How Was This Isometric Vector-looking Video Made?
As this is mostly hand drawn animated vector graphics you could do these kind of videos in most 2D animation software. Lighting in this case isn't rendered by the program but painted by the artist.
In most cases this would be done in Adobe After Effects as it offer very sophisticated timeline animation tools and works very well with vector graphics. There are also still quite a few people using Adobe Flash for these kind of animations.

You are not limited to these two software options though, you can definitely do this in Apple Motion or Sony Vegas aswell.

An artist would draw the single elements for the video in a vector graphics program like Illustrator or Inkscape and then these would be animated in a 2D animation software package like mentioned above.

You might want to have a look at this article from the maker of this specific video, it explains the design process quite well: https://www.behance.net/gallery/CBRE-Animated-Infographics/15921655