To make Gluten free pancakes, can I just substitute regular flour with Gluten free flour?
It depends on what you mean by gluten-free flour. If you are buying a gluten-free flour mix that it labeled for all-purpose use then you should be able to substitute that and get a reasonably good result. Substituting straight rice or almond flour in a standard recipe will not work well, because the mixes have a blend of ingredients designed to make it perform similar to flour. 

It may take some recipe/flour experimentation to get it as close to what you are used to, but will definetly make something edible. There are also various almond-flour based pancake recipes which work well.