Should I enable TRIM with a third party (non-Apple) SSD?
TRIM and Garbage Collection (GC) are not the same, and are both necessary to maintain performance after the drive has been used for a while. GC only takes place in the background when idle, or when the OS needs to write to a previously used block.

TRIM proactively zeros unused areas in the background. This is why you see a slight performance hit, but on an SSD this is negligible and is a lot faster than waiting for GC to work on demand after you've been using the SSD for a while.

Using the TRIM enabler app is not advised, but you can enable it via the terminal by following these steps.

Including the Steps below (as there seems to be a certificate issue with that particular link) :


  TRIM Enabler for OS X Lion, Mountain Lion, Mavericks
  
  OK. Now that Lion’s out, people want their SSD TRIM support back. I
  have one thing to say:
  
  DO NOT USE TRIM ENABLER (VERSION 1.1 OR 1.2) TO ENABLE TRIM ON LION.
  
  After a little inspection of this application, I found that instead of
  patching the file, it replaces an entire kernel extension. This means
  that when you use TRIM Enabler with Lion, it replaces a critical
  kernel extension, with lots of dependencies, with an older one (from
  Snow Leopard 10.6.8). This is bad. Very bad. While TRIM does become
  enabled, the kernel extension you now have has the potential to cause
  a ton of problems. That means anything from kernel panics, to disk I/O
  delays…and the dreaded spinning beach ball.
  
  After confronting the developer, Oskar Groth (who I refuse to link
  to), via his blog’s commenting system, I was told that I was simply
  trolling and spreading fear (even though I offered the alternative I
  share here). Apparently, the next version of TRIM Enabler will
  correctly patch the file, instead of replacing it, but that hasn’t
  happened yet.
  
  So, here’s the proper way to enable TRIM support. Run these commands
  in Terminal:
  
  
  Backup the file we’re patching
  
  
  sudo cp
  /System/Library/Extensions/IOAHCIFamily.kext/Contents/PlugIns/IOAHCIBlockStorage.kext/Contents/MacOS/IOAHCIBlockStorage
  /System/Library/Extensions/IOAHCIFamily.kext/Contents/PlugIns/IOAHCIBlockStorage.kext/Contents/MacOS/IOAHCIBlockStorage.original
  
  
  If you’re using OS X Yosemite, disable KEXT signing
  
  
  sudo nvram boot-args="kext-dev-mode=1"
  
  
  Patch the file to enable TRIM support
  
  
  FOR ML 10.8.5 AND MAVERICKS DP4+
  
  sudo perl -pi -e
  's|(\x52\x6F\x74\x61\x74\x69\x6F\x6E\x61\x6C\x00{1,20})[^\x00]{9}(\x00{1,20}\x54)|$1\x00\x00\x00\x00\x00\x00\x00\x00\x00$2|sg'
  /System/Library/Extensions/IOAHCIFamily.kext/Contents/PlugIns/IOAHCIBlockStorage.kext/Contents/MacOS/IOAHCIBlockStorage
  
  
  Force a refresh of the system’s kernel extension cache
  
  
  sudo touch /System/Library/Extensions/
  
  
  Now Reboot!
  
  
  a) If in the future you want to disable TRIM support
  
  FOR ML 10.8.5 AND MAVERICKS DP4+
  
  sudo perl -pi -e
  's|(\x52\x6F\x74\x61\x74\x69\x6F\x6E\x61\x6C\x00).{9}(\x00\x54)|$1\x41\x50\x50\x4C\x45\x20\x53\x53\x44$2|sg'
  /System/Library/Extensions/IOAHCIFamily.kext/Contents/PlugIns/IOAHCIBlockStorage.kext/Contents/MacOS/IOAHCIBlockStorage
  
  sudo touch /System/Library/Extensions/
  
  b) If something goes horribly wrong, restore the backup
  
  sudo cp
  /System/Library/Extensions/IOAHCIFamily.kext/Contents/PlugIns/IOAHCIBlockStorage.kext/Contents/MacOS/IOAHCIBlockStorage.original
  /System/Library/Extensions/IOAHCIFamily.kext/Contents/PlugIns/IOAHCIBlockStorage.kext/Contents/MacOS/IOAHCIBlockStorage
  
  All this patch does is simply replace the string “APPLE SSD” in the
  file IOAHCIBlockStorage with zeros. This happens to bypass the
  restriction of only allowing Apple branded SSDs. The backup of the
  original file is saved in the same directory as the original file.
  
  To check if it worked, open up About This Mac, click the “More Info…”
  button then the “System Report” button. In the list on the left,
  choose “Serial-ATA”. Click on your SSD Drive and in the lower half of
  the screen you should now see “TRIM Support: Yes” instead of “No”.
  
  Remember, if you have an older generation SSD, the hardware itself may
  not support TRIM …and therefore this patch won’t help you. This patch
  bypasses the restriction put in place by Apple to restrict TRIM
  support to Apple branded SSD drives.
  
  You WILL need to re-apply this patch after each major update of OS X.
  That means for 10.7.1, 10.7.2, etc.
  
  Credit where credits due, unlike the other TRIM Enabler, I originally
  found this on the InsanelyMac forums by digital_dreamer
  
  As a note, the MD5 checksums for the original and patched file on
  10.7.0 are as follows:
  
  Original: 155b426c856c854e54936339fbc88d72
  
  Modified: 945944136009c9228fffb513ab5bf734
  
  If you have already used the other TRIM Enabler, you can do the
  following: a) Attempt to copy and replace the extension from another
  Mac running the same version. b) Attempt to copy and replace the
  extension from the Recovery partition (Open up Disk Utility and Mount
  Recovery HD) c) Reinstall Lion d) Wait it out till 10.7.1 and hope
  that the extension is replaced in the update (but it may not be), then
  re-patch the file
  
  UPDATE
  
  a) Applying this patch does NOTHING else other than enable TRIM for
  3rd party SSD drives. If you start seeing other problems, they’re not
  because of this.
  
  b) Using this patch has no effect on hard disk drives. Firstly,
  mechanical hard disk drives do not understand the TRIM command, so it
  is discarded. Secondly, the Apple driver isn’t stupid enough to send
  TRIM commands to your hard disk. It knows the difference between an
  SSD and a HDD.
  
  c) The wiping free space option is ALWAYS greyed out, even on Apple
  based SSDs. As reported here, you can try using fsck -ffy in Single
  User Mode, but personally I haven’t tested it. I’m sure there isn’t
  too much to worry about, especially if your drive has garbage
  collection.
  
  d) If TRIM isn’t enabled after patching either a) you didn’t follow
  the steps correctly or b) your drive doesn’t support TRIM. If your
  drive doesn’t support TRIM, there’s no need to revert the patch, it
  simply has no effect.
  
  e) The TRIM patch is NOT vendor/model specific. You can patch the
  driver for any damn SSD drive. Hell, you can apply the patch if you
  only use HDDs, but that’d be a little silly.
  
  f) Regarding RAID and SSDs on Mac. I’m not completely sure but…if
  you’re using Apple RAID then I assume TRIM will work as usual. If
  you’re using a hackintosh and using a RAID controller (i.e. Intel
  ICHR), then no, RAID will not work. In either case, you should use a
  drive with garbage collection.
  
  UPDATE 2
  
  Regarding SSD durability and comments by Hyram:
  
  The durability of SSDs has sweet fuck all to do with Mac OS X TRIM.
  It’s a fact, and always has been, that SSDs aren’t as durable as hard
  disks. This is simply due it it being a new technology. SSDs fail
  often due to the wear on the cells incurred by reads and writes.
  
  If you don’t know what TRIM is, you probably shouldn’t be using a 3rd
  party SSD drive. Many have reported these commands don’t work, but
  that simply isn’t true. It just shows that a lot of people here don’t
  know how to use Terminal, don’t know what Bash is, nor Perl. These
  aren’t the sort of people that should be messing around with this.
  Instead, buy a SSD drive that offers garbage collection….or a Mac with
  an Apple SSD.
  
  There has also been some confusion about garbage collection and TRIM.
  TRIM is ALWAYS preferred over Garbage Collection and will likely yield
  better results. If you have garbage collection, you don’t necessarily
  need TRIM, but it’ll probably offer better performance and there’s
  always a chance there’ll be a degradation of speed over time.
  Therefore, when using Garbage Collection, you may have to take the
  drive out and do a secure erase so that everything is re-marked as
  free space.
  
  A drive will never fail because you haven’t enabled TRIM, even if it
  doesn’t have garbage collection. They simply become slower and the
  speed is not restored until you perform a destructive erase on the
  drive. However, drives that support TRIM, but do not have GC, and do
  not have TRIM enabled (in the OS) may fail more quickly than without
  enabling TRIM. In a very basic sense, since the SSD is no longer told
  what data to free up, when writing new data it will also re-write the
  deleted data, essentially causing more write cycles and wearing down
  the durability of the drive. If TRIM were enabled, the new data would
  be written without the deleted data, and hence less write cycles and
  extended durability. This ONLY relates to the combination of a drive
  that supports TRIM with no GC, while TRIM is disabled in the OS
  
  Running garbage collection and TRIM at the same time is NOT a problem.
  They’re designed to work together. You can look at it like so: TRIM is
  called by your OS each time space is freed up. Garbage Collection is
  run by the drive’s firmware when idle and determines which parts of
  the drive can be cleaned up and rearranged. TRIM is obviously more
  efficient and obviously the drive’s firmware is aware of the TRIM
  commands and accounts for this.
  
  As for the statements by Hyram, I believe some of them to be
  completely false. While it’s true that using TRIM and garbage
  collection at the same time is essentially using two mechanisms to do
  the same thing, the firmware on your SSD drive is designed to handle
  these things. All SSD manufacturers, GC or not, recommend the use of
  TRIM.
  
  There is zero evidence that Apple has specific code to handle their
  specific SSD hardware for reading and writing. TRIM is a standardized
  ATA command. However, it IS likely that Apple has designed their
  integrated SSDs (particularly in the Air) to not overheat. Basically,
  your SSD is likely to fail just as much in your MacBook as if it were
  surrounded by the same temperature in any other laptop.
  
  Posted on November 17, 2011