Hardness jumps in computational complexity?
One of the more interesting applied examples of hardness jumps can be observed in the following problem:

Consider a soccer league championship with $n$ teams: The problem of deciding whether a given team can (still) win the league is in $P$ if in a match, the winning team is awarded 2 points, the losing one 0 and each team is awarded 1 point in a draw match. But if we change the rules so that the winning team gets 3 points, the same problem becomes $NP$-hard. 

The result can be generalized for any $(0, 1, k)$-point rule for every $k > 2$ and even for only three remaining rounds.

Source: “Complexity Theory” by Ingo Wegener (http://portal.acm.org/citation.cfm?id=1076319)