How do I set a new reference point within Eagle CAD?
You have to group and move all components. However, I would not recommend moving the componets with a mouse, as the selected grid might not fit.

Instead, use the command move (&gt;0 0) (dX dY) to move the group a specific distance.

Example: move (&gt;0 0) (-10 0), to move the group 10mil to the left (if the grid unit is set to mil).