Manually cleaning up a threat detected by Sophos Anti-virus?
Minus the fact that Sophos is just a giant waste of resources and space on your mac. The easiest way to clean it up would be to close chrome and go to that path in terminal and delete the file. 

Open terminal and type the following: 

rm -f /Users/USER/Library/Caches/Google/Chrome/Default/Cache/f_000e36 


That should delete the file forcibly. 

Personal Note: 

Having to run antivirus on your mac to protect windows machines is like wearing a helmet at your desk cause the guy on the bike outside might get hit by a car....