## Protocol Section
### Identification Module
**NCT ID:** NCT01135979

**Brief Title:** Assessment of the Sympathetic Nervous System Blockade of the Upper Limb After a Brachial Plexus Block in Patients With End Stage Renal Failure

**Official Title:** Assessment of the Sympathetic Nervous System Blockade of the Upper Limb After a Brachial Plexus Block in Patients With End Stage Renal Failure

#### Organization Study ID Info
**ID:** 07AN007
#### Organization
**Class:** OTHER
**Full Name:** University of Nottingham
### Status Module
#### Completion Date
**Date:** 2012-12

**Type:** ESTIMATED

#### Expanded Access Info
#### Last Update Post Date
**Date:** 2013-03-06

**Type:** ESTIMATED

**Last Update Submit Date:** 2013-03-05

**Overall Status:** WITHDRAWN

#### Primary Completion Date
**Date:** 2012-12

**Type:** ESTIMATED

#### Start Date
**Date:** 2010-02

**Status Verified Date:** 2013-03

#### Study First Post Date
**Date:** 2010-06-03
**Type:** ESTIMATED
**Study First Submit Date:** 2010-06-02
**Study First Submit QC Date:** 2010-06-02
**Why Stopped:** Unable to recruit
### Sponsor Collaborators Module

#### Lead Sponsor

**Class:** OTHER

**Name:** University of Nottingham

#### Responsible Party

**Type:** SPONSOR

### Oversight Module

**Oversight Has DMC:** False

### Description Module

**Brief Summary:** The purpose of this study is to investigate what effect a local anesthetic nerve block of the arm in patients with end stage renal failure has upon blood flow in the skin of the arm.

**Detailed Description:** Aim

To quantify the degree of sympathetic blockade in the upper limb in patients with end stage renal failure produced during a regional anaesthetic technique, using laser Doppler flowmetry.

Hypothesis

Regional anaesthesia of the upper limb results in blockade of motor and sensory nerves, providing surgical and post-operative analgesia. Sympathetic nerves are also blocked resulting in local vasodilatation. This may be of benefit in surgery where enhanced blood flow is beneficial such as arterio-venous fistula creation. The degree and duration of sympathetic blockade produced by regional blocks however, has never been quantified. This study aims to quantify sympathetic blockade by measuring the changes in skin blood flow and skin temperature after placement of a brachial plexus block.

### Conditions Module

**Conditions:**

- Renal Failure

### Design Module

#### Design Info

**Observational Model:** COHORT

**Time Perspective:** PROSPECTIVE

#### Enrollment Info

**Type:** ACTUAL

**Study Type:** OBSERVATIONAL

### Arms Interventions Module

#### Arm Group 1

**Label:** Arterio-venous fistulae creation

### Eligibility Module

**Eligibility Criteria:** Inclusion Criteria:

* Patients with end stage renal failure
* Over 18 years of age
* Written consent obtained
* Due to undergo surgery for forearm fistula creation under a regional block

Exclusion Criteria:

* Smokers
* Damaged skin on the arm
* Circulatory disorders such as Raynaud's disease, systemic sclerosis, sickle cell trait or disease
* Current use of beta blockers
* undergoing haemodialysis for more than 12 months

**Minimum Age:** 18 Years

**Sampling Method:** NON_PROBABILITY_SAMPLE

**Sex:** ALL

**Standard Ages:**

- ADULT

- OLDER_ADULT

**Study Population:** Patients with end stage renal failure who are due to have a forearm fistula created

### Contacts Locations Module

#### Locations

**Location 1:**

**City:** Nottingham

**Country:** United Kingdom

**Facility:** Nottingham University Hospitals NHS Trust

**State:** Nottinghamshire

**Zip:** NG7 2UH

## Derived Section

### Condition Browse Module - Ancestors

- ID: D000007674

- Term: Kidney Diseases

- ID: D000014570

- Term: Urologic Diseases

- ID: D000052776

- Term: Female Urogenital Diseases

- ID: D000005261

- Term: Female Urogenital Diseases and Pregnancy Complications

- ID: D000091642

- Term: Urogenital Diseases

- ID: D000052801

- Term: Male Urogenital Diseases

- ID: D000051436

- Term: Renal Insufficiency, Chronic

- ID: D000002908

- Term: Chronic Disease

- ID: D000020969

- Term: Disease Attributes

- ID: D000010335

- Term: Pathologic Processes

### Condition Browse Module - Browse Branches

- Abbrev: BXS

- Name: Urinary Tract, Sexual Organs, and Pregnancy Conditions

- Abbrev: BC23

- Name: Symptoms and General Pathology

- Abbrev: All

- Name: All Conditions

- Abbrev: Rare

- Name: Rare Diseases

### Condition Browse Module - Browse Leaves

- ID: M10699

- Name: Kidney Failure, Chronic

- Relevance: HIGH

- As Found: End Stage Renal Failure

- ID: M26718

- Name: Renal Insufficiency

- Relevance: HIGH

- As Found: Renal Failure

- ID: M10698

- Name: Kidney Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M17319

- Name: Urologic Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M2875

- Name: Urogenital Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M27093

- Name: Female Urogenital Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M14127

- Name: Pregnancy Complications

- Relevance: LOW

- As Found: Unknown

- ID: M8399

- Name: Female Urogenital Diseases and Pregnancy Complications

- Relevance: LOW

- As Found: Unknown

- ID: M27095

- Name: Male Urogenital Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M26717

- Name: Renal Insufficiency, Chronic

- Relevance: LOW

- As Found: Unknown

- ID: M6147

- Name: Chronic Disease

- Relevance: LOW

- As Found: Unknown

- ID: M22700

- Name: Disease Attributes

- Relevance: LOW

- As Found: Unknown

- ID: T1303

- Name: Chronic Graft Versus Host Disease

- Relevance: LOW

- As Found: Unknown

### Condition Browse Module - Meshes

- ID: D000051437

- Term: Renal Insufficiency

- ID: D000007676

- Term: Kidney Failure, Chronic

### Misc Info Module

- Version Holder: 2024-05-24
