Do we negatively perceive people who wear glasses? Do we negatively perceive people who wear glasses? If so, why? Is it cultural stereotypes, a simple case of homophily, or is there more to it?
No, people wearing glasses are not generally perceived negatively. Glasses affect various dimensions of person perception differently. To name a few, a commonly reported effect you may want to read up on is the glasses stereotype: If you wear glasses, people will tend to think of you as smarter (e.g., Hellström &amp; Tekle, 1994, Terry &amp; Krantz, 1993), but less attractive compared to those not wearing glasses (Hasart &amp; Hutchinson, 1993; Lundberg &amp; Sheehan, 1994; Terry &amp; Kroger, 1976). This effect has been found regardless of whether the judges wear glasses themselves, although, when they do, the effect on attractiveness appears to be less pronounced (Terry &amp; Kroger, 1976).

It appears, this effect is also moderated by the type of glasses you wear:


  The results show that faces without glasses were seen more attractive and more likeable than faces with full-rim glasses. Faces with rimless glasses did not differ from faces without glasses in their attractiveness or likability rating. Regarding the ratings of successfulness, and intelligence, the results show that individuals wearing glasses (both rimless and full-rim) were rated as more successful and more intelligent than individuals not wearing glasses. Regarding trustworthiness, individuals with rimless glasses were rated as significantly more trustworthy than faces without glasses. Ratings of cooperativeness did not differ between the face versions.


(From this online summary of Leder, Forster &amp; Gerger, 2011)


Hasart, J. K., &amp; Hutchinson, K. L. (1993). The effects of eyeglasses on perceptions of interpersonal-attraction. Journal of Social Behavior and Personality, 8, 521-528.
Hellström, A., &amp; Tekle, J. (1994). Person perception through facial photographs: Effects of glasses, hair, and beard on judgments of occupation and personal qualities. European Journal of Social Psychology, 24, 693-705. doi:10.1002/ejsp.2420240606
Leder, H., Forster, M., &amp; Gerger, G. (2011). The glasses stereotype revisited: Effects of glasses on perception, recognition and impressions of faces. Swiss Journal of Psychology, 70, 211-222. doi:10.1024/1421-0185/a000059
Lundberg, J. K., &amp; Sheehan, E. P. (1994). The effects of glasses and weight on perceptions of attractiveness and intelligence. Journal of Social Behavior and Personality, 9, 753-760.
Terry, R. L. and Krantz, J. H. (1993), Dimensions of Trait Attributions Associated with Eyeglasses, Men's Facial Hair, and Women's Hair Length. Journal of Applied Social Psychology, 23: 1757–1769. doi: 10.1111/j.1559-1816.1993.tb01064.x
Terry, R. L., &amp; Kroger, D. L. (1976) Effects of eye correctives on ratings of attractiveness. Perceptual and Motor Skills: Volume 42, Issue , pp. 562-562.
doi: 10.2466/pms.1976.42.2.562