Aliases in Alfred: Keyword -> Open a specific folder in finder
Yes, you can. There are many ways to achieve the result you want. The easiest method is to create a workflow that contains all the aliases (keywords) that open folders/files in Finder. You must use Alfred 2 for this to work.


Open Alfred Preferences and choose Workflows tab.
Create a new workflow by choosing the plus sign in sidebar. You can name the 
workflow as Custom Paths/Searces.
Select the active workflow and select the plus sign at top right. Choose Inputs &gt; Keywords as your trigger. Fill in the keyword you want to use for as aliases. You’ll see one node is created in the workflow main panel.





Create a new node from Actions &gt; Launch Apps / Files. Drag the folders you wish to launch from Finder into the list.




You can create set of folders if you wish. But by far this is the one I prefer because it offers more flexibility than using scripts like Open ~/Desktop via Terminal.