Chocolate Cream Pie using coconut cream or Coconut milk?
Yes. I made a coconut cream pie this weekend using coconut milk.

Cream pies are set mostly by starch with help from the eggs.

The protein in the milk does not play a significant role in the pie structure. The fat from the milk is important to the texture. Pies made with whole milk are much more delightful than those made with skim.

Coconut milk, and especially coconut cream, has plenty of delightful fat and works well. You may find that the color is different and more translucent. Many recipes call for a mixture of coconut milk and regular milk.