Maximal classes for which largest independent set can be found in polynomial time?
An interesting paper to look at might be:

A. Brandstadt, V. V. Lozin, R. Mosca: Independent Sets of Maximum Weight in Apple-Free Graphs, SIAM Journal on Discrete Mathematics 24 (1) (2010) 239–254. doi:10.1137/090750822

The infinite class of apples is defined as cycles C_k, k>=5, each with a stalk.

You don't mention whether your notion of IS-easiness includes the weighted IS problem. Chair-free graphs (aka fork-free graphs) are known to be IS-easy:

V. E. Alekseev, Polynomial algorithm for finding the largest independent sets in graphs without forks, Discrete Applied Mathematics 135 (1-3) (2004) 3–16. doi:10.1016/S0166-218X(02)00290-1 

The tractability of the weighted case is a non-trivial extension, see:

V. V. Lozin, M. Milanic: A polynomial algorithm to find an independent set of maximum weight in a fork-free graph, Journal of Discrete Algorithms 6 (4) (2008) 595–604. doi:10.1016/j.jda.2008.04.001

Are there any other (interesting) classes where the weighted IS problem is significantly more difficult/intractable/open than the unweighted case?