Command line simulation using pspice
It is possible to automate simulation runs with (p)spice. The magic keyword is "shell scripting". This is easy to do on Linux, but a bit harder with PSpice on Windows. If the PowerShell in Windows is not your cut of tea, you may want to look into Python (windows shell script howto here). If you don't need flow control, you can write a batch file. My advise for tasks to be automated: switch to Linux and use the original spice, ngspice or gnucap.