Can the card disintegrate destroy creatures with indestructible?
No. Disintegrate cannot kill Zetalpa, Primal Dawn. Creature with indestructible cannot be killed with damage.

Rules quote from comprehensive rules:


  702.12b A permanent with indestructible can’t be destroyed. Such permanents aren’t destroyed by lethal damage, and they ignore the state-based action that checks for lethal damage (see rule 704.5g).


Disintegrate would exile Zetalpa only if Zetalpa would die. In your case Zetalpa won't leave the battlefield.