Which of MultiStatements is "out of sync"
Usually that refers to Stored routines with PREPARE + EXECUTE + DEALLOCATE_PREPARE.  Have you done all three of those, in that order?  Optionally, EXECUTE can be repeated.

If you are referring to stringing together statements with ;, don't do that; it is a security hole waiting for some hacker to jump into.

What client language are you using?

If you need more help, let's see your code.