Is it safe to encrypt data by simply randomizing chunks based on a permutation?
This is called a transposition cipher. It is the kind of thing that was commonplace before the invention of the computer, and some people were really good at breaking that in mere minutes (e.g. Edgar Allan Poe). In all generality, breakage is done by backtracking (wrong hypotheses on permutation elements leading to "impossible digraphs" that cannot occur in normal text).