My MacBook Has Run Out of Memory
Your Mac is designed to use as much RAM as it needs. &quot;Using all the memory&quot; is not a problem in itself, as long as Memory Pressure is green.
If you are not experiencing any problems, like slowdowns, or alerts saying &quot;Your computer has run out of memory&quot;, then stop worrying and get on with your work. ;-)
It's worth reading the better and more detailed explanations here:
iMac with 8GB RAM -- memory always almost full
If you don't have enough free space on your system storage volume, then that might cause problems.
(Oh, and stay away from CleanMyMac, too.)