Downloaded apps does not start, failed with error -10810
LSOpenURLsWithRole() failed with error ... is often an execute permissions error.
You can text the permissions of the overall app from terminal
ls -l path/to/app
but if that looks OK, you may need to test the executable within the app
ls -l path/to/app/Contents/MacOS/app
Simple example using Calculator…
$ ls -l /Applications/Calculator.app/Contents/MacOS/Calculator
-rwxr-xr-x  1 root  wheel  143648  3 Dec 06:43  
/Applications/Calculator.app/Contents/MacOS/Calculator

If you don't see the x execute permission, you can add it with
chmod +x path/to/app/Contents/MacOS/app
There's an alternative approach which may work.
On first run, rather than double-clicking, right-click &amp; select Open from the drop menu. This will bypass Gatekeeper's quarantine &amp; allow it to run. It should then remember this for subsequent launches.