How to create desktop shortcut for Chrome profile and run two or more profiles simultaneously?
Since there are several possible answers, I will introduce a more exotic one:


Download and install Platypus
Create a file chromedefault.sh in ~/Documents/scripts/ with the content:

#!/bin/bash
open -a "Google Chrome" --args --profile-directory=Default

Open Platypus with the following settings:



and create a new "app" ChromeDefault.
For a second app with the profile Other use another script chromeother.sh with appropriate changes: 

#!/bin/bash
open -a "Google Chrome" --args --profile-directory=Other


and call it ChromeOther.
Put both apps in the /Applications folder and create as many symlinks or aliases as needed.