How A330-200 or 243 would be much safer under the ETOPS terms?
ETOPS (Extended Twin Operations - at least that’s what it used to be called) is a set of rules comprising of flight planning, flight operations, aircraft maintenance, flight training and administrative procedures which are geared towards making aircraft operations safe in those regions where diversion airfields are not easily found, e.g. when crossing large oceans.

When these rules are obeyed (i.e. when operating under ETOPS), that should make flying very safe.