Is meaning-seeking behavior a biological optimization problem? In short, I'm interested in cognitive, neuroscientific, biological and/or computational perspectives on what we vaguely refer to as meaning seeking. Of course, this is a large topic, but any information would be highly appreciated.

Background

Humans tend to desire meaning in their lives. While it would be hard to agree on a precise definition of meaning, it often refers to positioning oneself in a way that is compatible with one's beliefs, ambitions and values, allowing the individual to make sense of the world and of himself, and to pursue whatever (often transcendental) goals he considers worthy (i.e. meaningful). In simpler words, meaning could refer to making peace with the perceived reality of the world and with oneself. At first glance, it seems to me that a meaningful existence requires the absence of cognitive dissonances, but I wonder what science would have to say about this, and if there is any empirical basis for claiming this. Or perhaps the questions is misformulated and such behavior should not be put into the domain of meaning?

Possible explanations

A simple evolutionary argument could be that meaning-seeking behavior originates from our impulse to belong (isolation means death), but how do we then explain hermits or dissidents or all other individuals who have effectively made themselves suffer/die in order to uphold meaning in their lives (i.e. dying for one's beliefs)? So the argument that meaning-seeking behavior is a purely evolutionary phenomenon that serves only to maximize one's potential for reproduction doesn't appear sufficient.

Questions


Can meaning seeking be thought of as an optimization problem of some
biological parameters on an individual level, e.g. in terms of
energy required for various cellular processes, homeostatic gene
expression dynamics etc.? For example, depression (which can have an
existential origin) is damaging to health and has been linked to
epigenetic modifications (Sun et al. 2012), so having a mechanism that would seek
to minimize such damage would seem to be beneficial for an organism.
Can we construct a more formal definition of meaning that would be
less anthropocentric? In other words, how far would we need to curb
the definition so that humans would no longer qualify as the only
meaning-seeking organisms? Or are we indeed the only species with the required neural capacity to express such behavior?
Could modern experimental methods such as EEG, fMRI, gene
expression profiling and epigenome sequencing be used to answer some of these questions at
least to a degree? E.g. would a comparison of individuals who claim
to live a meaningful life vs those who don't make any sense? Of
course, even if a some significant differences were observed, an
obvious next question would be what caused them, i.e. a mind-body-environment
problem ...


I'd be happy to know at least if there are some research groups or labs that try to tackle such questions.
it seems to me that a meaningful existence requires
  the absence of cognitive dissonances, but I wonder what science would
  have to say about this, and if there is any empirical basis for
  claiming this.


The difficulty, as you've pointed out, is that there isn't agreement on the definition of "meaning" in this context.  Meaning can be interpreted by different people (and cultures) variously as: "accomplishment", "social good", "altruism", "realizing potential", "inner peace", "knowledge", and on and on.


  the argument that meaning-seeking behavior is a purely evolutionary
  phenomenon that serves only to maximize one's potential for
  reproduction doesn't appear sufficient.


Read about evolutionary explanations for altruistic behaviour for example to see how this can be addressed: "Every single instance of altruistic behavior need not always increase inclusive fitness; ... it would be beneficial to err on the side of caution and usually be altruistic even if in most cases there were no benefits."


  how far would we need to curb the definition so that humans would no
  longer qualify as the only meaning-seeking organisms?


"Social good" and "altruism" are examples of meaning-seeking behaviours commonly found in many animal species.


  Could modern experimental methods such as EEG, fMRI, gene expression
  profiling and epigenome sequencing be used to answer some of these
  questions at least to a degree?


Sure, why not.  For example: "Altruism, the experiment suggested, was not a superior moral faculty that suppresses basic selfish urges but rather was basic to the brain, hard-wired and pleasurable."


  I'd be happy to know at least if there are some research groups or
  labs that try to tackle such questions.


The area of psychology most likely to address such an abstract concept as meaning-seeking is probably Humanistic Psychology: "Human beings are intentional, aim at goals, are aware that they cause future events, and seek meaning, value, and creativity."

You can read about research done in this field - there isn't very much of it though - and also about self-actualization (another common interpretation of meaning-seeking in psychology).