MakerBot replicator 2x glitches
I don't have a profile that has settings for the dissolvable filament anymore, but this is one I use for thin layers (second extruder at 232C my first extruder isn't working so just ignore that one).

You may want to try printing small simple objects with each extruder independently first to confirm that you have good settings, then try both together after you know you have good settings. ABS is a pain but mostly for warping and sticking to the build plate. The dissolvable filament I believe is PLA if you're using Makerbot materials.

{
       "_attached_extruders" : [ "mk8", "mk8" ],
       "_bot" : "replicator2x",
       "_extruders" : [ 0 ],
       "_materials" : [ "abs", "abs" ],
       "adjacentFillLeakyConnections" : false,
       "adjacentFillLeakyDistanceRatio" : 0,
       "anchorExtrusionAmount" : 5.0,
       "anchorExtrusionSpeed" : 2.0,
       "anchorWidth" : 2.0,
       "backlashEpsilon" : 0.050,
       "backlashFeedback" : 0.90,
       "backlashX" : 0.0,
       "backlashY" : 0.090,
       "bedZOffset" : 0.0,
       "bridgeAnchorMinimumLength" : 0.80,
       "bridgeAnchorWidth" : 0.80,
       "bridgeMaximumLength" : 80.0,
       "bridgeSpacingMultiplier" : 1.0,
       "coarseness" : 9.999999747378752e-005,
       "commentClose" : "",
       "commentOpen" : ";",
       "computeVolumeLike2_1_0" : false,
       "defaultExtruder" : 0,
       "defaultRaftMaterial" : 0,
       "defaultSupportMaterial" : 0,
       "description" : "External Definition",
       "doAnchor" : true,
       "doBacklashCompensation" : false,
       "doBreakawaySupport" : true,
       "doBridging" : true,
       "doDynamicSpeed" : false,
       "doDynamicSpeedGradually" : true,
       "doDynamicSpeedInteriorShells" : false,
       "doDynamicSpeedOutermostShell" : true,
       "doExponentialDeceleration" : false,
       "doExternalSpurs" : true,
       "doFixedLayerStart" : false,
       "doFixedShellStart" : true,
       "doInfills" : true,
       "doInsets" : true,
       "doInternalSpurs" : false,
       "doMixedRaft" : false,
       "doMixedSupport" : false,
       "doOutlines" : true,
       "doPrintLayerMessages" : false,
       "doPrintProgress" : true,
       "doPurgeWall" : false,
       "doRaft" : true,
       "doSplitLongMoves" : true,
       "doSupport" : true,
       "doSupportUnderBridges" : false,
       "endGcode" : "",
       "exponentialDecelerationMinSpeed" : 0.0,
       "extruderProfiles" : [
          {
             "bridgesExtrusionProfile" : "bridges",
             "feedDiameter" : 1.820000052452087,
             "feedstockMultiplier" : 0.9300000000000001,
             "firstLayerExtrusionProfile" : "firstLayer",
             "firstLayerRaftExtrusionProfile" : "firstLayerRaft",
             "floorSurfaceFillsExtrusionProfile" : "floorSurfaceFills",
             "infillsExtrusionProfile" : "infill",
             "insetsExtrusionProfile" : "insets",
             "layerHeight" : 0.20,
             "maxSparseFillThickness" : 0.20,
             "nozzleDiameter" : 0.40,
             "outlinesExtrusionProfile" : "outlines",
             "raftBaseExtrusionProfile" : "raftBase",
             "raftExtrusionProfile" : "raft",
             "restartExtraDistance" : 0.0,
             "restartExtraDistance2" : 0,
             "restartExtraRate" : 25.0,
             "restartExtraRate2" : -1,
             "restartRate" : 25.0,
             "restartRate2" : 25,
             "retractDistance" : 1.700000047683716,
             "retractDistance2" : 0,
             "retractRate" : 25.0,
             "retractRate2" : 50,
             "roofSurfaceFillsExtrusionProfile" : "roofSurfaceFills",
             "sparseRoofSurfaceFillsExtrusionProfile" : "sparseRoofSurfaceFills",
             "toolchangeRestartDistance" : 18.50,
             "toolchangeRestartRate" : 6.0,
             "toolchangeRetractDistance" : 19.0,
             "toolchangeRetractRate" : 6.0
          },
          {
             "bridgesExtrusionProfile" : "bridges",
             "feedDiameter" : 1.769999980926514,
             "feedstockMultiplier" : 0.9300000000000001,
             "firstLayerExtrusionProfile" : "firstLayer",
             "firstLayerRaftExtrusionProfile" : "firstLayerRaft",
             "floorSurfaceFillsExtrusionProfile" : "floorSurfaceFills",
             "infillsExtrusionProfile" : "infill",
             "insetsExtrusionProfile" : "insets",
             "layerHeight" : 0.20,
             "maxSparseFillThickness" : 0.20,
             "nozzleDiameter" : 0.40,
             "outlinesExtrusionProfile" : "outlines",
             "raftBaseExtrusionProfile" : "raftBase",
             "raftExtrusionProfile" : "raft",
             "restartExtraDistance" : 0.0,
             "restartExtraDistance2" : 0,
             "restartExtraRate" : 25.0,
             "restartExtraRate2" : -1,
             "restartRate" : 25.0,
             "restartRate2" : 25,
             "retractDistance" : 1.399999976158142,
             "retractDistance2" : 0,
             "retractRate" : 25.0,
             "retractRate2" : 50,
             "roofSurfaceFillsExtrusionProfile" : "roofSurfaceFills",
             "sparseRoofSurfaceFillsExtrusionProfile" : "sparseRoofSurfaceFills",
             "toolchangeRestartDistance" : 18.50,
             "toolchangeRestartRate" : 6.0,
             "toolchangeRetractDistance" : 19.0,
             "toolchangeRetractRate" : 6.0
          }
       ],
       "extruderTemp0" : 228,
       "extruderTemp1" : 232,
       "extrusionProfiles" : {
          "bridges" : {
             "fanSpeed" : 0.50,
             "feedrate" : 40.0
          },
          "firstLayer" : {
             "fanSpeed" : 0.50,
             "feedrate" : 10.0
          },
          "firstLayerRaft" : {
             "fanSpeed" : 0.50,
             "feedrate" : 50.0
          },
          "floorSurfaceFills" : {
             "fanSpeed" : 0.50,
             "feedrate" : 40.0
          },
          "infill" : {
             "fanSpeed" : 0.50,
             "feedrate" : 40.0
          },
          "insets" : {
             "fanSpeed" : 0.50,
             "feedrate" : 40.0
          },
          "outlines" : {
             "fanSpeed" : 0.50,
             "feedrate" : 10.0
          },
          "raft" : {
             "fanSpeed" : 0.50,
             "feedrate" : 90.0
          },
          "raftBase" : {
             "fanSpeed" : 0.50,
             "feedrate" : 10.0
          },
          "roofSurfaceFills" : {
             "fanSpeed" : 0.50,
             "feedrate" : 90.0
          },
          "sparseRoofSurfaceFills" : {
             "fanSpeed" : 0.50,
             "feedrate" : 90.0
          }
       },
       "fixedLayerStartX" : 0.0,
       "fixedLayerStartY" : 0.0,
       "fixedShellStartDirection" : 215.0,
       "floorSolidThickness" : 0,
       "floorSurfaceThickness" : 0,
       "floorThickness" : 1.0,
       "gridSpacingMultiplier" : 1.0,
       "infillDensity" : 0.3000000119209290,
       "infillOrientationInterval" : 90,
       "infillOrientationOffset" : 0,
       "infillOrientationRange" : 90,
       "infillShellSpacingMultiplier" : 0.70,
       "insetDistanceMultiplier" : 1.0,
       "jsonToolpathOutput" : false,
       "layerHeight" : 0.1199999973177910,
       "leakyConnectionsAdjacentDistance" : 0.0,
       "maxConnectionLength" : 10.0,
       "maxSparseFillThickness" : 0.1000000014901161,
       "maxSpurWidth" : 0.50,
       "minLayerDuration" : 5.0,
       "minLayerHeight" : 0.010,
       "minRaftBaseGap" : 0.0,
       "minSpeedMultiplier" : 0.30,
       "minSpurLength" : 0.40,
       "minSpurWidth" : 0.120,
       "minThickInfillImprovement" : 1.0,
       "modelFillProfiles" : {},
       "numberOfShells" : 2,
       "platformTemp" : 110,
       "purgeBucketSide" : 4.0,
       "purgeWallBaseFilamentWidth" : 2.0,
       "purgeWallBasePatternLength" : 10.0,
       "purgeWallBasePatternWidth" : 8.0,
       "purgeWallModelOffset" : 2.0,
       "purgeWallPatternWidth" : 2.0,
       "purgeWallSpacing" : 1.0,
       "purgeWallWidth" : 0.50,
       "purgeWallXLength" : 30.0,
       "raftAligned" : true,
       "raftBaseAngle" : 0.0,
       "raftBaseDensity" : 0.6999999880790710,
       "raftBaseLayers" : 1,
       "raftBaseRunGapRatio" : 0.8000000119209290,
       "raftBaseRunLength" : 15.0,
       "raftBaseThickness" : 0.3000000119209290,
       "raftBaseWidth" : 2.50,
       "raftExtraOffset" : 0.0,
       "raftFillProfiles" : {},
       "raftInterfaceAngle" : 45.0,
       "raftInterfaceDensity" : 0.3000000119209290,
       "raftInterfaceLayers" : 1,
       "raftInterfaceThickness" : 0.2700000107288361,
       "raftInterfaceWidth" : 0.4000000059604645,
       "raftModelSpacing" : 0.3499999940395355,
       "raftOutset" : 4.0,
       "raftSurfaceAngle" : 0.0,
       "raftSurfaceLayers" : 3,
       "raftSurfaceShellSpacingMultiplier" : 0.6999999880790710,
       "raftSurfaceShells" : 2,
       "raftSurfaceThickness" : 0.1400000005960465,
       "roofAnchorMargin" : 0.40,
       "roofSolidThickness" : 0,
       "roofSurfaceThickness" : 0,
       "roofThickness" : 1.0,
       "shellsLeakyConnections" : false,
       "solidFillOrientationInterval" : 90,
       "solidFillOrientationOffset" : -45,
       "solidFillOrientationRange" : 90,
       "sparseInfillPattern" : "hexagonal",
       "splitMinimumDistance" : 0.40,
       "spurOverlap" : 0.0010,
       "startGcode" : "",
       "startPosition" : {
          "x" : -112,
          "y" : -73.0,
          "z" : 0
       },
       "supportAligned" : false,
       "supportAngle" : 30.0,
       "supportDensity" : 0.2000000029802322,
       "supportExcessive" : false,
       "supportExtraDistance" : 0.50,
       "supportFillProfiles" : {},
       "supportLayerHeight" : 0.2000000029802322,
       "supportLeakyConnections" : false,
       "supportModelSpacing" : 0.2000000029802322,
       "supportRoofModelSpacing" : 0.4000000059604645,
       "thickLayerThreshold" : 0,
       "thickLayerVolumeMultiplier" : 1,
       "travelSpeedXY" : 150.0,
       "travelSpeedZ" : 23.0,
       "version" : "3.9.4"
    }