Will a nest work for my hvac system
Nests have no trouble with heat pumps
A simple, single-stage heat pump like yours shouldn't be an issue for a Nest, even the stripped down E model.  Your wiring goes as follows:

Red to R or Rc
Blue to C
White to AUX if present, or W1 if not
Yellow to Y1
Green to G
and Orange to O/B

Just remember to set your Nest up for a heat pump and set its O/B setting for an O wire if it isn't set that way already, and you should be good to go.