Does Titanium Backup work with system using Link2SD Titanium Backup is a root app that allows you to back up your apps and all their data.

Link2SD is a root app that moves all files an app stores in internal storage to a special partition on SD card, and creates symlinks into the internal storage in place of the original files.

Does Titanium Backup work with Link2SD? That is, does it correctly back up the files that the symlinks point to, or does it instead end up backing up just the symlinks?
Titanium Backup works fine with Link2SD. I've been using them together for about six months, with around 100 apps symlinked. There's no reason taking a backup would uninstall linked apps as Wolfgang reports, and I've also had zero issues restoring backups of linked apps, so it's clear that Titanium follows the symlinks correctly. In fact, I have just finished restoring all my apps from Titanium after flashing a ROM.

The only caveat is that when you restore in Titanium, Link2SD will not automatically link apps as they are restored, even if you set it up before restoring the rest of your apps. This is annoying, because it means you have to be conscious of your available internal memory and only restore in batches that will fit in your free space, then link the apps and do another batch.

Other than that, they work very smoothly alongside each other.