Pangram "Hello, World!"
Ruby,  119  112 bytes / score 17

puts [&quot;%x&quot;%((&quot;!\#&amp;+,-01245:;&lt;&gt;?@ABDEFIJKLNOQRUVWXYZ`dflqnry{|}&quot;=~/$/)^&quot;s8j9bePwGp7SgMTCvznH&quot;.to_i(36))].pack'h*'

Try it online!