General question about Capacitor sizes in DC circuits
Fully discharged capacitor will appear as dead short to anything that trying to charge it. The higher the capacitance, longer the time it will appear as shorted point to the power supply.

Thus, if you replace say a 1000uF with 68000uF in a power supply reservoir, and the overall impedance of the AC side is low enough, the main causality will be your rectifiers. It may not die immediately, but it will after some times due to very high inrush current. This depends on how many times the power cycling is done.

In high voltage DC application, huge capacitance will create hazardous voltage storage for longer than anticipated duration.

Another place where higher capacitance in DC circuit is not desirable is in timing applications. You may offset the original timing of the circuit by higher capacitance.