Is it possible to erase problematic memories? This question is inspired by a question I answered on Health. 


  Can we erase problematic memories to aid recovery from depression?


A depressed person asked how to erase specific unpleasant memories in order to manage his depression. My answer was basically "that's impossible, here is how you deal with these memories instead". And then somebody asked in the comments why it is impossible. 

I thought of tackling this question and realized I can't do it well. My best attempt was something like, "First, you have to find out which millions of neurons (out of the billions the person has) light up together to represent 'a memory', and we don't have a method for brain imaging with that resolution. Second, you have to stop them from activating in exactly that combination, while preserving their ability to activate in any other combination, and we have no idea how to achieve that". But this level of explanation does not satisfy me. It is very vague, and I'm not even certain it's correct. 

To our best knowledge, what would we have to do if we wanted to erase a specific memory of an event happening to a person? And how far is our technology from achieving each of the steps needed?
The notion of "selective memory loss" as erasing problematic memories presumes the existence of engrams, which is a theoretical localized, biological basis for memory. Despite exhaustive searching, we have not found any evidence of engrams in any animal with a nervous system, however. To the best of our knowledge, it's therefore impossible to erase memories, because there is nothing to erase―we have more or less concluded that engrams do not exist. Bruce (2001) aptly summarized Karl Lashley's seminal findings on the matter:


  In his well-known article “In Search of the Engram” published in 1950, Karl Spencer Lashley summarized his 33 years of research and theory on memory and the brain. He concluded that (1) memories are not localized but are instead distributed within functional areas of the cortex and (2) memory traces are not isolated cortical connections between inputs and outputs. Though not the first time he had expressed such convictions, their reiteration in this article was backed by Lashley's estimable reputation and expressive power and they have taken firm root in the collective knowledge of today's memory and neuropsychological research community.


We cannot have "selective memory loss", at least not in the sense of erasing individual memories, because there is no such thing as "a memory" in any tangible sense. In modern cognitive science, such as Baddeley's multi-modal model, memory is not so much considered a neural warehouse of remembrances as it is a distributed and generative process. It's not a question of technology.

References


Bruce, D. (2001). Fifty years since Lashley's In search of the Engram: refutations and conjectures. Journal of the History of the Neurosciences, 10(3), 308-318.