Project Euler # 20 factorial digit sum in Python
The standardlibrary module math already contains a factorial function. On my machine it is about 20 times faster than your function using n = 100. It also does not suffer from stack size limitations as yours does (try computing fact(3000)).

Alternatively you could learn about memoizing, which will help you in many Project Euler problems. Here it would be useful if you had to evaluate the factorial of many numbers (and even better if the numbers are increasing).

from functools import wraps

def memoize(func):
    cache = func.__cache = {}

    @wraps(func)
    def wrapper(*args, **kwargs):
        key = args, frozenset(kwargs.items())
        if key in cache:
            ret = cache[key]
        else:
            ret = cache[key] = func(*args, **kwargs)
        return ret
    return wrapper


@memoize
def fact(n):
    ...


Note that this decorator only works if your arguments are hashable (so no lists for example).



Since getting the sum of the digits of a number is something you will regularly need for Project Euler problems, you should make it a function on its own, which you put in a utils module, to be reused later:

def digit_sum(n):
    """Return the sum of the digits of `n`"""
    return sum(map(int, str(n)))


This will also be faster than your manual for loop or a list comprehension. Not by much, but it is measurable for very large numbers:

def digit_sum_list_comprehension(n):
    return sum(int(x) for x in str(n))

def digit_sum_for(n):
    total = 0
    for digit in str(n):
        total += int(digit)
    return total