Can I run my attic HVAC/Furance without an Air Cleaner/Purifier Filter
The Aprilaire 1410 air purifier is a larger, more efficient, longer lasting version of the typical 1 inch filters. I'm not really a fan of these frame-less filters as they can be hard to find locally. You can always get them online and have then in a day or two.
In addition to filtering out fine particles like dust, a filter also protects the HVAC system from larger particles that can damage the fan or condenser coils.  You should not run the system if there are no other filters besides this one.