Can a 4051 Multiplexer accept +/- 12v bipolar power
I suggest to have the audio signal centered at 6V and power the 4051 with GND and 12V (it works with voltage supply up to 15V) and use a simple level shifter from 5V TTL to 12V (either inverting as shown in the diagram below or non-inverting; whatever suits better) for the logic signals.







simulate this circuit &ndash; Schematic created using CircuitLab