Xposed framework greyed out. Should I be concerned?
I used Xposed some time ago and as far I can remember those buttons are grayed out because on marshmallow (possibly lollipop) you must flash framework files via .zip file. Maybe I'm wrong and forgot something. 
Are you sure it happened recently, that it wasn't there all the time?
However I don't think you should be concerned because Xposed and it's modules work fine (right?).
It says "Xposed framework 85 is active"