Safari bookmark to activate an Automator action
A file:// link (with the path to your desired program) can point to a workflow, application, or AppleScript on your local drive. Clicking the link will not run the application (this lack of functionality is generally considered to be a desirable security feature), but it will open a Finder window and select the file in question, so pressing ⌘O or ⌘↓ will run the desired program.