Is O4I2 sufficient to reprogram cells (ie induce pluripotency)?
No, the chemical O4I2 (thats a name, not a chemical formula btw) only helps to induce production of the Oct-4 transcription factor. Even if just this chemical is sufficient to express Oct-4 (which it might not be, I'm not really sure about that), you still need to induce transcription of other genes (usually Sox, cMyc &amp; Klf4) to obtain iPS cells.