Differential Amplifier with voltage divider for reference voltage
Either buffer the reference voltage, OR:

Consider the Thevenin equivalent of your reference circuit.  It's 2.5V with an impedance of 5K by inspection.  If you added that to your diff amp you would have 15K in the non-inverting input branch and 10K in the inverting input branch.

That would destroy your common-mode rejection, so you would want to replace R2 with a 5K resistance (Maybe 2 10K resistors in parallel) to keep the CMR from degrading.

Note that the CMR degrades rapidly if the resistor matching isn't good.  Off the top of my head I think the best you can do over tolerance with 1% resistors is about 48dB.  So if you need better consider using 0.1% tolerance resistor.

Also, you have a 0.1uF cap across R4, which will ruin your AC common mode rejection.  If you need AC CMR consider putting the same capacitance across R1, or removing the cap and filtering in a later stage.