Issues with uncompressed video in edting software
The limitation is certainly the disk I/O, which at 10GB/min is outside the capabilities of all but very high-end disk subsystems. 

It's generally true that you should work at the highest bit rate and bit depth your system is capable of so you have the headroom for processing, but your system simply isn't capable of working at the rates your asking of it.

Determine what you need as the end result and pick a reasonable level above that for editorial. Uncompressed 1080p is way overkill if your target is YouTube, for example. Usually, choose an all I-frame (no interframe compression) format and a bit rate that will allow your system to handle two or three streams at once. If your disks can handle 60MBytes/s random access, it can play 3 80Mbit/s sources for compositing, and so on. That's more than needed for all but the most demanding targets.