Preview is not responding since OS X Mavericks update
The first thing to try when encountering something like this is to move the preferences files to a new folder. I usually put them on the Desktop.

First, Quit Preview and then go to the Finder and move these files to the Desktop:


/Users/&lt;short user name&gt;/Library/Containers/com.apple.Preview
/Users/&lt;short user name&gt;/Library/com.apple.preview.*


Run Preview and see if it is fixed.

In the case of Preview, there probably isn't any information in these files that you will really miss, It should be stuff like the previously viewed files, and whatever is in the "Preferences" dialog.