STM32 MCU PCB layout review (crystal & decoupling & ADC)
220 ohm pull-up on NRST is too strong. Usually there is no pull-up at all, as the chip contains an internal pull-up. But I would leave the place for the resistor but not mount it so maybe a 10k can be put there later if necessary.

Don't put both pull-up and pull-down on BOOT0 pin. If you don't plan on using the built it bootloader and will only program via JTAG/SWD then you can just ground the BOOT0 pin or leave the 10k there.