Multisite setup with drush
For the first site:

drush qd --sites-subdir=&lt;directory name&gt;

For each successive site:

cd DRUPAL_ROOT_CREATED_ABOVE
drush qd --use-existing --sites-subdir=&lt;directory name&gt;


These will create sqlite databases.  Add --db-url with valid database credentials to use a pre-existing database.  Also add --db-su and --db-su-pw to make Drush create the database for you.

Haven't tried some of the steps in this workflow in a while; report any problems back in the Drush issue queue.  Also, you might want to use drush master instead of 6.x.  There's a issue in the queue that hasn't landed yet that makes drush qd better.

UPDATE: Drush quick-drupal does not appear to be well suited for multisite usage.  For subsiquent sites, call drush site-install with --sites-subdir and --db-url options.  See drush help si for more information on options that may be useful here.

For example

drush si --sites-subdir=&lt;folder&gt; --db-url=mysql://db_user:str0n6passw0rd@localhost/db_name