"gain of function" is such a vague term. if i choose only the largest horses to breed, am i not making a gmo and thus achieve a gain of function? if i catch a cold and develop immunity, did i not just naturally achieve gain of function? if i hybridize a citron and a bitter orange, did i not only prove life doesn't give you lemons, but that we manufactured lemons through gain of function? and suppose i bartered with the four primordial annihilators in a bid to blend my own genetics with psychic concepts in order to create primarch generals to conquer the galaxy, would i not be using gain of function to do so? i rest my case.
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