PLA infill/perimeter-layer to mimic real bone hardness
Generally, if you care about achieving a specific structure inside the "interior" part of a model to be printed, that structure needs to be part of your model rather than generated by a slicer. If it were me, I would programmatically generate a generic pattern for the pockets of hollowness in OpenSCAD over a region slightly larger than the bone, then subtract it from the solid bone. After that, slicer settings will be mostly irrelevant since it will be constrained by reproducing the layer outlines with lots of holes in them.

I haven't done this, or anything really comparable, but it should work.