Getting plumbing on the other side of support beams
I wanted to follow up on this in case anyone stumbles upon it.  I actually ended up using a relatively new solution -- a 2810HR Joist Reinforcer.  It's a 14-gauge steel plate which allowed for a larger bore (in my case I made it 4.5&quot;) through a 2x10 and I put one on each side of the headers. The IBC/IRC certification they have for the plates passed inspection with no issues.
Only recommendation I would make is to get a better square bit to drive the screws than the one the company provides.
Otherwise, it got my plumbing where it needed to go and it's incredibly sturdy so I'm not worried about the strength of support. Hope this helps someone in the future!