respectively.

**Measure:** Difference in life quality assessment

**Time Frame:** From discharge up to 12 months postoperatively

**Description:** Patients were scored on their subsequent level of cognitive function at 3, 6, and 12 months after discharge based on different scores on the Six-Item Screener (SIS).

The SIS is a brief cognitive assessment tool used primarily to screen for cognitive impairment. The SIS assesses orientation and recall, two critical components often affected in cognitive disorders such as dementia.It ranges from 0 to 6, with higher scores mean a better outcome in terms of cognitive function.

**Measure:** Difference in cognitive function

**Time Frame:** From discharge up to 12 months postoperatively

**Description:** Rates of complications and adverse events during hospitalization and 12 months after discharge.

**Measure:** Rate of complications and adverse events

**Time Frame:** From discharge up to 12 months postoperatively

### Eligibility Module

**Eligibility Criteria:** Inclusion Criteria:

* Patient (1 years to 89 years) presenting with clinical symptoms of traumatic brain injury
* Traumatic brain injury verified on cranial computed tomography or magnetic resonance imaging
* Written informed consent from patients or their next of kin according to the patient's cognitive status

Exclusion Criteria:

* patients ≥90 years of age
* patients who did not accept follow-up visits or were unable to complete follow-up assessments
* patients with incomplete information
* patients who did not obtain written informed consent
* patients with concomitant cancer or other serious illnesses

**Maximum Age:** 89 Years

**Minimum Age:** 1 Year

**Sampling Method:** NON_PROBABILITY_SAMPLE

**Sex:** ALL

**Standard Ages:**

- CHILD

- ADULT

- OLDER_ADULT

**Study Population:** TBI patients recruited from neurosurgical departments at 50 medical centers in China have apparent clinical symptoms that are confirmed by computed tomography or magnetic resonance imaging.

### Contacts Locations Module

#### Central Contacts

**Contact 1:**

**Email:** liuweimingnsok@sina.com

**Name:** Weiming Liu, M.D.

**Phone:** 13701182770

**Role:** CONTACT

**Contact 2:**

**Email:** shiyu199709@163.com

**Name:** Yu Shi, M.D.

**Phone:** 13611533819

**Role:** CONTACT

#### Locations

**Location 1:**

**City:** Beijing

**Country:** China

**Facility:** Beijing Fengtai You'anmen Hospital

**State:** Beijing

**Zip:** 100000

**Location 2:**

**City:** Beijing

**Country:** China

**Facility:** Beijing Huairou Hospital

**State:** Beijing

**Zip:** 100000

**Location 3:**

**City:** Beijing

**Country:** China

**Facility:** Beijing HuaSheng Rehabilitation Hospital

**State:** Beijing

**Zip:** 100000

**Location 4:**

**City:** Beijing

**Country:** China

**Facility:** Beijing Luhe Hospital,Capital Medical University

**State:** Beijing

**Zip:** 100000

**Location 5:**

**City:** Beijing

**Country:** China

**Facility:** Beijing Tsinghua Changgung Hospital

**State:** Beijing

**Zip:** 100000

**Location 6:**

**City:** Beijing

**Country:** China

**Facility:** Peking University People's Hospital

**State:** Beijing

**Zip:** 100000

**Location 7:**

**City:** Beijing

**Country:** China

**Facility:** Beijing Chaoyang Hospital, Capital Medical University

**State:** Beijing

**Zip:** 100020

**Location 8:**

**City:** Beijing

**Country:** China

**Facility:** Beijing Chaoyang Integrative Medicine Rescue And First Aid Hospital

**State:** Beijing

**Zip:** 100020

**Location 9:**

**City:** Beijing

**Country:** China

**Facility:** Beijing Daxing District People's Hospital

**State:** Beijing

**Zip:** 100020

**Location 10:**

**City:** Beijing

**Country:** China

**Facility:** Peking University International Hospital

**State:** Beijing

**Zip:** 100020

**Location 11:**

**City:** Beijing

**Contacts:**

***Contact 1:***

- **Email:** liuweimingnsok@sina.com

- **Name:** Weiming Liu, MD

- **Phone:** 13701182770

- **Phone Ext:** +86

- **Role:** CONTACT

***Contact 2:***

- **Name:** Weiming Liu, MD

- **Role:** PRINCIPAL_INVESTIGATOR

***Contact 3:***

- **Name:** Guoyi Gao, MD

- **Role:** SUB_INVESTIGATOR

***Contact 4:***

- **Name:** Dongling Sun, MD

- **Role:** SUB_INVESTIGATOR

**Country:** China

**Facility:** Beijing Tiantan Hospital, Capital Medical University

**State:** Beijing

**Zip:** 100070

**Location 12:**

**City:** Beijing

**Country:** China

**Facility:** Beijing Pinggu Hospital

**State:** Beijing

**Zip:** 101200

**Location 13:**

**City:** Beijing

**Country:** China

**Facility:** Beijing Changping Hospital

**State:** Beijing

**Zip:** 102200

**Location 14:**

**City:** Beijing

**Country:** China

**Facility:** Beijing Mentougou District Hospital

**State:** Beijing

**Zip:** 102300

**Location 15:**

**City:** Beijing

**Country:** China

**Facility:** Liangxiang Hospital

**State:** Beijing

**Zip:** 102400

**Location 16:**

**City:** Beijing

**Country:** China

**Facility:** The First Hospital of Fangshan District, Bejing

**State:** Beijing

**Zip:** 102400

**Location 17:**

**City:** Baoding

**Country:** China

**Facility:** Affiliated Hospital Of Hebei University

**State:** Hebei

**Zip:** 071000

**Location 18:**

**City:** Baoding

**Country:** China

**Facility:** Bao Ding No.1 Central Hospital

**State:** Hebei

**Zip:** 071000

**Location 19:**

**City:** Baoding

**Country:** China

**Facility:** The No.2 Hospital of Baoding

**State:** Hebei

**Zip:** 071000

**Location 20:**

**City:** Baoding

**Country:** China

**Facility:** Anguo Hospital

**State:** Hebei

**Zip:** 071200

**Location 21:**

**City:** Baoding

**Country:** China

**Facility:** Xiongxian Hospital

**State:** Hebei

**Zip:** 071800

**Location 22:**

**City:** Baoding

**Country:** China

**Facility:** The Fourth Central Hospital of Baoding City

**State:** Hebei

**Zip:** 072350

**Location 23:**

**City:** Baoding

**Country:** China

**Facility:** Gaobeidian Hospital

**State:** Hebei

**Zip:** 074099

**Location 24:**

**City:** Cangzhou

**Country:** China

**Facility:** Suning Hospital

**State:** Hebei

**Zip:** 062350

**Location 25:**

**City:** Chengde

**Country:** China

**Facility:** Affiliated Hospital Of Chengde Medical University

**State:** Hebei

**Zip:** 067000

**Location 26:**

**City:** Chengde

**Country:** China

**Facility:** Luanping Hospital

**State:** Hebei

**Zip:** 068250

**Location 27:**

**City:** Handan

**Country:** China

**Facility:** Handan Central Hospital

**State:** Hebei

**Zip:** 056000

**Location 28:**

**City:** Handan

**Country:** China

**Facility:** Hangang Hospital

**State:** Hebei

**Zip:** 056000

**Location 29:**

**City:** Handan

**Country:** China

**Facility:** Weixian Chinese Traditional Medicine Hospital

**State:** Hebei

**Zip:** 056800

**Location 30:**

**City:** Handan

**Country:** China

**Facility:** The No.1 Hospital Of Yongnian District Handan City

**State:** Hebei

**Zip:** 057150

**Location 31:**

**City:** Hengyang

**Country:** China

**Facility:** Raoyang People's Hospital

**State:** Hebei

**Zip:** 053900

**Location 32:**

**City:** Langfang

**Country:** China

**Facility:** Langfang People's Hospital

**State:** Hebei

**Zip:** 065000

**Location 33:**

**City:** Langfang

**Country:** China

**Facility:** Yanjiao Fuhe No.1 Hospital

**State:** Hebei

**Zip:** 065201

**Location 34:**

**City:** Langfang

**Country:** China

**Facility:** Dachang Hui Autonomous County People's Hospital

**State:** Hebei

**Zip:** 065300

**Location 35:**

**City:** Langfang

**Country:** China

**Facility:** Xianghe Hospital

**State:** Hebei

**Zip:** 065400

**Location 36:**

**City:** Shijiazhuang

**Country:** China

**Facility:** Hebei Medical University Third Hospital

**State:** Hebei

**Zip:** 050000

**Location 37:**

**City:** Shijiazhuang

**Country:** China

**Facility:** The Fourth Hospital of Hebei Medical University

**State:** Hebei

**Zip:** 050000

**Location 38:**

**City:** Shijiazhuang

**Country:** China

**Facility:** The Third Hospital Of Shijiazhuang

**State:** Hebei

**Zip:** 050000

**Location 39:**

**City:** Shijiazhuang

**Country:** China

**Facility:** Hebei Chest Hospital

**State:** Hebei

**Zip:** 050041

**Location 40:**

**City:** Shijiazhuang

**Country:** China

**Facility:** Jingxing Hospital

**State:** Hebei

**Zip:** 050300

**Location 41:**

**City:** Shijiazhuang

**Country:** China

**Facility:** Xibaipo Rescue Center

**State:** Hebei

**Zip:** 050411

**Location 42:**

**City:** Shijiazhuang

**Country:** China

**Facility:** Xinle Chinese Traditional Medicine Hospital

**State:** Hebei

**Zip:** 050700

**Location 43:**

**City:** Shijiazhuang

**Country:** China

**Facility:** Yuanshi Chinese Traditional Medicine Hospital

**State:** Hebei

**Zip:** 051130

**Location 44:**

**City:** Shijiazhuang

**Country:** China

**Facility:** Gaoyi Hospital

**State:** Hebei

**Zip:** 051330

**Location 45:**

**City:** Tangshan

**Country:** China

**Facility:** Tangshan Fengrun People's Hospital

**State:** Hebei

**Zip:** 063000

**Location 46:**

**City:** Tangshan

**Country:** China

**Facility:** Tangshan Workers' Hospital

**State:** Hebei

**Zip:** 063000

**Location 47:**

**City:** Tangshan

**Country:** China

**Facility:** People's Hospital Of Zunhua

**State:** Hebei

**Zip:** 064200

**Location 48:**

**City:** Xingtai

**Country:** China

**Facility:** Xingtai Central Hospital

**State:** Hebei

**Zip:** 054000

**Location 49:**

**City:** Xingtai

**Country:** China

**Facility:** LinCheng People's Hospital

**State:** Hebei

**Zip:** 054300

**Location 50:**

**City:** Xingtai

**Country:** China

**Facility:** Qinghe Central Hospital

**State:** Hebei

**Zip:** 054800

**Location 51:**

**City:** Tianjin

**Country:** China

**Facility:** Tianjin Hospital

**State:** Tianjin

**Zip:** 300000

#### Overall Officials

**Official 1:**

**Affiliation:** Beijing Tiantan Hospital

**Name:** Weiming Liu, M.D.

**Role:** PRINCIPAL_INVESTIGATOR

### IPD Sharing Statement Module

**IPD Sharing:** NO

### References Module

#### References

**Citation:** Capizzi A, Woo J, Verduzco-Gutierrez M. Traumatic Brain Injury: An Overview of Epidemiology, Pathophysiology, and Medical Management. Med Clin North Am. 2020 Mar;104(2):213-238. doi: 10.1016/j.mcna.2019.11.001.

**PMID:** 32035565

**Citation:** Galgano M, Toshkezi G, Qiu X, Russell T, Chin L, Zhao LR. Traumatic Brain Injury: Current Treatment Strategies and Future Endeavors. Cell Transplant. 2017 Jul;26(7):1118-1130. doi: 10.1177/0963689717714102.

**PMID:** 28933211

**Citation:** Jiang JY, Gao GY, Feng JF, Mao Q, Chen LG, Yang XF, Liu JF, Wang YH, Qiu BH, Huang XJ. Traumatic brain injury in China. Lancet Neurol. 2019 Mar;18(3):286-295. doi: 10.1016/S1474-4422(18)30469-1. Epub 2019 Feb 12.

**PMID:** 30784557

**Citation:** Stocchetti N, Carbonara M, Citerio G, Ercole A, Skrifvars MB, Smielewski P, Zoerle T, Menon DK. Severe traumatic brain injury: targeted management in the intensive care unit. Lancet Neurol. 2017 Jun;16(6):452-464. doi: 10.1016/S1474-4422(17)30118-7.

**PMID:** 28504109

**Citation:** Steyerberg EW, Wiegers E, Sewalt C, Buki A, Citerio G, De Keyser V, Ercole A, Kunzmann K, Lanyon L, Lecky F, Lingsma H, Manley G, Nelson D, Peul W, Stocchetti N, von Steinbuchel N, Vande Vyvere T, Verheyden J, Wilson L, Maas AIR, Menon DK; CENTER-TBI Participants and Investigators. Case-mix, care pathways, and outcomes in patients with traumatic brain injury in CENTER-TBI: a European prospective, multicentre, longitudinal, cohort study. Lancet Neurol. 2019 Oct;18(10):923-934. doi: 10.1016/S1474-4422(19)30232-7.

**PMID:** 31526754

**Citation:** Silverberg ND, Duhaime AC, Iaccarino MA. Mild Traumatic Brain Injury in 2019-2020. JAMA. 2020 Jan 14;323(2):177-178. doi: 10.1001/jama.2019.18134. No abstract available.

**PMID:** 31816030

**Citation:** Sun D, Jiang B, Ru X, Sun H, Fu J, Wu S, Wang L, Wang L, Zhang M, Liu B, Wang W; for the NESS-China investigators. Prevalence and Altered Causes of Traumatic Brain Injury in China: A Nationwide Survey in 2013. Neuroepidemiology. 2020;54(2):106-113. doi: 10.1159/000501911. Epub 2019 Dec 18.

**PMID:** 31851999

## Derived Section

### Condition Browse Module - Ancestors

- ID: D000001927

- Term: Brain Diseases

- ID: D000002493

- Term: Central Nervous System Diseases

- ID: D000009422

- Term: Nervous System Diseases

- ID: D000006259

- Term: Craniocerebral Trauma

- ID: D000020196

- Term: Trauma, Nervous System

### Condition Browse Module - Browse Branches

- Abbrev: BC10

- Name: Nervous System Diseases

- Abbrev: BC26

- Name: Wounds and Injuries

- Abbrev: All

- Name: All Conditions

- Abbrev: Rare

- Name: Rare Diseases

### Condition Browse Module - Browse Leaves

- ID: M5207

- Name: Brain Injuries

- Relevance: HIGH

- As Found: Brain Injury

- ID: M628

- Name: Brain Injuries, Traumatic

- Relevance: HIGH

- As Found: Traumatic Brain Injury

- ID: M17685

- Name: Wounds and Injuries

- Relevance: HIGH

- As Found: Injury

- ID: M5204

- Name: Brain Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M5742

- Name: Central Nervous System Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M9349

- Name: Craniocerebral Trauma

- Relevance: LOW

- As Found: Unknown

- ID: M22023

- Name: Trauma, Nervous System

- Relevance: LOW

- As Found: Unknown

- ID: T170

- Name: Acute Graft Versus Host Disease

- Relevance: LOW

- As Found: Unknown

### Condition Browse Module - Meshes

- ID: D000001930

- Term: Brain Injuries

- ID: D000070642

- Term: Brain Injuries, Traumatic

- ID: D000014947

- Term: Wounds and Injuries

### Intervention Browse Module - Browse Branches

- Abbrev: Infe

- Name: Anti-Infective Agents

- Abbrev: All

- Name: All Drugs and Chemicals

### Intervention Browse Module - Browse Leaves

- ID: M11767

- Name: Metronidazole

- Relevance: LOW

- As Found: Unknown

### Misc Info Module

- Version Holder: 2024-05-31
