How to update multiple columns of multiple rows in one SQL statement
You could supply the new values as a table (with the help of the VALUES row constructor), so that you could join it with the target table and use the join in the UPDATE statement, like this:

UPDATE
  tgt
SET
  Column1 = src.Column1,
  Column2 = src.Column2,
  Column3 = src.Column3,
  ...
FROM
  dbo.TargetTable AS tgt
  INNER JOIN
  (
    VALUES
    (1, 'a', 'k', 'x', ...),
    (2, 'b', 'l', 'y', ...),
    (3, 'c', 'm', 'z', ...)
  ) AS src (ID, Column1, Column2, Column3, ...)
    ON tgt.ID = src.ID
;