> resulting in systemic spike protein production  that's not what the study found.  > scp-nano analysis confirmed off-targeting of lnp-delivered mrna to the heart after intramuscular injection, ruling out trafficking of spike protein from the injection site to the heart as a major source of the spike protein signa l  they themselves don't come to any definitive conclusions:  > notably, the directly draining lymph node and, to an even greater extent, the cervical lymph nodes near the neck received notably higher doses of mrna than the other lymph nodes. this observation underscores the potential of lnps to facilitate an immune response in lymph nodes, thereby enhancing vaccine effectiveness.  > the observed lnp accumulation and proteome changes in heart tissue suggest a potential mechanism by which lnp-based mrna vaccines could contribute to the reported cardiac complications. nevertheless, further investigations are warranted as the exact lnp formulations and potentially the spike mrnas used here may differ from those in the approved mrna vaccines. thus, the potential causative mechanisms that we identified need to be explored further in future work.
Switzerland