AutoDock 4 -soft docking How could I turn on/off the smooth potential in AutoDock4? I need to do two docking. The first one is soft docking with smooth potential and the second is re-docking without the smooth potential.
The smooth parameter is an optional keyword and command that changes the smoothing potential. If not provided, the default is 0.5 angstroms by default. Try passing 0 with this keyword in the AutoGrid Parameter File to turn off smoothing potential.

See the AutoDock 4.2.5 documentation for more details.