16 bit RGB to vga converter circuit
Is this a good method? - well it's not production worthy, but if you learn something from it then it's probably good.

You don't give enough information so we all have to make assumptions, but you claim to have something almost working and you indicate you have your suspicions as to what is wrong so I'll use this as a learning opportunity.

Just don't try to put this into production ...

You suspect that the VGA input is loading the resistor network. You're right, The standard procedure then would be to put a voltage buffer between the R-2R network and the VGA input.  Choose a nice R-R (rail to rail) amplifier that is fast enough and put it on a clean supply.  Make sure it's input impedance is high so this it doesn't load the R-2R network also.

The other issue you will have is the noise from the Logic levels in particular the power supply noise on the MSB will drive straight into the VGA inputs, you'll see ripples going through your screen.  i.e. your PSRR will be 0 dB )or close enough) Simply put a digital buffer on the input that has a separate clean power supply, (shared with the O/P amplifier).  Slow down the edges on the input and output just to keep things well behaved.

This should work fairly well.  All the hand wringing about resistor accuracy is for the most part only important if you are looking for reproducibility from unit to unit.  The INL will be dominated by the resistor accuracy, and the reproducibility of the DNL will be dominated by the resistor mismatch.  But it is guaranteed to be Monotonic and given the human eye insensitivity to display gamma this should be mostly passible.  And yes, you may have posterization in your colour tones (i.e. the shading transitions will noticeably weird).

I've dropped a number of terms in here to help guide your research, INL, DNL, Monotonic and Gamma, look them up, understand them.

Exploring techniques and topologies, and learning the limits and why things are done the way they are and how they fail is an important way to learn.