 I just got my 2006 E350 4Matic and so far, things are going great. I love the power shade, the quality of the standard stereo system, and the integrated 6 disk changer.  The 4matic seems to have a little trouble choosing gears but that may by own perception. I love the distinguished look of the car and the maturity level it portrays since I'm only 28 and use the car mostly for business. 