Regexes for Google App Engine
Have you considered using named Route templates instead of capturing regular expressions? It could make the code more readable. Consider

Route("/task/refresh-user/&lt;username&gt;", RefreshUserHandler)


instead of

(r'/task/refresh-user/(.*)', RefreshUserHandler)


for example. (Of course, I don't know what kwargs RefreshUser actually wants, but you can change the angle-bracketed part to the appropriate name.)