Can I route individual websites to a multi-site Drupal installation? This isn't really Drupal-specific, but perhaps someone is already doing this with Drupal and can guide me. I host a few sites for my customers and several of those are Drupal-based, using a multi-site installation. No problems, except that those are not individual cPanel accounts, of course, and the customer cannot manage any part of their account -- I have to do it all.

Is it possible to set up my Drupal customers with individual cPanel accounts, yet route all their web traffic to the multi-site Drupal installation on my reseller account (typical reseller account on a shared host)?
I have never seen this done in cpanel. Maybe under your reseller account 
you could  create a instance of multi-site and then create sub-domains then
your clients could domain could be redirected to the subdomain?

Have you tried talking to the guys who created cpanel that might
be another resource 

http://forums.cpanel.net/forum.php