MacOS Sierra Keyboard layout changes to Windows keyboard layout in Microsoft Remote Desktop
There are currently two versions of RDC available; release 8.0.xx &amp; beta 8.2.xx - If one doesn't behave as you'd expect, I'd try the other. 

Beta from Microsoft Technet blog

More specifically, the Release version has always made you switch to using Windows standard  Ctrl ⌃   C   X   V  etc
The Beta allows you to use  Cmd ⌘    C   X   V  &amp; even though still a beta, is actually better in many respects.