Ensure that all Cron jobs work correctly
Maybe.

Considering there are 20 cron jobs and they all run 15 times a day and you’re using advanced queue, I would make sure to test in your production environment timeouts and memory issues. 

Personally I would use cron + drush making sure the php.ini for command line PHP has more than enough resources to accommodate whatever it is you’re doing. 

drush cron-run


https://cgit.drupalcode.org/ultimate_cron/tree/ultimate_cron.drush.inc?h=8.x-2.x#n77