EEPROM in beaglebone black
BeagleBone Black System Reference Manual 


  5.3.2: A single 32KB EEPROM is provided on I2C0 th
  at holds the board information. This
  information includes board name, serial number, and revision information


If you search for I²C in that document:


6.9.1: HDMI Framer The TDA19988 is a High-Definition Multimedia Interface (HDMI) 1.4a transmitter.
6.1.1: TPS65217C PMIC The main Power Management IC (PMIC) in the system
8.1: EEPROM Each cape must have its own EEPROM containing information that will allow the SW to identify the board and to configure the expansion headers pins as needed.


Whether or not you'll be running into problems is a matter if are you using any of these devices or a I²C device you wired up yourself.