Is prime-counting function #P-complete?
Some heuristic evidence: to the best of our knowledge  $\pi(n)$ looks like a simple function corrected by random fluctuations.  Thus I’d expect a poly-time machine with a $\pi(n)$ oracle to be no stronger than such a machine with a random oracle, and w.r.t. a random oracle $X$ adding a separate random oracle $Y$ to $\mathsf{P}$ gives $\#\mathsf{P}^X \not\subset \mathsf{P}^{XY}$ with probability 1 (here $Y$ corresponds to $\pi(n)$ and $X$ is an independent random oracle).