Carotenoid biosynthesis in yeast
The enzyme phytoene synthase is the first committed step in carotenoid biosynthesis. Saccharomyces cerevisiae doesn't have this enzyme, nor does it have the rest of the relevant pathway. Other yeasts such as Rhodotorula spp and Phaffia rhodozyma can make carotenoids.  

However, carotenoid biosynthesis has been engineered into S. cerevisiae.