well, an unhealthy life style will have some negative effects. first and formost it will come up in your epigenetics. this leads to some genes that should be turned off turning on and vica versa.  second, some activities also lead to specific cells having their genome effected. for instance smoking will casue dna damage in the epithelia of the lungs. third, stresses lead to an increase in ros, which damage proteins, and dna, primarily mitochondrial dna. but this is true for both scenarios you mentioned. generally drugs, smoking, drinking, this sort of thing has a more local dna damaging effect, contributing more to cancer then ageing (cancer is a form of local ageing). as opposed to the sedentary life style of the fat and spoilt, which leads to a more systemic, more general increas in ageing. as for not eating, this will have contradicting results. it will have positive effects on cell turnover speed, stem cell exhaustion and senescence, but it will have negative effects via stress, ros, and epigenetics.   this is not my place of work, just a lab i visited. i love microscopes and like to photograph and post them whenever possible. i in fact love all kinds of optical systems, hence the astro photography images, which are ones i made. > argument of authority if you want to throw around fallacies, know what they are. if i would have said "i am right because i have a degree", that would have been an argument from authority. but i never did that, did i...
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