Centriole genes Knock-out Experiment in Common experimental animals?
One of the chief components of centrosome is γ-Tubulin. 

In this study the authors have reported the effect of γ-Tubulin knockout in mice.

Quoting the abstract:


  Gamma-tubulin regulates the nucleation of microtubules, but knowledge
  of its functions in vivo is still fragmentary. Here, we report the
  identification of two closely related gamma-tubulin isoforms, TUBG1
  and TUBG2, in mice, and the generation of TUBG1- and TUBG2-deficient
  mice. TUBG1 was expressed ubiquitously, whereas TUBG2 was primarily
  detected in the brain. The development of TUBG1-deficient (Tubg1-/-)
  embryos stopped at the morula/blastocyst stages due to a
  characteristic mitotic arrest: the mitotic spindle was highly
  disorganized, and disorganized spindles showed one or two pole-like
  foci of bundled MTs that were surrounded by condensed chromosomes.
  TUBG2 was expressed in blastocysts, but could not rescue the TUBG1
  deficiency. By contrast, TUBG2-deficient (Tubg2-/-) mice were born,
  grew, and intercrossed normally. In the brain of wild-type mice, TUBG2
  was expressed in approximately the same amount as TUBG1, but no
  histological abnormalities were found in the Tubg2-/- brain. These
  findings indicated that TUBG1 and TUBG2 are not functionally
  equivalent in vivo, that TUBG1 corresponds to conventional
  gamma-tubulin, and that TUBG2 may have some unidentified function in
  the brain.


Another important gene is pericentrin. Fibroblasts from pericentrin knockout mice show abnormal spindles during mitosis have been studied.


  In agreement with a model in which pericentrin is required for correct
  spindle orientation, fibroblasts isolated from PCNT knockout mice show
  a significant increase in cells with disrupted astral microtubules and
  misoriented spindles (Fig. 2; unpublished data; Zheng, G., personal
  communication). Spindle misorientation is shown by an increase in the
  angle formed by the pole-to-pole spindle vector and the cell–substrate
  adhesion plane in pericentrin knockout compared with wild-type
  fibroblasts.


Apparently both TUBG and PCNT deletions (individually) are not lethal.