Loading data in mysql using LOAD DATA INFILE, replication safe?
Another answer has already been accepted, but I disagree with that answer, because your question first requires an understanding of the meaning of the term "unsafe" and the phrase "considered unsafe" when it is used related to MySQL replication.


  When speaking of the “safeness” of a statement in MySQL Replication, we are referring to whether a statement and its effects can be replicated correctly using statement-based format.
  http://dev.mysql.com/doc/refman/5.5/en/replication-rbr-safe-unsafe.html (emphasis added)


There is no such thing as an "unsafe" statement when you are using MIXED or ROW-based replication, because the entire premise of "unsafe" is related to how statement-based logging and replication work.  

Something "considered unsafe" doesn't mean it shouldn't be done -- it means the optimizer will consider it unsafe to log in statement-based mode and therefore that it will be automatically replicated using the row-based replication logging format if row-based logging is available -- that is, if you are not using binlog_format = STATEMENT -- which you should not be doing unless you have a specific reason to use it.  If you are not aware of a specific reason to use it, then you most likely do not have one, and you should used MIXED logging, so that the optimizer can choose how to replicate each statement.

http://dev.mysql.com/doc/refman/5.5/en/replication-formats.html