Weight of wheels vs. weight of tyres
Depending on your ability level this might be noticeable or it might not. Pro racers are often able to tell when as little as 100g is added somewhere on the bike (or geometry changes by .5 degrees for example).

With switching wheels the weight loss is felt in a couple different ways:


Overall weight On a bike that only weighs, let's say, 28 lbs (12,700g) a loss of .9 lbs (410g) is about 3% savings. If your bike weighed 100lbs it'd only be about 1%, so the impact of general weight savings is dependent on light the bike is already.
Rotational weight Heavier wheels are harder to spin up and slow down faster. Reducing that weight will reduce these effects. However, this comes mostly from the weight at the edge of the wheel (tires, tubes, rims), so if the weight savings are coming from a lighter hub, it will be less noticeable.


As usual, these all depend on the specifics of the wheel, the bike, and the rider and how all three interact. If your looking at dropping whole pounds by switching equipment I'd do it, but if it's just to save 50g, then it's probably not worth it.