RGB interface with MCU
I believe you can directly interface the pins with your microcontroller, but I don't think it will work. Here's why and why not:

Why:
Electrically, you're hooking up a large number of I/O signals between two devices. As long as these are both at the same voltage (3.3V in this case), you can certainly get data from point A to point B without breaking anything.

Why Not:
However, this is a 24-bit RGB interface which is a large parallel interface. You'll note that you have a clock and some sync signals on the interface as well. Display timing is very important -- you have 800*480 pixels to drive on that display. So to set one pixel, you must setup 24-bits of information on the wires (say you output white pixel, so 0xFF, 0xFF, 0xFF). Then you must clock in that data / indicate where on the panel that should appear. Then you need to repeat this process 383,999 remaining pixels.

Now, I note that there is no minimum clock frequency specified in the controller datasheet -- if this is just updating a logo every now and then, and it's acceptable to draw it slowly, you could potentially bit-bang that stuff out. But note that the datasheet expects a typical operating frequency of 40MHz -- that's all but impossible to bit-bang out of a microcontroller that has anything else to do.

If you find a processor with a dedicated LCD controller peripheral, it will likely offer a DMA or similar interface where it will take care of clocking data from memory to the display, instead of consuming CPU cycles to meet timing + get the data to the display.