Albacore wheel not supported on this platform (Mac OS X El Capitan)
Not sure about conda as I don't use it, but I can highly recommend pipenv which is the python.org recommended package management system for python.  

I have tested the following on my Mac and it worked like a dream  

mkdir albacore &amp;&amp; cd albacore
mv ../ont_albacore-2.1.10-cp36-cp36m-macosx_10_11_x86_64.whl .

# install pipenv if you don't have it
brew install pipenv  # or pip3 install pipenv

# the following will create a virtual environment and install albacore into it
pipenv install ont_albacore-2.1.10-cp36-cp36m-macosx_10_11_x86_64.whl

# activate the virtual environment
pipenv shell

read_fast5_basecaller.py -h


And that should bring up the albacore help menu and you're ready to go.