Genomic instability of cancer cells in h&e image
Histologic diagnosis of tumors is made using the so-called  WHO blue books.

Different tumors show different patterns of cellular and tissual aberrations.

On h&amp;e  karyorrexis and  pyknosis  are examples histological markers of nuclear aberration.

A recent  paper reviews the salient visual and subvisual morphological changes of cancer nuclei and their possible cause or etiology and significance.