Is longest common subsequence with bounded occurrences NP-complete?
This paper by Blin et al. (Hardness of Longest Common Subsequence for Sequences with Bounded Run-Lengths, CPM'12) provides a reduction from independent set to LCS where the Hamming weights of all strings are the same (it is $n-1$ where $n$ is the number of vertices in the independent set instance). Thus, the problem remains NP-complete under this assumption.