What does "Safe mode: Warning: The network does not appear to fully agree! Some miners appear to be experiencing issues." mean?
When Bitcoin detects that there is something seriously wrong with the network it gets into safe mode, disabling the majority of the methods exposed via its RPC API (only the okSafeMode methods will still work). It does that by filling up the error JSON node with an error code and the the generic error message you received so that the response will not be parseable:



The reasons that push it into safe mode can be a large valid/invalid fork, an invalid longest chain, etc.

Try adding these lines to your bitcoin.conf

checkblocks=10
checklevel=1


then restart bitcoind as well as your app and see if the issue is resolved. If not, try reindexing the blocks on your disk (via the -reindex param).

Also, consider using the -alertnotify hook to get custom notifications and/or to shut down your bitcoin apps every time this happens.