Pspice simulation ERROR
Well I can't help you with the PSice error message but I can point out problems: -


Pin 3 of U1A is not dc biased to any voltage reference - it will be just floating and this will certainly cause "real-life issues
You won't get a sinewave through the opto-isolator the way you are driving it - driving the LED with a sinewave will mean that the LED only conducts on the positive half cycle.
R3 is in series with the power feed to U1A and this looks problematic
No decouplers on the op-amp power supplies.
U2A's power rail seems to be cut


Some spice sims can allow noise and, if you want to add it to a sinewave, use two generators (one for noise and one for the sinewave) and put them in series i.e. they become additive. Some sims allow "real noise" signals to be inputted via something called a "user list".