LiPo protection circuit IC
An important question to ask yourself: Can I really not access the cells' individual wires?

Your best option is accessing the wires to all the cells, usually battery packs have balancing connectors, with in it wires to connect to the joints of each set of cells.

This is done, because LiPo cells are much more sensitive to cell-to-cell imbalance and will waste away much faster if you do not check the cell balancing regularly, preferably each time you charge and/or discharge. Alternatively you also should make sure no single cell ever discharges below a level of about 2.5V.

The 4 cell chips do all of that for you, if you choose an appropriate one. They will stop current flow when any one of the cells is depleted, in stead of when the entire pack reaches a lower limit, and they should be chosen to have some balancing feature, to alow you to fully charge all the cells.

A 1 cell device will only work with one single cell, because it expects the upper limit of 4.25V and lower limit of 2.5V, connecting a full pack of 4 cells to its terminals will at best just not work, but most likely turn it into a ball of smoke.