Restricting view to content associated with user profile
What you're wanting is a contextual filter for your view. Create a node view with a block display and in the Advanced section under Contextual Filter click the Add button. 

From there you can add Content: Author uid which will tell the view to filter by author UID. On the popup modal, under the WHEN THE FILTER IS NOT.... fieldset, select Provide default value with Type of Raw value from URL and Path component of 2. This essentially tells the view to pull the UID from Drupal's internal path (i.e. the XXX in /user/XXX when viewing a user page).

After saving the view, you should be able to place it your region to display against user profile pages.