Mechanism of DNA gyrase inhibitor
This might be a good article to read: http://www.ncbi.nlm.nih.gov/pubmed/24497635

Robert Kerns's lab has been doing a lot of work on fluoroquinolines, so look into his other work as an entry to the literature. And apparently X-ray crystals have been done for at least parts of this complex. There is some evidence for fluoroquinolines binding to DNA, then moving into the protein as it moves along the DNA.