Guidelines for twist cables
With an unbalanced signal i.e. signal and ground rather than + &amp; - signal wires, twisting the signal and ground will just couple more ground-wire current into your signal (by magnetic coupling). If this 0V current is power taken by some unspecified load then it will create interference.

At best it won't make a difference. At worse you could create a lot of noise on the signal and maybe even damage something. Best way with single-ended signals is to use coax.