How can I meet these PCB design conductivity/isolation requirements?
You need to consult your PWB laminate supplier and Process Engineer to ensure the solder mask and cleaning process can prevent contamination from affecting this value.  

The copper resistance is pretty straight forward with copper weight per area  and track width / length tables. However 3 Ω is fairly easy to accomplish with a welded stud, star washers//nuts/crimp lug / contacts + copper tracks. You need to take care about insulators and contact corrosion, but this is much easier than 100 MΩ.