advise for managing and troubleshooting modules
Unchecking the module does not uninstall it, it is just disabled. The schema related to the module is only removed when it is first disabled and then uninstalled.

If disabling and then enabling can solved your issues then do it.

But disabling and then enabling a module would not do any thing harmful except to remove and then add its record in system table and would invoke few hooks like hook_menu, hook_theme etc.