Is copper clad aluminum wiring safe to use?
Copper clad aluminum doesn't have the safety issues that aluminum wiring has for household branch circuits.  The cladding was applied with a special manufacturing process and it's held up over time.  

The NEC tables for aluminum wire sizing are also for copper clad aluminum, so larger gauge wire is required for a given ampacity than would be with copper.  So although you don't have to do anything special with it, but keep in mind that you can't for example put a 20A breaker on a circuit with 12 AWG copper clad aluminum - you're limited to 15A.  

I don't know if copper clad aluminum is available for power any more, I have not seen it.  It's likely that it came and went due to economics.  For a time copper was so much more expensive than aluminum it was worth making.  Now, the savings using aluminum are not enough to offset the manufacturing cost.  

There was some low grade network cable on the market recently that was copper clad aluminum.  It had a high failure rate, but it's not clear that the cladding was properly applied, etc.  It was sold with a counterfeit UL mark, clearly a fly by night product.  

The only reason I could see to replace it now is the possibility it may make a future buyer nervous should some future inspector note on their report that aluminum wiring was found in the house.