What are the differences between Orch OR and Hartley's vibratiuncles?
As far as I can tell, the common theme is that "vibration" is involved in both of them. But that's where the similarities seem to stop.

Hartley formulated specific hypotheses such as


  Pleasure is the result of moderate vibrations, pain of vibrations so violent as to break the continuity of the nerves. 


which we now know it's not exactly how these sensations are differentiated, but actually wasn't a bad prediction given the scientific knowledge at the time.

On the other hand Hartley postulated these vibrations to be transmitted by ether, which of course we now know does not exist.

Microtubules are real, but whether quantum vibrations in them have anything to do with consciousness is another matter. As far as I know there's no convincing evidence for it. The Orch OR article on Wikipedia discusses some theoretical criticism as well.