How do I denoise a microscope image? I'm working in a computer vision project, where the goal is to detect some specific parasites, but now that I have the images, I noticed that they have a watermark that specifies the microscope graduation. I have some ideas of how to remove this noise, like detecting the numbers and replace for the most common background or split the image but if I split the image I'll lose information.
I would like to hear some recommendations and guidelines of experts.
Example image below.
I am also not an expert, but I would consider this: The 50 µm watermark is burned in the image and it is complete black (0 0 0) in rgb. It has a significant influence to any analysis oyu make on the image regarding statistics like mean, median, edge detection etc.

So it needs to be removed. The easiest method to remove it would be to find out if you microscope has a setting to metadata this information instead of burning it in the image. 
If that is not available and you only have this image provided, then I personally would go as follows:


Segment the black "Noise" watermark area and 
use that selection as a mask to fill with the mean color.
Do your analysis. Be critical of whether it influences the results and refine if necessary. (E.g. if it still interferes with edge detection add some random noise).


Either that, or, if you can afford it - exclude the area of the watermark altogether from the analysis.

But please correct me if anyone knows better.