Tc and Th1 interaction and viral immune response
PlaysDice's answer:

Antigen presenting cells migrate from skin/mucosa to secondary lymphoid organs like lymph nodes/spleen/GALT and drive T cell activation and maturation.
T helper cells with CD8 and MHCII complex recognise the virus and kill it.

I think this is what is happening, for instance in HIV infection:



where


dendritic cell (ADCC) presentation of HIV infected CD4+ to MHCII and T helper cell
T helper cell activates cytokine release
Natural killer cells come and lyse the HIV infected CD4+ T lymphocyte