Relocated Home directory to exFAT partition => Skype freezes
The best way of resolving this would be to create a partition to hold just your Home folder and then use /etc/fstab to mount the partition at /Users/&lt;username&gt;.

Otherwise a symbolic link between the new location of your Home and /Users/&lt;username&gt;is the best way to go. ln -s &lt;new_home&gt; /Users/&lt;username&gt;. Of course this replaces the current /Users/&lt;newname&gt;.

Frankly, I find this too much trouble and usually just trim my Home folder by moving such things as my iTunes library, which is easy and well supported by iTunes.