Understanding relation between energy use, watts and amps
The Energy Guide numbers include a range of assumptions about room size, annual hours of operation, and cooling load. The manufacturers have to include values for standby power consumption as well. All of this means that while watts, amps, and volts are fundamentally related, the values reported on the label aren't. They are the result of specific testing requirements and reporting criteria that manufacturers must adhere to.

What you can assume is that in a similar application (such as the same room in your house) air conditioner (2) will cost you about 30% less to operate annually than air conditioner (1):

($65 - $50) / $50 = 30%



If you want to get into the details, you can read the Code of Federal Regulations -- Title 10 Energy -- Chapter II Department of Energy -- Subchapter D Energy Conservation -- Part 430 Energy Conservation Program for Consumer Products -- Subpart B Test Procedures -- Section 23 Test procedures for the measurement of energy and water consumption.

Here you'll find that assumed annual operation is 750 hours. More specifics are found in Appendix F to Subpart B of Part 430—Uniform Test Method for Measuring the Energy Consumption of Room Air Conditioners, which references  ANSI/AHAM RAC-1-2015
Room Air Conditioners, the testing standard that manufacturers need to follow when developing the numbers that go on the label.