Are there anything to care about in this universe?
I think Buddhism recommends you focus on what's virtuous and moral instead of on what's feels pleasurable.

For example, lying, killing, stealing -- are all to be avoided -- and that's important.

Conversely, generosity, kindness, keeping your promises -- that's important too.

There is a word -- sukha -- which might be translated "happiness". It's used in contexts like the Sukhavagga.

I suspect it's a happiness conditioned or caused by an absence not by a presence -- for example not happiness because you have something ("a chocolate bar") but happiness because of not having something ("anger", "greed", "remorse").