What's superposition and thread in RosettaCM?
Threading:
Start with a homologous protein. This protein can be thought of as two parts: (1) a backbone conformation and (2) a sequence of amino acids attached to the backbone. Threading occurs when you switch out the amino acids to those of your protein with unknown structure, but do not change the backbone conformation.
I believe the origin of the term is like beads on a string. The &quot;string&quot; does not change (the backbone geometry stays the same) but new &quot;beads&quot; (amino acids) are threaded onto certain positions.
The definition of superposition you found online is the correct definition for RosettaCM.