Can you Animate like in Stop Motion Animation? In Stop Motion Animation, the proccess is very simple, you have a piece of clay (or something else) and you tweak/remodel it after every frame.

Is there a workflow in blender, that lets you resculpt your model and move it, without rigging it, that is still practical?

For example like the transformation from bruce banner into hulk, while walking.
What you want to do can be done using shape keys. There are many tutorials on Youtube this is one of them Shape Keys Tutorial