How and what do I present at my PhD coursework
I'm going to be a bit more harsh than the current answers, and ask whether you knew what you were getting yourself into when you signed up for a multidisciplinary graduate program. What you describe is very common in such programs; you enter with significant knowledge in one field (e.g., comp sci), almost no knowledge in another (e.g., biology), and your task is to familiarize yourself with both to the extent that you can perform academic-level research that straddles both fields. Anecdotally, I went through a biomedical engineering PhD program, and every single student who went through the program experienced some degree of what you are describing. Without knowing specifics, your advisor is likely not responding because they take it for granted that you will learn to cope the same way that all his other students do.

The solution is simply to start at the beginning and take it from there. Clearly, you won't find help from your advisor, but there are many other resources. Find other students in a similar situation and create a study group. Talk to the TA. Use online materials and forums. If the course is simply too advanced, drop it for now and take (audit?) a lower-level (undergraduate?) course first. I know many students who did this. They ended up fine.

You will likely encounter a similar situation many times, where you need to familiarize yourself with a brand-new field, and this is a fine time to figure out how to do it.