Three opamp instrumentation amplifier vs single opamp implementation
First, many InAmps are integrated into one IC, also the three-opamp versions. Then the cost of the extra opamps isn't that high. Consider the extra cost of less than a mm^2 real estate against the total cost to create an IC.

Next, I've never seen a single-opamp inamp. There are two-opamp and three-opamp versions, and there's a reason why you can't make one with a single opamp: you need high impedance for both inputs, and that means neither can have feedback. 

edit
You probably mean a differential amplifier, like The Resistance comments below. Notice that the 2 input opamps are configured as non-inverting amplifiers, and that there's no feedback to the input pins, like you would have for an inverting amplifier. This way you get high-impedance amplifying buffer-amps before the actual differential amplifier.