TSQL Remove Characters from Text Value
I think you'd better create a filter table in which you put your replacement string pairs and then you can create a function to remove source string with your filter table.

Here is the example

use tempdb
-- filter table
create table dbo.Filter (id int identity, src varchar(100), tgt varchar(100));
-- populate a few filtering pairs
insert into dbo.Filter (src, tgt) 
values ('.xlsx', '')
     , ('csv', '')
     , ('__', '_')
     , ('-Jun-', '');


-- your source table
create table #s (mycol varchar(1000))
-- populate source column
insert into #s (mycol) 
values ('this .xlsx file is not __ created in -Jun- but in June')
     , ('this csv file should be removed  -Jun-')
go

-- filtering function
create function dbo.funcReplace (@s varchar(1000))
returns varchar(1000)
as
begin
    declare @src varchar(100), @tgt varchar(100);
    declare @curS cursor;
    set @curS = cursor for select src, tgt from dbo.Filter
    open @curS
    fetch next from @curS into @src, @tgt; 
    while @@fetch_status = 0
    begin
        set @s=replace(@s, @src, @tgt);
            fetch next from @curS into @src, @tgt; 
    end
    return @s;
end
go

-- before replacement
select bfr_replacement = mycol from #s

-- after replacement
select  after_replacment=dbo.funcReplace(mycol)
from #s 




In future, if you have more replacement needed, just add them to the table dbo.Filter and you do not need to change anything elsewhere.