Analogue switch TS3A475 does the direction matter?
No, it doesn't. But you need to make sure that the voltage is within the range specified in the datasheet (usually it must be between the supply rails of the switch), and also the switch has a non-zero resistance and a maximum allowed current through it. The switch resistance will be highly dependent on both temperature and voltage, so have to make sure that such variations won't unacceptably affect the performance of your entire system.