Could I use the Ogio Mach 5 bag for cycling?
Trying to stick to objective points. When choosing a backpack for cycling you need to consider a couple of things beyond normal backpack considerations.


Fit - can the straps keep it stable as you pedal or will it flap
around
Weight - does it add too much?
Back ventilation - will you back get too sweaty
Aerodynamics can also be a consideration - shape, flappy straps etc. 


Fit and aerodynamics are probably fine as this is meant for motorcycle use. You'll definitely want to check the weight. Back ventilation could be a problem as it obviously is meant to be worn over a heavy motorcycle jacket.