Connecting i2c slaves to master over RJ45 style cable?
If "daisy-chaining" means that data will come in on "I2C0" and be repeated out "I2C1", you shouldn't have many problems other than your slaves being too busy responding to interrupts to measure anything.

"Daisy-chaining" could also mean bussing them.

In either case, consider raising your voltage and/or using a buffer/line-driver (at least between the longest runs). This approaches a redesign of RS-232.

Simple and might be good enough:







simulate this circuit &ndash; Schematic created using CircuitLab