Primer cracks once it begins to dry over new Drydex spackling
All,

We ended up sanding off the peeled pieces, , re-spackling (using same brand but slightly older container I had in the garage), re-sand/clean, SKIPPED priming, and painted directly on it. Paint held without issues and wall looks good now. We are guessing that it was the DAP spackling and we had a bad tub that didn't handle the primer. We used the primer later in the week on a separate area and it held without issues to a different brand of spackling.

I honestly believe the overall correct answer would be Jeff Cates comment:
"Out of curiousity, I went to DAPs website and looked at reviews. An overall rating of 2.2 for this product, with lots of complaints about paint peel and bubble. I would suspect the spackle to be the issue. I keep a small amount of joint compound for repair purposes, and suggest you return the spackle. Buy a small tub of joint compound, dig the spackle out of the repair, then repair your area with the joint compound, dry, sand, prime, paint"