When/whether to do pre-submission inquiry at high impact journals
I have never found a pre-submission inquiry to be useful, and was always advised against it. The main argument is that it does not increase your chances of acceptance and just adds another hurdle to pass. Additionally, assuming you use a reference manager the difference in formatting between journals is usually minimal (or you can ignore some of the rules on your first submission).

However, I always submitted to journals that I know and read before, so I knew that the topic is generally appropriate. I would only consider a pre-submission inquiry if I am not sure whether the general topic is appropriate for the journal.