H Bridge not working on HV
The GND on the MCU, IR2110, and H-bridge all need to be shared. If any one of those is disconnected from any other, then things won't work. So if you disconnected you H-bridge GND (shown in your schematic which would be the negative terminal of your smoothing capacitor after the rectifier) from the GND on your MCU and gate-driver, reconnect them

The gate-driver and MCU need to share GNDs so they have a common reference with which to communicate with each other, and your gate driver needs to share the GND with your H-bridge since it is assuming the source is at GND when it tries to drive the low-side MOSFETs (since it is trying to use a GND referenced voltage to produce a gate-source voltage difference).