Honeywell zone panel turning on cool of instead of heat
To figure out if your Honeywell control board is bad, I would swap the two zones' wiring and see if that makes the heat work in the master bedroom but becomes broken in the main part of the house. Make sure you disconnect the power before you work on anything.

Label and disconnect your zone 1 damper and zone 1 thermostat wires, and connect them to zone 2. At the same time label and disconnect your zone 2 damper and zone 2 thermostat wires, and connect them to zone 1. Taking a picture might help if you get confused later.

This board should be able to control 4 zones, so if zone 1 or 2 is broken you may still be able to switch it to zone 3 or 4 on the board and not need to replace the control board.

If swapping the zones doesn't do anything, I would check if the thermostat wiring is bad. Connect your master bedroom thermostat directly to the Honeywell control board and see if that fixes it. If the problem stays the same, then we at least know it's not your thermostat wires when we continue troubleshooting.

Honeywell HZ322 Zone Panel Professional Installation Guide