How to change shortcut used for temporary zoom (accessibility feature)?
I found a limited solution:
Install free BetterTouchTool from http://blog.boastr.net
Go to Gestures/Normal Mice, click Add New Button, set Left Click, check ctrl and option modifiers.
At right, choose Predefined Action called Mouse Click Actions / More Mouse Buttons &amp; Modifiers, and simply choose Left Mouse Button (see attached image). Save, close the BTT window, and try left-clicking. Unfortunately clicking is the only thing you can do, for example you can't click+drag (at least it didn't work for me).