What are the uses of centrioles and matrix of centrosomes?
THis was too long for a comment.
It would be helpful for you to indicate what exactly you mean by &quot;cells can still function normally and grow&quot;.
There are a few observations related to your question about absence of centrioles (from your wiki page):

In Drosophila mitosis and development can occur to some extent in centriolar mutants, but &quot;they die shortly after birth&quot; due to flagellar and ciliar defects.

Some organisms do not have centrioles and use other mechanisms (e.g. angiosperms).


So, in the sections of your wiki page &quot;Fertility&quot;, &quot;Ciliogenesis&quot;, etc., those list the functional significance of centrioles.
If what you mean is &quot;what is the role of centrioles in mitosis&quot;, then we of course have a separate question. You can find a lot of resources on this topic via google searches.
As for your last question, about the synthetic sphere, you will have to spell out the experiment in much more detail- for example, what do you mean by &quot;synthetic sphere&quot;? A sphere defined by a lipid bilayer with gamma-TuRC (for example) on its surface and no other features is not a cell and won't go through a cell cycle.