Best way to build a 64-bit output multiplexer
Do these cartridges have any kind of "cartridge select" pin? If so, you could conceivably connect all the lines except for the select in parallel and just drive the appropriate select line.

If they don't have a select line, do the cartridges have any address(es) which cause the data lines to be released/"driven" to high impedance? If so, do the cartridges have a common address for all of the cartridges which do this? If they do, there's your cartridge select -- connect the data lines in parallel and connect as many address lines in parallel as you can; that gives you fewer lines you have to multiplex.

Failing all of that, you're stuck with a high pin count FPGA to do it, which is probably your best solution. I think that no matter what you'll want to go through the above exercises to minimize the number of uniquely driven lines. It sounds like an interesting project. Good luck!