Are infrequently-cited publications detrimental in academic hiring?
In my experience, those who like to evaluate by counting are happy to count citations and to count publications.  Thus, in their eyes you are generally better off with more publications, regardless of citation counts.

On the other hand (at least in my field of applied mathematics), when evaluation is done by actually looking at your body of work (and what others in your subfield say about it), papers that are rarely cited can still be very important if they are highly regarded.  For instance, perhaps you solved a major open problem so thoroughly as to leave little room for follow-up work -- such a paper is likely to be considered very important but not often cited except in reviews.