Can I make my distribution database use In-Memory OLTP?
Is it possible to have all the distribution tables use In-Memory OLTP (formerly known as Hekaton) for enhancing performance of the distribution database?


This is a good question and made me thinking. But .... the answer is NO as of SQL Server 2016 CTP 3.0.

The documentation says :


  Replication tables on the distributor cannot be configured as memory-optimized tables.