What's the best way to measure biodiversity?
A very good way to measure biodiversity would be to do environmental barcoding with high-throughput sequencing methods, and then use an algorithm that estimates genetic distance to get both species count estimates, and then calculate higher-level diversity, such as genera and families. Then you would repeat this procedure over several collections to obtain a species accumulation curve, so you could then estimate the asymptote. The future possibility of biogenereed organisms would not be worth reporting among the thousands of species at a given location.