Why doesn't this MOSFET driver work when load supply is isolated?
From the discussion above, in my opinion you should not be using the IRS10752LPBF.
As the IRS10752LPBF:

does not provide isolation
is intended for use with a bootstrap diode + capacitor, which you do not use and do not want as you want to be able to make this work without periodic switching (DC).

I would use this solution:



simulate this circuit &ndash; Schematic created using CircuitLab
As this provides:

isolation (left and right part of the circuit completely separated).

no bootstrap but using an external voltage (Vbs).


Note that &quot;high side switching&quot; using an N-channel MOSFET is more complex than &quot;low side switching&quot;, if possible I would use:



simulate this circuit