Module to view node in a grid layout with the ability to quickly change the reference
You don't really need a module - just some css.
If you are using the views module to create your html then something like this should suffice:

.view-content .views-row {
    display: inline-block;
    margin: 0 20px 10px 0;
    vertical-align: top;
    width: 207px;
    font-size: 0.8em;
}
.view-content .views-row img {
    width: 170px;
}
.view-content .views-row-1 {
    font-size: 1em;
    width: 439px;
}
.view-content .views-row-1 img {
    width: 350px;
}


Here is an example in jsfiddle: http://jsfiddle.net/42LHW/3/