What is Genome wide analysis and Locus specific analysis
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A locus (plur. loci) is a region of arbitrary size on a chromosome. A locus can be a single nucleotide or it can much larger (like $10^7$ sites).

A genome-wide analysis is therefore an analysis using the whole genome at once while a locus-specific analysis is the same analysis performed at the level of individual loci.

To make an analogy, if a genome-wide analysis is like a country-wide analysis, then a locus specific analysis is like a city specific analysis.

Without more context, it will not be possible to say more than that!