Every "INSERT" query check a combination of column's records
It sounds like what you are looking for is a "unique" constraint:

ALTER TABLE Table1 ADD UNIQUE(Series, Orders)


That will cause an error to be raised when you try create a row (by inserting new or updating an existing one) that duplicates an existing combination of Series and Order.

Depending on the rest of the database design, these columns might be a good candidate for a compound primary key which would also enforce uniqueness.

This is fundamentally basic database stuff, I would suggest you grab an introductory book or find a good tutorial online. Keywords that you should understand: primary key, foreign key, check constraint, unique constraint, surrogate key