Is Genshiken Second Generation a remake?
Genshiken Second Generation is actually a direct sequel to the original Genshiken. There's also a manga version which is available in English from Kodansha USA. The story follows the club under Ogiue's presidency after everyone else graduates other than Ogiue, Ohno, and Kuchiki. Susannah moves to Japan and joins, and they also recruit three new candidates: fujoshi Rika Yoshitake and Mirai Yajima, and crossdresser Kenjiro Hato. The other original Genshiken members also appear occasionally. There's a pretty big subplot about Hato and Madarame.

Genshiken 2 on Anime News Network.

The Wikipedia page, which discusses the new characters.