Solve the 15 Puzzle (the tile-sliding puzzle)
PyPy, 195 moves, ~12 seconds computation

Computes optimal solutions using IDA* with a 'walking distance' heuristic augmented with linear conflicts. Here are the optimal solutions:

 5  1  7  3
 9  2 11  4
13  6 15  8
 0 10 14 12
Down, Down, Down, Left, Up, Up, Up, Left, Down, Down, Down, Left, Up, Up, Up

 2  5 13 12
 1  0  3 15
 9  7 14  6
10 11  8  4
Left, Down, Right, Up, Up, Left, Down, Down, Right, Up, Left, Left, Down, Right, Right, Right, Up, Up, Left, Left, Down, Left, Up, Up, Right, Down, Down, Left, Up, Up, Right, Right, Right, Down, Left, Up, Right, Down, Down, Left, Left, Down, Left, Up, Up, Right, Up, Left

 5  2  4  8
10  0  3 14
13  6 11 12
 1 15  9  7
Left, Up, Up, Right, Right, Down, Left, Up, Left, Left, Down, Down, Right, Right, Up, Left, Left, Down, Down, Right, Right, Up, Right, Up, Left, Left, Up, Right, Down, Down, Right, Down, Left, Left, Up, Up, Left, Up

11  4 12  2
 5 10  3 15
14  1  6  7
 0  9  8 13
Down, Left, Down, Right, Up, Left, Left, Left, Down, Down, Right, Right, Right, Up, Left, Left, Left, Down, Right, Right, Up, Left, Up, Up, Left, Down, Down, Right, Down, Right, Up, Up, Right, Up, Left, Left, Left, Down, Right, Right, Right, Up, Left, Down, Left, Down, Left, Up, Up

 5  8  7 11
 1  6 12  2
 9  0 13 10
14  3  4 15
Up, Right, Down, Left, Left, Down, Left, Up, Right, Up, Right, Down, Down, Right, Up, Up, Left, Left, Left, Down, Down, Down, Right, Right, Up, Right, Down, Left, Up, Left, Up, Left, Down, Right, Down, Left, Up, Right, Down, Right, Up, Up, Left, Left, Up


And the code:

import random


class IDAStar:
    def __init__(self, h, neighbours):
        """ Iterative-deepening A* search.

        h(n) is the heuristic that gives the cost between node n and the goal node. It must be admissable, meaning that h(n) MUST NEVER OVERSTIMATE the true cost. Underestimating is fine.

        neighbours(n) is an iterable giving a pair (cost, node, descr) for each node neighbouring n
        IN ASCENDING ORDER OF COST. descr is not used in the computation but can be used to
        efficiently store information about the path edges (e.g. up/left/right/down for grids).
        """

        self.h = h
        self.neighbours = neighbours
        self.FOUND = object()


    def solve(self, root, is_goal, max_cost=None):
        """ Returns the shortest path between the root and a given goal, as well as the total cost.
        If the cost exceeds a given max_cost, the function returns None. If you do not give a
        maximum cost the solver will never return for unsolvable instances."""

        self.is_goal = is_goal
        self.path = [root]
        self.is_in_path = {root}
        self.path_descrs = []
        self.nodes_evaluated = 0

        bound = self.h(root)

        while True:
            t = self._search(0, bound)
            if t is self.FOUND: return self.path, self.path_descrs, bound, self.nodes_evaluated
            if t is None: return None
            bound = t

    def _search(self, g, bound):
        self.nodes_evaluated += 1

        node = self.path[-1]
        f = g + self.h(node)
        if f &gt; bound: return f
        if self.is_goal(node): return self.FOUND

        m = None # Lower bound on cost.
        for cost, n, descr in self.neighbours(node):
            if n in self.is_in_path: continue

            self.path.append(n)
            self.is_in_path.add(n)
            self.path_descrs.append(descr)
            t = self._search(g + cost, bound)

            if t == self.FOUND: return self.FOUND
            if m is None or (t is not None and t &lt; m): m = t

            self.path.pop()
            self.path_descrs.pop()
            self.is_in_path.remove(n)

        return m


def slide_solved_state(n):
    return tuple(i % (n*n) for i in range(1, n*n+1))

def slide_randomize(p, neighbours):
    for _ in range(len(p) ** 2):
        _, p, _ = random.choice(list(neighbours(p)))
    return p

def slide_neighbours(n):
    movelist = []
    for gap in range(n*n):
        x, y = gap % n, gap // n
        moves = []
        if x &gt; 0: moves.append(-1)    # Move the gap left.
        if x &lt; n-1: moves.append(+1)  # Move the gap right.
        if y &gt; 0: moves.append(-n)    # Move the gap up.
        if y &lt; n-1: moves.append(+n)  # Move the gap down.
        movelist.append(moves)

    def neighbours(p):
        gap = p.index(0)
        l = list(p)

        for m in movelist[gap]:
            l[gap] = l[gap + m]
            l[gap + m] = 0
            yield (1, tuple(l), (l[gap], m))
            l[gap + m] = l[gap]
            l[gap] = 0

    return neighbours

def slide_print(p):
    n = int(round(len(p) ** 0.5))
    l = len(str(n*n))
    for i in range(0, len(p), n):
        print(" ".join("{:&gt;{}}".format(x, l) for x in p[i:i+n]))

def encode_cfg(cfg, n):
    r = 0
    b = n.bit_length()
    for i in range(len(cfg)):
        r |= cfg[i] &lt;&lt; (b*i)
    return r


def gen_wd_table(n):
    goal = [[0] * i + [n] + [0] * (n - 1 - i) for i in range(n)]
    goal[-1][-1] = n - 1
    goal = tuple(sum(goal, []))

    table = {}
    to_visit = [(goal, 0, n-1)]
    while to_visit:
        cfg, cost, e = to_visit.pop(0)
        enccfg = encode_cfg(cfg, n)
        if enccfg in table: continue
        table[enccfg] = cost

        for d in [-1, 1]:
            if 0 &lt;= e + d &lt; n:
                for c in range(n):
                    if cfg[n*(e+d) + c] &gt; 0:
                        ncfg = list(cfg)
                        ncfg[n*(e+d) + c] -= 1
                        ncfg[n*e + c] += 1
                        to_visit.append((tuple(ncfg), cost + 1, e+d))

    return table

def slide_wd(n, goal):
    wd = gen_wd_table(n)
    goals = {i : goal.index(i) for i in goal}
    b = n.bit_length()

    def h(p):
        ht = 0 # Walking distance between rows.
        vt = 0 # Walking distance between columns.
        d = 0
        for i, c in enumerate(p):
            if c == 0: continue
            g = goals[c]
            xi, yi = i % n, i // n
            xg, yg = g % n, g // n
            ht += 1 &lt;&lt; (b*(n*yi+yg))
            vt += 1 &lt;&lt; (b*(n*xi+xg))

            if yg == yi:
                for k in range(i + 1, i - i%n + n): # Until end of row.
                    if p[k] and goals[p[k]] // n == yi and goals[p[k]] &lt; g:
                        d += 2

            if xg == xi:
                for k in range(i + n, n * n, n): # Until end of column.
                    if p[k] and goals[p[k]] % n == xi and goals[p[k]] &lt; g:
                        d += 2

        d += wd[ht] + wd[vt]

        return d
    return h




if __name__ == "__main__":
    solved_state = slide_solved_state(4)
    neighbours = slide_neighbours(4)
    is_goal = lambda p: p == solved_state

    tests = [
        (5,1,7,3,9,2,11,4,13,6,15,8,0,10,14,12),
        (2,5,13,12,1,0,3,15,9,7,14,6,10,11,8,4),
        (5,2,4,8,10,0,3,14,13,6,11,12,1,15,9,7),
        (11,4,12,2,5,10,3,15,14,1,6,7,0,9,8,13),
        (5,8,7,11,1,6,12,2,9,0,13,10,14,3,4,15),
    ]

    slide_solver = IDAStar(slide_wd(4, solved_state), neighbours)

    for p in tests:
        path, moves, cost, num_eval = slide_solver.solve(p, is_goal, 80)
        slide_print(p)
        print(", ".join({-1: "Left", 1: "Right", -4: "Up", 4: "Down"}[move[1]] for move in moves))
        print(cost, num_eval)