GRX crank with Ultegra groupset
It's set by the crank, and is like this because GRX is targeted at 135mm/142mm rear ends. GRX takes the same BB as any HT2 road crank.

It's enough to matter, but chainstay length is the other piece of how much it matters. Doing this kind of thing on super short chainstay bikes can yield pretty compromised results in terms of number of rough combinations, and at the other extreme may not be such a big deal.