Resolving TNS Permision Denied for XE on Windows 7
So I still don't know exactly what caused my issues.  But after spending way to much time trying to research it and tweak things, I got it working again.  The two items that I believe were most critical to the process were:

Updating/syncing my .ora files.  In particular I had some with references to localhost that had to be changed to my full machine name.

Granting my individual user full control on my oracle directory.  I found a reference elsewhere that noted that the permissions inherited from a group were not being honored correctly.