Why is there not an immune response to injected immunoglobulins?
If a head-to-head &quot;match&quot; between antibodies from two different people was to occur, a similar match would most likely have occurred already in the donor. People have the same tissues after all.
But in the donor; the B lymphocytes producing the antibodies had to go through the processes of &quot;central tolerance&quot; and &quot;peripheral tolerance&quot;.
This would weed out the cells producing autoantibodies.
Theoretically, nasty autoantibodies in the recipient could react with innocent antibodies in the donor though.