Why is elevated homocysteine considered a risk factor for angina?
Homocysteine:


Causes endothelial dysfunction and damage
Accelerates thrombin formation
Inhibits native thrombolysis
Promotes lipid peroxidation through free radical formation
Induces vascular smooth muscle proliferation
Promotes monocyte chemotaxis


Many observational epidemiological studies indicate that individuals with higher Homocysteine levels have increased risks of cardiovascular disease.