Disable opcache.use_cwd for Drupal
It really depends on your server and Drupal sites setup. 

opcache.use_cwd=0 can ONLY be used if you can ensure that there is no duplicate filenames in the PHP files that the server PHP engine may run.

Note that PHP files are not only those with .php extension, but any of them that begin with the php symbol, like .module, .inc, .install, .tpl.php and so on (whatever extension could be used really).

There are a lot of Drupal setups where these duplicate filenames exists, so opcache.use_cwd=0 must not be used, like:


Overriden core tpl files from your custom theme or sub-theme.
Multisite configurations, or multiple drupal installations running in the same PHP engine.


Note that in a single PHP engine, OpCache (if active) is shared between ALL the PHP files that are running on it, so name collisions will happen if any filename is duplicated, if the subdirectory info is not appended.