Can I create a drush make file and installation profile from existing site?
Profiler and Profile Builder, while useful, are for building a new profile using tools and libraries.  If you would like to convert an existing site into an installation profile, please see: 

http://drupal.org/node/1368242

This issue contains a Drush command to build a Drupal 7 installation profile from an existing site.  The issue is marked as "needs work" because the code templates for Drupal 6 are not in place yet, but if you're working on a D7 site, it should do the trick for you.