Printing 2 pages per sheet results in 4 pages
I have the same problem. The only way I manage to print 2 pages is printing it as a two-page layout PDF (which generates the expected two-pages per sheet layout), and then printing this as a one page per sheet. If I print directly, it will print 4 pages per sheet when I specify 2. This happens for the last 3 Mac OS versions, independent of the printer or program (I just checked with a PDF from Safari).

This happens from Sierra up to Movaje (as of now).