HTU21 on GY-21 breakout board I2C problem
Yes the setup runs completely. I found out that the bus hangs if I terminate communication by uploading new code to the board. I found a piece of code that releases the bus which works. See below:

#if defined(TWCR) &amp;&amp; defined(TWEN)
  TWCR &amp;= ~(_BV(TWEN)); //Disable the Atmel 2-Wire interface so we can control the SDA and SCL pins directly
#endif

  pinMode(SDA, INPUT_PULLUP); // Make SDA (data) and SCL (clock) pins Inputs with pullup.
  pinMode(SCL, INPUT_PULLUP);


  boolean SCL_LOW = (digitalRead(SCL) == LOW); // Check is SCL is Low.
  if (SCL_LOW) { //If it is held low Arduno cannot become the I2C master.
    return 1; //I2C bus error. Could not clear SCL clock line held low
  }

  boolean SDA_LOW = (digitalRead(SDA) == LOW);  // vi. Check SDA input.
  int clockCount = 20; // &gt; 2x9 clock

  while (SDA_LOW &amp;&amp; (clockCount &gt; 0)) { //  vii. If SDA is Low,
    clockCount--;
    // Note: I2C bus is open collector so do NOT drive SCL or SDA high.
    pinMode(SCL, INPUT); // release SCL pullup so that when made output it will be LOW
    pinMode(SCL, OUTPUT); // then clock SCL Low
    delayMicroseconds(10); //  for &gt;5uS
    pinMode(SCL, INPUT); // release SCL LOW
    pinMode(SCL, INPUT_PULLUP); // turn on pullup resistors again
    // do not force high as slave may be holding it low for clock stretching.
    delayMicroseconds(10); //  for &gt;5uS
    // The &gt;5uS is so that even the slowest I2C devices are handled.
    SCL_LOW = (digitalRead(SCL) == LOW); // Check if SCL is Low.
    int counter = 20;
    while (SCL_LOW &amp;&amp; (counter &gt; 0)) {  //  loop waiting for SCL to become High only wait 2sec.
      counter--;
      delay(100);
      SCL_LOW = (digitalRead(SCL) == LOW);
    }
    if (SCL_LOW) { // still low after 2 sec error
      return 2; // I2C bus error. Could not clear. SCL clock line held low by slave clock stretch for &gt;2sec
    }
    SDA_LOW = (digitalRead(SDA) == LOW); //   and check SDA input again and loop
  }
  if (SDA_LOW) { // still low
    return 3; // I2C bus error. Could not clear. SDA data line held low
  }

  // else pull SDA line low for Start or Repeated Start
  pinMode(SDA, INPUT); // remove pullup.
  pinMode(SDA, OUTPUT);  // and then make it LOW i.e. send an I2C Start or Repeated start control.
  // When there is only one I2C master a Start or Repeat Start has the same function as a Stop and clears the bus.
  /// A Repeat Start is a Start occurring after a Start with no intervening Stop.
  delayMicroseconds(10); // wait &gt;5uS
  pinMode(SDA, INPUT); // remove output low
  pinMode(SDA, INPUT_PULLUP); // and make SDA high i.e. send I2C STOP control.
  delayMicroseconds(10); // x. wait &gt;5uS
  pinMode(SDA, INPUT); // and reset pins as tri-state inputs which is the default state on reset
  pinMode(SCL, INPUT);
  return 0; // all ok
}


Thanks for pointing me in the right direction!