Why are most effects of the predicted climate change negative? Most of the commonly mentioned effects of the ongoing and predicted climate change are negative: more extreme weather effects, more destructive weather, more diseases, rapid extinctions, etc.

Why is this so?

It is clear that any rapid change brings many negative effects. We humans, as well as the biosphere, are adapted to the current conditions. Any sudden deviation from these conditions will take painful re-adaptation.

But my impression is that several of the commonly mentioned negative effects go beyond than what can be explained by just change. Is this really so?  If yes, would a cooling climate (beyond restoring pre-industrial conditions) bring more positive effects?
I would say that the reason is because human civilisation, and particularly agricultural practices, evolved and are adapted to the pre-industrial climate.  This means that any substantial change in the climate will require changes in our civilisation and agriculture, which inevitably has a cost.  So the reason that most of the changes are negative is not to do with the science, but to do with us.