Why is there a vent on the ductwork coming right from the furnace?
Furnace installers and/or home owners will put a register in the duct work to provide some heat in the winter to that area. The number of these supply registers is determined by the typical use and desired temperature of this area. I recommend that all basements should have at least 2 supply registers and 1 return register in the basement/equipment area just to keep that area slightly warm and the air fresh. If you are going to finish that area to be used as living space, then more supply and returns will be needed. Also you may want to close the supply registers in the summer when using the A/C since cold air is heavy and will move to the lowest level in the house. Keeping the register you originally inquired about either open or closed would be your choice.