How to style a view in Omega
Yes, Views Column Class is the best way to do it in my experience.

All you need to do is set the row class to an alpha grid class, and the number of columns for the display mode you're using, e.g.



and the module will take care of adding the alpha/omega classes to the appropriate elements on your page, giving you properly responsive views for very little work.

It's worth remembering that a 'row' in the context of a floated list is each individual item, not a row of x number of elements. So when you apply grid-4 etc, it's applied to each individual element, not the whole row. It can be confusing at first.