is nf kb an oncogene?
NF-κB mutation and cancer The p65 transactivator subunit of NF-κB, RelA, was recognized earlier as the potential oncogene (Gilmore, 2003). However, the mutations that confer Rel-A, c-Rel, or other NF-κB proteins with oncogenic potentialities are not abundant and are mainly limited to lymphoid malignancies.