Ways to highlight during a presentation
Mouseposé

When turned on, it dims the screen and puts a spotlight on the area
around the mouse pointer, easily guiding the audience‘s attention to
an area of interest.


Additionally, it has the mouse click visualization and typing visualization - both allowing your audience to see what you click and type.
They have a video on their site  that shows the software in action.

Ink2Go

Ink2Go is an extremely simple and powerful screen annotation and
recording software. Using Ink2Go you can easily write on top of any
other application currently active on the desktop, even on a running
video.

There is a 15 day free trail available at their website. They have both Windows and Mac versions.  In addition, there is a number of YouTube videos showing the product in action

This one may be a bit of overkill given all the features, but I have seen this at work in an education setting and it's excellent software.