Is using a key shortcut for restart (Cmd + Ctrl + Power) bad in any way?
Command + Control + Power button will force a restart without any intervention from the system. Applications will not be closed in a proper way and everything that is not yet written to disk will be lost.

It is definitely not safe.

You could use Command + Option + Control + Power button to shutdown and then Power button to start.


  Quit all apps (after giving you a chance to save changes to open documents), then shut down the computer