Python Word Jumble Game
In general this codes looks pretty good.  A couple of nits.
The Python Library is Huge:
I would suggest replacing the while word: loop block:
while word:
    position = random.randrange(len(word))
    jumble += word[position] # Jumble process 1
    word = word[:position] + word[(position + 1):] #Jumble process 2

With a library call like:
jumble = ''.join(random.sample(word, k=len(word)))

Main loop:
By using a break inside the main loop, it can be restructured to remove some extra code like:
while True:
    print('\nThe Jumble is:', jumble)
    guess = input('Your Guess: ')
    if guess == word:
        print(&quot;\nThat's it! You guessed it!\n&quot;)
        print('Thanks for playing')
        break
    
    print(&quot;Sorry, that's not it&quot;)

This removes an extra comparison and input()
Comments:
I am not a fan of right hand style comments.  I generally prefer a needed comment to proceed the line/block it is commenting.  You used reasonably descriptive variable names, I don't know that anything other than the header comment is providing much value.