Write SQL query to solve given problem: Among the genes with nucleic acid metabolism defects, how many of them can be found in the vacuole?. Keep the solution inside sql tag ```sql [SQL-Query] ```
SELECT COUNT(T1.GeneID) FROM Genes AS T1 INNER JOIN Classification AS T2 ON T1.GeneID = T2.GeneID WHERE T2.Localization = 'vacuole' AND T1.Phenotype = 'Nucleic acid metabolism defects'