How to launch an iOS Simulator with Safari open using a single command?
You can open a webpage in safari using : 

xcrun simctl openurl &lt;Device UDID&gt; http://www.google.com


You can determine the Device UDID by running xcrun simctl list

Just run both command using the &amp;&amp; operator. 

xcrun instruments -w "iPhone 6 (8.1 Simulator)" &amp;&amp; xcrun simctl openurl &lt;Device UDID&gt; http://www.google.com