Help with composition of a movie shot - direction of character's eyes
Shot 1 makes the most sense. In shot 1, your camera doesn't "cross the line" between the two characters. (That's an important cinematography rule; audiences unconsciously expect it.) Here's the easy way to apply this rule to a scene with 2 characters:

The character on the left of the frame in the wide shot should always be looking towards the right of the frame, and should keep looking towards the right of the frame in close ups and over-the-shoulder shots. (The opposite applies to the other character.)

Your character in red starts out on the left of the frame, and is facing the right of the frame (even though we see the back of his head). He needs to keep looking towards the right of the frame in subsequent shots in that scene. Shot 1 shows him looking towards the right of the frame, so that's the shot to use. :)