## Protocol Section
### Identification Module
**NCT ID:** NCT03084679

**Brief Title:** Characterization of Myocardial Interstitial Fibrosis and Cardiomyocyte Hypertrophy by Cardiac MRI in Heart Failure

**Official Title:** Characterization of Myocardial Interstitial Fibrosis and Cardiomyocyte Hypertrophy by Cardiac MRI In Heart Failure: Implication on Early Remodeling and on the Transition to Heart Failure

#### Organization Study ID Info
**ID:** HF-CMR-53967215800005404
#### Organization
**Class:** OTHER
**Full Name:** University of Campinas, Brazil
#### Secondary ID Infos
**Domain:** São Paulo Research Foundation
**ID:** FAPESP 2015/15402-2
**Type:** OTHER_GRANT
### Status Module
#### Completion Date
**Date:** 2020-07

**Type:** ESTIMATED

#### Expanded Access Info
**Last Known Status:** RECRUITING
#### Last Update Post Date
**Date:** 2019-06-05

**Type:** ACTUAL

**Last Update Submit Date:** 2019-06-03

**Overall Status:** UNKNOWN

#### Primary Completion Date
**Date:** 2019-06-01

**Type:** ESTIMATED

#### Start Date
**Date:** 2017-11-01

**Type:** ACTUAL

**Status Verified Date:** 2019-06

#### Study First Post Date
**Date:** 2017-03-21
**Type:** ACTUAL
**Study First Submit Date:** 2016-12-25
**Study First Submit QC Date:** 2017-03-20
### Sponsor Collaborators Module

#### Lead Sponsor

**Class:** OTHER

**Name:** University of Campinas, Brazil

#### Responsible Party

**Investigator Affiliation:** University of Campinas, Brazil

**Investigator Full Name:** Otavio Rizzi Coelho Filho

**Investigator Title:** Assistant Professor

**Type:** PRINCIPAL_INVESTIGATOR

### Oversight Module

**Is FDA Regulated Device:** False

**Is FDA Regulated Drug:** False

**Is US Export:** False

**Oversight Has DMC:** True

### Description Module

**Brief Summary:** The investigators hypothesised that novel MRI metrics derived from myocardium post-gadolinium T1 mapping analysis will improve the current knowledge about the role interstitial fibrosis and cardiomyocyte hypertrophy in the development of left ventricular (LV) remodelling and clinical Heart Failure (HF). The investigators believe that these recently described variables will be associated with prognostically important indices in HF development.

**Detailed Description:** Cardiac hypertrophy is one of the earliest manifestations of myocardial disease, representing a modifiable, prognostic response to hemodynamic stimuli across physiologic (e.g., exercise) and pathologic states (e.g., hypertension, aortic stenosis). The extent of myocardial hypertrophy is determined by a combination of cardiomyocyte size and extracellular volume (ECV) expansion/interstitial fibrosis: while physiologic (exercise-induced) hypertrophy reflects mostly reversible cardiomyocyte hypertrophy, pathologic hypertrophy (e.g., in heart failure) is a combination of both interstitial fibrosis (potentially irreversible) and cardiomyocyte hypertrophy (reversible). Current methods to delineate the potential for LV reverse remodeling (e.g., natriuretic peptides and echocardiographic or clinical markers) detect primarily advanced disease, missing a critical opportunity to intervene and follow patients at an early disease phase where myocardial pathology may be reversible. Therefore, establishing novel, quantitative metrics of myocardial tissue phenotype that define a transition from hypertrophy to fibrosis, and then to irreversible LV remodeling/dysfunction may facilitate targeting therapies at a modifiable stage of disease in HF. The investigator's group has recently extended cardiac T1 mapping MRI techniques to quantify the intracellular lifetime of water (τic) serially as an index of cardiomyocyte diameter, validating this technique histologically in mouse models of pressure overload.

### Conditions Module

**Conditions:**

- Heart Failure

**Keywords:**

- Heart Failure

- Hypertrophy

- Fibrosis

- Magnetic Resonance

### Design Module

#### Design Info

**Allocation:** RANDOMIZED

**Intervention Model:** PARALLEL

**Intervention Model Description:** Randomized trial in a 2:1 (intervention:control) proportion and in blocks of 6 participants.

##### Masking Info

**Masking:** NONE

**Primary Purpose:** TREATMENT

#### Enrollment Info

**Count:** 90

**Type:** ESTIMATED

**Phases:**

- NA

**Study Type:** INTERVENTIONAL

### Arms Interventions Module

#### Arm Group 1

**Description:** Heart Failure patients with preserved ejection fraction (HFpEF) randomized to this arm will keep receiving their conventional clinical care, being instructed to continue and maintain their usual daily activities.

**Label:** Conventional Clinical Care - HFpEF

**Type:** NO_INTERVENTION

#### Arm Group 2

**Description:** Heart Failure patients with preserved ejection fraction (HFpEF) randomized to this arm will keep receiving their conventional clinical care and participate in a supervised, facility based training program consisting of stretching exercises and aerobic exercise in treadmill.

**Intervention Names:**

- Other: Aerobic exercise in treadmill

- Other: Local strengthening exercises

- Other: Stretching exercises

**Label:** Supervised Exercise Training- HFpEF

**Type:** OTHER

#### Arm Group 3

**Description:** Heart Failure patients with reduced ejection fraction (HFrEF) randomized to this arm will keep receiving their conventional clinical care, being instructed to continue and maintain their usual daily activities.

**Label:** Conventional Clinical Care - HFrEF

**Type:** NO_INTERVENTION

#### Arm Group 4

**Description:** Heart Failure patients with reduced ejection fraction (HFrEF) randomized to this arm will keep receiving their conventional clinical care and participate in a supervised, facility based training program consisting of stretching exercises and aerobic exercise in treadmill.

**Intervention Names:**

- Other: Aerobic exercise in treadmill

- Other: Local strengthening exercises

- Other: Stretching exercises

**Label:** Supervised Exercise Training - HFrEF

**Type:** OTHER

### Interventions

#### Intervention 1

**Arm Group Labels:**

- Supervised Exercise Training - HFrEF

- Supervised Exercise Training- HFpEF

**Description:** 30-40min of aerobic exercise in treadmill. The aerobic intensity will be established by heart rate levels that corresponded to anaerobic threshold up to 10% below the respiratory compensation point obtained in the cardiopulmonary exercise test. This intensity corresponded to 60-72% peak V̇o2. During the exercise sessions, when a training effect will be observed, as indicated by a decrease by 8 to 10% in heart rate, the treadmill velocity or inclination will be increased to return to the target heart rate levels.

**Name:** Aerobic exercise in treadmill

**Type:** OTHER

#### Intervention 2

**Arm Group Labels:**

- Supervised Exercise Training - HFrEF

- Supervised Exercise Training- HFpEF

**Description:** 15 min of local strengthening exercises will be performed in major muscle groups (legs, arms and trunk muscles): three series of each exercise, 12-15 repetitions.

**Name:** Local strengthening exercises

**Type:** OTHER

#### Intervention 3

**Arm Group Labels:**

- Supervised Exercise Training - HFrEF

- Supervised Exercise Training- HFpEF

**Description:** 5-min stretching exercises will be performed in major muscle groups (legs, arms and trunk muscles)

**Name:** Stretching exercises

**Type:** OTHER

### Outcomes Module

#### Primary Outcomes

**Description:** Investigate whether rehabilitation compared to usual care is associated with significant favorable myocardial remodeling assessed by CMR determination of ECV.

**Measure:** Myocardial remodeling assessed by CMR in rehabilitation vs usual care.

**Time Frame:** 4 months

#### Secondary Outcomes

**Description:** Left Ventricular ejection fraction (%) will be determined by cardiac magnetic resonance using a previously described cine steady-state free precession imaging. All patients will be imaged with ECG gating and breath holding in a supine position. Patients will be imaged at baseline and after 4 months of the intervention.

**Measure:** Change in left ventricular ejection fraction

**Time Frame:** 4 months

**Description:** Right Ventricular ejection fraction (%) will be determined by cardiac magnetic resonance using a previously described cine steady-state free precession imaging. All patients will be imaged with ECG gating and breath holding in a supine position. Patients will be imaged at baseline and after 4 months of the intervention.

**Measure:** Change in right ventricular ejection fraction

**Time Frame:** 4 months

**Description:** Left ventricular mass absolute (g) and index (g/m2) will be determined by cardiac magnetic resonance using a previously described cine steady-state free precession imaging. All patients will be imaged with ECG gating and breath holding in a supine position. Patients will be imaged at baseline and after 4 months of the intervention.

**Measure:** Change in left ventricular mass (absolute/index)

**Time Frame:** 4 months

**Description:** Left ventricular diastolic volume absolute (ml) and index (ml/m2) will be determined by cardiac magnetic resonance using a previously described cine steady-state free precession imaging. All patients will be imaged with ECG gating and breath holding in a supine position. Patients will be imaged at baseline and after 4 months of the intervention.

**Measure:** Change in left ventricular diastolic volume (absolute/index)

**Time Frame:** 4 months

**Description:** Right ventricular diastolic volume absolute (ml) and index (ml/m2) will be determined by cardiac magnetic resonance using a previously described cine steady-state free precession imaging. All patients will be imaged with ECG gating and breath holding in a supine position. Patients will be imaged at baseline and after 4 months of the intervention.

**Measure:** Change in right ventricular diastolic volume (absolute/index)

**Time Frame:** 4 months

**Description:** Left ventricular systolic volume absolute (ml) and index (ml/m2) will be determined by cardiac magnetic resonance using a previously described cine steady-state free precession imaging. All patients will be imaged with ECG gating and breath holding in a supine position. Patients will be imaged at baseline and after 4 months of the intervention.

**Measure:** Change in left ventricular systolic volume (absolute/index)

**Time Frame:** 4 months

**Description:** Right ventricular systolic volume absolute (ml) and index (ml/m2) will be determined by cardiac magnetic resonance using a previously described cine steady-state free precession imaging. All patients will be imaged with ECG gating and breath holding in a supine position. Patients will be imaged at baseline and after 4 months of the intervention.

**Measure:** Change in right ventricular systolic volume (absolute/index)

**Time Frame:** 4 months

**Description:** Left ventricular stroke volume absolute (ml) and index (ml/m2) will be determined by cardiac magnetic resonance using a previously described cine steady-state free precession imaging. All patients will be imaged with ECG gating and breath holding in a supine position. Patients will be imaged at baseline and after 4 months of the intervention.

**Measure:** Change in left ventricular stroke volume (absolute/index)

**Time Frame:** 4 months

**Description:** Right ventricular stroke volume (absolute (ml) and index (ml/m2) will be determined by cardiac magnetic resonance using a previously described cine steady-state free precession imaging. All patients will be imaged with ECG gating and breath holding in a supine position. Patients will be imaged at baseline and after 4 months of the intervention.

**Measure:** Change in right ventricular stroke volume (absolute/index)

**Time Frame:** 4 months

**Description:** Late gadolinium enhancement (LGE) will be determined by cardiac magnetic resonance using a previously describe inversion recovery sequence after 10-15 minutes of a cumulative dose of 0,2 mmol/kg of gadolinium diethylenetriamine pentaacetic acid. All patients will be imaged with ECG gating and breath holding in a supine position. Patients will be imaged at baseline and after 4 months of the intervention.

**Measure:** Change in late gadolinium enhancement

**Time Frame:** 4 months

**Description:** LV mass/volume ratio (g/mL) will be determined by cardiac magnetic resonance using a previously described cine steady-state free precession imaging. All patients will be imaged with ECG gating and breath holding in a supine position. Patients will be imaged at baseline and after 4 months of the intervention.

**Measure:** Change in LV mass/volume ratio

**Time Frame:** 4 months

**Description:** VO2max will be evaluated by cardiopulmonary test. Patients will performed the cardiopulmonary test at baseline and after 4 months of the intervention.

**Measure:** Change in functional capacity

**Time Frame:** 4 months

**Description:** Quality of life will be evaluated by numerical score of Minnesota Questionnaire.

Patients will performed the Minnesota Questionnaire at baseline and after 4 months of the intervention.

**Measure:** Change in quality of life

**Time Frame:** 4 months

**Description:** Change in NT-proBNP with the intervention.

**Measure:** Change in N-Terminal pro-B-type Natriuretic Peptide (NT-proBNP)

**Time Frame:** 4 months

**Description:** Change in parameters of diastolic dysfunction assessed before and after the intervention.

**Measure:** Change in diastolic dysfunction assessed by transthoracic echocardiogram

**Time Frame:** 4 months

**Description:** Change in cardiac sympathetic function assessed by cardiac uptake of metaiodobenzylguanidine (MIBG) labeled with I-123. Patients will performed the MIBG study at baseline and after 4 months of the intervention.

**Measure:** Change in cardiac sympathetic function

**Time Frame:** 4 months

**Description:** τic will be determined by cardiac magnetic resonance T1 measurements acquired before and after administration of gadolinium diethylenetriamine pentaacetic acid (0,2mmol/kg), at 2 different time points (baseline and 4-moths after the intervention)

**Measure:** Change in intracellular lifetime of water (τic - a marker of cardiomyocyte hypertrophy)

**Time Frame:** 4 months

### Eligibility Module

**Eligibility Criteria:** Inclusion Criteria:

* Age\> 18 years
* Functional limitation (New York Heart Association Class II or worse)
* No contraindication to exercise (American College of Cardiology / American Heart Association criteria)
* Eligibility to take MRI (absence of metallic devices, and glomerular filtration rate \> 40ml / min / 1.73m2, etc.)
* Prior diagnosis of Heart Failure (by the Framingham criterion)
* Therapy with diuretic and euvolemia state (evaluated by cardiologist and cardiopulmonary exercise testing)
* Transthoracic echocardiogram

Exclusion Criteria:

* Severe ischemia in any stress test
* Hypertrophic cardiomyopathy or any infiltrative heart disease
* Chronic obstructive pulmonary disease , pulmonary hypertension (Pulmonary artery pressure\> 60mmHg)
* Severe left or right valve disease.
* Pacemaker or implantable cardioverter defibrillator
* Myocardial infarction or revascularization in 3 months
* Anemia (hemoglobin \<10 grams / dl) until 1 month before cardiopulmonary exercise testing

**Minimum Age:** 18 Years

**Sex:** ALL

**Standard Ages:**

- ADULT

- OLDER_ADULT

### Contacts Locations Module

#### Central Contacts

**Contact 1:**

**Email:** tavicocoelho@gmail.com

**Name:** OTAVIO R COELHO-FILHO, MD, MPH, PhD

**Phone:** 996038484

**Phone Ext:** +5519

**Role:** CONTACT

**Contact 2:**

**Email:** fermedesportiva@yahoo.com.br

**Name:** FERNANDO B CARDOSO, MD

**Phone:** 999203131

**Phone Ext:** +5519

**Role:** CONTACT

#### Locations

**Location 1:**

**City:** Campinas

**Contacts:**

***Contact 1:***

- **Email:** tavicocoelho@gmail.com

- **Name:** Otavio R Coelho Filho, MD, PhD

- **Phone:** +5519996038484

- **Role:** CONTACT

***Contact 2:***

- **Email:** fermedesportiva@yahoo.com.br

- **Name:** Fernando B Cardoso, MD

- **Phone:** +5519999203131

- **Role:** CONTACT

**Country:** Brazil

**Facility:** University of Campinas

**State:** São Paulo

**Status:** RECRUITING

#### Overall Officials

**Official 1:**

**Affiliation:** University of Campinas, Brazil

**Name:** OTAVIO R COELHO-FILHO, MD, MPH, PhD

**Role:** PRINCIPAL_INVESTIGATOR

### IPD Sharing Statement Module

**Description:** No plan to Share individual participant data.

**IPD Sharing:** NO

### References Module

#### References

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## Derived Section

### Condition Browse Module - Ancestors

- ID: D000006331

- Term: Heart Diseases

- ID: D000002318

- Term: Cardiovascular Diseases

- ID: D000010335

- Term: Pathologic Processes

- ID: D000020763

- Term: Pathological Conditions, Anatomical

### Condition Browse Module - Browse Branches

- Abbrev: BC23

- Name: Symptoms and General Pathology

- Abbrev: All

- Name: All Conditions

- Abbrev: BC14

- Name: Heart and Blood Diseases

### Condition Browse Module - Browse Leaves

- ID: M8485

- Name: Fibrosis

- Relevance: HIGH

- As Found: Fibrosis

- ID: M9421

- Name: Heart Failure

- Relevance: HIGH

- As Found: Heart Failure

- ID: M10035

- Name: Hypertrophy

- Relevance: HIGH

- As Found: Hypertrophy

- ID: M9419

- Name: Heart Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M22519

- Name: Pathological Conditions, Anatomical

- Relevance: LOW

- As Found: Unknown

### Condition Browse Module - Meshes

- ID: D000006333

- Term: Heart Failure

- ID: D000005355

- Term: Fibrosis

- ID: D000006984

- Term: Hypertrophy

### Intervention Browse Module - Browse Branches

- Abbrev: CNSDep

- Name: Central Nervous System Depressants

- Abbrev: All

- Name: All Drugs and Chemicals

- Abbrev: Ot

- Name: Other Dietary Supplements

### Intervention Browse Module - Browse Leaves

- ID: M4854

- Name: Benzocaine

- Relevance: LOW

- As Found: Unknown

- ID: T433

- Name: Tannic Acid

- Relevance: LOW

- As Found: Unknown

### Misc Info Module

- Version Holder: 2024-05-24
