Is it possible to disable Google Play indefinitely?
With ICS and up (i.e. Android 4.0+), or if you consider rooting your device, there is something else you could do:


Freeze the MarketUpdater using Androids Manage Applications (ICS and up) -- or, before ICS, e.g. TitaniumBackup
optionally uninstall all updates to the Playstore app


Alternatively, maybe even better (depending on the version of Market/Playstore app pre-installed on your device) -- but requires root (as the Legacy Play Store needs to be installed as system app):


Freeze the MarketUpdater as above
Freeze the Playstore app along =:-0
Install Legacy Play Store instead :-)


No more updates (as that Legacy Play Store won't be updated -- it's an older version of the Playstore/Market app, patched to be used in parallel to the recent version; it has some features which were removed from the current versions), and a less-overloaded Playstore app are the results.