How can I unmount a drive every time I reboot?
The following Hint on Mac OS X Hints details a way to do this. Basically you'll create (or modify) the file /etc/fstab and add a line similar to:

UUID=F0E430C1-5558-3BB3-9FA9-6904B663FEEA  none  hfs  rw,noauto


The actual UUID will vary, you can find the UUID for your disk in system.log:


  In Mac OS X Panther, Disk Utility and the diskutil command doesn't display the UUID value. But if you look in the system.log file, when the disk is mounted, you can see something similar to this (line breaks added for narrower display):

 … localhost diskarbitrationd[87]: disk1s9   hfs  
   77F3E84D-E0ED-3194-96A5-BED10893FFF4  FireWire HD    
   /Volumes/FireWire HD
 … localhost diskarbitrationd[87]: disk1s10  hfs  
   F0E430C1-5558-3BB3-9FA9-6904B663FEEA  Mac OS X Disc 
   /Volumes/Mac OS X Disc

  
  The string before the volume name is the UUID for the disk.