Computation of max H-free sets
Suppose $H$ has at least two vertices. The family of all $H$-free graphs is hereditary on induced subgraphs and the property of being $H$-free is non-trivial, where a property is non-trivial if it is true for infinitely many graphs and it is false for infinitely many graphs. Thus, the result of Lewis and Yannakakis [1] applies, showing that for all $H$ with at least two vertices, the problem is NP-complete.

[1] John M. Lewis, Mihalis Yannakakis: The Node-Deletion Problem for Hereditary Properties is NP-Complete. J. Comput. Syst. Sci. 20(2): 219-230 (1980)