Predict file size of a Huffyuv codec video stream
The answer is No. Besides the frame dimensions, there's the matter of content complexity. Without scanning the video and doing a first-pass as it were, it's not possible to predict the output size. A video consisting of a slideshow of very simple text slides will be much easier to compress than scenes of busy city life..etc.

The closest you may come to making some sort of prediction is to encode a few representative segments from the source file and compare those bitrates. If there isn't a large difference among the bitrates of the various encoded segments, then you may assume a bitrate in that range for the final output. Of course, this method can't account for anomalous segments in the video of very high or low complexity compared to the rest of it, so sample selection is important.