Macbook | Mouse and Trackpad Options
I'm guessing that you are talking about the setting that, for me (British English) shows in Settings > Trackpad > Scroll &amp; Zoom > "Scroll direction: natural".

This discussion talks about this issue, and several people mention Scroll Reverser.  It has separate options for "Reverse Trackpad" and "Reverse Mouse".  (I haven't tested your scenario, but I have used this software for other reasons.)