How to "find and replace" in a PDF on OS X?
As Tom Gewecke mentioned in a comment, Adobe Acrobat can do this.

I was also able to do this with PDFpen, as also suggested by Tom Gewecke.

Both apps seem great. Since both of them are quite pricey, though, I would also like to share a way to do this with the free and open source software LibreOffice.


Open the PDF with LibreOffice.
Click Edit in the panel, then Find &amp; Replace.... Use the feature as desired.
Click File in the panel, then select Export as PDF.... Save the PDF.


I suspect LibreOffice probably decodes and re-encodes the document. But in my case the new document looked precisely identical to the original (except for the edits, of course.)