Converting a 3x10 to 1x10 with QR dropouts (NOT Thru axle)
You should have no issues from a frame stand point. Just make sure you keep a good chain line and you're good to go!

There are lots of 1x10 QR bikes out there. And with the popularity of the 1x10 these days your options will be abundant. Also you will want to look into Narrow/wide chainrings for the front if you haven't already. With a good one a chain guide is not necessary unless you're doing downhill stuff.