Influence of artificial sunlight on the human body
Yes. Natural sunlight doesn't have a good substituent. 

Melatonin levels and circardian rhythms are directly affected by natural sunlight. 

As far as LEDs goes, a french study concluded that blue light may have photochemical risks and affect our retina.

Source

http://www.ledinside.com/knowledge/2014/4/effect_of_artificual_and_natural_light_on_the_human_body