Shimano Metrea ST-U5060-R compatibility
The Shimano compatibility charts say that Mattrea ST-U5060 is compatible with RD- R9000 (Dura Ace), R8000 (Ultegra) and R7000 (105) front and rear derailleurs.

Here are the compatibility charts - 

Rear drivetrain: http://productinfo.shimano.com/#/com/3.7?cid=C-453&amp;acid=C-454

Front drivetrain: http://productinfo.shimano.com/#/com/3.7?cid=C-453&amp;acid=C-455

Unsurprisingly according to Shimano Tiagra 4700 appears to only be compatible with itself. However, if someone has tried Tiagra derailleurs with 105 or Ultegra shifters (or vice versa) and knows it works, then Matrea shifters will work too.