SSRS email Subscription Not Working but local smtp is working
It was seriously LOL.

I gave NetworkService user full control to mailroot folder residing in  C:\inetpub\ and Vola email was sent from localsmtp.

I bet if someone has faced this problem and has find any solution like same.

Reason OF Solution - login context/User that is rendering report on ReportServer and creating an email template to throw it in pickup directory residing in C:\inetpub\mailroot  should be "Network Service"

Question/Doubt Left
Now the confusion left is can we change this user as my service account user i.e. local Administrator was having  full control on  mailroot folder but it was not working till i opted above mentioned solution.