Bitcoind and Bitcoin-cli on LAN I am attempting to run  bitcoind on a computer in my local area network (LAN) and then have bitcoin-cli access/communicate with that computer in lieu of running Bitcoin-QT on the same machine alongside bitcoind.

Is that possible?

Thus far I've tried to modify the bitcoin.conf but without success.
You can run bitcoind on one machine, and communicate with another over your LAN using bitcoind's JSON-RPC API.

Once bitcoind is running just hit your host machine's local network IP on port 8332 with your API calls. You can find out your local network IP of your host machine by typing ipconfig in your command prompt. 

You didn't mention how you were trying to communicate so let's say for example if you're using Python-BitcoinRPC 

from bitcoinrpc.authproxy import AuthServiceProxy

access = ServiceProxy("http://USERNAME:PASSWORD@192.168.2.1:8332")
access.getinfo()


Make sure you update the ServicProxy() function with the host's local IP, and your username and password from your bitcoin.conf.