Letter-scoring Scrabble class
Some comments:


score method: With functional - instead of imperative - style, you'll get write more compact code.
You may use the abstraction Hash#values_at.
letter_scores is constant. It can be a class constant, then.
String interpolation: Use "#{var} = #{value}" style.
[edit] As you say, word should be an argument of score, not the class initializer.


I'd write:

class Scrabble
  LETTER_SCORES = {...}

  def score(word)
    scores = LETTER_SCORES.values_at(*word.upcase.chars)
    scores.compact.reduce(0, :+)
  end
end

scrabble = Scrabble.new
puts("Type in one word for scrabble scorer:")
word = gets.strip
puts("Scrabble score for #{word} is #{scrabble.score(word)}")