Blowfish-448 Secure Key Generation Algorithm I am using blowfish-448, until now the keys have been generated using a crypto random number generator full filling the 448bits vector.
I read about exploit in case of weak keys and reflection keys attack.
Mine concern is if the generation approach we are using is secure or if does exist a more secure way.
I am using blowfish-448, until now the keys have been generated using
  a crypto random number generator full filling the 448bits vector.


This is fine assuming your cryptographic (pseudo-) random number generator is actually good. If this wasn't a valid strategy, this would have produced strong warnings about using Blowfish already.


  I read about exploit in case of weak keys and reflection keys attack.


Yes, there exist weak keys for blowfish, but hitting them when utilizing the full space has negligible probability (also it appears that they don't even break the full blowfish but rather a larger part than with normal keys).


  Mine concern is if the generation approach we are using is secure or
  if does exist a more secure way.


Yes, you really should migrate off Blowfish to AES. It will (most likely) be faster and likely more secure and you won't suffer from small-block attacks like Sweet32.