Use orConditionGroup with query (non entity)
I was able to get it to work by added the select method to the connection object like so:

$orConditionGroup = $connection-&gt;select($table)
                    -&gt;orConditionGroup()
                    -&gt;condition('address', $fulladdress, '!=')
                    -&gt;condition('full_name', $fullname, '!=')
                    -&gt;condition('telephone', $workphone, '!=');