Operating System becomes unstable after prolonged use
While your issue may go beyond this, there is one piece of behavior I've noticed with Google Chrome;

When you open a new window / tab, wait for the content to load. Wait for the Top Sites and everything else to appear. If you browse to a site while that's still loading, Chrome rarely allows me to browse to anything else. Wherein if I start having this problem and let the Top Sites content load, and THEN browse somewhere, it works pretty much perfectly and without any problems.

Whenever I'm "stuck" loading content, killing the tab takes time, at least a handful of seconds, but it does eventually happen.

However, I have never had massive computer instability as a result of Chrome, shutdown / restart has never failed to work.