Module to turn on/off the whole block region
I don't have a single great suggestions. Here are a few things that come to mind.


Wrap all the blocks in a single block. This way you could make a few "block groups".
Just don't use the block system. It's not very good. My personal favourite block handling mechanism is Panels (Everywhere) and Page manager
Panels Everywhere is capable of killing the entire block system. A peek into it's codebase could probably reveal how to do it on a region by region basis.