Can I use Regex in the Find and Replace tool? Does the Find and Replace tool support regex? I need to remove a certain section of an image url for all images in the 'field_body' column.

So if I had an image referenced as such 

http://craft.dev/uploads/image-600x400.png


I would be able to find all images that match that pattern and return the url to be 

http://craft.dev/uploads/image.png


Now I have very little experience with Regex but would this be a safe pattern to use (if I can with Craft that is...)?

(-[0-9]+x[0-9]+)
Nope, because MySQL doesn't support RegEx replacements in SQL statements.  It's been an open feature request since 2007, so feel free to add your vote.

There are some potential workarounds listed here, too.