Is there any research about effect of unfamiliar environment on stress?
I have found the following

Older people's cardiac responses as indicators of stress in familiar and unfamiliar environments (Lewis &amp; Phillips, 2012)

I also found:

Padilla, A. M., Alvarez, M., &amp; Lindholm, K. J. (1986). Generational status and personality factors as predictors of stress in students. Hispanic Journal of Behavioral Sciences, 8(3), 275-288.
DOI: 10.1002/dev.420220608


  stressful events center on loss of familial and cultural ties as well as on relative discomfort in an unfamiliar social environment


References

Lewis M. J. &amp; Phillips J. E. (2012). Older people's cardiac responses as indicators of stress in familiar and unfamiliar environments. Psychophysiology, 49(4): pp. 478-483
DOI: 10.1111/j.1469-8986.2011.01321.x PMID: 22176515