Can MySQL 5.6 be used with Drupal 6 and php 5.2.17 A server admin is looking to update the production mysql from the latest version 5.0 to latest 5.6. We are running a Drupal/Pressflow 6.22 and php 5.2.17. I believe this is going to bring on the apocalypse when it comes to things not working, but I need some concrete reasons on what may break and why. 

Do anyone have any experience running a drupal 6 on mysql 5.6? Or PHP 5.2 with MySQL 5.6?

I know mysql 5.1 in acted strict mode in MySQL. 

Anyone have any insight into if these will play nice with Drupal 6 and it's modules?
MySQL 5.6 works fine; using the mysqli driver. PHP 5.4 works after fixing a couple of notices, and php 5.2 works without any modifications.

In your settings.php file change $db_url = 'mysql://...' to $db_url = 'mysqli://...' to use the mysqli driver; it's that simple.