Is Virginia creeper safe to eat?
Virginia Creeper can be toxic if eaten. Both the leaves and berries should be considered poisonous and not eaten.

According to poison.org:


  Although they are pretty, Virginia creeper and wisteria can be harmful if they are chewed or swallowed. Both plants can cause mouth pain, nausea, vomiting, and diarrhea and should not be eaten.


Both the berries and leaves contain oxalate. While not everyone may have a severe reaction, it's difficult to predict when a reaction may happen, and thus it's best to never eat Virgina creeper.

Since you mention rhubarb in your question, rhubarb contains oxalate in it's leaves at toxic levels, only the rhubarb stalks are safe to eat. Rhubarb stalks do still have oxalate, but at lower concentrations, reducing the chance of illness or death.