Widgetkit Drupal alternative
Check out the Photowall project to see if it matches your requirements out of the box.

From the project page:


  Provides a Photowall (like Google) format for displaying images, using the JQuery Photowall plugin.


There is a nice demo showing what it does at the  JQuery Photowall link.

If it is not advanced enough for your tastes, I have another idea:

Since most of the power of the YooTheme Widgetkit for Joomla and Wordpress is provided by Javascript that runs in the browser and that should work just as well when it is launched from Drupal instead of Joomla/Wordpress, it should not be too hard to adapt the Drupal module Photowall to make use of the YooTheme Widgetkit Javascript plugin, instead of the JQuery Photowall Javascript plugin (but it will obviously require some custom development).