Search and Replace in multiple MySQL databases
Not really.

Instead, you could do something like

SELECT CONCAT("UPDATE ", table_schema, ".", table_name, 
                " SET foo = replace(foo, 'this', 'that');")
    FROM information_schema.tables
    WHERE ...


to generate the desired 50+ UPDATE statements.  Then copy and paste them into the mysql commandline tool.

(Or you could construct a shell script using that.  Or...)