Python 2.7 Powerball Game
Conditions

if ((one or two or three or four or five) &gt; 69)


one or two will return one if it isn't falsy (0 / None / False), you should use separate conditions, like so :

if (one &gt; 69 or two &gt; 69 or three &gt; 69...)


alternatively, you could just check the maximum value of your list

if (max(one, two, three, four, five) &gt; 69)


The same problem occur in this part : 

elif choice != ('R' or 'P')


it should be elif choice not in ('R','P')
variable names

instead of writing 

m=0#matches


directly use the variable matches, your code will be easier to understand
loops

for i in range(0,5): #If you only get normal numbers, no powerball.
    if human[i] in real:
      m += 1
    i += 1


you don't need to increase i in a for loop, it is done automatically
code structure

in the powerball function, you have the following blocks:

if powerball:
    price = 4

for i in range(0,5):#no powerball
...
for i in range(0,5):#yes powerball
    if powerball and human[i] == real:
        ...


You should change that in a if/else structure with the if powerball while counting the number of corresponding number outside : 

matches = 0
price = 0

for i in range(0,5):
    if human[i] in real:
        matches+=1

if human[5] == real[5]:# with powerball
    if matches == 0:
        price = 4
    elif matches == 1:
        price = 4
else:# without powerball
    if matches == 3:
        price = 7
    elif matches == 4:
        price = 100

multiple elif for variable assignation

(I don't know if this one is considered good practice, but it's faster to use and to add case)
instead of writing multiple elif, try to use a dictionary :

prices_for_matches = { 3 : 7,
                       4 : 100,
                       5 : 1000000}
if matches in prices_for_matches:
    price = prices_for_matches[matches]
else:
    price = 0



note i don't know much about powerball, but your solution doesn't care about the order of the balls (human[i] in real instead of human[i] == real[i]) or if the user selected multiple times the same number