Can large airliners be operated without ground support?
There's a good example which is the A319 LR which flies scientists down to Antartica. They utilize (very) little ground support, except for the stairs (they seem to have inbuilt ones in the front as well, although these are not used on site) and the trucks to offload the cargo. APU provides the power on the ground, and the aircraft has sufficient juice in the tanks to make the round trip without refuelling.


(source: smh.com.au)  

You can read up on it here. She does weekly flights from Hobart to Wilkins aerodrome in Summer. 4 hours and 30 minutes of flying right into the uninhabited :)