Database program with CSV import and ad-hoc SQL queries?
Filemaker Pro will be your best bet overall. It is easier to use than Access, and will give you what you want and more. It's going to be a learning curve with anything if you're used to Access, so just jump in to one of them.

Filemaker Pro - 

http://www.filemaker.com/products/filemaker-pro/

If you're wanting to do something SQL related though, then I'd check out the following: Sequelpro; Querious; Navicat; or MySQL Workbench.

Sequelpro is best out of all of these though, in my opinion, and it's completely free. Bam!

http://www.sequelpro.com/