Can Cyborg/ Trans-human reach enlightenment? When enlightenment is depended on a Human Body
This question is actually unanswerable. However a human being is vastly more complicated than a mere cyborg. The ability to achieve enlightenment. Whereas a cyborg would be created artificially, and is merely a mind and a body to accomplish some tasks. Therefore it doesn't seem plausible that a cyborg achieves enlightenment/Nirvana.

Edit:
Understood the clarification. The changes you mention, like enhanced body parts or something, may enhance man's capacity in the outside world but the alterations to the body structure/parts will have lots of unintended consequences. We don't clearly understand the ramifications and chemical
imbalances in the system. In the same way that we are able to interact seamlessly with mobile phones in our age of technology, man's capability will increase but seemingly at a cost of his/her own natural technology called the mind and body. It is still an artificial way rather than a natural style. 

Let's take a simple example. Are you able to meditate well with all the interactions you are having with your computer and mobile phone and Facebook/Twitter etc.,? If you are able to think about this you will understand how spiritual goal is unrelated and artificially enhancing life spans or body parts will be detrimental to a person's spiritual growth. Understand that man's body is already a well engineered machine. Just because we are insensitive to that and don't treat it well, doesn't mean our body is not an awesome machine. Our bodies are a vehicle too. We must oil it well and consume well in order to keep it running. But it has its life span and capabilities and we must respect that.