Is it posible for an android user to set up a work and personal profile and isolate whatsapp to personal profile
Yes this is possible.  You can do that with Island (and the released official version) is now available on Google playstore. 

"Island" is a sandbox environment to clone selected apps and isolate them from accessing your personal data outside the sandbox (including call logs, contacts, photos and etc) even if related permissions are granted. Device-bound data is still accessible (SMS, IMEI and etc).

How does it work


  Island takes advantage of the "managed profile" feature on Android
  5.0+, which is the also the base of "Android for Work", to create an isolated sandbox for apps and their data. App needs to be cloned in
  Island first. Afterwards, the clone can run parallel aside from the
  original one. (even with different accounts signed-in) It can be
  frozen on demand by Island. (NO ROOT REQUIRED)


 

The goal of Island to improve security by isolating an application thus improving privacy at the same time allowing parallel running with those from "mainland"