A Disabled User in need of Suggestions/Help (UI Question) I have a minor case if Cerebral Palsy which affects my left hand therefore using some of the keyboard shortcuts are impossible for me to use.  I’m using Blender 2.8.

Just a few Examples of the problem keyboard shortcuts (in Windows)…

Ctrl+Alt+LMB for (Bridging Edgeloops)

Shift+Ctrl+ALT+C for (Set Origin)

I have tried making Macros but they are too limited.

I’m hoping someone has any suggestions,
You might want to look at programs like Stroke Plus. It allows you to add multi-key keyboard shortcuts to mouse gestures,without having to take up more shortcut keys on a already crowded keyboard.
Really almost anything you can do with a keyboard such as type in commands or strings like an email address. You can assign gestures globally or per-program. 
See the video on the home page for a quick explanation. 
I have used this for years to speed up programming.