Sybase ASE monitoring tool of choice
Working with SybaseASE since last 7 years, I can tell that the newer versions of sybaseASE relies on MDA tables (just like SQLServer DMVs). The tools out there for SybaseASE monitoring are pretty expensive.

I my company, I have build reporting on the top of MDA tables. The prettiness of the graphs you have linked comes at cost. 

As a cheap alternative (It is a modest 6.99 U$K per core ) would be to use ASEProfiler or DBACockpit (sybase 16 and up).

As for the configuration settings, each environment is different, so the configuration settings will be different. Start with the common ones and monitor them sp_monitorconfig 'all', null, 'full' .. esp the reuse count should never be more than 0.


Data cache
procedure cache
max memory
partition the data cache 
have multiple data cache e.g. 2K, 8K or 16K.
Online engines (sybase 15.7 and up)
max lava operators


All above settings can be tuned using sp_sysmon.