2-wire MPU interface / 2-wire Serial Control Interface?
2-Wire Serial Interface is just a name for I2C. The Block Diagram on the first page of the datasheet shows the control lines, it also specifies that you can use 2- or 3-wire interface to communicate with it.

MPU stands for micro-processing/processor unit (it's your microcontroller, in other words).

Regarding using I2C, the Wikipedia article clearly states: "Vendors use the name TWI, even though I²C is not a registered trademark as of 2014-11-07."