Reply button not working
Does anything else not work, or is it just the “Reply” button? A few things you could try:


Restart Safari—or your computer. Sounds dumb, but it's amazing how often this does the trick.
Use the menu item “Safari -> Empty Cache…” to clear Safari’s cache.
Try to use your company’s webmail in another browser. There may be a subtle bug (or feature?) in the website’s code that Safari is not handling properly. Here are a few alternatives:

Mozilla Firefox
Google Chrome
Opera
OmniWeb
Camino
Internet Explorer, on Windows, just to check. Even in this day and age, some websites still only work properly with IE.
Netscape Navigator (Yuk yuk yuk. Just kidding, don’t download this. For the love of God, don’t download this.)