Can I replace hotend on Lulzbot Mini 2 with upcoming E3D Hermes?
Yes, E3D has a guide &quot;LulzBot Taz6 Hemera Upgrade&quot; if you'd like to make your own.
The upgrade requires you to print parts beforehand which are found here; note that:

We recommend printing the Hemera Mount in PETG, and the Fan Duct in ABS/ ASA or another high-temperature material.
Use an infill percentage of 25 % or higher.

The Hemera (the new name for the Hermes) toolheads are also available for purchase, e.g. here.