Completely uninstall Adobe CS5
I'd start with the actual uninstaller rather than the cleaner.


http://helpx.adobe.com/creative-suite/kb/uninstall-creative-suite-cs5-cs5.html


Adobe does do deep integration, and I've been known to just walk away from machines with too much adobe on them. If you feel the uninstaller isn't getting things clean enough, you can take it a step further as follows:


Perform a clean install of the OS
use Migration Assistant to bring in the user account rather than setting up a new user on the "clean" Mac
download the uninstaller onto the new admin account


At that point, you can run the uninstaller to clean out any ~/Library plugins that might be installed. It's overkill, but sometimes a clean start is better than trying to let uninstallers find every copy of files that have been zipped, moved, linked, etc...