Using multiple 4N25 optocouplers - Approach for compact PCB design?
Yes, there are quad optoisolators (one 16-pin package, either surface-mount (0.1&quot; or 0.05&quot; pitch) or old-fashioned DIP).

Just go to your favorite parametric search engine, such as Digikey's and select 4 channel optoisolator.
Product Index&gt;Isolators&gt;Optoisolators - Transistor, Photovoltaic Output
Around 150 choices with different packages, CTRs, voltage ratings etc.