How should i index this?
You don't need single column indexes on fields that are also the first column in multi column indexes.

However you shouldn't specify the column order just based on that. For best performance, you want the column that has the highest cardinality (ie "uniqueness") first in the column order.

I think that you should just get rid of the CREATED_AT single column index and keep the other single column ones.

The 3 double column indexes should all  have the CREATED_AT field first ordered DESC for maximum efficiency.