External Hard Drive Doesn't Initialize
If OS X cannot erase and partition a new drive, then either you have a rare corrupt data or hardware problem. Have you tried booting to recovery HD and using disk utility to repartition the drive entirely. 

Choose APM to make sure you can write a new partition map. Then repartition to how you want to use the drive. If that fails, seek hardware repair or start to isolate the cable or enclosure or drive as the thing that fails.