How to make MySQL replication reliable?
OBSERVATION #1

You mentioned Ask developers put all the temporary tables into a separated database

If your developers are using CREATE TEMPORARY TABLE commands to create temporary tables, they need to use CREATE TABLE instead. Here is why:

With MySQL Replication processing a temporary table, this is what occurs


1) Master run CREATE TEMPORARY TABLE
2) Command inserted into binary log
3) Replication copies this over to the Slave's Relay Logs via I/O Thread
4) Slave SQL Thread runs CREATE TEMPORARY TABLE
5) Slave  processes data with that temp table


Once in a while, someone may run STOP SLAVE; to run a backup. If STOP SLAVE; is issued just after step 4, the temp created disappears and so does its data. When you run START SLAVE; Replication breaks instantly complaining the table does not exist. This is normal because when a DB Connections terminates deliberately or accidently, all temp tables opened using CREATE TEMPORARY TABLE in the DB session are dropped. Running  STOP SLAVE; kill the SQL thread who was holding opening the temp table.

The only workaround for this is to create the table using CREATE TABLE instead of CREATE TEMPORARY TABLE. When run STOP SLAVE;, the temp table you created normally does not disappear.

I have seen this happen maybe 10 times in my DBA career. Fixing it using the binary logs to find out the name of the temp tables, to create those tables using CREATE TABLE, then starting replication up was the only maintenance possible without just brute force copying the master.

OBSERVATION #2

mk-table-sync only works on tables with primary keys and/or unique keys. It works maybe 99% of the time. I have seen instances where the checksum of a table on the master and slave were different. I would run mk-table-sync, there were still differences (Of course, I was doing mk-table-sync in circular replication with 3 masters, which can be a little dangerous. Using it in Master/Slave is far more stable)

OBSERVATION #3

You mentioned There is some unsafe queries. Does it get some problems with MIXED based replication?

It depends. The most popular unsafe query is any UPDATE or DELETE that uses ORDER BY ... LIMIT. With SBR, this could possibly cause MySQL to UPDATE or DELETE rows from a table on the Slave in a different order tham that of the Master. With RBR, I believe the exact changes in a row are more identifiable to UPDATE or DELETE on the Slave.

SOLUTION : Avoid using unsafe queries. Then, you will not worry !!! 

OBSERVATION #4

I just read your second link. ROFL !!! I am familiar with the poster of the answer.