Clarified Butter for Hot Sauce?
Assuming you mean something like a wing-sauce when you say hot sauce (where butter is added to pepper sauce near the end of the recipe): 
It would make only a slight difference, and many tasters will find no flavor difference. A clarified butter is a butter with milk solids and water removed---it changes the richness to some extent, but this will be mostly masked by the pepper sauce. The hotter and sharper the pepper sauce, the less the flavor of rich butter comes through.

If the recipe calls for a mild pepper sauce and large amounts of butter, then it may boost the flavor of the final sauce.