What are the limits of computation in this universe?
Seth Lloyd has a paper on the subject. You need energy to compute, but if you put too much energy into a small region, it forms a black hole. This slows down time (making the time it takes for the computation to complete relatively longer), and any computation done in the interior of a black hole is wasted, as the results cannot be extracted from the black hole and used. Seth calculates the limits on the amount of computation possible, and shows that for some measures of computation, the most computationally intensive environment possible in the universe would be that surrounding a black hole.