Increase font sizes for property names and values Using Blender 2.92.0
It seems this issue is kind of interesting.   I've adjusted the font  sizes to where they seem usable for me, great :)   However loading up a saved file *.blend file and the UI elements in Blender itself get changed.    Is there a way to get Blender to not resize its own UI settings when loading a drawing?  Or save off the portion of the UI settings and only load them or merge/replace them in the saved drawing file?
Expected:
Blender's UI fonts remain to a user's settings/preferences.
Actual:
New drawing just selecting General from startup splash screen (desired settings)

Open saved drawing:
To stop loaded files from changing your preferences, go to User Preferences under Edit &gt; Preferences and under the Save &amp; Load category, look for the Load UI checkbox. Uncheck it.

Then, while still in Preferences, go to the Interface category and click in the Resolution Scale text field. Enter a new value for the scale. You will want it to be some value greater than 1.