Shimano 11 speed road shifters with 10 speed hub?
It is possible to use MTB 11 speed cassette on a 8-9-10 speed freehub body.
Although not officially compatible, the recently introduced 105 derailleur RD-R7000-GS can physically shift up to 42t cog, but Shimano introduced also a 11-34 11-speed cassette which fits 10-speed freehub body, so there's plenty to choose from in 2019.