Is my Uponor ProPEX supply line plan efficient?
I see your plan as basically sound and a good design.  One additional thing you may consider.  Many people use softened cold water for toilets, showers, clothes washers, dish washer and sinks except kitchen.  Don't use softened water for drinking, cooking &amp; ice machine for health reasons and not to hose bibs because of volume. The softened water is less hard on your fixtures and they will be easier to keep clean.  Softened water in the shower is a little more pleasant and will extend the life of your soap products.  And as long as you have spent the money for the softener, you may as well reap the full benefits. You will also add apparent value to your house with softened cold water throughout the house.