Does Armory work with a pruned copy of the blockchain?
No, you'll need to make space for a full copy of the blockchain somewhere. AFAIK, Armory rescans the blockchain in order to build its own database only after Bitcoin Core has fully synchronized. Therefore, Armory needs access to a full copy of the blockchain which is currently about 118GiB. Armory's database itself then will take more than 20GiB additionally.