Manuscript was returned by the Editor to include more data, should I prepare "Response to Editor"?
If you mean "dispute the editor" then I don't recommend it. For the most part, if you don't generally follow the editor's advice as best you can, then you are likely to be rejected at the end. 

But if your response is of the form "these are the changes...", then yes, include a response, as they will make the editor's job easier and more likely to give you a fair and accurate review. 

There may be a difference of opinion, of course, about how much data is enough, but that can be worked out if everyone stays positive. Just don't try to tell an editor, who has all the power, how to do the job. That isn't a path to success.