Restore Note 4 on factory settings
Turn off the phone,. Once fully off hold volume down and power, it will bring you to the recovery menu, using the volume buttons navigate the menu and use power as your enter button, should have reset to factory or wipe user data as a option.  Not sure if it will need a on-screen button press but only other way is from that recovery menu you would be able to flash the partitions via adb or if you unlocked your bootloader it would auto wipe the user partition. Which doesn't need on screen confirmation.  But there are your options.