Which is better, single inverter or buffer + inverter?
Quick answer - neither.

First, your 20k input resistor is too small. If you calculate power dissipation you'll find it dissipates about 1 1/4 watts. A 100k, 1/2 watt device would be much better.

Second, your inverting circuit does not need the 500 ohm input resistor, which is clearly a holdover from your non-inverting design.

Third, the inverting portion of your buffer/amp should use larger resistors. This is not an absolute objection, since most op amps will provide the 8 mA or so needed, but the circuit will work just as well with 10k resistors, and draw less power. It will also allow smaller capacitors to be used for filtering.

With that said, there is no clear winner. The single inverter is obviously more reliable, since it has fewer components, but this is not the only consideration. How is the input voltage applied, and what sort of noise environment are you working in? If the circuit may operate with power on but not physical attachment to the power supply, and a hot connection made, the buffer/inverter is better, since the A/D input is always going to be within the 0 to 3.9 volt range. With the input disconnected, the inverter will float around, responding to static charges and the phase of the moon. The buffer configuration will also respond more gracefully to the connection process.

Either configuration can be made resistant to EMI, as follows







simulate this circuit &ndash; Schematic created using CircuitLab

Look at the tradeoffs, though. The buffer capacitor needs to be large, since the frequency response is dominated by the small value of R2, but the voltage across it is only 4 volts. The inverter capacitor can be much smaller, since it is working with the large input resistors, but it also sees 80 volts, and so need to be a much higher voltage unit. Note that, for high frequency (like RF) inputs, the inverter cannot use a feedback capacitor to control noise, since any noise above the frequency response of the op amp will not be attenuated.

Finally, since you are interfacing to high voltage, you should consider the intrinsic protection provided by the buffer/amp. If something goes wrong you have two possible devices which might (if you're lucky) provide some protection for your A/D converter and the processor which it connects to, as opposed to one. This is hardly guaranteed, but it's worth considering. I speak as someone who, long ago, had a dial-up modem connection using an external modem. The phone line was hit by lightning, and the modem destroyed, but the PC survived. It's not clear that an integrated modem would have done as good a job.

So in general there is no obvious winner. It all depends on your priorities.