Simple OTP/Fuse circuit
Sure, just use really low current fuses. You can find them as SMD package toos, in the 50mA range, more or less. A general purpose transistor can blow them without issues.
Or, in a production environment, a single jumper wire to physically cut works too!
For a more, well, 'sophisticated' way you can make a poor man antifuse essentially burning a component of your choice (VGS breakdown comes to mind). Not really elegant but it works.