Multiple 12V devices with one power supply
I'm wondering if I would need any type of isolation ...


That would be an isolating DC-DC converter and would be at least as big as the wall-wart which, presumably, has been sized for the load so you would lose the benefit.


  ... or noise reduction, ...


Some local capacitance might be a good idea but, in theory, shouldn't be required.


  ... and would the voltage fluctuate as I plug and unplug devices?


This depends on the transient response of the power supply and should be specified on the power supply datasheet.



One thing that you are assuming is that they all share a common ground connected to the 12 V common. This may not be the case.







simulate this circuit &ndash; Schematic created using CircuitLab

Figure 1. Any device with full-wave rectifier reverse polarity correction will have its internal ground raised by 0.7 V.

Introducing a device with input protection as shown in Figure 1 could result in problems. The internal ground will be 0.7 V above your common 0 V line. Connecting, for example, a USB lead to another device may correct the problem but now all the power return will be through the USB lead. If this isn't rated for the current the voltage may rise on that line. You could spend a lot of time debugging this and potentially causing some damage.

Proceed with wisdom and caution.