Periods of Heavy Speciation
My guess (as your question need heavy editing!!) would be MiRdup.


  MiRdup Goals:
  
  
  Validation of pre-miRNAs predictions
  Prediction of mature miRNA   
  
  
  Abstract: MicroRNAs (miRNAs) are short RNA species derived from hairpin-forming miRNA precursors (pre-miRNA)
  and acting as key post-transcriptional regulators. Most computational
  tools labeled as miRNA predictors are in fact pre-miRNA predictors and
  provide no information about the putative miRNA location within the
  pre-miRNA. Sequence and structural features that determine the
  location of the miRNA, and the extent to which these properties vary
  from species to species, are poorly understood. We have developed
  miRdup, a computational predictor for the identification of the most
  likely miRNA location within a given pre-miRNA or the validation of a
  candidate miRNA. MiRdup is based on a random forest classifier trained
  with experimentally validated miRNAs from miRbase, with features that
  characterize the miRNA-miRNA* duplex