Add a block to a region
The Drush extras project has commands for administering blocks.

Short instructions (following their README.txt):


Install this Drush add-on:

drush dl drush_extras

Determine desired module name and delta of block, and the desired region name and weight for adding the block:

drush block-show

Add the block to the region:

drush block-configure --module=block_module --delta=block_delta \
  --region=region_name --weight=-12



More instructions via:

drush help block-show
drush help block-configure
drush help block-disable