 I have never had this issue with a car before.  I loved my last Edge and my other vehicle is a Ford F150 which I love.  The 2016 Ford Edge Titanium has a vibration to it that sounds like buffeting from having the rear windows open.  If I ride in this car for more than 30 minutes I get a nasty headache.  This is the worst car I ever owned.  Finally had to get rid of this car, I figured out after taking test drives in other Edge models that it was the moon roof that caused the issue.  I am staying away from the Edge.