Is there a good method for choosing which cards to use in Deluxe Illuminati?
Sometimes I use a very targeted set of cards, for example, having lots of power zero cards, in a game where the player who loves playing Cthulu gets on everybody's nerves.

You can build sets of cards geared for more income, remove all the non-group cards, and anything that comes to mind.

But I cannot be bothered. Sometimes I'll remove some cards that just seem to water down the deck, but other than that, I really do use a mechanical shuffler like LittleBobbyTables says, and then I just take the top 50-100 cards off the top, and we use those. The games end up being random enough.