## Protocol Section
### Identification Module
**NCT ID:** NCT00088179

**Brief Title:** Pexelizumab in Patients Undergoing Coronary Artery Bypass Grafting With Cardiopulmonary Bypass (PRIMO-CABG II)

**Official Title:** A Multicenter, Randomized, Double-Blind, Parallel-group, Placebo-Controlled Study of Pexelizumab in Patients Undergoing Coronary Artery Bypass Grafting With Cardiopulmonary Bypass (PRIMO-CABG II)

#### Organization Study ID Info
**ID:** 2003141
#### Organization
**Class:** INDUSTRY
**Full Name:** Alexion Pharmaceuticals, Inc.
### Status Module
#### Completion Date
**Date:** 2005-10

**Type:** ACTUAL

#### Disp First Post Date
**Date:** 2017-02-16

**Type:** ACTUAL

**Disp First Submit Date:** 2017-02-15
**Disp First Submit QC Date:** 2017-02-15

#### Last Update Post Date
**Date:** 2018-02-22

**Type:** ACTUAL

**Last Update Submit Date:** 2018-02-20

**Overall Status:** COMPLETED

#### Primary Completion Date
**Date:** 2005-10

**Type:** ACTUAL

#### Start Date
**Date:** 2004-07

**Type:** ACTUAL

**Status Verified Date:** 2018-02

#### Study First Post Date
**Date:** 2004-07-23
**Type:** ESTIMATED
**Study First Submit Date:** 2004-07-21
**Study First Submit QC Date:** 2004-07-22
### Sponsor Collaborators Module

#### Collaborators

**Class:** INDUSTRY

**Name:** Procter and Gamble

#### Lead Sponsor

**Class:** INDUSTRY

**Name:** Alexion Pharmaceuticals, Inc.

### Description Module

**Brief Summary:** During a heart bypass procedure, a substance called "complement" is activated by the body. This "complement activation" causes an inflammatory response that can lead to side affects such as chest pain, heart attacks, stroke, heart failure, or death. The purpose of this study is to find out if the study drug (pexelizumab), that blocks "complement activation," can reduce such side effects and be given safely to patients requiring the bypass procedure with the use of the heart-lung machine.

### Conditions Module

**Conditions:**

- Coronary Artery Disease

**Keywords:**

- CABG

- CPB

### Design Module

#### Design Info

**Allocation:** RANDOMIZED

**Intervention Model:** PARALLEL

##### Masking Info

**Masking:** DOUBLE

**Primary Purpose:** TREATMENT

#### Enrollment Info

**Count:** 4000

**Phases:**

- PHASE3

**Study Type:** INTERVENTIONAL

### Arms Interventions Module

### Interventions

#### Intervention 1

**Name:** pexelizumab in conjunction with CABG

**Type:** DRUG

### Outcomes Module

#### Primary Outcomes

**Measure:** Reduction in mortality.

**Measure:** Reduction in MI incidence.

### Eligibility Module

**Eligibility Criteria:** Inclusion Criteria:

* be at least 18 years of age;
* have 2 or more of the following risk factors:

  • diabetes mellitus; • repeat CABG; • the need for urgent intervention, defined according to the ACC/AHA guidelines as being patients who are required to stay in the hospital due to medical factors, but may be scheduled and operated on within a normal scheduling routine, excluding patients who have had an MI within 48 hours of CABG; • female; • history of a neurologic event (cerebrovascular accident, transient ischemic attack or carotid endarterectomy); • history of congestive heart failure (NYHA CHF Class III or IV); • history of 2 MIs, or an MI that occurred greater than 48 hours but less than 4 weeks prior to CABG;
* provide Informed Consent.

Exclusion Criteria:

* requires salvage intervention as defined by the ACC/AHA guidelines 10 as being ongoing cardiopulmonary resuscitation on the way to the operating room;
* has current cardiogenic shock, acute left ventricular rupture, acute septal rupture or acute papillary muscle rupture;
* has any active bacterial or other infection which is clinically significant, in the opinion of the Investigator (e.g. evaluate the evidence based on WBC, temperature, cultures etc. as appropriate for the patient);
* has a known or suspected hereditary complement deficiency;
* has participated in any other investigational drug study or was exposed to an investigational agent or device within 30 days of randomization;
* is receiving, or is planning to receive, any other investigational drug or device, or will participate in any other research study within 30 days of randomization;
* is pregnant or breast-feeding.

**Minimum Age:** 18 Years

**Sex:** ALL

**Standard Ages:**

- ADULT

- OLDER_ADULT

### Contacts Locations Module

#### Locations

**Location 1:**

**City:** Birmingham

**Country:** United States

**Facility:** Brookwood Medical Center

**State:** Alabama

**Zip:** 35209

**Location 2:**

**City:** Birmingham

**Country:** United States

**Facility:** Baptist Medical Center Princeton

**State:** Alabama

**Zip:** 35211

**Location 3:**

**City:** Birmingham

**Country:** United States

**Facility:** Baptist Health Systems Montclair

**State:** Alabama

**Zip:** 35213

**Location 4:**

**City:** Birmingham

**Country:** United States

**Facility:** Medical Center East Hospital

**State:** Alabama

**Zip:** 35235

**Location 5:**

**City:** Birmingham

**Country:** United States

**Facility:** University of Alabama at Birmingham Hospital

**State:** Alabama

**Zip:** 35249-6810

**Location 6:**

**City:** Fairhope

**Country:** United States

**Facility:** Thomas Hospital

**State:** Alabama

**Zip:** 36532

**Location 7:**

**City:** Huntsville

**Country:** United States

**Facility:** Huntsville Hospital

**State:** Alabama

**Zip:** 35801

**Location 8:**

**City:** Mobile

**Country:** United States

**Facility:** Mobile Infirmary Medical Center

**State:** Alabama

**Zip:** 36607

**Location 9:**

**City:** Phoenix

**Country:** United States

**Facility:** Banner Good Samaritan Medical Center

**State:** Arizona

**Zip:** 85006

**Location 10:**

**City:** Tucson

**Country:** United States

**Facility:** Arizona Health Sciences Center

**State:** Arizona

**Zip:** 85724

**Location 11:**

**City:** Tucson

**Country:** United States

**Facility:** University Medical Center

**State:** Arizona

**Zip:** 85724

**Location 12:**

**City:** Tucson

**Country:** United States

**Facility:** Southern Arizona Veterans Affairs Health Care System

**State:** Arizona

**Zip:** 85732

**Location 13:**

**City:** Fort Smith

**Country:** United States

**Facility:** Sparks Regional Medical Center

**State:** Arkansas

**Zip:** 72901

**Location 14:**

**City:** Little Rock

**Country:** United States

**Facility:** Baptist Medical Center

**State:** Arkansas

**Zip:** 72205

**Location 15:**

**City:** Bakersfield

**Country:** United States

**Facility:** Bakersfield Heart Hospital

**State:** California

**Zip:** 93301

**Location 16:**

**City:** Daly City

**Country:** United States

**Facility:** Seaton Medical Center

**State:** California

**Zip:** 94015

**Location 17:**

**City:** Escondido

**Country:** United States

**Facility:** Palomar Medical Center

**State:** California

**Zip:** 92025

**Location 18:**

**City:** Laguna Hills

**Country:** United States

**Facility:** Saddleback Memorial Medical Center

**State:** California

**Zip:** 92653

**Location 19:**

**City:** Los Angeles

**Country:** United States

**Facility:** Los Angeles County-University of Southern California Medical Center

**State:** California

**Zip:** 90033

**Location 20:**

**City:** Los Angeles

**Country:** United States

**Facility:** University of Southern California University Hospital

**State:** California

**Zip:** 90033

**Location 21:**

**City:** Los Angeles

**Country:** United States

**Facility:** St. Vincent Medical Center

**State:** California

**Zip:** 90057

**Location 22:**

**City:** Los Angeles

**Country:** United States

**Facility:** Veterans Administration Greater Los Angeles Healthcare Sysytem

**State:** California

**Zip:** 90073

**Location 23:**

**City:** Oceanside

**Country:** United States

**Facility:** Tri City Medical Center

**State:** California

**Zip:** 92056

**Location 24:**

**City:** Orange

**Country:** United States

**Facility:** University of California Irvine Medical Center

**State:** California

**Zip:** 92868

**Location 25:**

**City:** Palo Alto

**Country:** United States

**Facility:** Veterans Administration Palo Alto Healthcare System

**State:** California

**Zip:** 94304

**Location 26:**

**City:** Pasadena

**Country:** United States

**Facility:** Huntington Memorial Hospital

**State:** California

**Zip:** 91105

**Location 27:**

**City:** Sacramento

**Country:** United States

**Facility:** Mercy General Hospital

**State:** California

**Zip:** 95819

**Location 28:**

**City:** San Diego

**Country:** United States

**Facility:** Sharp Memorial Hospital

**State:** California

**Zip:** 92123

**Location 29:**

**City:** San Francisco

**Country:** United States

**Facility:** Kaiser Permanente Medical Center

**State:** California

**Zip:** 94115

**Location 30:**

**City:** Denver

**Country:** United States

**Facility:** Porter Adventist Hospital

**State:** Colorado

**Zip:** 80210

**Location 31:**

**City:** Denver

**Country:** United States

**Facility:** Presbyterian St.Luke's Medical Center

**State:** Colorado

**Zip:** 80218

**Location 32:**

**City:** Denver

**Country:** United States

**Facility:** University of Colorado Health Sciences Center

**State:** Colorado

**Zip:** 80262

**Location 33:**

**City:** Bridgeport

**Country:** United States

**Facility:** St. Vincent's Medical Center

**State:** Connecticut

**Zip:** 06606

**Location 34:**

**City:** New Haven

**Country:** United States

**Facility:** Hospital of Saint Raphael

**State:** Connecticut

**Zip:** 06511

**Location 35:**

**City:** Newark

**Country:** United States

**Facility:** Christiana Hospital

**State:** Delaware

**Zip:** 19718

**Location 36:**

**City:** Atlantis

**Country:** United States

**Facility:** John F. Kennedy Medical Center

**State:** Florida

**Zip:** 33462

**Location 37:**

**City:** Clearwater

**Country:** United States

**Facility:** Morton Plant Hospital

**State:** Florida

**Zip:** 33756

**Location 38:**

**City:** Daytona Beach

**Country:** United States

**Facility:** Halifax Medical Center

**State:** Florida

**Zip:** 32114

**Location 39:**

**City:** Fort Lauderdale

**Country:** United States

**Facility:** North Ridge Medical Center

**State:** Florida

**Zip:** 33334

**Location 40:**

**City:** Gainesville

**Country:** United States

**Facility:** Shands Hospital at the University of Florida

**State:** Florida

**Zip:** 32610

**Location 41:**

**City:** Hudson

**Country:** United States

**Facility:** Regional Medical Center Bayonet Point

**State:** Florida

**Zip:** 34667

**Location 42:**

**City:** Jacksonville

**Country:** United States

**Facility:** Baptist Medical Center

**State:** Florida

**Zip:** 32207

**Location 43:**

**City:** Jacksonville

**Country:** United States

**Facility:** Memorial Hospital

**State:** Florida

**Zip:** 32216

**Location 44:**

**City:** Lakeland

**Country:** United States

**Facility:** Lakeland Regional Medical Center

**State:** Florida

**Zip:** 33805

**Location 45:**

**City:** Melbourne

**Country:** United States

**Facility:** Health First Holmes Regional Medical Center

**State:** Florida

**Zip:** 32901

**Location 46:**

**City:** Orlando

**Country:** United States

**Facility:** Orlando Regional Medical Center

**State:** Florida

**Zip:** 32801

**Location 47:**

**City:** Orlando

**Country:** United States

**Facility:** Florida Hospital

**State:** Florida

**Zip:** 32803

**Location 48:**

**City:** Pensacola

**Country:** United States

**Facility:** Sacred Heart Hospital

**State:** Florida

**Zip:** 32504

**Location 49:**

**City:** Rockledge

**Country:** United States

**Facility:** Wuesthoff Hospital

**State:** Florida

**Zip:** 32955

**Location 50:**

**City:** Saint Petersburg

**Country:** United States

**Facility:** Northside Hospital and Heart Institute

**State:** Florida

**Zip:** 33701

**Location 51:**

**City:** Sarasota

**Country:** United States

**Facility:** Sarasota Memorial Hospital

**State:** Florida

**Zip:** 34239

**Location 52:**

**City:** Tampa

**Country:** United States

**Facility:** University Community Hospital

**State:** Florida

**Zip:** 33613

**Location 53:**

**City:** Atlanta

**Country:** United States

**Facility:** Piedmont Hospital

**State:** Georgia

**Zip:** 30309

**Location 54:**

**City:** Atlanta

**Country:** United States

**Facility:** Emory University Hospital

**State:** Georgia

**Zip:** 30322

**Location 55:**

**City:** Decatur

**Country:** United States

**Facility:** Atlanta Veteran's Administration (VA) Medical Center

**State:** Georgia

**Zip:** 30033

**Location 56:**

**City:** Macon

**Country:** United States

**Facility:** Medical Center of Central Georgia

**State:** Georgia

**Zip:** 31208

**Location 57:**

**City:** Savannah

**Country:** United States

**Facility:** St. Joseph's/Candler Health System

**State:** Georgia

**Zip:** 31404

**Location 58:**

**City:** Savannah

**Country:** United States

**Facility:** St. Joseph's/Candler Health System

**State:** Georgia

**Zip:** 31419

**Location 59:**

**City:** Honolulu

**Country:** United States

**Facility:** Kaiser Permanente Moanalua Medical Center

**State:** Hawaii

**Zip:** 96819

**Location 60:**

**City:** Peoria

**Country:** United States

**Facility:** OSF Saint Francis Medical Center

**State:** Illinois

**Zip:** 61637

**Location 61:**

**City:** Springfield

**Country:** United States

**Facility:** Memorial Medical Center

**State:** Illinois

**Zip:** 62702

**Location 62:**

**City:** Springfield

**Country:** United States

**Facility:** St. John's Hospital

**State:** Illinois

**Zip:** 62769

**Location 63:**

**City:** Fort Wayne

**Country:** United States

**Facility:** Indiana Ohio Heart

**State:** Indiana

**Zip:** 46804

**Location 64:**

**City:** Indianapolis

**Country:** United States

**Facility:** Clarian Health Partners, Inc. Methodist Hospital

**State:** Indiana

**Zip:** 46202

**Location 65:**

**City:** Indianapolis

**Country:** United States

**Facility:** The Indiana Heart Hospital

**State:** Indiana

**Zip:** 46250

**Location 66:**

**City:** Indianapolis

**Country:** United States

**Facility:** The Heart Center of Indiana

**State:** Indiana

**Zip:** 46290

**Location 67:**

**City:** Des Moines

**Country:** United States

**Facility:** Iowa Heart Center

**State:** Iowa

**Zip:** 50314

**Location 68:**

**City:** Olathe

**Country:** United States

**Facility:** Olathe Medical Center

**State:** Kansas

**Zip:** 66061

**Location 69:**

**City:** Wichita

**Country:** United States

**Facility:** Galichia Heart Hospital

**State:** Kansas

**Zip:** 67202

**Location 70:**

**City:** Lexington

**Country:** United States

**Facility:** Central Baptist Hospital

**State:** Kentucky

**Zip:** 40503

**Location 71:**

**City:** Lexington

**Country:** United States

**Facility:** Veterans Affairs Medical Center

**State:** Kentucky

**Zip:** 40506

**Location 72:**

**City:** Lexington

**Country:** United States

**Facility:** University of Kentucky

**State:** Kentucky

**Zip:** 40536

**Location 73:**

**City:** Louisville

**Country:** United States

**Facility:** Jewish Hospital

**State:** Kentucky

**Zip:** 40202

**Location 74:**

**City:** Louisville

**Country:** United States

**Facility:** Norton Hospital

**State:** Kentucky

**Zip:** 40202

**Location 75:**

**City:** Louisville

**Country:** United States

**Facility:** University of Louisville Hospital

**State:** Kentucky

**Zip:** 40202

**Location 76:**

**City:** Houma

**Country:** United States

**Facility:** Terrebonne General Medical Center

**State:** Louisiana

**Zip:** 70360

**Location 77:**

**City:** Lacombe

**Country:** United States

**Facility:** Louisiana Heart Hospital

**State:** Louisiana

**Zip:** 70445

**Location 78:**

**City:** New Orleans

**Country:** United States

**Facility:** Tulane University Hospital and Clinic

**State:** Louisiana

**Zip:** 70112

**Location 79:**

**City:** New Orleans

**Country:** United States

**Facility:** Oschner Clinic Foundation

**State:** Louisiana

**Zip:** 70121

**Location 80:**

**City:** New Orleans

**Country:** United States

**Facility:** Pendleton Memorial Methodist Hospital

**State:** Louisiana

**Zip:** 70127

**Location 81:**

**City:** New Orleans

**Country:** United States

**Facility:** Touro Infirmary

**State:** Louisiana

**Location 82:**

**City:** Slidell

**Country:** United States

**Facility:** Slidell Memorial Hospital

**State:** Louisiana

**Zip:** 70458

**Location 83:**

**City:** Portland

**Country:** United States

**Facility:** Maine Medical Center

**State:** Maine

**Zip:** 04102

**Location 84:**

**City:** Baltimore

**Country:** United States

**Facility:** Sinai Hospital of Baltimore

**State:** Maryland

**Zip:** 21215

**Location 85:**

**City:** Baltimore

**Country:** United States

**Facility:** Union Memorial Hospital

**State:** Maryland

**Zip:** 21218

**Location 86:**

**City:** Salisbury

**Country:** United States

**Facility:** Peninusla Medical Center

**State:** Maryland

**Zip:** 21801

**Location 87:**

**City:** Towson

**Country:** United States

**Facility:** St. Joseph Medical Center

**State:** Maryland

**Zip:** 21204

**Location 88:**

**City:** Boston

**Country:** United States

**Facility:** Massachusetts General Hospital

**State:** Massachusetts

**Zip:** 02114

**Location 89:**

**City:** Boston

**Country:** United States

**Facility:** Beth Israel Deaconess Medical Center

**State:** Massachusetts

**Zip:** 02215

**Location 90:**

**City:** Hyannis

**Country:** United States

**Facility:** Cape Cod Hospital

**State:** Massachusetts

**Zip:** 02601

**Location 91:**

**City:** Springfield

**Country:** United States

**Facility:** Baystate Medical Center

**State:** Massachusetts

**Zip:** 01199

**Location 92:**

**City:** West Roxbury

**Country:** United States

**Facility:** Veterans Administration (VA) Boston Healthcare System

**State:** Massachusetts

**Zip:** 02132

**Location 93:**

**City:** Detroit

**Country:** United States

**Facility:** Henry Ford Health System

**State:** Michigan

**Zip:** 48202

**Location 94:**

**City:** Flint

**Country:** United States

**Facility:** McLaren Regional Medical Center

**State:** Michigan

**Zip:** 48532

**Location 95:**

**City:** Grand Rapids

**Country:** United States

**Facility:** Spectrum Health Hospitals

**State:** Michigan

**Zip:** 49503

**Location 96:**

**City:** Kalamazoo

**Country:** United States

**Facility:** Borgess Medical Center

**State:** Michigan

**Zip:** 49048

**Location 97:**

**City:** Lansing

**Country:** United States

**Facility:** Ingham Regional Medical Center

**State:** Michigan

**Zip:** 48910

**Location 98:**

**City:** Muskegon

**Country:** United States

**Facility:** West Shore Cardiology Research Department

**State:** Michigan

**Zip:** 46444

**Location 99:**

**City:** Royal Oak

**Country:** United States

**Facility:** William Beaumont Hospital

**State:** Michigan

**Zip:** 48073

**Location 100:**

**City:** Saginaw

**Country:** United States

**Facility:** Covenant Medical Center

**State:** Michigan

**Zip:** 48601

**Location 101:**

**City:** Rochester

**Country:** United States

**Facility:** Mayo Clinic College of Medicine

**State:** Minnesota

**Zip:** 55905

**Location 102:**

**City:** Kansas City

**Country:** United States

**Facility:** St. Luke's Health System

**State:** Missouri

**Zip:** 64111

**Location 103:**

**City:** Saint Louis

**Country:** United States

**Facility:** Saint Louis University Hospital

**State:** Missouri

**Zip:** 63110

**Location 104:**

**City:** Saint Louis

**Country:** United States

**Facility:** Saint Louis University

**State:** Missouri

**Zip:** 63110

**Location 105:**

**City:** Saint Louis

**Country:** United States

**Facility:** Des Peres Hospital

**State:** Missouri

**Zip:** 63122

**Location 106:**

**City:** Lincoln

**Country:** United States

**Facility:** Nebraska Heart Hospital

**State:** Nebraska

**Zip:** 68506

**Location 107:**

**City:** Camden

**Country:** United States

**Facility:** Cooper Hospital University Medical Center

**State:** New Jersey

**Zip:** 08035

**Location 108:**

**City:** Camden

**Country:** United States

**Facility:** Cooper Health System/University Medical Center

**State:** New Jersey

**Zip:** 08103

**Location 109:**

**City:** Camden

**Country:** United States

**Facility:** Our Lady Of Lourdes Medical Center

**State:** New Jersey

**Zip:** 08103

**Location 110:**

**City:** Hackensack

**Country:** United States

**Facility:** Hackensack University Medical Center

**State:** New Jersey

**Zip:** 07601

**Location 111:**

**City:** Morristown

**Country:** United States

**Facility:** Morristown Memorial Hospital

**State:** New Jersey

**Zip:** 07962-1956

**Location 112:**

**City:** Bronx

**Country:** United States

**Facility:** Montefiore Medical Center

**State:** New York

**Zip:** 10461

**Location 113:**

**City:** Brooklyn

**Country:** United States

**Facility:** Maimondes Medical Center

**State:** New York

**Zip:** 11219

**Location 114:**

**City:** Johnson City

**Country:** United States

**Facility:** United Health Services Hospital

**State:** New York

**Zip:** 13790

**Location 115:**

**City:** New York

**Country:** United States

**Facility:** New York Presbyterian Hospital

**State:** New York

**Zip:** 10021

**Location 116:**

**City:** New York

**Country:** United States

**Facility:** Mount Sinai Hospital

**State:** New York

**Zip:** 10029

**Location 117:**

**City:** Poughkeepsie

**Country:** United States

**Facility:** Vassar Brothers Medical Center

**State:** New York

**Zip:** 12601

**Location 118:**

**City:** Rochester

**Country:** United States

**Facility:** Rochester General Hospital

**State:** New York

**Zip:** 14621

**Location 119:**

**City:** Rochester

**Country:** United States

**Facility:** University of Rochester Medical Center

**State:** New York

**Zip:** 14642

**Location 120:**

**City:** Valhalla

**Country:** United States

**Facility:** Westchester Medical Center

**State:** New York

**Zip:** 10595

**Location 121:**

**City:** Chapel Hill

**Country:** United States

**Facility:** University of North Carolina at Chapel Hill Hospitals

**State:** North Carolina

**Zip:** 27599-7075

**Location 122:**

**City:** Durham

**Country:** United States

**Facility:** Duke University Medical Center

**State:** North Carolina

**Zip:** 27710

**Location 123:**

**City:** Greensboro

**Country:** United States

**Facility:** Moses H. Cone Memorial Hospital

**State:** North Carolina

**Zip:** 27401

**Location 124:**

**City:** Greenville

**Country:** United States

**Facility:** Pitt County Memorial Hospital

**State:** North Carolina

**Zip:** 27858

**Location 125:**

**City:** Bismarck

**Country:** United States

**Facility:** Medcenter One

**State:** North Dakota

**Zip:** 58501

**Location 126:**

**City:** Akron

**Country:** United States

**Facility:** Akron General Medical Center

**State:** Ohio

**Zip:** 44307

**Location 127:**

**City:** Cincinnati

**Country:** United States

**Facility:** The Christ Hospital

**State:** Ohio

**Zip:** 45219

**Location 128:**

**City:** Cincinnati

**Country:** United States

**Facility:** Good Samaritan Hospital

**State:** Ohio

**Zip:** 45220

**Location 129:**

**City:** Cincinnati

**Country:** United States

**Facility:** Bethesda North Hospital

**State:** Ohio

**Zip:** 45242

**Location 130:**

**City:** Cincinnati

**Country:** United States

**Facility:** University of Cincinnati Medical Center

**State:** Ohio

**Zip:** 45267-0542

**Location 131:**

**City:** Cleveland

**Country:** United States

**Facility:** University Hospitals Health System

**State:** Ohio

**Zip:** 44106-5011

**Location 132:**

**City:** Cleveland

**Country:** United States

**Facility:** The Cleveland Clinic Foundation

**State:** Ohio

**Zip:** 44195

**Location 133:**

**City:** Columbus

**Country:** United States

**Facility:** Riverside Methodist Hospital

**State:** Ohio

**Zip:** 43214

**Location 134:**

**City:** Dayton

**Country:** United States

**Facility:** The Dayton Heart Hospital

**State:** Ohio

**Zip:** 45408

**Location 135:**

**City:** Toledo

**Country:** United States

**Facility:** The Toledo Hospital

**State:** Ohio

**Zip:** 43606

**Location 136:**

**City:** Zanesville

**Country:** United States

**Facility:** Good Samaritan Hospital

**State:** Ohio

**Zip:** 43701

**Location 137:**

**City:** Oklahoma City

**Country:** United States

**Facility:** Oklahoma University Medical Center

**State:** Oklahoma

**Zip:** 73104

**Location 138:**

**City:** Oklahoma City

**Country:** United States

**Facility:** INTEGRIS Baptist Medical Center

**State:** Oklahoma

**Zip:** 73112

**Location 139:**

**City:** Oklahoma City

**Country:** United States

**Facility:** Oklahoma Heart Hospital

**State:** Oklahoma

**Zip:** 73120

**Location 140:**

**City:** Bend

**Country:** United States

**Facility:** St. Charles Medical Center

**State:** Oregon

**Zip:** 97701

**Location 141:**

**City:** Portland

**Country:** United States

**Facility:** Legacy Good Samaritan Hospital

**State:** Oregon

**Zip:** 97210

**Location 142:**

**City:** Doylestown

**Country:** United States

**Facility:** Doylestown Hospital

**State:** Pennsylvania

**Zip:** 18901

**Location 143:**

**City:** Langhorne

**Country:** United States

**Facility:** St. Mary Medical Center

**State:** Pennsylvania

**Zip:** 19067

**Location 144:**

**City:** Philadelphia

**Country:** United States

**Facility:** Hahnemann University Hospital

**State:** Pennsylvania

**Zip:** 19102

**Location 145:**

**City:** Philadelphia

**Country:** United States

**Facility:** Presbyterian Medical Center

**State:** Pennsylvania

**Zip:** 19104

**Location 146:**

**City:** Philadelphia

**Country:** United States

**Facility:** Temple University Hospital

**State:** Pennsylvania

**Zip:** 19140

**Location 147:**

**City:** Pittsburgh

**Country:** United States

**Facility:** Allegheny General Hospital

**State:** Pennsylvania

**Zip:** 15212

**Location 148:**

**City:** Pittsburgh

**Country:** United States

**Facility:** University of Pittsburgh Medical Center

**State:** Pennsylvania

**Zip:** 15213

**Location 149:**

**City:** Upland

**Country:** United States

**Facility:** Crozer Chester Medical Center

**State:** Pennsylvania

**Zip:** 19013

**Location 150:**

**City:** West Chester

**Country:** United States

**Facility:** The Chester County Hospital

**State:** Pennsylvania

**Zip:** 19380

**Location 151:**

**City:** Charleston

**Country:** United States

**Facility:** Roper St. Francis Healthcare

**State:** South Carolina

**Zip:** 29401

**Location 152:**

**City:** Rapid City

**Country:** United States

**Facility:** Rapid City Regional Hospital

**State:** South Dakota

**Zip:** 57701

**Location 153:**

**City:** Chattanooga

**Country:** United States

**Facility:** The Chattanooga Heart Institute

**State:** Tennessee

**Zip:** 37404

**Location 154:**

**City:** Jackson

**Country:** United States

**Facility:** Jackson-Madison County General Hospital

**State:** Tennessee

**Zip:** 38301

**Location 155:**

**City:** Memphis

**Country:** United States

**Facility:** Baptist Memorial Hospital

**State:** Tennessee

**Zip:** 38120

**Location 156:**

**City:** Nashville

**Country:** United States

**Facility:** Baptist Hospital

**State:** Tennessee

**Zip:** 37203

**Location 157:**

**City:** Nashville

**Country:** United States

**Facility:** Vanderbilt University Medical Center

**State:** Tennessee

**Zip:** 37232-8815

**Location 158:**

**City:** Oak Ridge

**Country:** United States

**Facility:** Methodist Medical Center

**State:** Tennessee

**Zip:** 37830

**Location 159:**

**City:** Austin

**Country:** United States

**Facility:** Heart Hospital of Austin

**State:** Texas

**Zip:** 78756

**Location 160:**

**City:** Dallas

**Country:** United States

**Facility:** Medical City Dallas Hospital

**State:** Texas

**Zip:** 75230

**Location 161:**

**City:** Houston

**Country:** United States

**Facility:** Christus Saint Joseph Hospital

**State:** Texas

**Zip:** 77002

**Location 162:**

**City:** Houston

**Country:** United States

**Facility:** Michael E. DeBakey Veterans Affairs Medical Center

**State:** Texas

**Zip:** 77030-4298

**Location 163:**

**City:** Houston

**Country:** United States

**Facility:** Memorial Hermann Hospital

**State:** Texas

**Zip:** 77030

**Location 164:**

**City:** Houston

**Country:** United States

**Facility:** Methodist Hospital

**State:** Texas

**Zip:** 77030

**Location 165:**

**City:** Houston

**Country:** United States

**Facility:** St. Luke's Episcopal Hospital - Texas Heart

**State:** Texas

**Zip:** 77030

**Location 166:**

**City:** Houston

**Country:** United States

**Facility:** The Methodist Hospital

**State:** Texas

**Zip:** 77030

**Location 167:**

**City:** Lubbock

**Country:** United States

**Facility:** Covenant Medical Center

**State:** Texas

**Zip:** 79410

**Location 168:**

**City:** San Antonio

**Country:** United States

**Facility:** TexSan Heart Hospital

**State:** Texas

**Zip:** 78201

**Location 169:**

**City:** San Antonio

**Country:** United States

**Facility:** Northeast Baptist Hospital

**State:** Texas

**Zip:** 78217

**Location 170:**

**City:** Salt Lake City

**Country:** United States

**Facility:** University of Utah Hospital

**State:** Utah

**Zip:** 84132

**Location 171:**

**City:** Arlington

**Country:** United States

**Facility:** Virginia Hospital Center

**State:** Virginia

**Zip:** 22205

**Location 172:**

**City:** Charlottesville

**Country:** United States

**Facility:** University of Virginia Health System

**State:** Virginia

**Zip:** 22908

**Location 173:**

**City:** Falls Church

**Country:** United States

**Facility:** Inova Fairfax Hospital

**State:** Virginia

**Zip:** 22042-3300

**Location 174:**

**City:** Mechanicsville

**Country:** United States

**Facility:** Memorial Regional Medical Center

**State:** Virginia

**Zip:** 23116

**Location 175:**

**City:** Norfolk

**Country:** United States

**Facility:** Sentara Norfolk General Hospital

**State:** Virginia

**Zip:** 23507

**Location 176:**

**City:** Richmond

**Country:** United States

**Facility:** CJW Medical Center

**State:** Virginia

**Zip:** 23225

**Location 177:**

**City:** Richmond

**Country:** United States

**Facility:** Henrico Doctors' Hospital

**State:** Virginia

**Zip:** 23229

**Location 178:**

**City:** Seattle

**Country:** United States

**Facility:** University of Washington Medical Center

**State:** Washington

**Zip:** 98195-6310

**Location 179:**

**City:** Tacoma

**Country:** United States

**Facility:** Saint Joseph Medical Center

**State:** Washington

**Zip:** 98405

**Location 180:**

**City:** Charleston

**Country:** United States

**Facility:** Charleston Area Medical Center

**State:** West Virginia

**Zip:** 25304

**Location 181:**

**City:** La Crosse

**Country:** United States

**Facility:** Gundersen Lutheran Medical Center

**State:** Wisconsin

**Zip:** 54601

**Location 182:**

**City:** Milwaukee

**Country:** United States

**Facility:** St. Luke's Medical Center

**State:** Wisconsin

**Zip:** 53215

**Location 183:**

**City:** Besancon

**Country:** France

**Facility:** Hopital Minjoz

**Zip:** 25030

**Location 184:**

**City:** Dijon

**Country:** France

**Facility:** Hopital du Bocage

**Zip:** 21031

**Location 185:**

**City:** Grenoble

**Country:** France

**Facility:** Hopital Albert Michallon

**Zip:** 38043

**Location 186:**

**City:** Paris

**Country:** France

**Facility:** Hopital Europeen Georges Pompidou

**Zip:** 75908

**Location 187:**

**City:** Erlangen

**Country:** Germany

**Facility:** Zentrum fuer Herzchirurgie der Frederick-Alexander-Universitaet

**Zip:** 91054

**Location 188:**

**City:** Leiden

**Country:** Netherlands

**Facility:** Leiden University Medical Center

**Zip:** 2333

#### Overall Officials

**Official 1:**

**Affiliation:** Alexion Pharmaceuticals, Inc.

**Name:** Peter X Adams, MD

**Role:** STUDY_DIRECTOR

**Official 2:**

**Affiliation:** University of Washington

**Name:** Edward Verrier, MD

**Role:** STUDY_CHAIR

### References Module

#### References

**Citation:** Smith PK, Shernan SK, Chen JC, Carrier M, Verrier ED, Adams PX, Todaro TG, Muhlbaier LH, Levy JH; PRIMO-CABG II Investigators. Effects of C5 complement inhibitor pexelizumab on outcome in high-risk coronary artery bypass grafting: combined results from the PRIMO-CABG I and II trials. J Thorac Cardiovasc Surg. 2011 Jul;142(1):89-98. doi: 10.1016/j.jtcvs.2010.08.035. Epub 2010 Sep 28.

**PMID:** 20880552

## Derived Section

### Condition Browse Module - Ancestors

- ID: D000003327

- Term: Coronary Disease

- ID: D000017202

- Term: Myocardial Ischemia

- ID: D000006331

- Term: Heart Diseases

- ID: D000002318

- Term: Cardiovascular Diseases

- ID: D000001161

- Term: Arteriosclerosis

- ID: D000001157

- Term: Arterial Occlusive Diseases

- ID: D000014652

- Term: Vascular Diseases

### Condition Browse Module - Browse Branches

- Abbrev: BC14

- Name: Heart and Blood Diseases

- Abbrev: All

- Name: All Conditions

- Abbrev: BC23

- Name: Symptoms and General Pathology

### Condition Browse Module - Browse Leaves

- ID: M6549

- Name: Coronary Disease

- Relevance: LOW

- As Found: Unknown

- ID: M6546

- Name: Coronary Artery Disease

- Relevance: HIGH

- As Found: Coronary Artery Disease

- ID: M19506

- Name: Myocardial Ischemia

- Relevance: LOW

- As Found: Unknown

- ID: M10543

- Name: Ischemia

- Relevance: LOW

- As Found: Unknown

- ID: M9419

- Name: Heart Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M4469

- Name: Arteriosclerosis

- Relevance: LOW

- As Found: Unknown

- ID: M4465

- Name: Arterial Occlusive Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M17400

- Name: Vascular Diseases

- Relevance: LOW

- As Found: Unknown

### Condition Browse Module - Meshes

- ID: D000003324

- Term: Coronary Artery Disease

### Misc Info Module

- Version Holder: 2024-05-24
