Decidability of factoring algebraic equations
Interesting question. Factorization of functions, including factorization of polynomials is in fact a classical problem throughout history of mathematics.  

For the sake of contradiction, assume that $$x^2 + y^3 - e^{z} = f(x)*g(y)*h(y,z)$$

For the sake of simplicity, assume that $f, g, h$ are continuously differentiable inside $D$, the place where we are interested.

Now treating $y$ and $z$ as constant, take partial derivative with respect to $x$. (Aha, you might say, why didn't I think of that?!)

$$2x = f'(x)*g(y)*h(y,z)$$

Since $2x$ is not constant, $f'(x)$ cannot be constant 0. Shrinking $D$ if necessary to make sure $f'(x)$ is never 0, we have $$2x/f'(x) = g(y)*h(y,z)$$
That means, both $2x/f'(x)$ and $g(y)*h(y,z)$ are constant functions since the former is constant w.r.t. to $y$ and $z$ and the latter is constant w.r.t. to $x$. So we will have
$$ -e^z=\frac{\partial(x^2+y^3-e^z)}{\partial z} = \frac{\partial(f(x)*g(y)*h(y,z)}{\partial z}=\frac{\partial(f(x)*\text{(some constant)})}{\partial z}=0$$
which cannot be true.

The above reasoning should give you a pretty good idea that particular factorization cannot hold nicely because of too many independences between the variables in the factorization. In fact, we can show that no such $f,g,h$ exist without assuming continuity of any of $f, g, h$, as long as it is required that equality holds for a small 3D space. Note that 2D space will not be enough since we can have, letting $x=0$, $$0 + y^3-e^z=1*1*(y^3-e^z)$$

It will require some work to formulate the more general questions of decidability of function factorizations clearly enough so that it might be able to have a clear answer. It looks like if many dependencies are required, then the set of problems is probably decidable. If you are interested enough, you could try formulating those problems and raising new questions.

For related result on polynomials, we can search for "decidability of polynomial factorization".