Mandrill - webhooks for two different sites?
If you must use the same account on both environments, Drupal/CiviCRM hooks could potentially support this? (All of this answer is likely more work than just using the provider's supported test mode, though!)

You can pick any hook that fires before Mte.callback gets fired, and trigger rejection / invalidation based on any of the incoming data including the secret key or contact details in the request.

CMS boot hooks (eg Drupal hook_init) or CRM config hook (hook_civicrm_config) happen early but on many requests so will add overhead; if possible I'd do this as late and specifically as possible - hook_civicrm_apiWrappers could be just the ticket if it works for this usage? Alternatively you could just throw some interception in settings.php / civicrm.settings.php / environment-specific settings.development.php.

If the secret keys aren't suitable, you could look for test-specific properties of the submitted contact data.

That might look like,

// Lives in settings.php so it's not in your committed code.
$mandrill_secrets = [
  'development' =&gt; 'devkey',
  'production' =&gt; 'livekey'
];


Boot time: obtain current environment, put in $environment:


Drupal environment module
strpos($_SERVER['SERVER_NAME'], '.demo.example')
Whatever you want to use ...


Before CiviCRM has a chance to respond to civicrm/ajax/mte/callback: If the supplied secret doesn't match the current environment, unset it or make it invalid.

if (isset($_GET['mandrillSecret']) &amp;&amp; $_GET['mandrillSecret'] != $mandrill_secrets[$environment]) {
  $_GET['mandrillSecret'] = 'invalid';
}