New MBP with Sierra, /usr/local/bin no longer accessible unless root
In my almost default install of macOS (10.12.0 > updated to 10.12.1) the directories have the following owners and permissions:

drwxr-xr-x   4 root  wheel  sunlnk            136 Oct  2 22:42 . #/usr/local
drwxr-xr-x@ 13 root  wheel  restricted,hidden 442 Oct  3 01:01 .. #/usr
    com.apple.FinderInfo     32 
    com.apple.rootless    0 
drwxr-xr-x  26 root  wheel  -                 884 Oct 17 03:36 bin
drwxr-xr-x   5 root  wheel  -                 170 Oct 17 03:35 share


There is no obvious reason why the permissions are set that tight - Apple explicitly states that third-party apps and installers can continue to write to /usr/local. If a normal user wouldn't be able to read or execute files there, the directory would miss its point.

So simply change the permissions of /usr/local/bin (and /usr/local if necessary) to 755.