Optimal table design for a medical center rental service and recurrent shifts
You could have a bookings table like this:


bookings
--------
  id (PK)
  user_id (FK to table with all medical professionals)
  room_id (FK to table with all rooms)
  start_date - datetime value
  end_date - datetime value


This structure will let you track which professional is using which room, and when:


bookings
--------
id  | user_id  | room_id  | start_date    | end_date
---------------------------------------------------------
1   | 001      | 123      | 20140101T1030 | 20140101T1045
2   | 001      | 123      | 20140101T1100 | 20140101T1115
3   | 002      | 120      | 20140101T1000 | 20140101T1100


To track historic data, you'll probably want to use "soft" deletes on rooms and professionals so that even if you decide to delete Dr. Phillips from the list of current renters, you can still look up when he used which rooms. Your application will have to be smart enough to not create new bookings with professionals/rooms that are marked as "deleted".


professionals
-------------
  id
  name
  deleted
  (other fields...)

rooms
-----
  id
  deleted
  (other fields)



Example:


professionals
-------------
id  | name       | deleted
----+------------+--------
1   | Dr. Philips| N
2   | Dr. Nick R.| Y

rooms
-----
id  | deleted
----+--------
123 | N
120 | N
837 | Y


To handle recurring appointments, you could start with something like this:


recurring_bookings
------------------
  id (PK)
  user_id (FK to med. professionals)
  room_id (FK to rooms)
  day_of_week (could be FK to table/enum of days of week)
  start_time
  end_time (or you could have a "duration", in minutes, if you prefer)
  start_of_recurrence
  end_of_recurrence

recurring_bookings
------------------
id   | user_id    | room_id   | day_of_week | start_time | end_time | start_of_recurrence | end_of_recurrence
-----+------------+-----------+-------------+------------+----------+---------------------+------------------
1    | 001        | 120       | MONDAY      | 1030       | 1100     | 2014-01-01          | 2014-12-31
2    | 001        | 120       | WEDNESDAY   | 1030       | 1100     | 2014-01-01          | 2014-12-31



The above example shows a user with a recurring booking every monday and wednesday in room 120, running from 10:30 to 11:00 AM. It also shows that the period over which both recurrences are defined runs from 2014-01-01 to 2014-12-31

The tricky part is handling exceptions. For example, suppose a user wants to eliminate only one instance of a recurring booking, because they'll be on vacation that week. One strategy might to think of the recurring bookings table as a rule-set which can be used to populate real bookings into the main bookings table. So that way, you use recurring_bookings to populate all appointments for a user in bookings, and then rmeove or modify them from bookings as needed. This requires you to pre-populate a lot of data into your main bookings table (based on start_of_recurrence and end_of_recurrence), which you may or may not want to do, for recurring appointments. To handle open-ended recurring appointments, it might require a bit more work. Also, the above example assumes all recurring bookings are weekly. Some of them may be daily or yearly or monthly, and may have conditions such as "first Wednesday of every month". 

I will admit that I haven't tried to build a system with recurring bookings like this, so this design should be considered a suggestion for a starting point. It will probably need some work. To get an idea of one way this is done, try creating and then manipulating recurring appointments in Outlook (if you have access to it).