How to handle 2 years hiatus after PhD?
Universities are often very aware of the equity issues facing academics (usually women) who have career gaps due to family responsibilities such as maternity leave. A two-year hiatus is not ideal, but rather than trying to hide it in a CV, it might work in his favour if he lists it explicitly in his CV, e.g.:
2014-2015: career hiatus due to family care responsibilities.

If he can be clear about what these caring responsibilities entailed, all the better, as people reading it will be more inclined to believe he is not bullshitting. E.g.
2014-2015: career hiatus to to family care responsibilities (primary carer for our baby, now in day care) or (caring for a terminally ill father) or (unavoidable primary care for a mentally ill sister, now recovered). 
It will probably help if he can make clear that these care responsibilities are now over, but if not, it is still worth being up-front.

If your friend can add to this by showing evidence of relevant activity during the hiatus, this will help too. Activity could include publishing papers from his PhD or adding to his skills by completing Coursera courses.

While looking for an academic position, your friend should also, if possible, improve his CV by working in a voluntary position in a research group -- perhaps the group with which he did his PhD or someone to whom his PhD supervisor can recommend him. This can usually be listed on the CV as an "adjunct" or "visiting" academic position. While acting in such a voluntary position, he should make sure he impresses the people he is working with to get favourable reference letters and should aim to be doing publishable work.