Delete a block of all layouts
here it is, tried it with a custom content block and a views block

i executed the code in php/devel from devel_php module

$storage = \Drupal::entityTypeManager()-&gt;getStorage('entity_view_display');
foreach ($storage-&gt;loadMultiple() as $display) {
  foreach ($display-&gt;getSections() as $section) {
    foreach ($section-&gt;getComponents() as $component) {
      // Custom views block
      // $to_delete_plugin_id = 'views_block:my_news-block_1';
      // Custom block
      $to_delete_plugin_id = 'block_content:fb4ad848-0f3c-4296-a6ba-1a9da886335b';
      if ($component-&gt;getPluginId() == $to_delete_plugin_id) {
        $section-&gt;removeComponent($component-&gt;getUuid());
        $display-&gt;save();
      }
    }
  }
}


for a particular node :

// This can be adapted to be used for a set of nodes
$node = node_load(42);
$display = $node-&gt;layout_builder__layout;

foreach ($display-&gt;getSections() as $section) {
  foreach ($section-&gt;getComponents() as $component) {
    // Custom views block
    // $to_delete_plugin_id = 'views_block:my_news-block_1';
    // Custom block
    $to_delete_plugin_id = 'block_content:fb4ad848-0f3c-4296-a6ba-1a9da886335b';
    if ($component-&gt;getPluginId() == $to_delete_plugin_id) {
      $section-&gt;removeComponent($component-&gt;getUuid());
      $node-&gt;save();
    }
  }
} 


Hope this helps :)