Is it possible to forward signed transaction using bitcoind prune mode?
Is it possible to perform createrawtranscation , signrawtransaction and sendrawtransaction rpc call using bitcoin in prune mode?

Yes
I did the transactions in below link using pruned node:
https://bitcoin.stackexchange.com/a/99679/103136
rescanblockchain might be required if you are using any imported addresses in the transactions and it will work only for blocks saved on disk
I had to use rescanblockchain in this example: https://bitcoin.stackexchange.com/a/99112/103136