Can I run multiple instances of Skype on one computer?
multiple copies of Skype can only run under separate user accounts, making for some unfortunate but not critical overhead. create another user account on your Mac, either business or personal. then from the other one, open Terminal and do:

$ su - [your other username]
$ /Applications/Skype.app/Contents/MacOS/Skype &amp;


after which you can close the terminal.

edit: after running this after a bit, i should note that you will run into fun issues like separate clipboards, links opening in separate browsers, and possibly other multi-user issues which i havent run into yet.