How to drive a E1144CS021 (EPD display)?
In short, you don't.  Or rather you only do it by connecting to a timing controller.

EPD's are not a simple drive a voltage and then you see an image.  they require complex waveforms and timing to move the particles around in the display. Indirect evidence of this is in section three of a data-sheet for that part: Here is as snipped picture.



This is not a development for even experienced EE's who don't have a display or EPD background.

However, there are a number of micro-controllers that have specific timing controllers built into them to drive EPD's. Grab one of those.