Quick release lever for wheel is stuck
Best bet with quick releases when they are hard to remove because of the frame in the way is to get a rag, place it against the frame and then use a long-handled screwdriver to pry it up. That works all the time in the bike-shop I work at. Good luck! 

EDIT

I should actually say, if you have carbon fiber release levers, be VERY careful not to crack/crush it, otherwise that's gonna have to meet the wheelie bin.