Variant of 2-SUM Problem using Hashtable with multi-threading
functions

split the work you want to do in logical functions. I try to limit the work that is done in the general script (and thus the global namespace) as much as possible. Lookups of local variable are supposed to be faster, but it make the code easier to read and test as well, so win-win.

hashing

Why device your own hashing? just dumping all the numbers in a set will eliminate all the duplicates, and 1M integers is a limited amount of memory. Certainly a lot less that the defaultdict you use

global variable ans

Instead of passing the global variable ans, the easiest way would be to use the fact that in a numeric context (like sum), True equals 1 and False equals 0, so you can just return True or False in two_sum_present

my take on this:

read the file

Using the fact that a file is an iterator, I would do something like this

def read_file(filename):
    with open(filename, 'r') as file:
        return set(map(int, file))


find the target

About the same as your two_sum_present with my remarks incorporated

def find_target(numbers, target):
    for i in numbers:
        if target - i in numbers and 2 * i != target:
            return True
    return False


iterate over the interval

def find_sums(numbers, start=-10000, end=10000):
    for target in range(start, end + 1):
#         print(target)
        yield find_target(numbers, target)


putting it together

def main(filename, start=-10000, end=10000):
    numbers = read_file(filename)
#     print(f'numbers found: {len(numbers)}')
    return sum(find_sums(numbers, start, end))

if __name__ == '__main__':
    filename = 'data/_6ec67df2804ff4b58ab21c12edcb21f8_algo1-programming_prob-2sum.txt'
    print(main(filename, -100, 100))


All in all, it took 43 seconds to scan those 201 numbers on my system, to find 5 matches. Reading the file took about .6s of that time

This solution is essentially the same as sum(any(n-x in numbers and 2*x != n for x in numbers) for n in range(-100, 101)), but that one took 59s

Multithreading

If you want to, you can divide out all the call to find_target to different workers/cores/... In this case, a frozenset instead of a set might be more appropriate since it's immutable, and will give less problems with concurrency

distinct

As noted by Gareth Rees, the original question is ambiguous on what is mean with distinct numbers x,y. To cover the second interpretation, You can change the set to a collections.Counter, and change the test criterium slightly

from collections import Counter

def read_file_distinct(filename):
    with open(filename, 'r') as file:
        return Counter(map(int, file))

def find_sums_distinct(numbers, start=-10000, end=10000):
    for target in range(start, end + 1):
#         print(target)
        yield find_target_distinct(numbers, target)

def find_target_distinct(numbers, target):
    for i in numbers:
        if target - i in numbers and (2 * i != target or numbers[i] &gt; 1):
            return True
    return False

def main_distinct(filename, start=-10000, end=10000):
    numbers = read_file_distinct(filename)
#     print(f'numbers found: {len(numbers)}')
    return sum(find_sums_distinct(numbers, start, end))


This has an effect on speed, though


%timeit main(filename, -10, 10)



4.51 s ± 32.5 ms per loop (mean ± std. dev. of 7 runs, 1 loop each)



%timeit main_distinct(filename, -10, 10)



6.42 s ± 48.4 ms per loop (mean ± std. dev. of 7 runs, 1 loop each)


distinct 2

A slightly different, faster approach can be used to tackle the 2nd interpretation

def find_sums_distinct2(numbers, repetitions,start=-10000, end=10000):
    for target in range(start, end + 1):
#         print(target)
        yield find_target_distinct2(numbers, repetitions, target)

def find_target_distinct2(numbers, repetitions, target):
    for i in numbers:
        if target - i in numbers and (2 * i != target or i in repetitions):
            return True
    return False

def main_distinct2(filename, start=-10000, end=10000):
    numbers = read_file_distinct(filename)
    repetitions = {k for k, v in numbers.items() if ((v &gt; 1) and (start &lt; k &lt; end))}
#     print(repetitions)
    numbers = set(numbers)
#     print(f'{len(numbers)} numbers found, {len(repetitions)} repetitions')
    return sum(find_sums_distinct2(numbers, repetitions, start, end))



%timeit main_distinct2(filename, -10, 10)



4.92 s ± 160 ms per loop (mean ± std. dev. of 7 runs, 1 loop each)