Is there a conflict between dependent origination and right effort?
Where we don't have a choice:


stop, maintain or prolong, create phenomena and influence, control arising and passing of phenomena. Even at a grosser level the influence is limited. 


Where we have a choice:


not being reactive to sense stimulus but proactive to it
influence and regulate your mind towards skillful states and away from unwholesome states


Exercising the latter help you to fabricate better existence or stop fabrications altogether. 

There are two places to work on breaking the cycle of Dependent Origination (DO). 


To keep your mind free from delusion focus on arising and passing of phenomena. 
Keep your mind equanimous and devoid of craving and clinging thus not reacting to sense stimulus with unwholesome mental states


Like any other processes DO needs it's fuel to continue. The fuel is an untamed mind influenced by craving. So you can extinguish this process by not feeding it with it's fuel, i.e. be equanimous without clinging and craving towards sensations and being mindful of arising and passing of phenomena of the aggregates. The existing fuel will burn out and DO will collapse. You can catalyse this process by actively calming the fabrications, i. e. do some fire fighting.