How to make a whole block clickable?
Here's a possible solution. In your view, exclude all fields add field 'Global: Custom text'. You may also have to add fields to generate the appropriate path to the user profile.

Then, add the token replacement patterns for the excluded fields. You can either 1) wrap this output in an anchor with the appropriate path /user/[uid] (a field you may have to add, or you may be able to use the user's alias), or 2) in the rewrite section, tick 'Output this field as a link' and specify the path there (also use replacement patterns from UID or the alias).