Re-purpose USB cable to carry I2C
There should be no problem.  The original Nunchuk for the Nintendo Wii game system connected to the Wii Remote via a 1 to 1.2m (3.5 to 4 feet) long cable, very similar to a USB cable (six pin connector, but only four were used). The Nunchuk contained a a 2-axis joystick, two buttons and a 3 axis ±2g accelerometer and used a I2C interface to communicate with the remote, running at 100 kHz as documented here and here.  Sparkfun even sells a little breakout board for hobbyists building their own interfaces.