MEGA I2C and interrupts on 0,1
No, there is nothing you can do.

Both the SCL pins and both the SDA pins are physically connected together by copper tracks. They are in effect the same pin. If you use I2C you can't use INT0 or INT1. You have INT2 and INT3 though (pins 18 and 19), as well as Pin Change Interrupts on a large number of other pins.