## Protocol Section
### Identification Module
**NCT ID:** NCT01558479

**Acronym:** PaGeR

**Brief Title:** The Parkinson's Genetic Research Study

**Official Title:** The Parkinson's Genetic Research Study (PaGeR)

#### Organization Study ID Info
**ID:** 36777
#### Organization
**Class:** OTHER
**Full Name:** University of Washington
### Status Module
#### Completion Date
**Date:** 2026-10-31

**Type:** ESTIMATED

#### Expanded Access Info
#### Last Update Post Date
**Date:** 2024-05-14

**Type:** ACTUAL

**Last Update Submit Date:** 2024-05-11

**Overall Status:** RECRUITING

#### Primary Completion Date
**Date:** 2026-10-31

**Type:** ESTIMATED

#### Start Date
**Date:** 2009-09

**Type:** ACTUAL

**Status Verified Date:** 2024-05

#### Study First Post Date
**Date:** 2012-03-20
**Type:** ESTIMATED
**Study First Submit Date:** 2012-03-16
**Study First Submit QC Date:** 2012-03-16
### Sponsor Collaborators Module

#### Lead Sponsor

**Class:** OTHER

**Name:** University of Washington

#### Responsible Party

**Investigator Affiliation:** University of Washington

**Investigator Full Name:** Cyrus Zabetian

**Investigator Title:** Professor of Neurology

**Type:** PRINCIPAL_INVESTIGATOR

### Oversight Module

**Oversight Has DMC:** False

### Description Module

**Brief Summary:** The Parkinson's Genetic Research Study (PaGeR), headed by Dr. Cyrus Zabetian, is searching for genes that increase the risk of developing Parkinson's disease (PD) and related disorders. The study is a joint effort by neurologists and researchers across the United States and is sponsored by the National Institutes of Health. The coordinating center for PaGeR is located at the University of Washington and the VA Puget Sound Health Care System in Seattle.

**Detailed Description:** PaGeR is focusing on families in which two or more people have been diagnosed with PD. Past research suggests that such "multiplex" families might hold the key to the discovery of new PD genes.

To take part in PaGeR, participants will be asked to complete a questionnaire and to undergo an interview, a neurological exam, a short memory test, and a blood draw. Enrollment in the study usually takes between one and two hours. There is no cost to participate, and all study information is kept strictly confidential.

There are a number of designated sites across the country where families can enroll. However, for family members who are unable to travel to one of these sites, other arrangements can be made.

### Conditions Module

**Conditions:**

- Parkinson's Disease

**Keywords:**

- Parkinson's Disease

- Genetics

- Family Research

- Hereditary Neurodegenerative Diseases

### Design Module

#### Bio Spec

**Description:** Blood or saliva

**Retention:** SAMPLES_WITH_DNA

#### Design Info

**Observational Model:** FAMILY_BASED

**Time Perspective:** CROSS_SECTIONAL

#### Enrollment Info

**Count:** 5000

**Type:** ESTIMATED

**Study Type:** OBSERVATIONAL

### Arms Interventions Module

#### Arm Group 1

**Description:** Has a diagnosis of Parkinson's disease

**Label:** Case

#### Arm Group 2

**Description:** No diagnosis of Parkinson's disease

**Label:** Control

#### Arm Group 3

**Description:** Has a family history of Parkinson's disease. Can be affected or unaffected with Parkinson's disease

**Label:** Family Member

### Eligibility Module

**Eligibility Criteria:** Inclusion Criteria:

* Over 18 years of age
* Member of a family in which there are two or more living individuals who have been diagnosed with Parkinson's disease

Exclusion Criteria:

* Under 18 years of age

**Healthy Volunteers:** True

**Minimum Age:** 18 Years

**Sampling Method:** NON_PROBABILITY_SAMPLE

**Sex:** ALL

**Standard Ages:**

- ADULT

- OLDER_ADULT

**Study Population:** Families in which two or more people have been diagnosed with Parkinson's disease.

### Contacts Locations Module

#### Central Contacts

**Contact 1:**

**Name:** Jennifer Pate

**Phone:** 1-855-646-4221

**Role:** CONTACT

**Contact 2:**

**Email:** kcapawa@uw.edu

**Name:** Khryss Capawa

**Phone:** (206) 277-3956

**Role:** CONTACT

#### Locations

**Location 1:**

**City:** Atlanta

**Contacts:**

***Contact 1:***

- **Email:** bsommer@emory.edu

- **Name:** Barbara Sommerfield, MSN, RN

- **Phone:** 404-728-6944

- **Role:** CONTACT

**Country:** United States

**Facility:** Emory University/ Wesley Woods Health Center

**State:** Georgia

**Status:** RECRUITING

**Zip:** 30329

**Location 2:**

**City:** Cincinnati

**Contacts:**

***Contact 1:***

- **Email:** katie.krier@uc.edu

- **Name:** Jatue Krier

- **Phone:** 513-558-0169

- **Role:** CONTACT

**Country:** United States

**Facility:** University of Cincinnati

**State:** Ohio

**Status:** RECRUITING

**Zip:** 45267

**Location 3:**

**City:** Portland

**Contacts:**

***Contact 1:***

- **Name:** Susan O'Connor

- **Phone:** 503-220-8262

- **Phone Ext:** 53262

- **Role:** CONTACT

**Country:** United States

**Facility:** Portland VA Medical Center

**State:** Oregon

**Status:** RECRUITING

**Zip:** 97239

**Location 4:**

**City:** Seattle

**Contacts:**

***Contact 1:***

- **Name:** Jennifer Pate

- **Phone:** 855-646-4221

- **Role:** CONTACT

***Contact 2:***

- **Name:** Cyrus Zabetian, MD, MS

- **Role:** PRINCIPAL_INVESTIGATOR

**Country:** United States

**Facility:** VA Puget Sound Health Care System

**State:** Washington

**Status:** RECRUITING

**Zip:** 98108

**Location 5:**

**City:** Seattle

**Contacts:**

***Contact 1:***

- **Name:** Jennifer Pate

- **Phone:** 855-646-4221

- **Role:** CONTACT

***Contact 2:***

- **Name:** Cyrus Zabetian, MD, MS

- **Role:** PRINCIPAL_INVESTIGATOR

**Country:** United States

**Facility:** University of Washington

**State:** Washington

**Status:** RECRUITING

**Zip:** 98118

#### Overall Officials

**Official 1:**

**Affiliation:** University of Washington, VA Puget Sound Health Care System

**Name:** Cyrus Zabetian, MD, MS

**Role:** PRINCIPAL_INVESTIGATOR

### References Module

#### See Also Links

**Label:** Study Website

**URL:** http://www.thepagerstudy.org

## Derived Section

### Condition Browse Module - Ancestors

- ID: D000020734

- Term: Parkinsonian Disorders

- ID: D000001480

- Term: Basal Ganglia Diseases

- ID: D000001927

- Term: Brain Diseases

- ID: D000002493

- Term: Central Nervous System Diseases

- ID: D000009422

- Term: Nervous System Diseases

- ID: D000009069

- Term: Movement Disorders

- ID: D000080874

- Term: Synucleinopathies

- ID: D000019636

- Term: Neurodegenerative Diseases

### Condition Browse Module - Browse Branches

- Abbrev: BC10

- Name: Nervous System Diseases

- Abbrev: All

- Name: All Conditions

- Abbrev: BC16

- Name: Diseases and Abnormalities at or Before Birth

- Abbrev: BC04

- Name: Neoplasms

- Abbrev: BC17

- Name: Skin and Connective Tissue Diseases

- Abbrev: BC18

- Name: Nutritional and Metabolic Diseases

### Condition Browse Module - Browse Leaves

- ID: M13213

- Name: Parkinson Disease

- Relevance: HIGH

- As Found: Parkinson's

- ID: M21558

- Name: Neurodegenerative Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M22092

- Name: Heredodegenerative Disorders, Nervous System

- Relevance: LOW

- As Found: Unknown

- ID: M22494

- Name: Parkinsonian Disorders

- Relevance: LOW

- As Found: Unknown

- ID: M25603

- Name: Ganglion Cysts

- Relevance: LOW

- As Found: Unknown

- ID: M16358

- Name: Synovial Cyst

- Relevance: LOW

- As Found: Unknown

- ID: M4774

- Name: Basal Ganglia Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M5204

- Name: Brain Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M5742

- Name: Central Nervous System Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M12029

- Name: Movement Disorders

- Relevance: LOW

- As Found: Unknown

- ID: M2217

- Name: Synucleinopathies

- Relevance: LOW

- As Found: Unknown

### Condition Browse Module - Meshes

- ID: D000010300

- Term: Parkinson Disease

### Misc Info Module

- Version Holder: 2024-05-24
