Create directories for outputs based on setting
Any time there's a repeating pattern that's very obvious like this you
might consider using another loop, or a function, or some other
abstraction mechanism available.  To me this also looks like example
code - please post the actual code you're using!

So first a few comments:


x is True isn't very idiomatic unless you really want to check for
specifically one of the true values, True.  Otherwise just write
that as x (keeping in mind that some values like the empty tuple or
list are actually falsy.
Some expressions are repeated in the if test and the body of the
if - in those cases you likely want to have a variable to only
evaluate the expression once for better readability.
Consider using some functional idioms like
map to make
the code more succinct too.
Take a look at PEP8 for
variable naming - in Python it's usually
snake case.


So how with that said, how could this all look like?

for path in map(os.path.dirname, file_path_list):
    x = os.path.join(path, settings['outputDirNameOut1'])
    if not os.path.exists(x):
        os.makedirs(x)

    y = os.path.join(path, settings['outputDirNameA'])
    if settings['A'] and not os.path.exists(y):
        os.makedirs(y)

    z = os.path.join(path, settings['outputDirNameB'])
    if settings['B'] and not os.path.exists(z):
        os.makedirs(z)

    a = os.path.join(path, settings['outputDirNameC'])
    if settings['C'] and not os.path.exists(a):
        os.makedirs(a)
        os.makedirs(os.path.join(path, settings['outputDirNameOut2']))

    b = os.path.join(path, settings['outputDirNameOut2'])
    if settings['D'] and not os.path.exists(b):
        os.makedirs(b)


Now you just have to come up with more sensible variable names.  Also I
have the feeling that the double makedirs in the fourth case is a
copy&amp;paste error?

Going with that assumption this can be simplified further:

names = ['outputDirNameOut1', 'outputDirNameA', 'outputDirNameB',
         'outputDirNameC', 'outputDirNameOut2']
dirs = [settings[name] for name in names]
for path in map(os.path.dirname, file_path_list):
    for dir in dirs:
        x = os.path.join(path, dir)
        if not os.path.exists(x):
            os.makedirs(x)


At that point I can't see any more obvious changes.



Edit: That assumption doesn't hold and I also skipped some part of the
logic.  Therefore I'd suggest writing and using a local function:

def foo(name):
    x = os.path.join(path, settings[name])
    if not os.path.exists(x):
        os.makedirs(x)

for path in map(os.path.dirname, file_path_list):
    foo('outputDirNameOut1')

    if settings['A']:
        foo('outputDirNameA')

    if settings['B']:
        foo('outputDirNameB')

    if settings['C']:
        foo('outputDirNameC')
        foo('outputDirNameOut2')

    if settings['D']:
        foo('outputDirNameOut2')