Is 1 propeller always more efficient than 2?
Ducts are only used for highly loaded propellers of a very small radius, namely the fan stage of turbofan engines. For lower disk loadings a shroud or duct would create more friction drag than it saves in efficiency.

If the tip Mach number of the propeller is low enough (say below Mach 0.9), then the single propeller of maximum diameter will be the most efficient way to create thrust. This condition is met when both flight speed and thrust per propeller disk area (disk loading) are low.

As the aircraft gets faster, the tip Mach number can best be limited by reducing the propeller diameter. Now more blades will be needed in order to create the desired thrust, and interference between them will reduce efficiency. Also, the higher disk loading will result in more swirl losses, and now it becomes attractive to run a second, counter-rotating propeller behind the first. The two can be either close together or - even better - on opposite ends of the aircraft.