Battery management system for 3.7v
The safety problem is that if any cell goes short circuit, the other parallel cells could drive a very large current through it. You therefore require a fuse in series with each cell.

The practicality problem is that with 1s109p, you have a very low voltage high current battery. A boost converter from 3v to 48v will not have the highest efficiency, and you will need very thick cables from the battery to the converter. It would be far better to have a higher voltage, lower capacity battery, say 8s13p, or 6s18p. You will get better efficiency from a smaller ratio boost converter, and require much smaller cables from the battery to the converter.