Strategy for using a Virtual Learning Environment (aka Blackboad/WebCT/Moodle)
Moodle
I recommend you to try a demo site of Moodle. It would be specially helpful to try one that has content. Here you can find one. You can choose which role to use, so you will be able to see what students see and to see some settings for each activity.
Moodle's documentation is the bible for using Moodle. You just have to make sure to review the documentation of the current version of your site. For instance, the capabilities of versions 1.9 or lower are much more limited than those of versions 2.0 or higher. However, if you are beginner I suggest you to visit first the demo site. Moodle's documentation could be more difficult to grasp if you do not know how a site works.
Contents
I am not sure if you are going to use Moodle as a support for classes (&quot;blended learning&quot;) or if you are going to teach an e-learning class. However, regardless of the kind of use, here you can find interesting ideas and concepts about distance education using Moodle. These ideas will be useful even if you are teaching a blended learning class. This document explains some principles for distance education (e.g., the course interface should be simple and intuitive).
Tips

The module called &quot;Lesson&quot; is very flexible to show and assess content. Some creative users have used it to simulate a situation where students have to make choices. Depending on those choices the module shows them different contents or questions.
The &quot;Workshop&quot; module allows you to implement a peer review system in a class.
The &quot;Assignment&quot; module can be used as an &quot;electronic mail box&quot;. Students can submit their project reports online.
In the newer versions of Moodle there is an option to create a &quot;Rubric&quot;. So you can quickly evaluate projects clicking on the rubric.
You can set up a &quot;Wiki&quot; in the course's page. For instance, you can ask students to use the Wiki to document their progress on a project, so you can directly comment in there.
You can create groups of students in the course's page. One of the advantages of this is that you can implement forums for each group, so students can exchange messages within their groups.
If you are teaching a class that uses a lot of math, you can write in Moodle using Latex syntaxis.