Improving Lottery Simulation
It's more of a style preference, but instead of the paragraph with if and elif's, I would do

winnings += payouts_dictionary[numb_wins]


where

payouts_dictionary = {6: WIN_SIX, 5: WIN_FIVE, 4: WIN_FOUR, 3: WIN_THREE, 2: 0, 1: 0, 0: 0}


is defined as a constant before the loop.