Disable all Mac system keyboard shortcuts whilst using nano
Seems the conflict would most of the time be a Meta keybinding where Meta = CMD key on a Mac. The Nano website has a keybinding section of documentation here. You may need to configure a .nanorc and redefine those keybindings that conflict with macOS.
https://www.nano-editor.org/dist/latest/nano.html#Rebinding-Keys
The macOS Terminal under the Profile -&gt; Keyboard has a checkbox for Use Option as Meta key.  Seems to work for the nano meta keys.  This is per Profile in Terminal.