Creating New Keyboard Shortcots fur Lock Screen and Spotlight search
You can use KeyRemap4MacBook to map key combinations to other key combinations:

&lt;autogen&gt;__KeyToConsumer__ KeyCode::L, VK_COMMAND | ModifierFlag::NONE, ConsumerKeyCode::EJECT, ModifierFlag::CONTROL_L | ModifierFlag::SHIFT_L&lt;/autogen&gt;

&lt;autogen&gt;__KeyToKey__ KeyCode::SPACE, VK_CONTROL | ModifierFlag::NONE, KeyCode::SPACE, ModifierFlag::COMMAND_L&lt;/autogen&gt;

See the source for the key code values and predefined settings.