Situations where changes in advisor/lab interests makes you feel lost
The desirability of such a situation varies from person to person. Some people, but I doubt many, would love the independence. But others (most?) need more guidance, especially at the start and possibly near the end. 

But if you need more guidance then you need to find a way to get it. A co-advisor? A different advisor? Something. 

But just going along as you are is probably counterproductive. 

An outside possibility is that, provided the advisors "business" interest has research potential, that you could get involved with that as a source of ideas and research opportunities. I don't know if this is actually possible or desirable, of course.