Sql Max value from multiple columns in Computed Column
First thing... I'm not advocating THAT you do this... I'm simply showing you HOW to do this. If your table experiences high volume inserts and/or updates, you could see a noticeable performance hit. Using scalar UDFs in computed columns will force all queries against the table to run serially.

Start by creating a scalar function similar to the following...

CREATE FUNCTION dbo.GreatestOfThreeInts
/* ================================================================================================
Scalar function created for the sole purpose of calculating the MaxVal computed column on dbo.Test.
================================================================================================ */
(
    @C1 INT,
    @C2 INT,
    @C3 INT
)
RETURNS INT WITH SCHEMABINDING --, RETURNS NULL ON NULL INPUT --&lt;&lt; use this if NULLs are a possibility..
AS 
BEGIN 
    DECLARE @MaxVal INT = ( SELECT MAX(x.Val) FROM ( VALUES (@C1), (@C2), (@C3) ) x (Val) );
    RETURN ISNULL(@MaxVal, 0);
END;
GO


Either create your table with a PERSISTED computed column or, if the table already exists, use the ALTER / ADD syntax to add the PERSISTED computed column...

CREATE TABLE dbo.Test (
    C1 INT NOT NULL,
    C2 INT NOT NULL,
    c3 INT NOT NULL,
    MaxVal AS dbo.GreatestOfThreeInts(C1, C2, C3) PERSISTED NOT NULL    -- persist the value so that it doesn't need to be constantly recomputed
    );
GO

CREATE NONCLUSTERED INDEX ix_Test_MaxVal ON dbo.Test (MaxVal) INCLUDE (C1, C2, c3);
GO 


Why do I keep saying PERSISTED?... Buy once, cry once... Unless you have a very write heavy usage pattern, you'll be better off computing the values on inserts &amp; updates, than every time you reference the column in a select... Especially if that column is going to be used in a predicate or sorting operation.

Sooo... Let's see it in action...

INSERT dbo.Test (C1, C2, c3) VALUES
    (123,456,789),
    (345,478,123),
    (523,321,852),
    (111,471,951),
    (874,320,357),
    (965,102,478);
GO 

SELECT * FROM dbo.Test t ORDER BY t.MaxVal OPTION(QUERYTRACEON 176);
GO 

SELECT * FROM dbo.Test t WHERE t.MaxVal &gt;= 800 AND t.MaxVal &lt; 900 OPTION(QUERYTRACEON 176);
GO 


Results...

C1          C2          c3          MaxVal
----------- ----------- ----------- -----------
345         478         123         478
123         456         789         789
523         321         852         852
874         320         357         874
111         471         951         951
965         102         478         965


C1          C2          c3          MaxVal
----------- ----------- ----------- -----------
523         321         852         852
874         320         357         874


Hope this helps,
Jason



Edit #1: A BIG THANK YOU to Erik for adding the link, pointing out the fact that using a scalar UDF to compute a column will prevent the optimizer from considering a parallel execution plan... Even when the computed column is persisted. A fact that I actually knew but completely omitted from my initial answer. What I didn't know is the OPTION(QUERYTRACEON 176) thing... Picking up that little nugget, more than covered the cost of admission for me!

Edit #2: Without inviting the religious debate of "NULL vs NOT NULL" column constraints, I'll simply state that my personal "default" is make all columns NOT NULL unless there is a compelling reason to do otherwise... That said, @MartinSmith makes some good points... Including the fact that the OP, by not specifying NULLability, made all columns NULLable. Plus, after the back &amp; forth, I was just curious to see if the RETURN ISNULL(@MaxVal, 0); was doing anything other than irritating people reading the T_SQL...
Short answer... It does not.

The following includes the introduction of a "control" table (no computed column) and NULLable versions of dbo.GreatestOfThreeInts &amp; dbo.Test (dbo.GreatestOfThreeInts_2 &amp; dbo.Test_2)

CREATE FUNCTION dbo.GreatestOfThreeInts_2
/* ==================================================================================================
Scalar function created for the sole purpose of calculating the MaxVal computed column on dbo.Test_2.
================================================================================================== */
(
    @C1 INT,
    @C2 INT,
    @C3 INT
)
RETURNS INT WITH SCHEMABINDING
AS 
BEGIN 
    DECLARE @MaxVal INT = ( SELECT MAX(x.Val) FROM ( VALUES (@C1), (@C2), (@C3) ) x (Val) );
    RETURN @MaxVal;
END;
GO




CREATE TABLE dbo.Test_2 (
    C1 INT NULL,
    C2 INT NULL,
    c3 INT NULL,
    MaxVal AS dbo.GreatestOfThreeInts_2(C1, C2, C3) PERSISTED   -- persist the value so that it doesn't need to be constantly recomputed
    );
GO

CREATE NONCLUSTERED INDEX ix_Test2_MaxVal ON dbo.Test_2 (MaxVal) INCLUDE (C1, C2, c3);
GO 




CREATE TABLE dbo.Control (
    C1 int NOT NULL,
    C2 int NOT NULL,
    c3 int NOT NULL,
    MaxVal INT NOT NULL
    );
GO

CREATE NONCLUSTERED INDEX ix_Control_MaxVal ON dbo.Control (MaxVal) INCLUDE (C1, C2, c3);
GO




And because the 6 rows in my original answer isn't much of a test, the following will load all 3 tables with 1 million rows of test data...

-- clear out any existing data...
TRUNCATE TABLE dbo.Test;
GO 
TRUNCATE TABLE dbo.Test_2;
GO 
TRUNCATE TABLE dbo.Control;
GO 

-- add 1M rows of test data...
WITH 
    cte_n1 (n) AS (SELECT 1 FROM (VALUES (1),(1),(1),(1),(1),(1),(1),(1),(1),(1)) n (n)), 
    cte_n2 (n) AS (SELECT 1 FROM cte_n1 a CROSS JOIN cte_n1 b),
    cte_n3 (n) AS (SELECT 1 FROM cte_n2 a CROSS JOIN cte_n2 b),
    cte_Tally (c1, c2, c3) AS (
        SELECT TOP (1000000)
            ABS(CHECKSUM(NEWID())) % 9000 + 1000,   -- randomly generate INTs between 1000 and 9999
            ABS(CHECKSUM(NEWID())) % 9000 + 1000,   -- no, I don't have an actual reason for using that specific range...
            ABS(CHECKSUM(NEWID())) % 9000 + 1000    -- 
        FROM
            cte_n3 a CROSS JOIN cte_n3 b
        )
INSERT dbo.Test (C1, C2, c3)
SELECT 
    t.c1, 
    t.c2, 
    t.c3
FROM
    cte_Tally t;
GO

-- use dbo.Test to insert dbo.Test_2 &amp; dbo.Control so all 3 tables will have the exact same data values...
-- (to compare actual insert performance, use the cte_Tally to load all tables)

INSERT dbo.Test_2 (C1, C2, c3)
SELECT 
    t.C1, t.C2, t.c3
FROM
    dbo.Test t;
GO

INSERT dbo.Control (C1, C2, c3, MaxVal)
SELECT 
    t.C1, t.C2, t.c3, t.MaxVal
FROM
    dbo.Test t;
GO