Prevent quad view from resetting? Is there a way to prevent the quad view (CTRL+ALT+Q) from resetting? 

I'm using the quad view with the "Lock" option disabled. Each time I maximize and minimize a viewport in the quad view, the top right viewport gets reset and becomes the last view I was in.
NO, it's not possible: modified quad views reset to the default if you exit quad view.

A workaround would be to create a new screen layout that has your modified quad view.