Doubt about using TPM for statistics
This is a common question, and the answer is while you can calculate this, it's not statistically robust.
You're likely to arrive at false conclusions.
Why is this?
Because while TPM is something you can calculate from a single sample, your question involves multiple replicates and those replicates vary between each other.
Counts in units of TPM are missing information about the variation between samples.
This extra information affects fold change estimates, and is why differential analysis of sequencing data is complicated.
See this answer to a related question, and this often-cited blog post for more information.