How can I mitigate the luck factor of drawing destination tickets in Ticket To Ride?
Find a new game. 

Taking of tickets in Ticket to Ride is supposed to be a high risk/high reward action that has the potential to lose you a significant amount of points. Once you try to mitigate an aspect of a game, you're changing how the game plays in ways that weren't intended by the designer. At this point, it's better to find a new game that more closely aligns with your board gaming preferences. There are over 82,000 games in the Board Game Geek database, and one of them is sure to have the aspects of Ticket to Ride that you enjoy while eliminating the randomness of drawing cards.

My suggestion would be Hansa Teutonica. This is also a strategy game that focuses on taking routes, but instead of taking tickets for points, you are taking actions over the course of the game. One game session should take you about the same amount of time as Ticket to Ride. Hansa Teutonica also has the benefit of multiple paths to victory, so it will have a longer shelf life than Ticket to Ride.