Moving from a R2 university to a R1 university
Who can say how individuals would react, but I would find it preposterous if anyone counted it against you. Of course, the competition for such faculty positions is very fierce, so make sure that you build a record of accomplishment in your first job and build a strong "stable" of collaborators. 

The difference between a given R1 and a given R2 can be quite small, and not consistent across fields. Do the best you can and you will be more likely to have the best career you can have. It is more up to you than to somewhat arbitrary and subjective designations. 

It may take a while to move up, of course. And don't give colleagues the impression that you are unhappy or that you think you are "below your station".