Questions about differential probes
Here's what our probe experts had to say:

Yes! You can use the N2752A differential probe for single-ended measurement. There are two ways you can make single ended measurement with the N2752A. 


Connect the – input of the probe to signal ground and + input to the signal, and select the probe input mode to single-eneded.
The N2752A offers what we call "InfiniiMode" – it can do all three: differential, single-ended and common mode. Use either a solder-in tip or a socketed tip to use InfiniiMode. Connect the ground input to the signal ground, and either +,- or both signal inputs to two input nodes of differential signals. Select the InfiniiMode input on scope to ‘Single ended A’ or ‘Single ended B’. You then can look at either + side or – side of the differential signal.


For question 2:

You are right. With a 10:1 attenuation ratio probe, 50 V input to the probe is attenuated down to 5V and is fed into the input of the scope. With 5V max input on the scope, you may want to choose a probe with higher than 10:1 attenuation ratio such as 20:1 or 50:1 to ensure the voltage input to the scope stays within the max input range of the scope. 

But the problem is that a 50 ohm terminated active probe with >10:1 attenuation ratio is hardly found in the market. Most of the high voltage probe is 1 Mohm terminated. Does your scope have only 50 ohm input? If so, one way to get around is to use a high impedance adapter to the input of the scope, turning input impedance of the scope to 1 Mohm from 50 ohm. Then you may choose a variety of high voltage probe terminated into 1 Mohm.