Does TokuDB need any regular cleanup/maintenance?
Percona has a github page on the following


OPTIMIZE TABLE (which references another Percona Blog)
ANALYZE TABLE


There is lots of info explaining why.

For example, there are messages stored in non-leaf nodes of Fractal Trees. All those messages are pushed way down to leaf nodes. This simplifies retrieval of stats needed by the Query Optimizer.

Please read those links and learn way more.