Gene knockdown vs gene knockout vs knocksideways?
Hello and welcome Adil Amchi.
In genetics and molecular biology there are differences between the terms knock-out, knock-down and (the lesser known term) knock-sideways.
Knock-sideways: Inactivates proteins. Could be done using small molecule inhibitors.
Knock-out: Gene removal, no gene expression. Could be done using CRISPR.
Knock-down: Gene expression is reduced. Could be done using interference RNA.
(Another reference for Knock-sideways:

&quot;Importantly, the rapidity of the “knock-sideways” system allowed the researchers to observe a phenotype distinct from siRNA-mediated knockdown of the same protein...&quot;)