How does oxygen deprivation affect neural activity?
A stroke results in impaired blood flow. A lack of blood supply to the brain results in prolonged cortical hypoxia, cells die. Neuronal cells have a relatively high background metabolism, for example because of their reliance on ion pumping that costs energy. A lack of oxygen can kill a cell and therefore deplete the brain of thousands and thousands of neurons after a serious stroke. Depletion of certain areas of the brain of cells will reduce the output to other areas, and decrease the input to that area. Moreover, epileptic foci may appear, resulting in epileptic discharges in the brain, referred to as post-stroke seizures. 

Upon recovery, gross rearrangements may occur in the brain, alongside gross changes in cellular activities throughout the affected areas, due to the brain's plasticity.

Having said that, if the oxygen depletion is short, I don't see any reason why there should be gross changes in neuronal behavior after recovery.