Zoned thermostat in every bedroom
This is easily achieved with a mini-split unit for each room - that is also usually the most energy-efficent approach.

There are split systems with a single outside unit feeding up to 4 separate inside units (perhaps more, but that's the most I've noticed) but they have worse efficiency numbers than the one-head, one outside unit systems.

And, of course, a window unit in each room also achieves the same end, but less efficiently and with a somewhat cruder look (and without heating, normally.)

While you can set up zones via dampers in ducts from a central unit, the central unit will be operating inefficiently most of the time since it has to be sized for the entire house load, but would often be cooling a much smaller load.