Execute query cache on startup - Reasonable?
please refer to this link? this should answer your question 

Yes, 100% reasonable to make use of the MySQL caching system! 

How to &quot;warm up&quot; a cold DB server? 


  Warm-up is needed because the best performance of a database is
  achieved when its various caches are populated with the most relevant
  data, since reading from memory is generally substantially faster than
  reading from disk.
  
  InnoDB has the InnoDB buffer pool. MyISAM has the key cache and the OS
  cache. Then there's also the MySQL query cache. MySQL has the open
  table cache. Some or all of these structures contribute to the ideal
  performance of a server. When a server is handling traffic that is
  characteristic of its workload, it tends to have the most frequently
  used -- and therefore presumably the most relevant data -- already
  cached.
  
  Take the load off of an active MySQL server and you will not see it
  start closing tables and evicting data from its caches. If you leave
  it running, then come back to it tomorrow, you should find that it's
  still as warm as you left it.