What does it mean to combine in-solution capture of chosen RAD tags to target sequencing reads to desired loci?
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Schematic overview of the new RAD protocol and RAD capture (Rapture) method. (A) RAD tag isolation. Two wells are depicted in each of two different plates. Genomic DNA is digested with a restriction enzyme and ligated to biotinylated well barcode adaptors (yellow and blue bars). (B) RAD tag isolation and library preparation. DNA from each well is pooled platewise, mechanically sheared, and incubated with streptavidin beads. Following washing, DNA is cleaved from the beads leaving the well barcodes. Finally, a library preparation is performed where a unique plate barcode is added (red and purple bars). (C) Rapture. Multiple plate libraries are pooled, hybridized to biotinylated oligonucleotide baits corresponding to the targeted RAD tag loci, and captured to produce the final library enriched for the loci of interest.