Wacom Bamboo Create Driver for MacOS 10.12
On 10/12/2016, Wacom posted Driver 5.3.7-6, which is certified for macOS 10.9x - 10.12x. I installed the driver and it works as expected.

Updated Wacom driver.  

UPDATE -> macOS 10.13 High Sierra

(9/17/2017)
The current drivers work after upgrading to macOS 10.13 (High Sierra), but the installer removed the Prefs Pane (System Preferences) module. This means that you can continue to use the Bamboo after upgrading, but you will not be able to make any changes to the settings. I have put in a trouble ticket with Wacom on this, and will post any updates here as I receive new information.

I will also do some more research to see if there is a way to get around the prefs pane issue.

SECOND UPDATE -> macOS 10.13 High Sierra

(10/22/1017)
Wacom has posted updated drivers that support macOS 10.13 High Sierra:
http://www.wacom.com/en-us/support/product-support/drivers

But they do not support the older devices, which include the Bamboo Create.