Using base 80 for compressing files
While you will need fewer 80-based numbers than 2-based numbers (bits) to encode the same file, the only way to store these 80-based numbers on a computer is to encode them as bits. So you do not gain anything.

In fact you actually lose space, since 80 is not a power of 2: You will need 7 bits for each 80-based number, but in these 7 bits you could instead encoed 128 different states, if you used them directly.