Re-creating complex CSS footer layout in Drupal
I'd set up one region for those menus, in that region have 3 x menu blocks (http://drupal.org/project/menu_block), 1) Who Are You, 2) Quicklinks 3) Admissions.

CSS will be your friend to get the required layouts.

The "Who Are You" menu should be easy, float the menu block left and fix the width. The same for the "Admissions" menu.

The middle menu will be similar but all you need to do is have a wider fixed width menu block, fix the width of the menu items and float them left. Then you'll have to order the menu items to make them appear in the correct columns.

The text below the menus should simply be 2-3 more standard text blocks just styled appropriately.

I hope this makes sense. I'll be interested to see how other developers would attack this.

Cheers.