 Long time MB owner, this E350 has had issues from when we drove it off the lot, the worst issue is the terrible transmission shifting, which is a safety issue when driving at highway speeds. There is an intermittent problem with a long hesitation when you step on the gas to pass or avoid something and the car accelerating. The "premium" leather seats (they are not standard and are not on most cars sold) are very uncomfortable because they pivot above the base, so if you dive in any position other than a right angle the bottom of the seat back pushes into the small of your back. Our brand new car had loose parts and noises which were corrected, but is that what you expect from this car?