In the life-cycle of the HIV virus, how does the created DNA enter the nuclear membrane?
Some proteins are transported from cytoplasm to nucleus by the importin family through nuclear pore. These proteins have a specific sequence called Nuclear Localization Sequence (NLS) and the importin family recognizes NLS to import them. Recently it has been clear that the accessory protein vps which is translated from viral RNA and composes pre-integration complex (PIC) with viral DNA has atypical sequence like NLS.
So. it has been thought that DNA from HIV is imported into host nucleus by importin family with PIC.