Are Mr.5 and Miss Valentine still alive?
The Ton-Ton no mi was eaten by Machivise.
The Pamu-Pamu no Mi was eaten by Gladius.

The two fruits eaten by Miss Valentine and Mr. 5 are the Kilo-Kilo no mi and Bomu-Bomu no mi respectively.

The Kilo-Kilo no mi and the Ton-Ton no mi are both similar but they have differences:


The Kilo-Kilo no mi allows a user to change their weight from 1 - 10,000 kg. This means the user can decrease their weight below normal as well as increase it up to 10,000 kg.  
The Ton-Ton no mi allows a user to increase their weight by presumably any amount


The Bomu-Bomu no mi and the Pamu-Pamu no mi are also indeed similar but have differences, which are noted on the Wikia page for Pamu-Pamu no mi:


  This ability is very similar to the Bomu Bomu no Mi, as they both involve explosions. The main difference is that while Mr. 5 is able to turn himself or any part of him into a bomb, Gladius can cause himself or inorganic objects to swell up and rupture explosively.


Both Miss Valentine and Mr. 5 are believed to be alive at this time.