is there any over the counter medicine for leg cramps?
3) Diphenhydramine (Benadryl) 12.5 mg to 50 mg nightly (available over the counter). 4) Plaquenil (hydroxychloroquine sulfate) daily for two weeks, then once per week. 5) Quinine is the best-studied drug for nocturnal leg cramps and has been found effective in some studies.