Have any aircraft ever been attacked by chemical, biological, radiological or nuclear weapons? Information security compromises?
What immediately comes to mind is the Lockheed XF-90, an early US jet fighter, which had a very strong and heavy airframe. For that reason, the second prototype (of only two ever built) was subjected in 1952 to three nuclear bomb tests in the Nevada desert (not in flight, however. It was sitting on the ground).

At this time, an unguided nuclear-armed air-to-air missile, the Douglas AIR-2 Genie, was developed and tested once in 1957. Several USAF officers were standing below the test spot, but no aircraft were used as targets. The missile was fired by an F-89 Scorpion and could be carried by the F-101, the F-104 and the F-106.

The purpose of the AIR-2 was to attack tight formations of Tupolev Tu-4 bombers in the days before guided SAM missiles were available.

I am sure the Russians had their own score of nuclear tests on aircraft, but I do not know anything specific.