Calculating polarity and hydrophobicity of a ligand/small molecule I have lot of SMILES IDs of the ligands. What I am interested in is the polarity and hydrophobicity score of each of the ligands.

In other words, does ligand have more polar groups and can it make more polar interactions or is it more hydrophobic?

Does anybody know the way/software to look at it?

Best
You can calculate their polar surface area or logo using rdkit or openbabel. Other molecular properties may be available as well.