Applications frequently become permanently unresponsive
OK,

I will work with you on this step by step.

First to eliminate the following:

process plugin-container[1362] caught causing excessive wakeups. EXC_RESOURCE supressed due to audio playback
9/11/14 7:58:33.000 AM kernel[0]: process firefox[1359] caught causing excessive wakeups. Observed wakeups rate (per sec): 163; Maximum permitted wakeups rate (per sec): 150; Observation period: 300 seconds; Task lifetime number of wakeups: 61563


These messages are triggered by a plugin that you're running.

Go to Tools : Add-Ons : Plugins (in Firefox), and one-by-one, for each plugin listed, please do the following:

1) Disable the plugin.
2) Restart Firefox and check if you still see the message.


Update and part 2:


Your Preview is generating lots of problems?

Lets start with obvious.


  Open Preview:
  
  File,
  
  Open Recent,
  
  Clear Menu


The reason: There seems to be a croup file in your Preview.