innodb high i/o , some parameters make mysql crash
Check the logs.  There should be some clue of what caused the crash.  I don't think the settings that you highlighted would cause a crash, but let's change them some:

innodb_buffer_pool_size = 40G        -- good
innodb_buffer_pool_instances = 16    -- 16 is "good enough"; more is "diminishing returns"
innodb_buffer_pool_chunk_size = 128M -- only needed for dynamically changing bp
max_connection = 1000


('instances' has only a small impact on performance.)  If my advice is not good, read the Windows-specific recommendations in https://dev.mysql.com/doc/refman/5.7/en/innodb-parameters.html#sysvar_innodb_buffer_pool_instances

If you have HDD (not SSD), then lower some settings:

innodb_io_capacity = 400
innodb_read_io_threads = 16
innodb_thread_concurrency = 0
innodb_write_io_threads = 16


If you are concerned about performance, turn on the slowlog with long_query_time=1 so you can catch the naughtier queries.

innodb_dedicated_server does not exist until 8.0.3.