Is it theoretically possible to create an aircraft like this?
The idea has been tried. This WWII aircraft is built around the idea very much like yours: engine in the main fuselage, pilots/passengers in the nacelle. 

It must be reasons to choose this design. The design requirements were:


One engine.
Crew one or two 
Best possible view into to all sides
(reconnaissance aircraft).


For the passenger aircraft as pictured it is probably just not optimal.