CIRCUITSAT ∈ DTIME(2^n/n^c) ⟹ NP ≠ EXP?
$\mathsf{CircuitSat\in DTIME(2^n)}$ does not imply $\mathsf{NP\subseteq DTIME(2^n)}$ since the reduction might increase the input's size. Suppose for example that $L\in NP$ and the reduction from $L$ to $\mathsf{CircuitSat}$ maps strings of length $n$ to strings of length $n^c$ (for all $n\in\mathbb{N}$), then applying the reduction and using a naive exponential time algorithm for circuit sat yields a $2^{n^c}$ time algorithm for $L$.

If however you can place an NP-complete problem in a subexponential time class, e.g. $n^{\log n}$, then $NP\neq EXP$, since $n^{O(\log n)}$ is closed under polynomial transformations, i.e. $n\mapsto n^c$.