Karabiner F1 to Launch Safari?
Modify private.xml and add:

&lt;item&gt;
   &lt;name&gt;F1 Safari&lt;/name&gt;
   &lt;identifier&gt;f1_safari&lt;/identifier&gt;
   &lt;autogen&gt;__KeyToKey__ KeyCode::F1, KeyCode::VK_OPEN_URL_APP_Safari&lt;/autogen&gt;
&lt;/item&gt;


Then enable it in Change Key. Depending on your settings (Consumer Keys or F1-F12 for the F-keys) in System Preferences -> Keyboard -> Keyboard -> F-key behavior you may have to hit the fn-key also.