Can Anpanman die if he loses his entire head?
No, Anpanman does not die if his entire head comes off. When getting a new head made by Uncle Jam, his damaged head comes off before the new one is put on. Although having no head means he is unable to fight, it doesn't kill him. On top of this, I remember watching a scene where, instead of taking only part of his head off to feed the hungry, he takes off his whole head and survived. It is not fully explained how.