Different game modes for Thunderstone
There are a number of variants listed in the rulebooks (Wrath of the Elements, in particular, has solo play and epic variants printed in it among others).  Having tried most of them out, I have to say that I still greatly prefer just the basic scenario.  In particular, the small size of the Village stacks means that any longer variants tend to turn into just grinding towards the end, as there is little purchasing one can do once the premium Village stacks are exhausted.