Is it possible to use Arduino PWM for audio within a PAM8493 amplifier?
Are you using a basic Arduino board (not I2S) and a sampling frequency of 8&nbsp;kHz or 16&nbsp;kHz? That could interfere with the default switching frequency of 260&nbsp;kHz. 

My suggestion is to use a low pass RC filter.
You might have to lower the signal level from the Arduino.
The PAM8403 requires a series capacitor and resistor at the input (those are probably already on the amplifier module).
In the end you probably need a voltage divider with a capacitor to ground for each channel.

I don't know if your PWM library has volume control. The TMRh20 has a function to set the volume.

The overall quality will be reasonable, but not very good. There are MP3 shields that can play mp3 files from a SD memory card. Those have better quality.

[ADDED]
I think I have misunderstood your question. Sorry. I'm still not sure that I understand your question now.

Wiki of DFPlayer Mini: DFRobot:DFPlayer Mini
Code on Github for DFPlayer Mini: Github:DFPlayer Mini
The PAM8403 has no volume control, you need to adjust the audio signal that is going to the PAM8403 module.
The DFPlayer Mini code has functions for volume, volumeUp, volumeDown and readVolume. However, it does not seem to have a function to select a specific file.

The Adafruit Music Maker shield is in two versions, one has an amplifier onboard: Adafruit:Music Maker MP3 Shield for Arduino w/3W Stereo Amp - v1.0. With that shield, you can play a file by its name. It can also set the volume. I suppose that is what you want ?