How do I get a user profile's picture from entity_metadata_wrapper()?
You can get the information about user picture indirectly as follows:

$user_picture = $user_wrapper-&gt;value()-&gt;picture;


I said indirectly, since the picture object itself is not an entity wrapper anymore, so you cannot chain it further using entity_metadata_wrapper functions. However, it should have all the information you need about the user picture, like the fid, filename, uri, filemime, filesize, metadata, and any other fields that could be attached to a file, for instance using File Entity module.