Error when upgrading to 4.6.9 on Drupal 7
Errors such as 'No such file or directory' or 'Failed to open resource' normally suggest that CiviCRM couldn't find certain files where it was expecting to.

The first thing to check is that all your CiviCRM files have been put in the correct place according to the installation/upgrade documentation; and the configuration in your settings file.

This was answered by Hershel and in this case CiviCRM had been unpacked into a sub-directory.