ComBat for batch effects removal on scRNA-seq data Is it possible to use sva's ComBat for batch effects removal on scRNA-seq data?

Is there any difference between RNA-seq and scRNA-seq data which doesn't allow to use ComBat on single-cell data? (I am thinking about extreme sparsity, > 80%). If so, are there alternatives?
Look at this recent paper that uses ComBat on scRNA-seq data for batch effect removal and states that it "successfully does so".

I also suggest that you check out this publication on Distribution Matching Residual-Nets. Authors evaluated their method also on scRNA-seq data and thus it may be something you are looking for. I personally played a bit with their code and found it straightforward to use.