 We bought our Sienna new in 2006 and have driven 48,000 miles.  The vehicle has been back to the shop 7 times and repairs are now costing us staggering sums of money.  If you like this vehicle, be sure to get the extended warranty.  The driver's side automatic sliding door just broke and cost $1800 to fix.  The dealer said this is a common problem.  The rear hatch won't close on its own and the dealer can't fix it.  After 10k miles and 35k miles, we had to have both sliding doors fixed as loose parts were rattling loudly.  The run-flat tires are terrible.  They wear out at 15k miles and cost $1000 to replace.  The vehicle doesn't come with a spare tire.