Best way to control around 250 LEDs
What's the budget?  Do you already have the LEDs?

For that many, I'd probably try to use some "neopixels" (LEDs with WS2812 or similar controller).  It can make the wiring much simpler by allowing daisy chain.  And you can stick on multiple power supplies if you need based on the number of LEDs and the brightness.

You only need one data pin if they're all in one string