Life cycle of proteins
Protein half-lives range from less than 30 min (e.g., oxidoreductases) to more than 200 hr (e.g., some nucleic-acid binding proteins) and up to, at least, 2000 hr [Rahman &amp; Sadygov, 2017, PLoS One 12(7): e0180428].

More ubiquitination sites, shorter half-life; more/larger intrinsically disordered regions, shorter half-life; more tightly coupled with the cell cycle, shorter half-life.

Note: Not all eukaryotic proteins are degraded via the ubiquitin-proteasome proteolytic pathway.



http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180428