Move multiple databases from C: to D: at once
I use Powershell for this sort of work.  In fact, I use Powershell to generate Powershell, because I have a script that will loop through my databases and generate my final move script.  You will have to move each database one at a time, but this will at least help you script 90% of the work.

#load SMO
Add-PSSnapin SqlServerCmdletSnapin100
Add-PSSnapin SqlServerProviderSnapin100
#Added line if using SQL Server 2012 or later
Import-module SQLPS
[System.Reflection.Assembly]::LoadWithPartialName('Microsoft.SqlServer.SMO') | out-null

#Create server object and output filename 
$server = New-Object -TypeName Microsoft.SqlServer.Management.Smo.Server "localhost"
$outputfile=([Environment]::GetFolderPath("MyDocuments"))+"\FileMover.ps1"

#set this for your new location
$newloc="X:\NewDBLocation"

#get your databases
$db_list=$server.Databases

#build initial script components
"Add-PSSnapin SqlServerCmdletSnapin100" &gt; $outputfile
"Add-PSSnapin SqlServerProviderSnapin100" &gt;&gt; $outputfile
"Import-Module SQLPS" &gt;&gt; $outputfile 
"[System.Reflection.Assembly]::LoadWithPartialName('Microsoft.SqlServer.SMO') `"localhost`" | out-null" &gt;&gt; $outputfile
"`$server = New-Object -TypeName Microsoft.SqlServer.Management.Smo.Server " &gt;&gt; $outputfile

foreach($db_build in $db_list)
{
    #only process user databases
    if(!($db_build.IsSystemObject))
    {
        #script out all the file moves
        "#----------------------------------------------------------------------" &gt;&gt; $outputfile
        "`$db=`$server.Databases[`""+$db_build.Name+"`"]" &gt;&gt; $outputfile

        $dbchange = @()
        $robocpy =@()
        foreach ($fg in $db_build.Filegroups)
        {
            foreach($file in $fg.Files)
            {
                $shortfile=$file.Filename.Substring($file.Filename.LastIndexOf('\')+1)
                $oldloc=$file.Filename.Substring(0,$file.Filename.LastIndexOf('\'))
                $dbchange+="`$db.FileGroups[`""+$fg.Name+"`"].Files[`""+$file.Name+"`"].Filename=`"$newloc`\"+$shortfile+"`""
                $robocpy+="ROBOCOPY `"$oldloc`" `"$newloc`" $shortfile /copyall /mov"

            }
        }

        foreach($logfile in $db_build.LogFiles)
        {
            $shortfile=$logfile.Filename.Substring($logfile.Filename.LastIndexOf('\')+1)
            $oldloc=$logfile.Filename.Substring(0,$logfile.Filename.LastIndexOf('\'))
            $dbchange+="`$db.LogFiles[`""+$logfile.Name+"`"].Filename=`"$newloc`\"+$shortfile+"`""
            $robocpy+="ROBOCOPY `"$oldloc`" `"$newloc`" $shortfile /copyall /mov"
        }

        $dbchange+="`$db.Alter()" 
        $dbchange+="Invoke-Sqlcmd -Query `"ALTER DATABASE ["+$db_build.Name+"] SET OFFLINE WITH ROLLBACK IMMEDIATE;`" -Database `"master`"" 

        $dbchange &gt;&gt; $outputfile
        $robocpy &gt;&gt; $outputfile

        "Invoke-Sqlcmd -Query `"ALTER DATABASE ["+$db_build.Name+"] SET ONLINE;`" -Database `"master`""  &gt;&gt; $outputfile
    }
}


The output will be a FileMover.ps1 script in your MyDocuments folder that looks something like this:

    Add-PSSnapin SqlServerCmdletSnapin100
    Add-PSSnapin SqlServerProviderSnapin100
    Import-Module SQLPS
    [System.Reflection.Assembly]::LoadWithPartialName('Microsoft.SqlServer.SMO') "localhost" | out-null
    $server = New-Object -TypeName Microsoft.SqlServer.Management.Smo.Server 
    #----------------------------------------------------------------------
    $db=$server.Databases["AdventureWorks2012"]
    $db.FileGroups["PRIMARY"].Files["AdventureWorks2012_Data"].Filename="X:\NewDBLocation\AdventureWorks2012_Data.mdf"
    $db.LogFiles["AdventureWorks2012_Log"].Filename="X:\NewDBLocation\AdventureWorks2012_log.ldf"
    $db.Alter()
    Invoke-Sqlcmd -Query "ALTER DATABASE [AdventureWorks2012] SET OFFLINE WITH ROLLBACK IMMEDIATE;" -Database "master"
    ROBOCOPY "C:\DBData" "X:\NewDBLocation" AdventureWorks2012_Data.mdf /copyall /mov
    ROBOCOPY "C:\DBFiles\Log" "X:\NewDBLocation" AdventureWorks2012_log.ldf /copyall /mov
    Invoke-Sqlcmd -Query "ALTER DATABASE [AdventureWorks2012] SET ONLINE;" -Database "master"
    #----------------------------------------------------------------------
    $db=$server.Databases["AdventureWorks2012DW"]
    $db.FileGroups["PRIMARY"].Files["AdventureWorksDW2012_Data"].Filename="X:\NewDBLocation\AdventureWorksDW2012_Data.mdf"
    $db.LogFiles["AdventureWorksDW2012_Log"].Filename="X:\NewDBLocation\AdventureWorks2012DW_log.ldf"
    $db.Alter()
    Invoke-Sqlcmd -Query "ALTER DATABASE [AdventureWorks2012DW] SET OFFLINE WITH ROLLBACK IMMEDIATE;" -Database "master"
    ROBOCOPY "C:\DBData" "X:\NewDBLocation" AdventureWorksDW2012_Data.mdf /copyall /mov
    ROBOCOPY "C:\DBData" "X:\NewDBLocation" AdventureWorks2012DW_log.ldf /copyall /mov
    Invoke-Sqlcmd -Query "ALTER DATABASE [AdventureWorks2012DW] SET ONLINE;" -Database "master"

...


Caveats


The script moves all files, no matter their source location, to the
same destination.  You will need to tweak for custom location paths.
The script is designed to run on the server you need to move the
files on (see all usages of localhost').  Replace localhost with your
instance name if you run this remotely. 
The user you run this as
needs access to all folder paths involved in the move, both for
updating the SQL server filename information and for moving the
files.
I use the InvokeSQLCmd for Offline/Online execution because of the funky nature of the .SetOffline() and .SetOnline methods.  I've found this to be more reliable.