what can attackers do between two end hosts
Attacks like this can be prevented by TLS.
Quote from Wikipedia:

The TLS protocol aims primarily to provide privacy and data integrity between two or more communicating computer applications.2:3 When secured by TLS, connections between a client (e.g., a web browser) and a server (e.g., wikipedia.org) have one or more of the following properties:

The connection is private (or secure) because symmetric cryptography is used to encrypt the data transmitted. The keys for this symmetric encryption are generated uniquely for each connection and are based on a shared secret negotiated at the start of the session (see TLS handshake). The server and client negotiate the details of which encryption algorithm and cryptographic keys to use before the first byte of data is transmitted (see § Algorithm below). The negotiation of a shared secret is both secure (the negotiated secret is unavailable to eavesdroppers and cannot be obtained, even by an attacker who places themselves in the middle of the connection) and reliable (no attacker can modify the communications during the negotiation without being detected).

The identity of the communicating parties can be authenticated using public-key cryptography. This authentication can be made optional, but is generally required for at least one of the parties (typically the server).

The connection is reliable because each message transmitted includes a message integrity check using a message authentication code to prevent undetected loss or alteration of the data during transmission.