What do reviewers look for in a paper?
Generally speaking, they are looking for something new which contributes to the current literature of the field.
If your paper fits in this context (i.e. you believe your paper will enhance/improve current methods or even solve particular problem, then you got publishable work regardless of the reviewing output.  

For a particular journal, other factors are added to the significance of the work (for example journal scope, writing level, paper format and methodology).