Reloading JavaScript only
A possible solution is entering the following code into the console, where "xxx" is a part of the name of the script you want refreshed, and "yyy" its exact adress; the string after the question mark has to be changed each time to force Chrome not to cache it.

jQuery("[src*=xxx]").replaceWith('&lt;script type="text/javascript" src="http://yyy?m2fua6ijsufsds"&gt;&lt;/script&gt;')


It could probably make for a nice useful mini module, which would provide a button/shortcut that would automate the call.