cooler out of memory
It seems to be some kind of a memory leak in pandas's read_csv, maybe due to it doing gzip-decompression.

Doing the decompression in a separate process and piping the result into cooler cload pairs should do the trick.

gzip -dc GSE109344_monkey_fibro_allValidPairs.txt.gz | cooler cload pairs -c1 2 -p1 3 -c2 5 -p2 6 /data/chromInfo.rheMac2.
simple.txt:${BINSIZE} - /data/${FILE}.cool