Run Drush command with Gulp
Try:
The first thing you’ll need is to import the dependency for “child process.” Next, you’ll want to set up an array variable containing all the paths to files you want auto-cache clearing setup for. This will basically be any Drupal template file. I would start with the main template directories you know you need it set up for and then add the additional paths along the way. Once we have our variables set, we then build our “clearcache” task using the “child_process” dependency that is shown below. Once we have all the pieces setup, we combine them in a watch task and let the magic happen! Using this task in your workflow will save you so much time, and even more importantly, save you the headache of clearing your cache every 2 minutes.
If you do run into some issues having your task running, make sure your Drush is setup and working in your command line as these Gulp task relies on Drush to complete its work.
code:

var cp = require('child_process');
var drupal_files = "paths/to/your/drupal/files/you/want/auto-cache-clearing";
 
// Clearcache Task
gulp.task('clearcache', function(done) {
  return cp.spawn('drush', ['cache-rebuild'], {stdio: 'inherit'})
  .on('close', done);
});
 
gulp.watch(drupal_files, ['clearcache']);

Source: http://serversideguy.com/2018/02/05/how-can-i-automatically-clear-cache-for-drupal-using-gulp/