Minimal Number of Fixed Size Sets to contain all Sets
If the sets are chosen randomly, then for the parameters you chose, the problem can be solved efficiently.  In particular, the following trivial algorithm will output the correct answer with high probability: take each set of $S$, pad it by adding 10 random elements, and output the result (all sets of $S$, padded).

This might sound wasteful, but for the parameters you mentioned, if the sets are chosen randomly, it's unlikely you can do better.  You can only do better if there exist two sets $s,t \in S$ that can be covered by a 25-element set, i.e., such that $|s \cup t| \le 25$.  This happens only if $s,t$ have at least 5 elements in common (i.e., $|s \cap t| \ge 5$).

Now when $s,t$ are chosen uniformly at random from all possible sets of size 15, the probability that they have two elements at random is very small.  It is approximately ${15 \choose 5}^2/1000^5 \approx 9 \times 10^{-9}$.  Also, there are ${1000 \choose 2}^2$ possible pairs $s,t$, so by a union bound, the probability that there exist two such sets $s,t$ is about $0.0045$.  This means there is only a small probability that you can cover two sets from $S$ by a single set of size 25, if the sets of $S$ are chosen randomly.

In general, for your problem, one approach would be to find all pairs of sets $s,t \in S$ that overlap in at least 5 elements.  Build a graph where $S$ is the vertex set and you add an edge between $s,t$ if $|s \cap t| \ge 5$.  Find a maximum matching in this graph.  Then you can use this to build a set of 25-size sets (one 25-size set per edge in the matching, plus one set per vertex not touched by the matching).  However, if the sets are generated randomly, this is unnecessary as it is unlikely  to find any pair of sets that overlap in at least 5 elements.

Anyway, if the sets are chosen uniformly at random, the problem is uninteresting for the parameters you gave.  If the sets aren't chosen uniformly at random and have some structure, I recommend that you edit the question to describe this structure.