Python file with several function definitions
In case the number of arguments is really long then you can use **kwargs to avoid cluttering up arguments in function definition block. I would also avoid naming the function as "main" and replace it with something like "execute".

def execute(**kwargs):
  name = kwargs.get('name', 'Bill')
  # get other values
  pass

if __name__ = "__main__":
  execute(*sys.argv[1:])