The 3x3 Hexa Prime Square Puzzle
05AB1E, 23 21 bytes

Uses CP-1252 encoding.

œJvy3ôD€SøJìHDps2›*P—


Too slow for TIO.

Explanation

œJ                     # all permutations of input as strings
  v                    # for each permutation
                       # EXAMPLE: 2E3815DD5
   y3ô                 # split in pieces of 3
                       # EXAMPLE: ['2E3','815','DD5']
      D                # duplicate
                       # EXAMPLE: ['2E3','815','DD5'], ['2E3','815','DD5']
       €SøJ            # zip the copy to swap rows and columns 
                       # EXAMPLE: ['2E3','815','DD5'], ['28D','E1D','355']
           ì           # attach them to the same list
                       # EXAMPLE: ['2E3','815','DD5','28D','E1D','355']
            H          # convert from base 16 to base 10
                       # EXAMPLE: [739, 2069, 3541, 653, 3613, 853]
             D         # duplicate
                       # EXAMPLE: [739, 2069, 3541, 653, 3613, 853],[739, 2069, 3541, 653, 3613, 853]
              p        # check first copy for primality
                       # EXAMPLE: [739, 2069, 3541, 653, 3613, 853],[1,1,1,1,1,1]
               s2›     # check that each in second copy is larger than 2
                       # EXAMPLE: [1,1,1,1,1,1],[1,1,1,1,1,1]
                  *    # pairwise multiplication
                       # EXAMPLE: [1,1,1,1,1,1]
                   P   # product (1 if all were primes larger than 2, else 0)
                       # EXAMPLE: 1
                    —  # if 1, print y
                       # EXAMPLE: 2E3815DD5