Shortest directed path connecting given subset of vertices
This problem is NP-complete, by reduction from Hamiltonian path. Given an instance $G=(V,E)$ of Hamiltonian path, add a new vertex $s$ connected to all original vertices; this edges are directed from $s$, and all the original graph edges are bidirectional. Give all edges unit weight. There is a path from $s$ visiting all of $V$ of weight $|V|$ if and only if $G$ has a Hamiltonian path.