For a bathroom pex plumbing should I go with trunk-branch or with a home run manifold plumbing layout?
I home run cold tap water lines 1/2&quot; as close to supply as possible so I can get cold water ground temperature for drinking with the shortest wait possible - assumes your tap water is good quality.  Not sure if you'll be drinking the cold water from the bathroom.
I home run hot water lines as close to the hot water tank as possible so again I wait the minimum amount of time to get the water at the tank temperature.
If I was only re-doing this bathroom I might do the last mile here as if it was homerun plumbing up to your take off point and if/when you redo the rest you could update it.