Best edge finish for spill resistance?
Standing water is a problem for any wood-based product, as the water will eventually find its way to the unfinished sides of the planks and be absorbed, causing swelling, heaving, mold, and all sorts of unpleasantness.  At that point, the affected flooring will have to be removed and replaced, which isn't quick or easy.

Accidental spills of water or beverages, if cleaned up quickly, are much less of a concern.  A flooring that cannot withstand the wear and tear of everyday life wouldn't be very popular or last very long.

If you're concerned about long-term standing water (an appliance or fixture prone to leaking or dumping water, or a basement that regularly floods), consider a vinyl or tile flooring, which are much less susceptible to moisture.  If you're only concerned about the occasional spill, a wood-based flooring product is fine as long as you attend to the spill quickly.

Just as an aside, what you call "V-fit" is commonly referred to as "beveled" or "beveled-edge", and is generally aesthetic.  The beveled edges are still covered by the laminate surface (commonly mylar), rather than being "raw".