High RAM memory usage
In general, you want to utilize as much RAM as possible (leaving enough for the O/S, etc), since that means data is in-memory instead of being on disk.  

For a CRM system serving 100 people, you may find 16GB of RAM dedicated to the server is not enough.  My phone has 8GB of RAM, for instance, and it's just a phone.  

In-memory access times for data is a couple of orders of magnitude faster than accessing data on disk.