Does there exist an oracle $A$ such that $(P^{\#P})^{A} \neq PSPACE^{A}$?
On popular request, here is my comment as an answer:

There is an oracle separating $\mathrm{PP}$ from $\mathrm{PSPACE}$: Jacobo Toran, A combinatorial technique for separating counting complexity classes, ICALP 1989. The best result for $\mathrm{P}^\mathrm{PP}$ that I know is a conditional result by Heribert Vollmer: Relating polynomial time to constant depth. TCS, 207: 159-170, 1998.