Submitting manuscripts from a phd thesis when my supervisor is not available to review the final draft due to health issues
My suggestion is that you submit in the normal way, but several days (say a week) beforehand, send her/him a note that you are submitting, along with a copy of the paper. You seem to indicate that the supervisor should be a co-author (field dependent)and if so, do that also. 

In your note say that submission is pending unless you are advised against it. Make the note itself short so that little effort needs to be spent to make a quick decision. In particular, don't ask for a review and revision of the paper. 

"I expect to submit the enclosed next week unless you advise differently... I will wait if you prefer.". 

If you don't get a request to wait then just submit it. If they are well enough to review it, they probably will. 

Of course, if there are no time constraints/limitations, you can also just wait. 

But note that if the situation is dire and your advisor is near death then it is time for you to step in to the legacy along with his/her other students. You will have sole responsibility for these situations soon enough in that case.