Shortcut to take screenshot and save to specific folder
With native macOS You can only change the default save location for all screenshots to one location. The screenshot commands can't be split to have some screenshot commands go to one location, whilst other commands go to another location.
If your Mac is running Mojave or later, you can easily change the default screenshot location in the Options menu in the Screenshot app.
More information about Screenshots and the Screenshot app can be found at this Apple Support document. It is possible to customize the default macOS Shortcuts to key sequences you want to use, but you can't associate individual keystrokes with different save locations.