How do 尤's 2021 meanings appertain to 尢?
尢 and 尤 are not related at all.
尢 is a crippled man with deformed legs as contrasted with the man in 大 having straight legs. Thus it means lame or crippled.
This character is no longer used in modern scripture and is written as 尪 with an additional 王 phonetic component.
尤 is possibly a variant form of hand 又 with an extra stroke probably representing a wound or wart which later became 疣.
Origins for 尤 is unclear to me though, but 又 is definitely a part of 尤.