Why is flying in a slip uncomfortable?
A slip is uncoordinated flight and this shifts the effective gravity vector you experience.  Passengers in the back are also at a disadvantage without a visual horizon in front of them.  This can induce a mismatch between what the passengers can see versus what they are physically experiencing.  In some people this can cause discomfort and potentially vertigo.

Other discomfort can be psychological in nature that the airplane isn't behaving how they expect.  Passengers expect if a plane isn't turning that the wings are level.  If you are flying when the plane lands in a crosswind with a slight bank and touching down with one main gear, then the other main gear, many passengers will comment that the landing was incorrect because the main gear didn't all touch down together and the pilot was flying "sideways".  They don't realize the wind requires this technique and that the landing was in fact correct.  The perception of things not being right, however, can cause discomfort in some passengers.