What are the most efficient layouts of multiple runways?
In order to increase the number of operations that can be handled at a runway, you want them configured so as to allow "simultaneous independent approaches," which means that the 2 (or more) runways can be operational without the need to coordinate between them. 

The biggest factor is the distance between the two runways. The greater the distance between them, the less impact they have on each other, not just in terms of number of operations per hour, but also in terms of visibility minima for instrument approaches.

The other factor that needs to be considered is the wind, and as you can see from the Chicago airport layout, there are parallel groups of runways that effectively form a triangle, such that there is never a crosswind component that exceeds 30 degrees. The layout at Las Cruces, NM, which is usually very windy, shows the format better than Chicago, even though they are single runways:



The last issue is the type of radar available, and the faster the radar sweep, the less delay there is between the position of the aircraft and their depiction on the radar screen, allowing the controllers to closely monitor the approaches.