Is my Bitcoin address valid for mining? I am looking at the specific block at height 680175.
When comparing the address which received the block reward
# bitcoin-cli validateaddress 1KFHE7w8BhaENAswwryaoccDb6qcT6DbYY
{
  &quot;isvalid&quot;: true,
  &quot;address&quot;: &quot;1KFHE7w8BhaENAswwryaoccDb6qcT6DbYY&quot;,
  &quot;scriptPubKey&quot;: &quot;76a914c825a1ecf2a6830c4401620c3a16f1995057c2ab88ac&quot;,
  &quot;isscript&quot;: false,
  &quot;iswitness&quot;: false
}

to my newly generated address
# bitcoin-cli validateaddress bc1q403w7zrj74azzunk89srt2m3vuajatlmskcktm
{
  &quot;isvalid&quot;: true,
  &quot;address&quot;: &quot;bc1q403w7zrj74azzunk89srt2m3vuajatlmskcktm&quot;,
  &quot;scriptPubKey&quot;: &quot;0014abe2ef0872f57a217276396035ab71673b2eaffb&quot;,
  &quot;isscript&quot;: false,
  &quot;iswitness&quot;: true,
  &quot;witness_version&quot;: 0,
  &quot;witness_program&quot;: &quot;abe2ef0872f57a217276396035ab71673b2eaffb&quot;
}

there are some differences in the scriptPubKey and the witness program. Are these differences relevant for mining?
The inferred PubKey hash of the miner address is c825a1ecf2a6830c4401620c3a16f1995057c2ab. Would my PubKey hash be abe2ef0872f57a217276396035ab71673b2eaffb?
When a miner finds a valid block, the coinbase transaction they included in their block pays out the mining reward to their own address. Mining rewards can be sent to any type of output. The only special restriction on coinbase transaction outputs is that they can only be spent after a maturation period of 100 confirmations.
You are looking at two different address types:

bc1q403w7zrj74azzunk89srt2m3vuajatlmskcktm is a Pay to Witness Public Key Hash (P2WPKH) address
1KFHE7w8BhaENAswwryaoccDb6qcT6DbYY is a Pay to Public Key Hash
(P2PKH) address.

P2WPKH addresses are the more block weight efficient successor of P2PKH addresses. Spending funds received to P2WPKH addresses takes less than half the blockweight as spending funds received to P2PKH addresses.

The inferred PubKey hash of the miner address is c825a1ecf2a6830c4401620c3a16f1995057c2ab. Would my PubKey hash be abe2ef0872f57a217276396035ab71673b2eaffb?

Yes, that's correct.