CiviMail: How can I retarget the non-opens and/or non-clicks in CiviCRM?
While we dont use it for privacy reasons it should be perfectly doable. Reports usually have the option to add its resulting contacts to a group.

If you dont mind german here is a screenshot from a mailing report for demo mailing with tracking:



Each link provides a report/search with a selected subset of contacts.

Additionally you can use the extended search to define your target group however you like and create groups or smart groups from there.