Questions about Cohesin - what does the ATPase domain do, and any suggested PDBs to look at?
This article :
Prakash Arumugam, Stephan Gruber, Koichi Tanaka, Christian H. Haering, Karl Mechtler, Kim Nasmyth,
&quot;ATP Hydrolysis Is Required for Cohesin's Association with Chromosomes&quot;,
Current Biology,
Volume 13, Issue 22,
2003,
at
https://www.sciencedirect.com/science/article/pii/S0960982203008042
Their conclusion is:
&quot;Conclusions: Cohesin complexes whose heads have been connected by Scc1 must hydrolyze ATP in order to associate stably with chromosomes. If chromosomal association is mediated by the topological entrapment of DNA inside cohesin's ring, then ATP hydrolysis may be responsible for creating a gate through which DNA can enter. We suggest that ATP hydrolysis drives the temporary disconnection of Scc1 from Smc heads that are needed for DNA entrapment and that this process is promoted by Scc2/4.&quot;