## Protocol Section
### Identification Module
**NCT ID:** NCT00000279

**Brief Title:** Novel Medications for Opiate Detoxification - 4

**Official Title:** Novel Medications for Opiate Detoxification

#### Organization Study ID Info
**ID:** NIDA-09250-4
#### Organization
**Class:** OTHER
**Full Name:** Yale University
#### Secondary ID Infos
**ID:** P50DA009250
**Link:** https://reporter.nih.gov/quickSearch/P50DA009250
**Type:** NIH
**ID:** P50-09250-4
### Status Module
#### Completion Date
**Date:** 1999-08

**Type:** ACTUAL

#### Expanded Access Info
#### Last Update Post Date
**Date:** 2020-06-18

**Type:** ACTUAL

**Last Update Submit Date:** 2020-06-17

**Overall Status:** COMPLETED

#### Primary Completion Date
**Date:** 1999-08

**Type:** ACTUAL

#### Start Date
**Date:** 1994-09

**Status Verified Date:** 2020-06

#### Study First Post Date
**Date:** 1999-09-21
**Type:** ESTIMATED
**Study First Submit Date:** 1999-09-20
**Study First Submit QC Date:** 1999-09-20
### Sponsor Collaborators Module

#### Collaborators

**Class:** NIH

**Name:** National Institute on Drug Abuse (NIDA)

**Class:** FED

**Name:** VA Connecticut Healthcare System

#### Lead Sponsor

**Class:** OTHER

**Name:** Yale University

#### Responsible Party

**Type:** SPONSOR

### Description Module

**Brief Summary:** The purpose of this study is to evaluate novel medications for opiate detoxification.

### Conditions Module

**Conditions:**

- Opioid-Related Disorders

- Substance-Related Disorders

**Keywords:**

- Opioid-Related Disorders

### Design Module

#### Design Info

**Primary Purpose:** TREATMENT

#### Enrollment Info

**Phases:**

- PHASE2

**Study Type:** INTERVENTIONAL

### Arms Interventions Module

### Interventions

#### Intervention 1

**Name:** Clonidine

**Type:** DRUG

### Outcomes Module

#### Primary Outcomes

**Measure:** Withdrawal severity

### Eligibility Module

**Eligibility Criteria:** Please contact site for information.

**Minimum Age:** 18 Years

**Sex:** ALL

**Standard Ages:**

- ADULT

- OLDER_ADULT

### Contacts Locations Module

#### Locations

**Location 1:**

**City:** New Haven

**Country:** United States

**Facility:** VA Connecticut Healthcare System

**State:** Connecticut

**Zip:** 06519

#### Overall Officials

**Official 1:**

**Affiliation:** VA Connecticut Healthcare System

**Name:** Thomas R Kosten, M.D.

**Role:** PRINCIPAL_INVESTIGATOR

### References Module

#### References

**Citation:** AM J Drug & Alc. Abuse 21(4): 453-467, 1995; Neuropsychopharm 13(4): 323-333, 1995; Neuropsychopharm 14(3): 187-193, 1996; J Pharma & Experimental Therapeutics 276(3): 1128-1135, 1996.

## Derived Section

### Condition Browse Module - Ancestors

- ID: D000064419

- Term: Chemically-Induced Disorders

- ID: D000001523

- Term: Mental Disorders

- ID: D000079524

- Term: Narcotic-Related Disorders

### Condition Browse Module - Browse Branches

- Abbrev: BC25

- Name: Substance Related Disorders

- Abbrev: BXM

- Name: Behaviors and Mental Disorders

- Abbrev: All

- Name: All Conditions

### Condition Browse Module - Browse Leaves

- ID: M21837

- Name: Substance-Related Disorders

- Relevance: HIGH

- As Found: Substance-Related Disorders

- ID: M12244

- Name: Opioid-Related Disorders

- Relevance: HIGH

- As Found: Opioid-Related Disorders

- ID: M30302

- Name: Chemically-Induced Disorders

- Relevance: LOW

- As Found: Unknown

- ID: M4815

- Name: Mental Disorders

- Relevance: LOW

- As Found: Unknown

- ID: M14473

- Name: Psychotic Disorders

- Relevance: LOW

- As Found: Unknown

- ID: M2057

- Name: Narcotic-Related Disorders

- Relevance: LOW

- As Found: Unknown

### Condition Browse Module - Meshes

- ID: D000019966

- Term: Substance-Related Disorders

- ID: D000009293

- Term: Opioid-Related Disorders

### Intervention Browse Module - Ancestors

- ID: D000000700

- Term: Analgesics

- ID: D000018689

- Term: Sensory System Agents

- ID: D000018373

- Term: Peripheral Nervous System Agents

- ID: D000045505

- Term: Physiological Effects of Drugs

- ID: D000000959

- Term: Antihypertensive Agents

- ID: D000013565

- Term: Sympatholytics

- ID: D000001337

- Term: Autonomic Agents

- ID: D000058647

- Term: Adrenergic alpha-2 Receptor Agonists

- ID: D000000316

- Term: Adrenergic alpha-Agonists

- ID: D000000322

- Term: Adrenergic Agonists

- ID: D000018663

- Term: Adrenergic Agents

- ID: D000018377

- Term: Neurotransmitter Agents

- ID: D000045504

- Term: Molecular Mechanisms of Pharmacological Action

### Intervention Browse Module - Browse Branches

- Abbrev: Analg

- Name: Analgesics

- Abbrev: CNSDep

- Name: Central Nervous System Depressants

- Abbrev: All

- Name: All Drugs and Chemicals

- Abbrev: AnAg

- Name: Antihypertensive Agents

### Intervention Browse Module - Browse Leaves

- ID: M4033

- Name: Analgesics, Opioid

- Relevance: LOW

- As Found: Unknown

- ID: M6232

- Name: Clonidine

- Relevance: HIGH

- As Found: ABT-

- ID: M27371

- Name: Opiate Alkaloids

- Relevance: LOW

- As Found: Unknown

- ID: M4032

- Name: Analgesics

- Relevance: LOW

- As Found: Unknown

- ID: M4277

- Name: Antihypertensive Agents

- Relevance: LOW

- As Found: Unknown

- ID: M16344

- Name: Sympatholytics

- Relevance: LOW

- As Found: Unknown

- ID: M20746

- Name: Adrenergic Agents

- Relevance: LOW

- As Found: Unknown

- ID: M3668

- Name: Adrenergic alpha-Agonists

- Relevance: LOW

- As Found: Unknown

- ID: M3673

- Name: Adrenergic Agonists

- Relevance: LOW

- As Found: Unknown

- ID: M20504

- Name: Neurotransmitter Agents

- Relevance: LOW

- As Found: Unknown

### Intervention Browse Module - Meshes

- ID: D000003000

- Term: Clonidine

### Misc Info Module

- Version Holder: 2024-05-24
