Building complex sentences based on a data structure
Remove the last item

You are not going to avoid the stepping over each item at least once. However the replace and be avoided by removing the last item.

One iteration

Use a for loop,  building the string as you step over each item. Before the loop pop the last item, then after the loop push it back to keep the array intact.  You can then add the last item after the conjunction.

I will use options rather than alternatives as in the bottom example it is more semantically fitting.

function toHumanReadable(options) {
    const toStr = opt =&gt; `"${Array.isArray(opt) ? `${opt[0]}" with "${opt[1]}` : opt}"`;
    const last = options.pop(); 
    var res = 'Consider using ';
    for (const opt of options) { res += toStr(opt) + ', ' }
    options.push(last);
    return res + `or ${toStr(last)} instead.`; 
}
const alt1 = [ "flex", "float" , ["background-size", "background-image" ] ];
const readable = toHumanReadable(alt1);


or you can make options an argument array, and don't need to push the last item back onto the array. It does mean an extra iteration.

function toHumanReadable(...options) {
    const toStr = opt =&gt; `"${Array.isArray(opt) ? `${opt[0]}" with "${opt[1]}` : opt}"`;
    const last = options.pop(); 
    var res = 'Consider using ';
    for (const opt of options) { res += toStr(opt) + ', ' }
    return res + `or ${toStr(last)} instead.`; 
}

const alt1 = [ "flex", "float" , ["background-size", "background-image" ] ];
const readable = toHumanReadable(...alt1);


Reusable

I am guessing this is just one of a many similar human readable strings. To make the function reusable you can add some arguments

The next version requires two iterations, but does not need the replace. This time the last item is popped from a copy of the options array and the conjunction is added via joining the joined options and the last option.

function toHumanReadable(options, open, close, conjunction) {
    options = options.map(opt =&gt; Array.isArray(opt) ? opt.join('" with "') : opt);
    const last = options.pop();
    return `${open} "${[options.join('", "'), last].join(`", ${conjunction} "`)}" ${close}`;
}

const alt1 = [ "flex", "float" , ["background-size", "background-image" ] ];
const readable = toHumanReadable(alt1, "Consider using", "instead.", "or");


Example usage



setTimeout(()=&gt; { // just for snippet to put relevant code at top

  const alt1 = [ "flex", "float" , ["background-size", "background-image" ] ];
  const alt2 = [ "foo", ["bar","poo"], ["min-width", "max-height" ] ];
  log(toHumanReadable(alt1, sentenceTypes.anyOf));
  log(toHumanReadable(alt2, sentenceTypes.oneOf));
  log(toHumanReadable(alt1, sentenceTypes.allOf));   
},0);

function toHumanReadable(options, {open, close, conjunction}) {
    options = options.map(opt =&gt; Array.isArray(opt) ? opt.join('" with "') : opt);
    const last = options.pop();
    return `${open} "${[options.join('", "'), last].join(`", ${conjunction} "`)}" ${close}`;
}

const sentenceTypes = {
   create(name, open, close, conjunction) { this[name] = {open, close, conjunction} }
};
sentenceTypes.create("anyOf", "Consider using", "instead.", "or");
sentenceTypes.create("oneOf", "Use any one of", "to stay consistent.", "or");
sentenceTypes.create("allOf", "All the following", "are required.", "and");
function log(t){txt.appendChild(Object.assign(document.createElement("div"),{textContent:t}))}
body {
font-family: arial;
font-size: small;
}
&lt;div id="txt"&gt;&lt;/div&gt;