ARM Cortex reset button and debug interface (SWD)
Discharge energy of a 100nF capacitor at 3.3V is roughly 550 nanoJoules. That's not a lot.

The debug interface will probably have strong drivers or an open collector that will cope with this. It has to be fairly robust in order to survive ambient electrostatic discharge while not plugged in. If that's a recommended circuit or one used by someone else then I'm sure it will be fine. If you're really worried put another one of those 22R in series with it; you can swap it later for 0R on the PCB if you want.