Choosing between ipex connector and SMA Connector for LoRa, LTE and GPS
The biggest advantage of using different types of connectors is the electrical connection. As you get bigger beefier connectors, you're darn sure that you're making a good connection eventually all the way to the antenna. 

I've designed a few boards using U.FL connections and they work well but they're meant for smaller more embedded products. (Think iPhones) They also are prone to popping off if you're not careful with your assemblies during the assembly process.

If you have the room, go for a connector that you can make a solid connection with. Even if you can't use a right angle SMA you can use a SMA that sticks straight out of the board. That way your connection is still inside and protected from the elements.