Can a view limiting device be used in an aircraft requiring two pilots?
There is no regulation against doing so provided that the third person in the cockpit is type rated for PIC privileges on the aircraft and has a waiver from the FAA to operate the aircraft as a single pilot (they are available with some additional training.)  In practice, this would almost never occur both for safety reasons and cost.  In addition full motion simulators are available for most aircraft type rated for a two person flight crew, so it would just be more feasible to carry out the training in one of these using simulated IMC, which is arguably more realistic and accurate than flying the real thing under the hood.