Can someone improve this C# code Its working but I don't think its the best way of doing it. I also changed variable names just to let you know,

       string [] columnN = AnotherString.Split(',');  //Another String is something like this = "HEhehehehehE heeh, aSKdjhkaaksjd, asldkhja slkdlk, asdajsdlka, asdljkasd, asdkasjdasd, asdasdasdl, askdjasd"
                AnotherString = "";
                int i = 0;

            foreach (string cN in columnN)
            {
                if (!string.IsNullOrEmpty(Res.ResourceManager.GetString(cN.ToLower().Trim())))
                    AnotherEmptyString += Res.ResourceManager.GetString(cN.ToLower().Trim());
                else
                    AnotherString += cN;
                i++;

                if (i &lt; columnN.Length)
                    AnotherString += ",";
            }


I saved all resources in lower case, also if in case cN doesn't got any resource won't it will give an exception.
Your code should work ok. However, I would have used a list to store the intermediate results, and then string.Join to create the result. (Also perhaps Linq to filter the data, but then someone not familiar with Linq will have trouble maintaining the code.) Something like

string[] columnN = AnotherString.Split(',');
string[] stringList = new string[columnN.Length];

for (int i = 0; i &lt; columnN.Length; i++)
{
    string cN = columnN[i];
    string resource = Res.ResourceManager.GetString(cN.ToLower().Trim()));
    stringList[i] = resource ?? cN;
}

AnotherString = string.Join(",", stringList);