What are the differences in strategy going first vs going second, vice versa, in Scrabble?
There's no real difference other than, if you go first, you get an advantage worth roughly 10 points (because you are starting on a double word score tile, and if you can make a 5-letter word, also a double letter score tile).
Only thing worth noting if you go first is not to give up easy double crosses on the double letter score tiles near the starting tile. For example, if your starting word is FAME, you should not play it such that the two vowels are next to the double letter score tiles.