how many moles of water are present in 45.0g?
The average mass of one H2O molecule is 18.02 amu. The number of atoms is an exact number, the number of mole is an exact number; they do not affect the number of significant figures. The average mass of one mole of H2O is 18.02 grams. This is stated: the molar mass of water is 18.02 g/mol.