What is the meaning of the title, "Dorohedoro"?
The most probable meaning of the title Dorohedoro is &quot;mud-sludge&quot;, which is consisted of doro (mud) and hedoro (sludge).
This is referred to in volume 10, chapter 56 of the manga (not yet covered in the anime) when Ai ...

 recalled his experience after jumping into the lake,

 

 &quot;When I fell into the lake, and mud (doro) and smelly sludge (hedoro) coiled around me, it felt as if I had become this warped city itself.&quot;