Why are applications (like Adobe Fireworks and Appcelerator Titanium) crashing on startup?
According to your crash log (thread 7 crashed) - it's trying to start up the updater and the updater is crashing attempting to read the preferences - so it's quite possible several of your preference files have been corrupted.

First thing I'd recommend is to open up Disk Utility, click on your startup drive and click Verify Disk to be sure that it's not a symptom of directory damage. If that checks out fine I'd recommend deleting the appropriate preference files from your Preferences folder (eg. com.adobe.Fireworks.plist from your Preferences folder) and see if that sorts things out.