Would an F-15 or similar stand in be able to continue flight at high speed if it lost its canopy?
Several F15's have had incidents of canopy loss, and all the ones I have found came back and landed safely. The latest incident I can find was in 2014 off Okinawa. I see no reason why there would be any such catastrophic failure of anything on the aircraft unless the canopy impacted some part of the aircraft as it departed. Ejection systems are designed to allow the crew to exit the aircraft at pretty much the entire flight envelope. Yes, at supersonic speeds the crewmember will probably be sore for quite some time, but it's been tested and used in real life and it works.