Connect to more than one Arduino with Adobe AIR
This seems to be possible with as3Glue as per the docs:

as3Glue is an ActionScript 3 library that enables communication between Flash/Flex/AIR applications and Arduino boards. It can together with one or several Arduino boards be used to monitor sensors (such as rotary encoders and motion detectors), control actuators (such as LEDs and motors) and interface other electronics (such as RFID readers) from Flash, Flex and AIR applications.

as3Glue can be used with as3-arduino-connector as mentioned in the docs:

Using with as3Glue
Download either the SWC or Source Code from the Downloads section of this project for a patched version of as3Glue. This patched version has the exact same interfaces as v20, with a notable exception of the constructor. When you instantiate a new &quot;Arduino&quot; object, replace the IP address and port with the COM port and baud rate. For example :
public var myArduino:Arduino = new Arduino(&quot;COM10&quot;, 57600);