Native Sybase ODBC driver
You don't actually have to specify the ODBC driver as long as the driver is in the library path.  

[MyIQboxOfDoom] 
CommLinks=tcpip(ip=myiqboxofdoom;port=5000;DOBROADCAST=NONE;VERIFY=NO)
AutoStop=no


and connect using

dbisql -c "dsn=MyIQboxOfDoom;uid=myuser;pwd=mypass" -nogui