Write two single line functions to encode and decode base64
Python 2, 437 characters

As a first improvement to your Python solution, you can cut down on the references to the long string of characters 'abc...ABC...0123456789+/':

def fromb64(m):
    return (lambda A:''.join([chr(int(w,2)) for w in [(''.join([''.join([bin(A.index(x))[2:].zfill(6) for x in m if x in A])[y:y+8] for y in range(0,len(''.join([bin(A.index(x))[2:].zfill(6) for x in m if x in A])),8)])+'a')[:-(len(m)-len(m.replace('=','')))*2-1][z:z+8] for z in range(0,len(''.join([bin(A.index(x))[2:].zfill(6) for x in m if x in A])),8)] if len(w)==8]))('ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/')


This is just (lambda A: {{what you did, but with that string replaced by A}})(that string).