USB-C replacing 6-Pin FTDI Header
Firstly I would strongly advise against this - it will be completely electrically incompatible with USB-C, meaning accidentally connecting it to a USB host or device would be potentially damaging to both.
There are other reversible connectors available, including simple dual row pin header, which would allow physical identification that it is not intended to be used with a USB-C ecosystem along with mechanical prevention of doing so.
If this is more than just a personal hobby project - i.e. you plan to make a product that others will use - then I can't stress strongly enough that this would be a bad idea.

If you wish to continue, yes you can repurpose the connector as shown. Again you would need to make sure you only connect it to something expecting your completely different usage.
The only thing you could change is to connect CTS to the Rx1+/Rx2+ pins for extra flexibility. You could add a simple jumper of you want it connecting to GND.