## Protocol Section
### Identification Module
**NCT ID:** NCT04025879

**Brief Title:** A Study of Neoadjuvant Chemotherapy Plus Nivolumab Versus Neoadjuvant Chemotherapy Plus Placebo, Followed by Surgical Removal and Adjuvant Treatment With Nivolumab or Placebo for Participants With Surgically Removable Early Stage Non-small Cell Lung Cancer

**Official Title:** A Phase 3, Randomized, Double-blind Study of Neoadjuvant Chemotherapy Plus Nivolumab Versus Neoadjuvant Chemotherapy Plus Placebo, Followed by Surgical Resection and Adjuvant Treatment With Nivolumab or Placebo for Participants With Resectable Stage II-IIIB Non-small Cell Lung Cancer

#### Organization Study ID Info
**ID:** CA209-77T
#### Organization
**Class:** INDUSTRY
**Full Name:** Bristol-Myers Squibb
#### Secondary ID Infos
**ID:** 2019-000262-38
**Type:** EUDRACT_NUMBER
### Status Module
#### Completion Date
**Date:** 2024-09-30

**Type:** ESTIMATED

#### Expanded Access Info
#### Last Update Post Date
**Date:** 2024-04-08

**Type:** ACTUAL

**Last Update Submit Date:** 2024-04-05

**Overall Status:** ACTIVE_NOT_RECRUITING

#### Primary Completion Date
**Date:** 2023-07-26

**Type:** ACTUAL

#### Start Date
**Date:** 2019-11-05

**Type:** ACTUAL

**Status Verified Date:** 2024-04

#### Study First Post Date
**Date:** 2019-07-19
**Type:** ACTUAL
**Study First Submit Date:** 2019-07-17
**Study First Submit QC Date:** 2019-07-17
### Sponsor Collaborators Module

#### Lead Sponsor

**Class:** INDUSTRY

**Name:** Bristol-Myers Squibb

#### Responsible Party

**Type:** SPONSOR

### Oversight Module

**Is FDA Regulated Device:** False

**Is FDA Regulated Drug:** True

**Oversight Has DMC:** True

### Description Module

**Brief Summary:** The main purpose of the study is to examine if periadjuvant (neoadjuvant, then adjuvant) immunotherapy will prolong event free survival in participants with early stage non-small cell lung cancer.

### Conditions Module

**Conditions:**

- Carcinoma, Non-Small-Cell Lung

### Design Module

#### Design Info

**Allocation:** RANDOMIZED

**Intervention Model:** PARALLEL

##### Masking Info

**Masking:** DOUBLE

**Who Masked:**

- PARTICIPANT

- INVESTIGATOR

**Primary Purpose:** TREATMENT

#### Enrollment Info

**Count:** 482

**Type:** ACTUAL

**Phases:**

- PHASE3

**Study Type:** INTERVENTIONAL

### Arms Interventions Module

#### Arm Group 1

**Intervention Names:**

- Biological: Nivolumab

- Drug: Carboplatin

- Drug: Cisplatin

- Drug: Paclitaxel

- Drug: Pemetrexed

- Drug: Docetaxel

**Label:** Neoadj. Nivo+ Pt-based Doublet Chemo followed by Adj. Nivo

**Type:** EXPERIMENTAL

#### Arm Group 2

**Intervention Names:**

- Drug: Carboplatin

- Drug: Cisplatin

- Drug: Paclitaxel

- Drug: Pemetrexed

- Drug: Placebo

- Drug: Docetaxel

**Label:** Neoadj. Plac. + Pt-based Doublet Chemo followed by Adj.Plac.

**Type:** PLACEBO_COMPARATOR

### Interventions

#### Intervention 1

**Arm Group Labels:**

- Neoadj. Nivo+ Pt-based Doublet Chemo followed by Adj. Nivo

**Description:** Specified dose on specified days

**Name:** Nivolumab

**Other Names:**

- Opdivo, BMS936558

**Type:** BIOLOGICAL

#### Intervention 2

**Arm Group Labels:**

- Neoadj. Nivo+ Pt-based Doublet Chemo followed by Adj. Nivo

- Neoadj. Plac. + Pt-based Doublet Chemo followed by Adj.Plac.

**Description:** Specified dose on specified days

**Name:** Carboplatin

**Type:** DRUG

#### Intervention 3

**Arm Group Labels:**

- Neoadj. Nivo+ Pt-based Doublet Chemo followed by Adj. Nivo

- Neoadj. Plac. + Pt-based Doublet Chemo followed by Adj.Plac.

**Description:** Specified dose on specified days

**Name:** Cisplatin

**Type:** DRUG

#### Intervention 4

**Arm Group Labels:**

- Neoadj. Nivo+ Pt-based Doublet Chemo followed by Adj. Nivo

- Neoadj. Plac. + Pt-based Doublet Chemo followed by Adj.Plac.

**Description:** Specified dose on specified days

**Name:** Paclitaxel

**Type:** DRUG

#### Intervention 5

**Arm Group Labels:**

- Neoadj. Nivo+ Pt-based Doublet Chemo followed by Adj. Nivo

- Neoadj. Plac. + Pt-based Doublet Chemo followed by Adj.Plac.

**Description:** Specified dose on specified days

**Name:** Pemetrexed

**Type:** DRUG

#### Intervention 6

**Arm Group Labels:**

- Neoadj. Plac. + Pt-based Doublet Chemo followed by Adj.Plac.

**Description:** Specified dose on specified days

**Name:** Placebo

**Type:** DRUG

#### Intervention 7

**Arm Group Labels:**

- Neoadj. Nivo+ Pt-based Doublet Chemo followed by Adj. Nivo

- Neoadj. Plac. + Pt-based Doublet Chemo followed by Adj.Plac.

**Description:** Specified dose on specified days

**Name:** Docetaxel

**Type:** DRUG

### Outcomes Module

#### Primary Outcomes

**Measure:** Event-Free Survival (EFS) as Assessed by Blinded Independent Central Review (BICR)

**Time Frame:** 5 Years from randomization

#### Secondary Outcomes

**Measure:** Overall Survival (OS)

**Time Frame:** Up to 5 years from randomization

**Measure:** Pathologic Complete Response (pCR) Rate as Assessed by Blinded Independent Pathology Review (BIPR)

**Time Frame:** At the time of surgery, between week 12 to week 18

**Measure:** Major Pathological Response (MPR) Rate as Assessed by Blinded Independent Pathology Review

**Time Frame:** Up to 8 weeks following completion of neoadjuvant surgery, approximately study week 22

**Measure:** Incidence of Serious Adverse Events (SAEs)

**Time Frame:** Up to 80 weeks

**Measure:** Incidence of Adverse Events (AEs)

**Time Frame:** Up to 80 weeks

### Eligibility Module

**Eligibility Criteria:** Inclusion Criteria:

* Participants with suspected or histologically confirmed Stage IIA (\> 4 cm) to IIIB (T3N2) non-small cell lung carcinoma (NSCLC) with disease that is considered resectable
* No brain metastasis
* Treatment-naive for NSCLC (no prior systemic anti-cancer treatment)
* Ability to provide surgical or biopsy tumor tissue for biomarkers
* Eastern Cooperative Oncology Group (ECOG) Performance Status of ≤ 1

Exclusion Criteria:

* Participants with an active, known or suspected autoimmune disease
* Any positive test for hepatitis B virus or hepatitis C virus or human immunodeficiency virus (HIV)
* Any previous anti-cancer treatment including cytotoxic, IO treatment, targeted agents, or radiotherapy for NSCLC
* Prior treatment with any anti-PD-1, anti-PD-L1, anti-PD-L2, or anti-CTLA-4 antibody, or any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways

Other protocol-defined inclusion/exclusion criteria apply

**Minimum Age:** 18 Years

**Sex:** ALL

**Standard Ages:**

- ADULT

- OLDER_ADULT

### Contacts Locations Module

#### Locations

**Location 1:**

**City:** Tampa

**Country:** United States

**Facility:** Local Institution - 0104

**State:** Florida

**Zip:** 33612

**Location 2:**

**City:** Atlanta

**Country:** United States

**Facility:** Local Institution - 0040

**State:** Georgia

**Zip:** 30342

**Location 3:**

**City:** Augusta

**Country:** United States

**Facility:** Local Institution - 0120

**State:** Georgia

**Zip:** 30912

**Location 4:**

**City:** Chicago

**Country:** United States

**Facility:** Local Institution - 0145

**State:** Illinois

**Zip:** 60611

**Location 5:**

**City:** Chicago

**Country:** United States

**Facility:** Local Institution - 0078

**State:** Illinois

**Zip:** 60612

**Location 6:**

**City:** Orland Park

**Country:** United States

**Facility:** Local Institution - 0121

**State:** Illinois

**Zip:** 60462

**Location 7:**

**City:** Bethesda

**Country:** United States

**Facility:** Rcca Md Llc

**State:** Maryland

**Zip:** 20817

**Location 8:**

**City:** Boston

**Country:** United States

**Facility:** Local Institution - 0074

**State:** Massachusetts

**Zip:** 02215

**Location 9:**

**City:** Boston

**Country:** United States

**Facility:** Local Institution - 0076

**State:** Massachusetts

**Zip:** 02215

**Location 10:**

**City:** Traverse City

**Country:** United States

**Facility:** Local Institution - 0086

**State:** Michigan

**Zip:** 49684

**Location 11:**

**City:** Lebanon

**Country:** United States

**Facility:** Local Institution - 0100

**State:** New Hampshire

**Zip:** 03756

**Location 12:**

**City:** Cincinnati

**Country:** United States

**Facility:** Local Institution - 0055

**State:** Ohio

**Zip:** 45220

**Location 13:**

**City:** Cleveland

**Country:** United States

**Facility:** Local Institution - 0102

**State:** Ohio

**Zip:** 44106

**Location 14:**

**City:** Houston

**Country:** United States

**Facility:** Local Institution - 0054

**State:** Texas

**Zip:** 77030

**Location 15:**

**City:** Fredericksburg

**Country:** United States

**Facility:** Local Institution - 0103

**State:** Virginia

**Zip:** 22408

**Location 16:**

**City:** Ciudad Autonoma Beunos Aires

**Country:** Argentina

**Facility:** Local Institution - 0032

**State:** Buenos Aires

**Zip:** 1431

**Location 17:**

**City:** ABB

**Country:** Argentina

**Facility:** Local Institution - 0031

**State:** Ciudad Autónoma De Buenos Aires

**Zip:** C1199ABB

**Location 18:**

**City:** Buenos Aires

**Country:** Argentina

**Facility:** Local Institution - 0043

**Zip:** CP1280AEB

**Location 19:**

**City:** Caba

**Country:** Argentina

**Facility:** Local Institution - 0030

**Zip:** 1426

**Location 20:**

**City:** Sydney

**Country:** Australia

**Facility:** Local Institution - 0020

**State:** New South Wales

**Zip:** 2050

**Location 21:**

**City:** Heidelberg

**Country:** Australia

**Facility:** Local Institution - 0033

**State:** Victoria

**Zip:** 3084

**Location 22:**

**City:** Melbourne

**Country:** Australia

**Facility:** Local Institution - 0122

**State:** Victoria

**Zip:** 3065

**Location 23:**

**City:** North Ballarat

**Country:** Australia

**Facility:** Local Institution - 0023

**State:** Victoria

**Zip:** 33500

**Location 24:**

**City:** Edegem

**Country:** Belgium

**Facility:** Local Institution - 0002

**Zip:** 2650

**Location 25:**

**City:** Liege

**Country:** Belgium

**Facility:** Local Institution - 0005

**Zip:** 4000

**Location 26:**

**City:** Roeselare

**Country:** Belgium

**Facility:** Local Institution - 0001

**Zip:** 8800

**Location 27:**

**City:** Belo Horizonte

**Country:** Brazil

**Facility:** Local Institution - 0035

**State:** Minas Gerais

**Zip:** 30130-090

**Location 28:**

**City:** Ijui

**Country:** Brazil

**Facility:** Local Institution - 0029

**State:** RIO Grande DO SUL

**Zip:** 98700-000

**Location 29:**

**City:** São Paulo

**Country:** Brazil

**Facility:** Local Institution - 0034

**State:** SAO Paulo

**Zip:** 05652-900

**Location 30:**

**City:** Sao Paulo

**Country:** Brazil

**Facility:** Local Institution - 0036

**State:** São Paulo

**Zip:** 01509-010

**Location 31:**

**City:** São Paulo

**Country:** Brazil

**Facility:** Local Institution - 0106

**Zip:** 01321-001

**Location 32:**

**City:** Oshawa

**Country:** Canada

**Facility:** Local Institution - 0062

**State:** Ontario

**Zip:** L1G 2B9

**Location 33:**

**City:** Beijing

**Country:** China

**Facility:** Local Institution - 0115

**State:** Beijing

**Zip:** 100021

**Location 34:**

**City:** Beijing

**Country:** China

**Facility:** Local Institution - 0096

**State:** BEI

**Zip:** 100142

**Location 35:**

**City:** Fuzhou

**Country:** China

**Facility:** Local Institution - 0137

**State:** Fujian

**Zip:** 350001

**Location 36:**

**City:** Fuzhou

**Country:** China

**Facility:** Local Institution - 0136

**State:** Fujian

**Zip:** 350014

**Location 37:**

**City:** Hubei Sheng

**Country:** China

**Facility:** Local Institution - 0151

**State:** Hubei

**Zip:** 430079

**Location 38:**

**City:** Changsha

**Country:** China

**Facility:** Local Institution - 0092

**State:** Hunan

**Zip:** 410000

**Location 39:**

**City:** Changsha

**Country:** China

**Facility:** Local Institution - 0093

**State:** Hunan

**Zip:** 410000

**Location 40:**

**City:** Changsha

**Country:** China

**Facility:** Local Institution - 0091

**State:** Hunan

**Zip:** 410008

**Location 41:**

**City:** Shanghai

**Country:** China

**Facility:** Local Institution - 0098

**State:** Shanghai

**Zip:** 200010

**Location 42:**

**City:** Shanghai

**Country:** China

**Facility:** Local Institution - 0165

**State:** Shanghai

**Zip:** 200030

**Location 43:**

**City:** Shanghai

**Country:** China

**Facility:** Local Institution - 0113

**State:** Shanghai

**Zip:** 200433

**Location 44:**

**City:** Chengdu

**Country:** China

**Facility:** Local Institution - 0088

**State:** Sichuan

**Zip:** 610041

**Location 45:**

**City:** Hangzhou

**Country:** China

**Facility:** Local Institution - 0099

**State:** Zhejiang

**Zip:** 310016

**Location 46:**

**City:** Shanghai

**Country:** China

**Facility:** Local Institution - 0095

**Zip:** 200032

**Location 47:**

**City:** Praha 2

**Country:** Czechia

**Facility:** Local Institution - 0041

**Zip:** 128 08

**Location 48:**

**City:** Praha 4

**Country:** Czechia

**Facility:** Local Institution - 0042

**Zip:** 140 59

**Location 49:**

**City:** Besancon

**Country:** France

**Facility:** Local Institution - 0073

**Zip:** 25030

**Location 50:**

**City:** La Tronche

**Country:** France

**Facility:** Local Institution - 0037

**Zip:** 38700

**Location 51:**

**City:** Montpellier

**Country:** France

**Facility:** Local Institution - 0050

**Zip:** 34295

**Location 52:**

**City:** Paris Cedex 18

**Country:** France

**Facility:** Local Institution - 0038

**Zip:** 75018

**Location 53:**

**City:** Paris Cedex 20

**Country:** France

**Facility:** Local Institution - 0051

**Zip:** 75970

**Location 54:**

**City:** Rennes Cedex 9

**Country:** France

**Facility:** Local Institution - 0083

**Zip:** 35033

**Location 55:**

**City:** Rouen

**Country:** France

**Facility:** Local Institution - 0146

**Zip:** 76000

**Location 56:**

**City:** Köln

**Country:** Germany

**Facility:** Local Institution - 0110

**State:** Nordrhein-Westfalen

**Zip:** 51109

**Location 57:**

**City:** Berlin

**Country:** Germany

**Facility:** Local Institution - 0085

**Zip:** 13353

**Location 58:**

**City:** Frankfurt

**Country:** Germany

**Facility:** Local Institution - 0065

**Zip:** 60488

**Location 59:**

**City:** Georgsmarienhuette

**Country:** Germany

**Facility:** Local Institution - 0072

**Zip:** 49124

**Location 60:**

**City:** Hamm

**Country:** Germany

**Facility:** Local Institution - 0071

**Zip:** 59063

**Location 61:**

**City:** Heidelberg

**Country:** Germany

**Facility:** Local Institution - 0108

**Zip:** 69126

**Location 62:**

**City:** Immenstadt

**Country:** Germany

**Facility:** Local Institution - 0109

**Zip:** 87509

**Location 63:**

**City:** Loewenstein

**Country:** Germany

**Facility:** Local Institution - 0064

**Zip:** 74245

**Location 64:**

**City:** Ludwigsburg

**Country:** Germany

**Facility:** Local Institution - 0147

**Zip:** 71640

**Location 65:**

**City:** Luebeck

**Country:** Germany

**Facility:** Local Institution - 0063

**Zip:** 23538

**Location 66:**

**City:** Moers

**Country:** Germany

**Facility:** Local Institution - 0070

**Zip:** 47441

**Location 67:**

**City:** Muenchen

**Country:** Germany

**Facility:** Local Institution - 0066

**Zip:** 81675

**Location 68:**

**City:** Dublin

**Country:** Ireland

**Facility:** Local Institution - 0016

**Zip:** D24 DH74

**Location 69:**

**City:** Forlì

**Country:** Italy

**Facility:** Local Institution - 0024

**Zip:** 47014

**Location 70:**

**City:** Milano

**Country:** Italy

**Facility:** Local Institution - 0026

**Zip:** 20122

**Location 71:**

**City:** Parma

**Country:** Italy

**Facility:** Azienda Ospedaliera Di Parma

**Zip:** 43126

**Location 72:**

**City:** Nagoya-shi

**Country:** Japan

**Facility:** Local Institution - 0135

**State:** Aichi

**Zip:** 4640021

**Location 73:**

**City:** Kashiwa-shi

**Country:** Japan

**Facility:** Local Institution - 0124

**State:** Chiba

**Zip:** 2778577

**Location 74:**

**City:** Kitakyushu-shi

**Country:** Japan

**Facility:** Local Institution - 0129

**State:** Fukuoka

**Zip:** 8078556

**Location 75:**

**City:** Kobe-shi

**Country:** Japan

**Facility:** Local Institution - 0127

**State:** Hyogo

**Zip:** 6500047

**Location 76:**

**City:** Kanazawa-shi

**Country:** Japan

**Facility:** Local Institution - 0144

**State:** Ishikawa

**Zip:** 9208641

**Location 77:**

**City:** Yokohama

**Country:** Japan

**Facility:** Local Institution - 0125

**State:** Kanagawa

**Zip:** 241-8515

**Location 78:**

**City:** Sendai-shi

**Country:** Japan

**Facility:** Local Institution - 0131

**State:** Miyagi

**Zip:** 9800873

**Location 79:**

**City:** Sakai-shi

**Country:** Japan

**Facility:** Local Institution - 0126

**State:** Osaka

**Zip:** 5918555

**Location 80:**

**City:** Kitaadachigun

**Country:** Japan

**Facility:** Local Institution - 0130

**State:** Saitama

**Zip:** 3620806

**Location 81:**

**City:** Bunkyo-ku

**Country:** Japan

**Facility:** Local Institution - 0142

**State:** Tokyo

**Zip:** 1138431

**Location 82:**

**City:** Bunkyo-ku

**Country:** Japan

**Facility:** Local Institution - 0133

**State:** Tokyo

**Zip:** 1138603

**Location 83:**

**City:** Chuo-ku

**Country:** Japan

**Facility:** Local Institution - 0143

**State:** Tokyo

**Zip:** 1040045

**Location 84:**

**City:** Chuo-ku

**Country:** Japan

**Facility:** Local Institution - 0134

**State:** Tokyo

**Zip:** 5418567

**Location 85:**

**City:** Fukushima-shi

**Country:** Japan

**Facility:** Local Institution - 0132

**Zip:** 960-1295

**Location 86:**

**City:** Hiroshima

**Country:** Japan

**Facility:** Local Institution - 0128

**Zip:** 734-8551

**Location 87:**

**City:** Guadalajara

**Country:** Mexico

**Facility:** Local Institution - 0077

**State:** Jalisco

**Zip:** 44280

**Location 88:**

**City:** Monterrey

**Country:** Mexico

**Facility:** Local Institution - 0027

**State:** Nuevo Leon

**Zip:** 64460

**Location 89:**

**City:** Chihuahua

**Country:** Mexico

**Facility:** Local Institution - 0028

**Zip:** 31000

**Location 90:**

**City:** Groningen

**Country:** Netherlands

**Facility:** Local Institution - 0004

**Zip:** 9700RB

**Location 91:**

**City:** Rotterdam

**Country:** Netherlands

**Facility:** Local Institution - 0003

**Zip:** 3015 GD

**Location 92:**

**City:** Kraków

**Country:** Poland

**Facility:** Local Institution - 0049

**State:** Małopolskie

**Zip:** 31-202

**Location 93:**

**City:** Hato Rey

**Country:** Puerto Rico

**Facility:** Local Institution - 0117

**Zip:** 00917

**Location 94:**

**City:** Cluj-Napoca

**Country:** Romania

**Facility:** Local Institution - 0013

**State:** Cluj

**Zip:** 400015

**Location 95:**

**City:** Bucuresti

**Country:** Romania

**Facility:** Local Institution - 0011

**Zip:** 022328

**Location 96:**

**City:** Floresti

**Country:** Romania

**Facility:** Local Institution - 0012

**Zip:** 407280

**Location 97:**

**City:** Moscow

**Country:** Russian Federation

**Facility:** Local Institution

**Zip:** 115478

**Location 98:**

**City:** Saint-Petersburg

**Country:** Russian Federation

**Facility:** Local Institution

**Zip:** 197758

**Location 99:**

**City:** St. Petersburg

**Country:** Russian Federation

**Facility:** Local Institution

**Zip:** 194291

**Location 100:**

**City:** St. Petersburg

**Country:** Russian Federation

**Facility:** Local Institution

**Zip:** 198255

**Location 101:**

**City:** Madrid

**Country:** Spain

**Facility:** Local Institution - 0046

**Zip:** 28006

**Location 102:**

**City:** Majadahonda - Madrid

**Country:** Spain

**Facility:** Local Institution - 0044

**Zip:** 28222

**Location 103:**

**City:** Valencia

**Country:** Spain

**Facility:** Local Institution - 0045

**Zip:** 46026

**Location 104:**

**City:** Kaohsiung City

**Country:** Taiwan

**Facility:** Local Institution - 0149

**Zip:** 807

**Location 105:**

**City:** Kaohsiung

**Country:** Taiwan

**Facility:** Local Institution - 0119

**Zip:** 833

**Location 106:**

**City:** New Taipei City

**Country:** Taiwan

**Facility:** Local Institution - 0116

**Zip:** 235

**Location 107:**

**City:** Taipei City

**Country:** Taiwan

**Facility:** Local Institution - 0112

**Zip:** 100225

**Location 108:**

**City:** Taunton

**Country:** United Kingdom

**Facility:** Local Institution - 0007

**Zip:** TA1 5DA

#### Overall Officials

**Official 1:**

**Affiliation:** Bristol-Myers Squibb

**Name:** Bristol-Myers Squibb

**Role:** STUDY_DIRECTOR

### References Module

#### References

**Citation:** Leal TA, Ramalingam SS. Neoadjuvant therapy gains FDA approval in non-small cell lung cancer. Cell Rep Med. 2022 Jul 19;3(7):100691. doi: 10.1016/j.xcrm.2022.100691.

**PMID:** 35858590

**Citation:** Hong WX, Sagiv-Barfi I, Czerwinski DK, Sallets A, Levy R. Neoadjuvant Intratumoral Immunotherapy with TLR9 Activation and Anti-OX40 Antibody Eradicates Metastatic Cancer. Cancer Res. 2022 Apr 1;82(7):1396-1408. doi: 10.1158/0008-5472.CAN-21-1382.

**PMID:** 35135810

#### See Also Links

**Label:** BMS Clinical Trial Information

**URL:** https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html

**Label:** BMS Clinical Trial Patient Recruiting

**URL:** https://www.bmsstudyconnect.com/content/studyconnect/us/en/clinical-trials/NCT04025879.html

## Derived Section

### Condition Browse Module - Ancestors

- ID: D000002283

- Term: Carcinoma, Bronchogenic

- ID: D000001984

- Term: Bronchial Neoplasms

- ID: D000008175

- Term: Lung Neoplasms

- ID: D000012142

- Term: Respiratory Tract Neoplasms

- ID: D000013899

- Term: Thoracic Neoplasms

- ID: D000009371

- Term: Neoplasms by Site

- ID: D000009369

- Term: Neoplasms

- ID: D000008171

- Term: Lung Diseases

- ID: D000012140

- Term: Respiratory Tract Diseases

### Condition Browse Module - Browse Branches

- Abbrev: BC04

- Name: Neoplasms

- Abbrev: All

- Name: All Conditions

- Abbrev: BC08

- Name: Respiratory Tract (Lung and Bronchial) Diseases

### Condition Browse Module - Browse Leaves

- ID: M5534

- Name: Carcinoma

- Relevance: LOW

- As Found: Unknown

- ID: M11172

- Name: Lung Neoplasms

- Relevance: LOW

- As Found: Unknown

- ID: M5546

- Name: Carcinoma, Non-Small-Cell Lung

- Relevance: HIGH

- As Found: Carcinoma, Non-Small-Cell Lung

- ID: M5540

- Name: Carcinoma, Bronchogenic

- Relevance: LOW

- As Found: Unknown

- ID: M5260

- Name: Bronchial Neoplasms

- Relevance: LOW

- As Found: Unknown

- ID: M14979

- Name: Respiratory Tract Neoplasms

- Relevance: LOW

- As Found: Unknown

- ID: M16658

- Name: Thoracic Neoplasms

- Relevance: LOW

- As Found: Unknown

- ID: M11168

- Name: Lung Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M14977

- Name: Respiratory Tract Diseases

- Relevance: LOW

- As Found: Unknown

### Condition Browse Module - Meshes

- ID: D000002289

- Term: Carcinoma, Non-Small-Cell Lung

### Intervention Browse Module - Ancestors

- ID: D000000972

- Term: Antineoplastic Agents, Phytogenic

- ID: D000000970

- Term: Antineoplastic Agents

- ID: D000050257

- Term: Tubulin Modulators

- ID: D000050256

- Term: Antimitotic Agents

- ID: D000050258

- Term: Mitosis Modulators

- ID: D000045504

- Term: Molecular Mechanisms of Pharmacological Action

- ID: D000074322

- Term: Antineoplastic Agents, Immunological

- ID: D000082082

- Term: Immune Checkpoint Inhibitors

- ID: D000004791

- Term: Enzyme Inhibitors

- ID: D000005493

- Term: Folic Acid Antagonists

- ID: D000019384

- Term: Nucleic Acid Synthesis Inhibitors

### Intervention Browse Module - Browse Branches

- Abbrev: ANeo

- Name: Antineoplastic Agents

- Abbrev: All

- Name: All Drugs and Chemicals

- Abbrev: Micro

- Name: Micronutrients

- Abbrev: Hemat

- Name: Hematinics

- Abbrev: Vi

- Name: Vitamins

### Intervention Browse Module - Browse Leaves

- ID: M19537

- Name: Paclitaxel

- Relevance: HIGH

- As Found: Surgery

- ID: M231

- Name: Albumin-Bound Paclitaxel

- Relevance: LOW

- As Found: Unknown

- ID: M6182

- Name: Cisplatin

- Relevance: LOW

- As Found: Unknown

- ID: M1854

- Name: Nivolumab

- Relevance: HIGH

- As Found: Prospective

- ID: M1668

- Name: Docetaxel

- Relevance: HIGH

- As Found: Physical

- ID: M18650

- Name: Carboplatin

- Relevance: HIGH

- As Found: System

- ID: M264

- Name: Pemetrexed

- Relevance: HIGH

- As Found: General

- ID: M26197

- Name: Tubulin Modulators

- Relevance: LOW

- As Found: Unknown

- ID: M26196

- Name: Antimitotic Agents

- Relevance: LOW

- As Found: Unknown

- ID: M1346

- Name: Antineoplastic Agents, Immunological

- Relevance: LOW

- As Found: Unknown

- ID: M2342

- Name: Immune Checkpoint Inhibitors

- Relevance: LOW

- As Found: Unknown

- ID: M7951

- Name: Enzyme Inhibitors

- Relevance: LOW

- As Found: Unknown

- ID: M8618

- Name: Folic Acid

- Relevance: LOW

- As Found: Unknown

- ID: M17546

- Name: Vitamin B Complex

- Relevance: LOW

- As Found: Unknown

- ID: M8619

- Name: Folic Acid Antagonists

- Relevance: LOW

- As Found: Unknown

- ID: T447

- Name: Folinic Acid

- Relevance: LOW

- As Found: Unknown

- ID: T446

- Name: Folic Acid

- Relevance: LOW

- As Found: Unknown

- ID: T448

- Name: Folate

- Relevance: LOW

- As Found: Unknown

- ID: T475

- Name: Vitamin B9

- Relevance: LOW

- As Found: Unknown

### Intervention Browse Module - Meshes

- ID: D000017239

- Term: Paclitaxel

- ID: D000077143

- Term: Docetaxel

- ID: D000016190

- Term: Carboplatin

- ID: D000077594

- Term: Nivolumab

- ID: D000068437

- Term: Pemetrexed

### Misc Info Module

- Version Holder: 2024-05-24
