How do I uninstall an application? If I want to completely uninstall an application from the home screen or list of applications; how do I do it?
You can uninstall an application from the Market or from the Manage Applications settings screen.

From Marketplace:


Start the Market app.
Hit the menu button and select Downloads.
Find the app you want to uninstall and select it.
Hit the Uninstall button at the bottom.


From Manage Applications:


From your Home screen hit the menu button and select Settings.
Select "Applications"
Select "Manage Applications"
Find the app you want to uninstall and select it.
Hit the Uninstall button at the top.


EDIT: I wanted to add a 3rd method that Rohan Singh had in his answer.

From your Home screen:


Tap and hold on the icon of the application you want to uninstall.
When the trash can appears near the bottom center of the screen, drag and hold the icon there.
After the tap &amp; hold / drag &amp; hold some text will appear indicating that you can uninstall by dropping the application's icon on the trash can.
Release your finger over the trash can and you'll be taken to the same uninstall screen you can get to through Manage Applications in your Settings.