powering 12V 5m/16ft 5050 RGB LED Strip with 16V power adapter?
Increasing the voltage by that much will significantly increase the LED current - much more than you might think.

Most of those strips have 3- LEDs in series per section.  The forward voltage on a Green or Blue LED is about 3.2V.  The Red LEDs are about 1.7V each.

The intended voltage for those strips is about 12V.  Let's use that as a starting point.

The increase in current for the Green and Blue LEDs is going to be about:

@ 12V: 12V - (3 * 3.2V) = 2.4V across the current limit resistors

@ 14V: 14V - (3 * 3.2V) = 4.4V across the current limit resistors

@ 16V: 16V - (3 * 3.2V) = 6.4V across the current limit resistors

So: increasing the supply voltage from 12V to 14V is going to increase the LED current by (4.4 / 2.4 * 100%) = 183%

Increasing the supply voltage from 12V to 16V is going to increase the LED current by (6.4 / 2.4 * 100%) = 267%

The situation is a little better with the Red LEDs.  Doing the same math as above results in the following voltages across the current limit resistors for the Red LEDs:

12V: 6.9V across the current limit resistor 

14V: 8.9V across the resistor

16V: 10.9V across the resistor.  

That results in a 129% increase in current if running at 14V; a 158% increase in current if running at 16V.

I strongly suspect that the current limit resistors are going to be really unhappy.  You will most likely also notice that the Red LED didn't get as bright as the Green &amp; Blue LEDs at the higher voltages.

Bottom line: run the strips at the manufacturer's maximum voltage and feed power from both ends if possible.