Device configuration for a Canon LIDE 30
I had the same problem with a LiDE 30, SANE, and OS 10.9.1 and solved it by setting my photo-editing application (Photoline) to open in 32-bit mode. Then the application recognized the SANE Twain interface.

I tested that technique on GraphicConverter 9. Launch in default mode: scanner not recognized. Launch in 32-bit mode: scanner found.

To open an application in 32-bit mode, Get Info on the application and check "Open in 32-bit mode."

Image Capture and Preview don't offer this check box, so they may be limited to 64-bit mode only.