Buddhist perspective on uncertainty
Your health, wealth, reputation, career, family are all impermanent. Your life is also impermanent. Nothing lasts forever and everything changes over time. Nothing bad like disease and death can be avoided forever. Nothing good like your loved ones can be preserved forever. This is anicca.

This causes uncertainty for individuals when they think about their future. Uncertainty is one way to summarize the effect of impermanence. Uncertainty is maybe a more directly meaningful term to people than impermanence.

Anicca is also discussed in the context of the five aggregates being impermanent and in fact, all conditioned things being impermanent and changing.

The Buddha saw only a limited future based on cause and effect. Just as if you see the cloudy sky and forecast rain. The Buddha's prediction of the future is not because all events in the future are fixed and predetermined.

In Buddhism, the only thing that's permanent and fixed is Nibbana.