Extend mysql 5.5 tablespace to another drive on windows
mysql have "working dir" where all the schemas' dirs are stored. You have to: 


stop your mysql 
move the dir with desired schema to the new huge drive 


mv D:\path\to\workingdir\dbschema F:\dbschema


make the link from the new location to the old working dir:


mklink \D F:\dbschema D:\path\to\workingdir\dbschema


start your mysql


Test that approach on some noncritical schema, indeed.