defining node multicolumn layout with twig template
Make a copy of node.html.twig and rename the copy to node--[content-type-name].html.twig which goes inside your theme's template folder.

Then in node--[content-type-name].html.twig find and delete {{ content }} and instead in there you put 

{{ content.title }} 
{{ content.body }} 
{{ content.field_name }}


This is how you can render your fields individually. 

Then, you can wrap them inside an id or class divs. Ex:

&lt;div class="something"&gt;{{ content.field_name }}&lt;/div&gt;
&lt;div class="something-else"&gt;{{ content.field_name_other }}&lt;/div&gt;