What kind of screw is this?
That screw you show is designed to cut its own thread as it enters the hole - the tip has the thread cut almost to the end of the tip to start the cutting process.

As long as the root diameter is fractionally smaller than the hole it is going into then it should be fine - as long as it is perpendicular to the hole it will go in fine, if it goes in at an angle then it will "block" or lock-up before it get fully home.

The ones I have used are definitely designed to be used in metal and the tip is hardened for that purpose.