TUSB2046B crystal not oscillating
ESR of 80 Ohms might ask for too much of negative resistance from the circuit, and the oscillator won't start. You might need to reduce or remove the R78 resistor.

Also keep in mind that if the hub is not connected to active host and is not enumerated, it will fall into SUSPEND mode in 3 ms time frame, and the oscillator might stop. The oscillator is usually shut down to meet low-power requirement in USB SUSPEND mode.

To get out of the SUSPEND, a simple method is just to keep the upstream D+ shorted to ground, emulating the USB_RESET bus condition. When seeing the USB_RESET on the bus, every USB device must wake up, and the oscillator should start.