Proteins in water vs proteins in crystal
Protein crystals are not like crystals of more commonly found substances like salt [NaCl] or diamond [carbon only.]  These materials do not include other atoms in their crystal structures.  For instance, a crystal of NaCl will contain sodium ions and chloride ions.  X-ray crystallography of that material will, after mathematical processing, show electron density peaks of two varieties, each easily distinguished by intensity as either a sodium ion or chloride ion.  Any other electron density peaks will be few and far between, as well as clearly identifiable as an interloper.

Because most proteins have hydrophilic regions on the exterior surface of the structure, crystals of proteins actually contain a considerable fraction of water molecules within the crystal itself.  These water molecules are part of the crystal because they are interacting with those hydrophilic residues on the tertiary surface of the protein, both by hydrogen bonding, in some cases, and less specific polar interactions in other cases.   This is at least one of the reasons why obtaining a crystal of any random protein is not at all a routine endeavor.  The large proportion of water in these crystals make them very fragile once they do form, as well as not necessarily likely to form in the first place.

If you go into the technical literature to look at the electron density maps that the more commonly diagrammed structure maps are derived from, you'll be able to actually trace water molecules surrounding the individual protein molecules.

In fact, in the days of development of protein crystallography, assigning correct specific atoms to the various electron density peaks was a decidedly non-trivial task.

Effectively, despite being a crystal, the microenvironment experienced by the protein within the crystal is very much like that in an aqueous environment.  The hydrophobic interactions &amp; hydrophilic interactions will not be very different from those in solution.

That is, the crystalline state achieved is not, in fact, "a complete change of surrounding environment" to use the phrase that you've used in your post.