Should I believe Query Store runtime stats?
Pathology!

This could happen to queries in ways that wouldn't impact the plans:


Heaps: Forwarded Fetches
Indexes: Internal fragmentation


Additionally some selects that cause writes may trigger additional reads if there are stats updates, spills, spools, etc. Though none of those show in your plan, someone else may some along later and find this tidbit useful.

Heaps

DROP TABLE IF EXISTS dbo.el_heapo;
CREATE TABLE dbo.el_heapo ( col1 BIGINT, col2 VARCHAR(8000) DEFAULT 'A' );

INSERT dbo.el_heapo ( col1 )
SELECT TOP 1000000
       x.rn
FROM   (   SELECT     ROW_NUMBER() OVER ( ORDER BY ( SELECT 1 / 0 )) AS rn
           FROM       sys.messages AS m
           CROSS JOIN sys.messages AS m2 ) AS x;


Run a simple query:

SELECT COUNT_BIG(*)
FROM   dbo.el_heapo;

Table 'el_heapo'. Scan count 1, logical reads 2718 
CPU time = 62 ms,  elapsed time = 62 ms.


Look at the table: No forwarded fetches.

SELECT OBJECT_NAME(ddips.object_id) AS TableName, 
       ddips.index_type_desc, 
       ddips.forwarded_record_count
FROM   sys.dm_db_index_physical_stats(DB_ID(), 
                                      OBJECT_ID('dbo.el_heapo'), 
                                      0, 
                                      NULL, 
                                      'DETAILED') AS ddips;


Cause some forwarded fetches:

UPDATE dbo.el_heapo
SET    col2 = REPLICATE('Z', 1000)
WHERE  col1 % 3 = 0;


If you run the count and forwarded fetch query again, you should see:

~330k forwarded fetches

Table 'el_heapo'. Scan count 1, logical reads 380564
 SQL Server Execution Times:
   CPU time = 359 ms,  elapsed time = 360 ms.


But the execution plan will be the same.

Indexes

Create a dummy table do I don't mess up my real Users table:

SELECT *
INTO dbo.TempUsers
FROM StackOverflow2013.dbo.Users AS u;

CREATE UNIQUE CLUSTERED INDEX c ON dbo.TempUsers(Id);


Check on the table size:

SELECT   TOP 2147483647 
         s.name AS schema_name,
         OBJECT_NAME(ps.object_id) AS table_name,         
         i.name AS index_name,
         ps.row_count,
         ps.in_row_used_page_count,
         (ps.reserved_page_count * 8. / 1024.) AS reserved_MB,
         (ps.lob_reserved_page_count * 8. / 1024.) AS reserved_LOB_MB,
         (ps.row_overflow_reserved_page_count * 8. / 1024.) AS reserved_row_overflow_MB
FROM     sys.dm_db_partition_stats AS ps
JOIN     sys.objects AS so
    ON  ps.object_id = so.object_id
    AND so.is_ms_shipped = 0
    AND so.type &lt;&gt; 'TF'
JOIN     sys.schemas AS s
    ON s.schema_id = so.schema_id
JOIN sys.indexes AS i
    ON ps.object_id = i.object_id
    AND ps.index_id = i.index_id
ORDER BY ps.object_id, ps.index_id, ps.partition_number


Should be 44,450 pages and 348MB.

Simple query:

SELECT COUNT(*)
FROM dbo.TempUsers AS tu

Table 'TempUsers'. Scan count 1, logical reads 44439
   CPU time = 219 ms,  elapsed time = 229 ms.


Update the DisplayName column to be the max length (nvarchar 40):

UPDATE t
SET t.DisplayName = t.DisplayName + REPLICATE('A', 40 - (DATALENGTH(t.DisplayName) / 2))
FROM dbo.TempUsers AS t


Now the table is much larger:

88,392 pages, 691MB.

Query results:

Table 'TempUsers'. Scan count 1, logical reads 88381
   CPU time = 250 ms,  elapsed time = 245 ms.