Quickly switch monitors
In the absence of any other answers, I'd say 'no'. Even if you swap monitors from left to right in System Prefs > Displays, they retain their 'physical' layout, merely change which way you need to move the mouse to swap over.

Though... a thought - what if you assign each monitor to be a different Space &amp; swap Spaces for each monitor? I can't test as I don't use that method &amp; don't want to break my existing setup just to experiment.