Print message only if checkbox field is alter using form alter
You can use form_state instead of form in your submit handler and use default_value of check box in your form alter

$form['account']['checkbox'] = array(
    '#type' =&gt; 'checkbox',
    '#title' =&gt; 'Test check',
    '#default_value' =&gt; 0,
   );


and then your submit handler will go like this

function module_simplenews_unsubscribe($form, &amp;$form_state) {

  if ($form_state['values']['checkbox'] == 0) {
    drupal_set_message(t("You are checked"));
  }
 if ($form_state['values']['checkbox'] == 1) {

    drupal_set_message(t("You are unchecked"));
  }


Use debug tools for proper index of form_state for checkbox.