Circuit simulation too slow on LTSpice
Check the reltol/voltol etc. options. Either with the .option command, or behind the hammer icon (4th icon in the bar). Make the tolerances higher for faster simulation speeds while sacrificing accuracy.
You have a floating node behind a reactive element at C5. It's good practice to avoid floating nodes in a circuit. I guess this node is where the output appears? Easiest case: put a high value resistor to ground there.
Try finding a different model for your used ICs if all fails.