Apple review process: Penalty for updating an app before it has been reviewed
To submit a new build of an app for review, the current build must be removed from review. This sets the status to Developer Rejected, which is equivalent to a review rejection. Once you have changed the build, you can submit it for review once again, which will put it at the back of the queue.


  Removing a build removes your app version from Apple’s review queue and changes its status to Developer Rejected. When you resubmit your app, the review process starts over from the beginning.


Source: iTunes Connect Developer Guide - Viewing and Changing Your App’s Status and Availability - Removing a Build from Review