Single Supply Audio Amplifier
Your DC bias is wrong.  R4 should be returned to virtual ground, not actual ground.  As it is, the op-amp is doing its best to amplify the 4.5 V to 450 V.

You could fix the circuit by replacing R4 with a 2k to ground and a 2k to Vcc.

A good first step in debugging this kind of circuit is to measure the DC voltages with no signal applied.

Edit: The capacitor in series with R4 is a better solution because you don't have to worry about DC offsets or resistor tolerance.