Down sampling an EEG signal I have a set of 10 minute EEG signals that were sampled at 400 Hz and have 16 channels which corresponds to a 16x240000 matrix. These EEG signals belong to two different classes. I am trying to classify these 10 minute segments using a Neural Network, in particular a LSTM.

Since the size of the matrix is very large, even after I split them into time segments, I would like to first reduce the number of samples. My current approach for pre-processing is to use wavelet transform for denosing  and down sample to at least 200 Hz. This results in a 16x1200 matrix. 

I was also looking at ICA as a feature extractor and reduce the size.

My question is, how do I tell which method is better suited for my task? Will downsampling the signal lead to a significant loss in information? 

I will appreciate any suggestions. Thank you.

Edit:
 - The data corresponds to two stages of seizure: 


Preictal: Right before the seizure
Interictal: in between seizure


-The data was captured from 3 different patients and using 16 electrodes, sampled at 400Hz.
Actually I am not quite sure if you should/need to downsample it with conventional methods. Did you consider using CNN (with stride larger than 1) first and then feed segment of the output to LSTM? The former step gives you some downsampling effect but it is probably better than any conventional preprocessing methods since those layers will be trainable and the whole model can be trained end-to-end (assuming that you have sufficient data).