Interfacing with USB connector in simulation
I'm afraid the answer to your question is that this is most likely not possible.

If you describe your system and goals in more detail, someone may suggest a possible alternative. A few doubts and questions that come to my mind are (sorry if I've totally misunderstood your situation):


What simulator are you using? 
Do you really have a working model for the USB controller? USB devices are usually a microcontroller running a nontrivial amount of code, which is very complicated to simulate at the level of Spice, or even Verilog.
If you do have a working simulation, how fast does it run? PC USB drivers are time-sensitive and will expect quick responses from the USB device.  I would expect a behavioral simulation of a microcontroller running code from a ROM to run on the order of 10 minutes real time per 1 millisecond simulation time.