Can a miRNA be upregulated and downregulated in the same disease
Since diseases are frequently complex, it is not surprising to find specific genes (both miRNA coding genes or protein coding genes) being deferentially regulated when different studies of similar-sounding-diseases are compared. In other words, things like glioblastoma or Pacreatic Cancer should be treated as labels describing grossly similar disease states (i.e. excessive proliferation of glia and pancreatic cells, respectively), rather than as labels of specific cellular state associated with a particular gene expression pattern.