IR2110 Mosfet Driver - Separate VSS and COM (power-logic ground)
No, I do not think that this will work. The problem is -5 V at Vss and -30 V will be shorted through the IC as it is not designed for this.

According to the datasheet Vss and Com must be at the same voltage level. They are separated to allow better separattion between the grounds for small signals like noise. But not for a difference of many volts DC !

Most likely there will be 2 antiparallel diodes between Vss and Com for ESD protection. You can check this with a multimeter in diode test mode. I expect that you will find these diodes present and that would mean that Vss and Com must be at the same DC voltage. In your schematic these diodes would short the -5 V and the -30 V and you would destroy your Chip !!!

Also in the block diagram on page 4 of the datasheet I do not see any measures to allow a different ground level at the input. The "floating" circuit as mentioned in the datasheet is only the circuit which drives the PMOS. It has this "HV level shift" making this possible.