Eating rarely but a lot, or often but little
Eating many small meals or eating large meals is irrelevant. The only thing that matters is getting the right amount of calories needed for your body to function properly.
Fat accumulation does not happen if you do not go over your daily calorie limit.
After a big meal your food is not only stored as fat but as a polysaccharide form of glucose called glycogen that is stored in the liver and or muscles for later use.
Therefore, there is no better way to eat, it depends on what size you like your meals to be as long as you stay within your calorie range.

See http://www.choosemyplate.gov for more information.