How to remap "right option" key to "control + option + command + shift" in Karabiner?
You can edit the karabiner json file:
~/.config/karabiner/karabiner.json

Look for this part in your profile:

"complex_modifications": {
    "rules": [ ]
}


Then add a new rule:

                "rules": [
                    {
                        "manipulators": [
                            {
                                "description": "Change right option to command+control+option+shift.",
                                "from": {
                                    "key_code": "right_option",
                                    "modifiers": {
                                        "optional": [
                                            "any"
                                        ]
                                    }
                                },
                                "to": [
                                    {
                                        "key_code": "left_command",
                                        "modifiers": [
                                            "left_control",
                                            "left_option",
                                            "left_shift"
                                        ]
                                    }
                                ],
                                "type": "basic"
                            }
                        ]
                    }
                ]
            }


Restart the karabiner, it should work now.