When are neuropeptides loaded into vesicles?
Neuropeptides are packaged in the soma via the Golgi into dense core vesicles, similar to how other types of secreted proteins are packaged.

These vesicles are transported to axon terminals where they await release signals.



Sossin, W. S., Fisher, J. M., &amp; Scheller, R. H. (1989). Cellular and molecular biology of neuropeptide processing and packaging. Neuron, 2(5), 1407-1417.

Wong, M. Y., Zhou, C., Shakiryanova, D., Lloyd, T. E., Deitcher, D. L., &amp; Levitan, E. S. (2012). Neuropeptide delivery to synapses by long-range vesicle circulation and sporadic capture. Cell, 148(5), 1029-1038.