Smoke along a motion Path I'm interested in recreating Reaper's smoke transformations from the Overwatch Shorts. In the video below, they showcase how they achieved this. I'd like to know if it is achievable in Blender: 

BlizzCon 2016 Overwatch Animated Short | Reaper's Smoke Animation
Particles can be used to emit smoke, and I've seen something quite similar to what you posted.

The current version of Blender allows a lot of particle tricks, like particles fighting flocking etc..

It might take Blender a bit more time to render, but smoke is pretty good from blender. Here is Death-Eater (Harry Potter effect) that's quite close to what you seem to be looking for.