DAC controlled constant current source
The LT3092 itself is designed for full-floating applications -- the only reason the application circuit you mentioned is GND-referenced is because it's assuming a GND referenced DAC output.  Using an isolated DAC output that floats with the rest of the regulator is the conceptually simplest way around this:







simulate this circuit &ndash; Schematic created using CircuitLab

Caveats:


U2 needs to be a low-power digital isolator solution (phototransistor output optos are too piggy) that can run off of 2.7-3V
R1 and R2 are a matched pair -- and should be the best matched resistor pair you can get your paws on
I wasn't able to fit all the decoupling caps in the above schematic -- C1 is the regulator output cap, and C2 and C3 are representative decoupling caps.
The Iq of the ICs flows into the load, limiting the minimum current (this is true for the LT3092 by itself with its 500&micro;A Iq -- I picked the parts to not add to it significantly.
Vin needs to be at least 3V higher than the desired minimum voltage at Iout in order for stuff to work.
The LTC2641 can be replaced with another suitable (2.7-3V operation, low power, SPI compatible, unipolar 0-VREF output with a min 2V VREF) DAC, and the LT6656-2 can be replaced with any other suitable 2.048V reference
2V references aren't a thing, so we use a 2.048V ref instead -- this introduces a portion of the high end of the DAC's range that isn't quite usable unless you want to trim the R1/R2 divider -- you may wish to introduce a trim there anyway to deal with Iq issues as the LT3092 will lose regulation if you try to ask it to flow less current than its own Iq. (i.e. a low end trim)
U3 needs to be a low-Iq (preferably MOS-pass-device), high voltage (needs to withstand max Vin-Vout differential for the circuit), low noise, low dropout regulator -- these are rather hard to find. (Most micropower PNP LDOs consume way more than their Iq when starting up, and most MOS LDOs aren't high voltage capable.)  It also helps if it's stable with ceramic caps -- if C1 being piezoelectric turns out to be a bother, a film cap can be subbed for it penalizing naught but space.
Analog isolators were considered briefly, but accurate/precise analog isolation is far harder than accurate/precise DAC outputs, and consumes more power as well