Somatic tumor only variant calling? I'm evaluating possibilites for somatic tumor variant calling without paired-normal samples. I'm aware of the consequences without a normal sample.

All the popular variant calling tools such as Strelka, VarScan etc require a normal sample.

What are the some of the possibilites I have? I'm looking for good sensitivity in exchange for higher false positives.
There is a recent paper that attempts to do this:


  ISOWN: accurate somatic mutation identification in the absence of
  normal tissue controls.
  
  In this work, we describe the development, implementation, and
  validation of ISOWN, an accurate algorithm for predicting somatic
  mutations in cancer tissues in the absence of matching normal tissues.
  ISOWN is available as Open Source under Apache License 2.0 from
  https://github.com/ikalatskaya/ISOWN