Does the $\mathsf{TC^0}$ hierarchy collapse?
We know of no good lower bounds (meaning, say, a superpolynomial lower bound for a language in $\mathsf{NEXP}$) for depth 2 threshold circuits (unbounded weights). Depth 3 circuits built from majority gates, i.e. $\mathsf{TC}^0_3$ contains this class, and thus we know no good lower bounds for this class either.