Are there any bike tires that can hold 500 lbs (225 kg) each?
At those weights you're looking at three wheels minimum and maybe four.  

Simply loading 1000 pounds (500 kg) onto a trailer will be difficult without a lifter of some sort, and you would have to balance it perfectly over the axle.  On a car trailer, nose weight can be several hundred kilos acceptably, but on your bike any more than 2-5 kilos could see the whole thing rotate on the axle while loading.

Three wheels with a super-low slung platform would be safer.

You'll also require power brakes because 500 kilos is a LOT of weight.  I've ridden with 100 kilos on a trailer and it was really too much - had problems getting moving, and it was hard to get over intersections from stopped.

A 2 degree upslope in the road to go over a railway crossing damn-near stopped me cold, and the similar downslope on the other side was a surprise too.

Also check with your local road rules about what constitutes a maximum size and weight for a bicycle.  Could be the dimensions you're planning make the bike too big and could be classed as something else.

Don't be a danger to yourself and other road users - this project sounds dangerous.  I'm all for bikes in life, but look to hire movers or use a car trailer for this one.



bikecalculator.com says that a 500 kilo bike with a 75 kilo rider doing 150 watts on the flat will achieve around 15 km/h (9 mph)  Same combo with a bike of 10 kilos is 28 km/h

I haven't got a good calculation for stopping time for those masses from those velocities, but 5 times the weight will take a minimum of 5 times as long and your stopping distance will be much greater, to the point it would be unsafe for you and others to be sharing the roadway.