## Protocol Section
### Identification Module
**NCT ID:** NCT00099879

**Brief Title:** Study of BMS-275183 in Patients With Pre-treated Non-small Cell Lung Cancer

**Official Title:** A Randomized, Two-Cohort Phase II Study of Two Doses of BMS-275183 Given on a Weekly Schedule in Patients With Pre-Treated Non-Small Cell Lung Cancer

#### Organization Study ID Info
**ID:** CA165-020
#### Organization
**Class:** INDUSTRY
**Full Name:** Bristol-Myers Squibb
### Status Module
#### Disp First Post Date
**Date:** 2010-03-02

**Type:** ESTIMATED

**Disp First Submit Date:** 2010-02-27
**Disp First Submit QC Date:** 2010-02-27

#### Last Update Post Date
**Date:** 2010-03-02

**Type:** ESTIMATED

**Last Update Submit Date:** 2010-02-27

**Overall Status:** TERMINATED

#### Primary Completion Date
**Date:** 2006-03

**Type:** ACTUAL

**Status Verified Date:** 2007-08

#### Study First Post Date
**Date:** 2004-12-22
**Type:** ESTIMATED
**Study First Submit Date:** 2004-12-21
**Study First Submit QC Date:** 2004-12-21
### Sponsor Collaborators Module

#### Lead Sponsor

**Class:** INDUSTRY

**Name:** Bristol-Myers Squibb

### Description Module

**Brief Summary:** The purpose of this clinical research study is to learn if BMS-275183 can shrink or slow the growth of the cancer in subjects with non-small cell lung cancer (NSCLC). The safety of this treatment will also be studied.

### Conditions Module

**Conditions:**

- Non-small Cell Lung Cancer

### Design Module

#### Design Info

**Allocation:** RANDOMIZED

**Primary Purpose:** TREATMENT

**Phases:**

- PHASE2

**Study Type:** INTERVENTIONAL

### Arms Interventions Module

### Interventions

#### Intervention 1

**Name:** BMS-275183

**Type:** DRUG

### Eligibility Module

**Eligibility Criteria:** Inclusion Criteria:

* Advanced or metastatic pretreated NSCLC
* Measurable disease
* Adequate hematologic, hepatic and renal functions
* ECOG Performance Status of 0-2

Exclusion Criteria:

* Inability to swallow capsules
* Recent significant cardiovascular disease
* Woman who are pregnant or breastfeeding

**Minimum Age:** 18 Years

**Sex:** ALL

**Standard Ages:**

- ADULT

- OLDER_ADULT

### Contacts Locations Module

#### Locations

**Location 1:**

**City:** Sacramento

**Country:** United States

**Facility:** Local Institution

**State:** California

**Location 2:**

**City:** New Haven

**Country:** United States

**Facility:** Local Institution

**State:** Connecticut

**Location 3:**

**City:** Atlanta

**Country:** United States

**Facility:** Local Institution

**State:** Georgia

**Location 4:**

**City:** Maywood

**Country:** United States

**Facility:** Local Institution

**State:** Illinois

**Location 5:**

**City:** Detroit

**Country:** United States

**Facility:** Local Institution

**State:** Michigan

**Location 6:**

**City:** Pittsburgh

**Country:** United States

**Facility:** Local Institution

**State:** Pennsylvania

**Location 7:**

**City:** Nashville

**Country:** United States

**Facility:** Local Institution

**State:** Tennessee

**Location 8:**

**City:** Brussels

**Country:** Belgium

**Facility:** Local Institution

**Location 9:**

**City:** Leuven

**Country:** Belgium

**Facility:** Local Institution

**Location 10:**

**City:** Besancon

**Country:** France

**Facility:** Local Institution

**State:** Cedex

**Location 11:**

**City:** Saint-Herblain

**Country:** France

**Facility:** Local Institution

**State:** Cedex

**Location 12:**

**City:** Belfort

**Country:** France

**Facility:** Local Institution

**Location 13:**

**City:** Parma

**Country:** Italy

**Facility:** Local Institution

**Location 14:**

**City:** Roma

**Country:** Italy

**Facility:** Local Institution

**Location 15:**

**City:** Amsterdam

**Country:** Netherlands

**Facility:** Local Institution

**Location 16:**

**City:** Groningen

**Country:** Netherlands

**Facility:** Local Insitution

**Location 17:**

**City:** Barcelona

**Country:** Spain

**Facility:** Local Institution

**Location 18:**

**City:** Madrid

**Country:** Spain

**Facility:** Local Institution

**Location 19:**

**City:** Shefield

**Country:** United Kingdom

**Facility:** Local Institution

**State:** Yorkshire

**Location 20:**

**City:** Manchester

**Country:** United Kingdom

**Facility:** Local Institution

## Derived Section

### Condition Browse Module - Ancestors

- ID: D000012142

- Term: Respiratory Tract Neoplasms

- ID: D000013899

- Term: Thoracic Neoplasms

- ID: D000009371

- Term: Neoplasms by Site

- ID: D000009369

- Term: Neoplasms

- ID: D000008171

- Term: Lung Diseases

- ID: D000012140

- Term: Respiratory Tract Diseases

- ID: D000002283

- Term: Carcinoma, Bronchogenic

- ID: D000001984

- Term: Bronchial Neoplasms

### Condition Browse Module - Browse Branches

- Abbrev: BC04

- Name: Neoplasms

- Abbrev: BC08

- Name: Respiratory Tract (Lung and Bronchial) Diseases

- Abbrev: All

- Name: All Conditions

### Condition Browse Module - Browse Leaves

- ID: M11172

- Name: Lung Neoplasms

- Relevance: HIGH

- As Found: Lung Cancer

- ID: M5546

- Name: Carcinoma, Non-Small-Cell Lung

- Relevance: HIGH

- As Found: Non-Small Cell Lung Cancer

- ID: M5534

- Name: Carcinoma

- Relevance: LOW

- As Found: Unknown

- ID: M14979

- Name: Respiratory Tract Neoplasms

- Relevance: LOW

- As Found: Unknown

- ID: M16658

- Name: Thoracic Neoplasms

- Relevance: LOW

- As Found: Unknown

- ID: M11168

- Name: Lung Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M14977

- Name: Respiratory Tract Diseases

- Relevance: LOW

- As Found: Unknown

- ID: M5540

- Name: Carcinoma, Bronchogenic

- Relevance: LOW

- As Found: Unknown

- ID: M5260

- Name: Bronchial Neoplasms

- Relevance: LOW

- As Found: Unknown

### Condition Browse Module - Meshes

- ID: D000008175

- Term: Lung Neoplasms

- ID: D000002289

- Term: Carcinoma, Non-Small-Cell Lung

### Misc Info Module

- Version Holder: 2024-05-24
