swapping crankset and chainline compatibility
Yes, that's enough to create situations where you may have chain rub that can't be adjusted out in some additional gears on most road bikes. There are other factors, namely chainstay length - bikes with "pushed" chainstay lengths, i.e. 405mm-ish or less, are notably more finicky about this kind of thing.

How important this is depends on your riding habits. 

It sounds like you're looking at a power crank with a chainline that's either oriented more towards a road disc rear end (135mm as opposed to 130) or trying to do both with only one product.