> in 11 studies comprising 1,784 patients with age ranging between 18 and 83 years and average treatment follow-up of 17 months, meta-analytic estimate of the mean baseline change was 27 (95% confidence interval 154). the meta-analysis did not demonstrate unequivocal significant increase in serum t levels. the increase was not uniform among all studies reported. sensitivity analysis showed that no single study contributed decisively to the outcome or could be attributed to drug action. the reported increases in t levels with finasteride or dutasteride in men with low baseline serum t may be attributed, in part, to increased trapping of t by unsaturated sex hormone binding globulin (shbg) due to dissociation of 5-dihydrotestosterone. in men with high baseline t levels, there appears to be no change in serum t levels. 10 studies reported luteinizing hormone, follicle-stimulating hormone, shbg, and estradiol values and none reported significant changes in their levels, suggesting that observed changes in serum t levels are unlikely mediated by gonadotropins levels or peripheral conversion of t to estradiol. > conclusion > 5-ri therapy is not associated with consistent and significant increases in serum t levels. tldr, don't worry about it bro, you got this. > what? most grown men in the bald cult resemble oversized babies such significant response, big ups bro.
United States