Shift and enlarge voltage out of DAC
Would it be possible to amplify by 10 and set the positive input on
the op amp to a 1.25 V ref? Or do i perhaps have to do it in two steps?

You need to offset by +1.1363636 volts and no, you don't need two steps.
Think about the op-amp output at 0 volts and the signal input at a steady 1.25 volts. The potential divider formed by R and 10R means that the inverting-input needs to be at: -
$$+1.25\cdot\dfrac{10}{10+1} = \text{+1.1363636 volts}$$
To achieve that you need to apply +1.1363636 volts to your op-amp's non-inverting input: -