Can trimmer and throttle be used for controlling large aircraft
To some extent, yes. There was United Airlines Flight 232 in which catastrophic failure in the tail engine destroyed all the hydraulic lines. The plane was crash-landed in Sioux City, Iowa after the pilots controlled the aircraft using only the two intact wing engines. The trimmer might not produce as large as an effect on larger aircraft as on smaller ones; control of the engines would be enough because they affect the aircraft more than the trimmer due to their thrust.

However, if the damage is so severe that a control surface is destroyed or locked into a certain position, the engines might not be able to counteract that.