Search set, return item
If all your queries are similar to the example, you would obviously benefit from storing the data in a dict where a tuple of two values is the key, and the value is a list of ints -- all of the third items that share the same key.

from collections import defaultdict

stuff_dict = defaultdict(list)
for t in stuff_tuple:
    stuff_dict[t[:2]].append(t[2])

for item in stuff_dict['hello', 241]:
    print item