Can concrete screws or the holes be reused?
If you look at the information on the manufacturer's web site, they are careful to say not to re-use the fastener, but they do not specifically say not to re-use the hole.  

I am a bit surprised and even find it odd that Simpson, whose instructions and product information is usually very thorough, would leave this in a gray area.  

I personally would not re-use the hole if you need to rely on these fasteners delivering their rated pullout value.  To be honest, I have used lots of this type of fastener and I find them very convenient to use, but I don't have great confidence in them.
 If you wobble a little when drilling a hole in masonry, it's going to be a little oversized, and that could significantly weaken the hold of this kind of anchor.  

If you just need it to resist shear, I would not worry about it.  If pullout strength is critical, you could easily re-drill the hole bigger for use with a different type of anchor.