Multiple regex replacements I receive a string with a lot of characters that I don't need and I am trying to remove them and replace them with characters that I am able to work with. My current structure has me redefining the var multiple times which I feel is not efficient and can probably be done better. Please let me know of a more effective way I can do this.

I define the date then remove the unwanted characters then append the date to the "clean" string with and underscore:

var d = Date.now()
  var article = a.replace(/ |\./g, "_")
  article = article.replace(/\r?\n|\r/g,"")
  article = article.replace(/\$|\#|\[|\]/g, "")
  article = d + "_" + article


This does work but I am curious if there is a better way.
First, since you already did so inside of your two last expressions, with the same replacement:

article = article.replace(/\r?\n|\r/g,"")
article = article.replace(/\$|\#|\[|\]/g, "")


I'm puzzled why you didn't simply put both in a unique regexp:

article = article.replace(/\r?\n|\r|\$|\#|\[|\]/g, "")


Then to integrate with the 1st one, you might choose to:


join the two distincts replacements in a single line:  

var article = a.replace(/ |\./g, "_").replace(/\r?\n|\r|\$|\#|\[|\]/g, "")

or use a map approach, either suche the one pointed by @greybeard's link, or like this way (even if it might look a bit too sohpisticated for only two cases):  

var replacements = new Map([
    [/ |\./g, '_'],
    [/\r?\n|\r|\$|\#|\[|\]/g, '']
    ]),
    article = a;
replacements.forEach(function(value, key){
      article = article.replace(key, value);
    });



The most interesting aspect in this latter solution is that it may be easily expanded if more replacements are needed.



EDIT following a good suggestion from @Niet the Dark Absol.

As soon as there are several unique characters to look for, with the same replacement, this kind of regexp /(a|b|c)/ can be replaced by /[abc]/, which is both simpler and more efficient!

Any of the above proposed solutions can be improved this way, so the latter one becomes:

    var replacements = new Map([
        [/[ .]/g, '_'],
        [/[\r\n$#[\]]/g, '']
        ]),
        article = a;
    replacements.forEach(function(value, key){
          article = article.replace(key, value);
        });