Is entropy being lost when the hash of a secret has a specific format?
From the linked page, a minikey is a 30-character string over the base58 alphabet with the first byte fixed to 'S', so effectively 29 characters. This gives a space of $log_2(58^{29}) \approx 169.88$ bits. Assuming that SHA is a random function, the probability of the hash starting with an 0-byte after appending a ? is 1/256, so this check loses 8 bits of entropy giving just over 161 bits of security.