Possibility of hardware wallets being 'unsupported' in the future?
Sure, it's possible that the physical hardware spec could cease to be commonplace (we've seen it before with floppy disks, tapes, PS/2 etc.)

However, Hardware wallets follow BIP39/44/49. In the event that the wallet is lost, unsupported, destroyed, or the company dies, you can always recover your coins by using a software wallet such as Electrum, or even manually. Many open source tools exist to recover coins from seeds.

If at any point the hardware wallets are being deprecated because of actual hardware reasons, it's almost a given that newer wallets will be created, and you will be able to just import your seed from the old one to carry on transacting as normal.