Using a TFT display that has no controller
The datasheet seems pretty thorough, and the core functionality looks pretty straightforward. Once everything is set up, you clock in RGB values one pixel at a time. First you go across a row, then down a column.The relevant control signals are:

DR[7:0] - 8-bit red value for the current pixel
DG[7:0] - 8-bit green value for the current pixel
DB[7:0] - 8-bit blue value for the current pixel
DCLK - When this goes high, the pixel data is latched. When it goes low, the LCD switches to the next horizontal pixel
DE - When this is high, pixel data can be latched. I think when it goes low the LCD switches to the next row, but I'm not sure whether it's independent of DCLK.
U/D - Selects whether to go up or down a row when DE toggles
R/L - Selects whether to go left or right a pixel when DCLK toggles

So the basic flow will be (from the start of the first row)

Initial conditions: DE=1, DCLK=0
Step 1: Set the RGB values for the pixel via DR, DG, and DB.
Step 2: Drive DCLK high to latch the RGB values.
Step 3: Drive DCLK low to select the next pixel in the row.
Step 4: Repeat steps 1-3 800 times total to set every pixel in the row.
Step 5: Drive DE low to select the next row.
Step 6: Drive DE high to enable pixel writes.
Step 7: Repeat steps 1-6 600 times total to cover every row.

There are lots of timing constraints on these steps. Section 5 has the specs for those.
There are some other control signals, voltage references, and a serial interface. I'm not sure what the serial interface is for, but I didn't look very thoroughly. None of them looks terribly complicated.
All that being said, using this LCD will be very difficult. This is a complex mixed-signal system. Plus, as described in section 4a, you need six separate voltage supplies. There are some example schematics for switching regulators in section G, but each of those is a project in itself.
Studying the datasheet could be very educational, but I don't recommend this as a project for a beginner.