Handwritten presentation slides?
I see essentially two possibilities:


Write out your slides on paper, then scan them.
Get a Tablet &amp; Pen combination and write directly "to your computer". I don't have experience with hand-writing slides this way, but I recently acquired a Wacom Intuos Pen which you could use for this. It has the additional benefit that you can use it in web conferences to write on a shared web whiteboard (this is the use case I personally got it for).


In case 1, you can scan your notes directly to PDF and present them. If you want to mix "classical" slides with your handwritten slides, you will need to mix PowerPoint or Beamer slides with graphics files containing your handwritten slides. You may need to experiment a bit with what picture format works best here, in terms of both file size and graphics quality.

In case 2, you can create PowerPoint presentations and write directly into the presentation with your Pen, which makes integrating "classical" and handwritten slides quite a bit easier.