Oracle intermittent performance problem
As you're on 11gR2 and suitably licensed (make sure you check!), I would recommend taking a look at the SQL monitor. This gives a detailed breakdown of all SQL statements that took more ~5s to execute in the past 24 hours.

Using this, you can see the duration of each step in the execution plan, along with I/O and wait details. This will enable you to see why it's taking so long. 

The quick SQL executions won't appear by default, but you can add the /*+ MONITOR */ hint to force them in.

You can get a graphical view of the plan using Enterprise Manager or SQL developer. You can also get a text version using SQL. Have a read of this oracle-base article for more details on using the SQL monitor.

It's possible that the reason for the differences is because the SQL is flipping between two execution plans. You can spot this by looking in the AWR to see this. To do this you'll need to find the sql_id for the statement(s) that are causing you issues. You can do this with:

select sql_id
from   v$sql
where  sql_text like '%your query here%'
and    sql_text not like '%not this%';


To find if there's changes, have a read of Kerry Osborne's unstable plans article and look for the "awr_plan_change" script.

If you are switching between plans, you can force it to keep the good plan using SQL profiles. Again, Kerry Osborne has a detailed article on this.

Note that it's possible that the SQL you're interested in isn't stored in the AWR, as only the worst performing statements are kept. We can force details of it to be kept by "coloring" it however, as discussed by Dion Cho.