USB single chip ESD protector for two connectors through a power switch
The function of the ESD protection IC is to short high voltage spikes. If you reverse-bias a diode over its reverse breakdown voltage it will start conducting. Positive spikes will short to GND and negative spikes will short to V+. You can connect V+ to the 5V rail. Also use a 5.1V zener from Vcc to gnd to clamp the voltage.