Ways to speed up IN queries under PostgreSQL
IN() using many parameters will result in many cases in a sequential table scan. That might be slow, depending on table size and speed of your system.

Create a temporary table with all your variables and join on this table:

CREATE TEMP TABLE t AS 
  SELECT * FROM (VALUES(1),(2),(3)) x(twitter_user_id);

SELECT 
  twitter_personas.* 
FROM twitter_personas 
  JOIN t USING(twitter_user_id);


Use EXPLAIN to see the difference between the queryplans.