How to render user picture from page.html.twig file I am using

node.Owner

To print out things like user name, for instance to print the first name out (which is a custom field) it is simply.

{{ node.Owner.field_first.value }}

However if I try to do the same for the user picture I get an error. I have tried

{{ node.Owner.user_picture.value }}
{{ node.Owner.user_picture}}
{{ node.Owner.user_picture.0.value }}
{{ node.Owner.user_picture.content }}

None of these work ?
You can either do

{{ node.author_picture.content }} 

or 

{{ content.author_picture }}