How does the drug MBC effect the depolymerization of microtubules in eukaryotic cells?
Carbendazim inhibits microtubule polymerization by directly binding to tubulin, preventing subunits from interacting. Therefore, mytotic spindle malforms and potentially causes aneuploidy in affected cells. Mechanisms of resistance are often shown to be changes in membrane permeability to the compound.



CARBENDAZIM (addendum)