## Protocol Section
### Identification Module
**NCT ID:** NCT04756479

**Acronym:** COVID-AGEBRU

**Brief Title:** Mortality Due to COVID-19 in the COVID-AGEBRU Study

**Official Title:** Predictors of Intrahospital Mortality in Older Patients Admitted Due to COVID-19 in the COVID-19 AGEBRU Study

#### Organization Study ID Info
**ID:** COVID-19 AGE-BRUGMANN 2020/111
#### Organization
**Class:** OTHER
**Full Name:** Brugmann University Hospital
### Status Module
#### Completion Date
**Date:** 2020-06-30

**Type:** ACTUAL

#### Expanded Access Info
#### Last Update Post Date
**Date:** 2022-04-06

**Type:** ACTUAL

**Last Update Submit Date:** 2022-03-28

**Overall Status:** COMPLETED

#### Primary Completion Date
**Date:** 2020-06-30

**Type:** ACTUAL

#### Start Date
**Date:** 2020-03-01

**Type:** ACTUAL

**Status Verified Date:** 2022-03

#### Study First Post Date
**Date:** 2021-02-16
**Type:** ACTUAL
**Study First Submit Date:** 2021-02-08
**Study First Submit QC Date:** 2021-02-15
### Sponsor Collaborators Module

#### Lead Sponsor

**Class:** OTHER

**Name:** Brugmann University Hospital

#### Responsible Party

**Investigator Affiliation:** Brugmann University Hospital

**Investigator Full Name:** Murielle Surquin

**Investigator Title:** Geriatrics Department

**Type:** PRINCIPAL_INVESTIGATOR

### Oversight Module

**Is FDA Regulated Device:** False

**Is FDA Regulated Drug:** False

**Oversight Has DMC:** False

### Description Module

**Brief Summary:** The COVID-Age Brugmann study aims to identify the clinical predictors of mortality risk in older patients admitted to an acute care unit due to COVID-19

**Detailed Description:** The COVID-19 disease has been shown to be associated to higher mortality risk and health adverse consequences. Despite of the fact that the SAR-COV2 virus has been shown that affects every populations, the negative impact is higher in older people, pointing this population as the most severely affected.

The COVID-Age Brugmann study aims to identify if comorbidity, geriatric syndromes, and health issues at admission are associated to mortality risk in older patients admitted to an acute care unit due to COVID-19

### Conditions Module

**Conditions:**

- Covid19

- Old Age; Debility

- Morbidity, Multiple

### Design Module

#### Design Info

**Observational Model:** CASE_ONLY

**Time Perspective:** RETROSPECTIVE

#### Enrollment Info

**Count:** 160

**Type:** ACTUAL

**Study Type:** OBSERVATIONAL

### Outcomes Module

#### Primary Outcomes

**Description:** Vital status was obtained from medical records

**Measure:** All-cause mortality during hospital admission (admission up to discharge time)

**Time Frame:** Through study completion, an average of one month.

#### Secondary Outcomes

**Description:** Clinical and demographical conditions, and geriatric syndromes

**Measure:** Prevalence of medical diseases and geriatric syndromes

**Time Frame:** Through study completion, an average of one month.

### Eligibility Module

**Eligibility Criteria:** Inclusion Criteria:

* Patients aged 70 and older
* Patients admitted to an acute care geriatric unit due to COVID-19
* Patients with COVID-19 by PCR, serology or CT scan suggestive of this disease

Exclusion Criteria:

* No other demographic or clinical exclusion criteria will be applied

**Minimum Age:** 70 Years

**Sampling Method:** NON_PROBABILITY_SAMPLE

**Sex:** ALL

**Standard Ages:**

- OLDER_ADULT

**Study Population:** Consecutive patients aged 70 and over hospitalized in an acute care unit in Brugmann university hospital, in Belgium, due to COVID-19 in the period Mars to June 2020.

### Contacts Locations Module

#### Locations

**Location 1:**

**City:** Brussels

**Country:** Belgium

**Facility:** CHU Brugmann

**Zip:** 1020

#### Overall Officials

**Official 1:**

**Affiliation:** CHU Brugmann, Director of the Geriatrics Department

**Name:** Murielle MS Surquin, MD PhD

**Role:** PRINCIPAL_INVESTIGATOR

### References Module

#### References

**Citation:** Mendes A, Serratrice C, Herrmann FR, Genton L, Perivier S, Scheffler M, Fassier T, Huber P, Jacques MC, Prendki V, Roux X, Di Silvestro K, Trombert V, Harbarth S, Gold G, Graf CE, Zekry D. Predictors of In-Hospital Mortality in Older Patients With COVID-19: The COVIDAge Study. J Am Med Dir Assoc. 2020 Nov;21(11):1546-1554.e3. doi: 10.1016/j.jamda.2020.09.014. Epub 2020 Sep 15.

**PMID:** 33138936

**Citation:** Menager P, Briere O, Gautier J, Riou J, Sacco G, Brangier A, Annweiler C, Geria-Covid Study Group OBOT. Regular Use of VKA Prior to COVID-19 Associated with Lower 7-Day Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Cohort Study. Nutrients. 2020 Dec 24;13(1):39. doi: 10.3390/nu13010039.

**PMID:** 33374341

**Citation:** Miralles O, Sanchez-Rodriguez D, Marco E, Annweiler C, Baztan A, Betancor E, Cambra A, Cesari M, Fontecha BJ, Gasowski J, Gillain S, Hope S, Phillips K, Piotrowicz K, Piro N, Sacco G, Saporiti E, Surquin M, Vall-Llosera E. Unmet needs, health policies, and actions during the COVID-19 pandemic: a report from six European countries. Eur Geriatr Med. 2021 Feb;12(1):193-204. doi: 10.1007/s41999-020-00415-x. Epub 2020 Oct 15. Erratum In: Eur Geriatr Med. 2021 Jun;12(3):667.

**PMID:** 33057981

## Derived Section

### Condition Browse Module - Ancestors

- ID: D000011024

- Term: Pneumonia, Viral

- ID: D000011014

- Term: Pneumonia

- ID: D000012141

- Term: Respiratory Tract Infections

- ID: D000007239

- Term: Infections

- ID: D000014777

- Term: Virus Diseases

- ID: D000018352

- Term: Coronavirus Infections

- ID: D000003333

- Term: Coronaviridae Infections

- ID: D000030341

- Term: Nidovirales Infections

- ID: D000012327

- Term: RNA Virus Infections

- ID: D000008171

- Term: Lung Diseases

- ID: D000012140

- Term: Respiratory Tract Diseases

- ID: D000010335

- Term: Pathologic Processes

### Condition Browse Module - Browse Branches

- Abbrev: BC01

- Name: Infections

- Abbrev: BC08

- Name: Respiratory Tract (Lung and Bronchial) Diseases

- Abbrev: All

- Name: All Conditions

- Abbrev: BC23

- Name: Symptoms and General Pathology

### Condition Browse Module - Browse Leaves

- ID: M2561

- Name: COVID-19

- Relevance: HIGH

- As Found: COVID-19

- ID: M1175

- Name: Frailty

- Relevance: HIGH

- As Found: Debility

- ID: M13904

- Name: Pneumonia

- Relevance: LOW

- As Found: Unknown

- ID: M13914

- Name: Pneumonia, Viral

- Relevance: LOW

- As Found: Unknown

- ID: M10283

- Name: Infections

- Relevance: LOW

- As Found: Unknown

- ID: M6368

- Name: Communicable Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M14978

- Name: Respiratory Tract Infections

- Relevance: LOW

- As Found: Unknown

- ID: M17522

- Name: Virus Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M20490

- Name: Coronavirus Infections

- Relevance: LOW

- As Found: Unknown

- ID: M6555

- Name: Coronaviridae Infections

- Relevance: LOW

- As Found: Unknown

- ID: M23685

- Name: Nidovirales Infections

- Relevance: LOW

- As Found: Unknown

- ID: M15149

- Name: RNA Virus Infections

- Relevance: LOW

- As Found: Unknown

- ID: M11168

- Name: Lung Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M14977

- Name: Respiratory Tract Diseases

- Relevance: LOW

- As Found: Unknown

### Condition Browse Module - Meshes

- ID: D000086382

- Term: COVID-19

- ID: D000073496

- Term: Frailty

### Misc Info Module

- Version Holder: 2024-05-24
